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Biodegradable Fibers (biodegradable + fiber)
Selected AbstractsTissue Repair: Wet-Spun Biodegradable Fibers on Conducting Platforms: Novel Architectures for Muscle Regeneration (Adv. Funct.ADVANCED FUNCTIONAL MATERIALS, Issue 21 2009Mater. Bio-synthetic platforms, consisting of a conducting polymer substrate overlaid with aligned biodegradable fibers promote the linear growth (ex vivo) of partially differentiated muscle fibers, consistent with the structural requirements of skeletal muscle in vivo, as described by J. M. Razal et al. on page 3381. The conducting surface facilitates development of electrical stimulation paradigms for optimizing muscle growth and development ex vivo that may potentially be applied to repair diseased or damaged muscle. [source] Wet-Spun Biodegradable Fibers on Conducting Platforms: Novel Architectures for Muscle RegenerationADVANCED FUNCTIONAL MATERIALS, Issue 21 2009Joselito M. Razal Abstract Novel biosynthetic platforms supporting ex vivo growth of partially differentiated muscle cells in an aligned linear orientation that is consistent with the structural requirements of muscle tissue are described. These platforms consist of biodegradable polymer fibers spatially aligned on a conducting polymer substrate. Long multinucleated myotubes are formed from differentiation of adherent myoblasts, which align longitudinally to the fiber axis to form linear cell-seeded biosynthetic fiber constructs. The biodegradable polymer fibers bearing undifferentiated myoblasts can be detached from the substrate following culture. The ability to remove the muscle cell-seeded polymer fibers when required provides the means to use the biodegradable fibers as linear muscle-seeded scaffold components suitable for in vivo implantation into muscle. These fibers are shown to promote differentiation of muscle cells in a highly organized linear unbranched format in vitro and thereby potentially facilitate more stable integration into recipient tissue, providing structural support and mechanical protection for the donor cells. In addition, the conducting substrate on which the fibers are placed provides the potential to develop electrical stimulation paradigms for optimizing the ex vivo growth and synchronization of muscle cells on the biodegradable fibers prior to implantation into diseased or damaged muscle tissue. [source] Nerve Repair: A Conducting-Polymer Platform with Biodegradable Fibers for Stimulation and Guidance of Axonal Growth (Adv. Mater.ADVANCED MATERIALS, Issue 43 200943/2009) Effective functional innervation of medical bionic devices, as well as re-innervation of target tissue in nerve and spinal cord injuries, requires a platform that can stimulate and orientate neural growth. Gordon Wallace and co-workers report on p. 4393 that conducting and nonconducting biodegradable polymers show excellent potential as suitable hybrid substrata for neural regeneration and may form the basis of electrically active conduits designed to accelerate nerve repair. [source] A Conducting-Polymer Platform with Biodegradable Fibers for Stimulation and Guidance of Axonal GrowthADVANCED MATERIALS, Issue 43 2009Anita F. Quigley A biosynthetic platform composed of a conducting polypyrrole sheet embedded with unidirectional biodegradable polymer fibers is described (see image; scale bar,=,50 µm). Such hybrid systems can promote rapid directional nerve growth for neuro-regenerative scaffolds and act as interfaces between the electronic circuitry of medical bionic devices and the nervous system. [source] Tissue Repair: Wet-Spun Biodegradable Fibers on Conducting Platforms: Novel Architectures for Muscle Regeneration (Adv. Funct.ADVANCED FUNCTIONAL MATERIALS, Issue 21 2009Mater. Bio-synthetic platforms, consisting of a conducting polymer substrate overlaid with aligned biodegradable fibers promote the linear growth (ex vivo) of partially differentiated muscle fibers, consistent with the structural requirements of skeletal muscle in vivo, as described by J. M. Razal et al. on page 3381. The conducting surface facilitates development of electrical stimulation paradigms for optimizing muscle growth and development ex vivo that may potentially be applied to repair diseased or damaged muscle. [source] Wet-Spun Biodegradable Fibers on Conducting Platforms: Novel Architectures for Muscle RegenerationADVANCED FUNCTIONAL MATERIALS, Issue 21 2009Joselito M. Razal Abstract Novel biosynthetic platforms supporting ex vivo growth of partially differentiated muscle cells in an aligned linear orientation that is consistent with the structural requirements of muscle tissue are described. These platforms consist of biodegradable polymer fibers spatially aligned on a conducting polymer substrate. Long multinucleated myotubes are formed from differentiation of adherent myoblasts, which align longitudinally to the fiber axis to form linear cell-seeded biosynthetic fiber constructs. The biodegradable polymer fibers bearing undifferentiated myoblasts can be detached from the substrate following culture. The ability to remove the muscle cell-seeded polymer fibers when required provides the means to use the biodegradable fibers as linear muscle-seeded scaffold components suitable for in vivo implantation into muscle. These fibers are shown to promote differentiation of muscle cells in a highly organized linear unbranched format in vitro and thereby potentially facilitate more stable integration into recipient tissue, providing structural support and mechanical protection for the donor cells. In addition, the conducting substrate on which the fibers are placed provides the potential to develop electrical stimulation paradigms for optimizing the ex vivo growth and synchronization of muscle cells on the biodegradable fibers prior to implantation into diseased or damaged muscle tissue. [source] | ||||||||||