Biocompatible Materials (biocompatible + material)

Distribution by Scientific Domains
Polymers and Materials Science60%
Medical Sciences40%

Selected Abstracts

Biocompatible materials for bladder substitution

BJU INTERNATIONAL, Issue 9b 2008
Yuval Ben-Moshe
First page of article [source]

Silk Fibroin Waveguides: Biocompatible Silk Printed Optical Waveguides (Adv. Mater.

ADVANCED MATERIALS, Issue 23 2009
23/2009)
The cover shows an artistic rendition that merges silk and fiber optics. Supercontinuum white light is guided through a glass optical fiber that surrounds and illuminates silkworm cocoons. The silkworm cocoons shown here are used as the starting point of an extraction process to isolate pure silk fibroin protein in an aqueous solution. The silk is then reconstituted in the form of optical waveguides, as described by Fiorenzo Omenetto and co-workers on p. 2411, opening new opportunities to guide light in an entirely organic and biocompatible material. [source]

Cytotoxicity and Cell Cycle Effects of Bare and Poly(vinyl alcohol)-Coated Iron Oxide Nanoparticles in Mouse Fibroblasts

ADVANCED ENGINEERING MATERIALS, Issue 12 2009
Morteza Mahmoudi
Super-paramagnetic iron oxide nanoparticles (SPIONs) are recognized as powerful biocompatible materials for use in various biomedical applications, such as drug delivery, magnetic-resonance imaging, cell/protein separation, hyperthermia and transfection. This study investigates the impact of high concentrations of SPIONs on cytotoxicity and cell-cycle effects. The interactions of surface-saturated (via interactions with cell medium) bare SPIONs and those coated with poly(vinyl alcohol) (PVA) with adhesive mouse fibroblast cells (L929) are investigated using an MTT assay. The two SPION formulations are synthesized using a co-precipitation method. The bare and coated magnetic nanoparticles with passivated surfaces both result in changes in cell morphology, possibly due to clustering through their magnetostatic effect. At concentrations ranging up to 80,×,10,3,M, cells exposed to the PVA-coated nanoparticles demonstrate high cell viability without necrosis and apoptosis. In contrast, significant apoptosis is observed in cells exposed to bare SPIONs at a concentration of 80,×,10,3,M. Nanoparticle exposure (20,80,×,10,3,M) leads to variations in both apoptosis and cell cycle, possibly due to irreversible DNA damage and repair of oxidative DNA lesions, respectively. Additionally, the formation of vacuoles within the cells and granular cells indicates autophagy cell death rather than either apoptosis or necrosis. [source]

Tailoring Polymeric Hydrogels through Cyclodextrin Host,Guest Complexation

MACROMOLECULAR RAPID COMMUNICATIONS, Issue 3 2010
Xuhong Guo
Abstract A close correllation between molecular-level interactions and macroscopic characteristics of polymer networks exists. The characteristics of the polymeric hydrogels assembled from ,-cyclodextrin (,-CD) and adamantyl (AD) substituted poly(acrylate)s can be tailored through selective host,guest complexation between ,-CD and AD substituents and their tethers. Dominantly, steric effects and competitive intra- and intermolecular host,guest complexation are found to control poly(acrylate) isomeric inter-strand linkage in polymer network formation. This understanding of the factors involved in polymeric hydrogel formation points the way towards the construction of increasingly sophisticated biocompatible materials. [source]

Keratoprosthesis surgery: Eastern European and Russian devices

ACTA OPHTHALMOLOGICA, Issue 2009
ZF ZAGORSKI
Purpose To present the development and current status of keratoprosthesis surgery in Eastern Europe. Methods Collection of data from coauthors and other surgeons involved in k-pro surgery. Results Large numbers of surgeries were performed in Filatov's Institute in Odessa (Ukraine), where over 1000 different types of devices developed by Puchkovskaya, Yakimienko and Golubenko were imlanted since 1966. The last model, s.c. "universal separable device" was implanted in over 750 with the best results (extrusion occured in about 2.5% cases). K-pro devices in Russia were mostly developed by S. Fyodorov Z. Moroz, V. Zuyev, ?. Krasnov, V. Volkov, R. Gundorova, N. Ushakov and V. Bedilo. Over 1500 surgeries sine 1969 resulted in the visual aquity improvement in 94% of cases. Haptics were made of titanium, stainless steel and also biocompatible materials (xenopericardium). In Poland about 100 surgeries were performed using mostly Russian and Ukrainian devices. The results were less favorable than in countries of origin. Small numbers were also implanted in other East European states. Conclusion In former Soviet Union keratoprosthesis surgery was well developed in selected centers (Moscow, Odessa). Surgeons in these places have gained extraordinary experience performing hundredes of surgeries. The results presented by the authors were excellent, however they were less favorable in the hands of surgeons from other countries. [source]