Younger Groups (younger + groups)

Distribution by Scientific Domains

Selected Abstracts

Cancer Pain: An Age-Based Analysis

PAIN MEDICINE, Issue 10 2010
Carmen R. Green MD
Abstract Objective., Although cancer pain (consistent and breakthrough pain [BTP; pain flares interrupting well-controlled baseline pain]) is common among cancer patients, its characteristics, etiology, and impact on health-related quality of life (HRQOL) across the lifespan are poorly understood. Design., This longitudinal study examines age-based differences and pain-related interference in young and old patients with cancer-related pain over 6 months. Patients in the community with stage III or IV breast, prostate, colorectal, or lung cancer, or stage II,IV multiple myeloma with BTP completed surveys (upon initial assessment, 3 and 6 months) assessing consistent pain, BTP, depressed affect, active coping ability, and HRQOL using previously validated measures. Results., Respondents (N = 96) were 70% white and 66% female, with a mean age of 57 ± 10 years. There were no significant differences in pain severity based upon age. However, the younger group experienced more pain flares with greater frequency (P = 0.05). The oldest group had better emotional functioning at baseline but worse physical functioning at 6 months. Younger groups also had worse cognitive functioning at 6 months (P = 0.03). Pain interference was independent of age. Conclusions., These data provide evidence for the significant toll of cancer pain on overall health and well-being of young and old adults alike but demonstrate an increased toll for younger adults (especially financially). Beyond race and gender disparities, further health care disparities in the cancer and cancer pain were identified by age, illustrating the need for additional research across the lifespan in diverse cancer survivors. [source]

Acute ischemic stroke and transient ischemic attack in the very old , risk factor profile and stroke subtype between patients older than 80 years and patients aged less than 80 years

J. I. Rojas
Old age groups have different risk profile and stroke features compared to younger groups. Our aim was to examine the risk factor profile and stroke subtype in patients older than 80 years with ischemic stroke. Data of 535 patients with ischemic stroke or transient ischemic attack (TIA) were prospectively recorded. Cardiovascular risk factors and stroke subtype in individuals aged 80 years or older were compared with patients under 80. Of 535 patients a total of 179 were over 80 years (33.5%). The mean age was 84.4 ± 4.4 years (61.8%; 111 women). The most common risk factors included hypertension (82.7%) and hyperlipidemia (40.2%). Lacunar stroke was the most frequent subtype of stroke (41.7%). When the groups were compared, we observed the following risk factors more frequently in the group older than 80: female patients (P = <0.001), hypertension (OR = 1.62), atrial fibrillation (OR = 2.64); whereas diabetes (OR = 0.54), hyperlipidemia (OR = 0.57), smoking (OR = 0.17) and obesity (OR = 0.58) were more frequent in the group younger than 80. In the old group we found a high incidence of ischemic stroke in women. We also found a higher frequency of hypertension and atrial fibrillation. The available and future epidemiological data will provide a better knowledge about the effect of typical risk factors in old people. [source]

Ultrasonographic changes of the female bladder neck during development

Abstract Background: Our previous study showed that the anteroposterior vesical wall angle (APVA) at the bladder neck on transabdominal ultrasonography varied widely between women. The present study examines whether the APVA changes during development in girls with a normal bladder. Methods: Seventy-four females aged 0,29 years with normal bladders were examined by transabdominal ultrasonography. They were divided into six age groups and their APVA was measured in the supine position by sagittal ultrasonography. Intravenous urography was conducted to examine bladder neck descent and bladder neck opening. Results: The APVA ranged from 85 to 200°. The mean APVA in girls aged 0,4 years was 129 ± 30° (±SD) and the mean APVA in girls aged 5,9 years was 135 ± 25°. The mean APVA at ages 10,14 years was 161 ± 26°; at 15,19 years, 164 ± 33°; at 20,24 years, 164 ± 18°; and at 25,29 years, 163 ± 16°. The APVA values of these four groups were significantly larger (P < 0.05) than those of the two younger groups. No bladder abnormalities were found on intravenous urography. Conclusion: The APVA was small in some girls under 10 years of age, but the APVA of girls aged over 10 years was similar to that in young adults. The APVA may reflect bladder base plate tone and be partially related to hormonal changes in females during development. [source]

Analysing patterns of religious participation in post-communist Eastern Europe1

Ariana Need
ABSTRACT It is generally thought that processes of modernization generic to industrialized societies have resulted in a process of secularization with respect to conventional religious participation and observance in most Western countries. It is not at all clear, however, whether the post-communist societies of Eastern Europe have followed this pattern. In this we paper we examine whether levels of religiosity in ten post-communist societies , five generally Catholic in orientation and five Orthodox , are consistent with secularization theory, or whether instead they display, as some have suggested, the impact of seven decades of atheistic communism followed by a recent resurgence among the young. For this purpose we examine denominational membership and church attendance using descriptive and multivariate analysis of large-scale national sample surveys conducted in the mid-1990s. We find that age and educational differences in participation rates follow patterns expected on the basis of secularization theory with no evidence of resurgence among younger groups. Also, however, Catholic participation rates are significantly higher than Orthodox ones, indicating the importance of denomination in understanding patterns of religiosity in the post-communist context. [source]

Aquaporin-3 gene and protein expression in sun-protected human skin decreases with skin ageing

Ji Li
ABSTRACT Backgroud/Objectives:, Aquaporin 3 (AQP3) is a protein implicated in skin hydration. AQP3 null mice have relatively dry skin, reduced skin elasticity, and delayed recovery of barrier function after removal of the stratum corneum which is also present in skin of old people. A feature of skin aging is the change in both water content and barrier function of the skin. We investigated the expression of aquaporin 3 in non sun-exposed human skin, normal human keratinocytes and fibroblasts from different age groups to further understand the relationship between AQP3 and intrinsic skin aging. Methods:, We investigated the expression of aquaporin3 (AQP3) in normal human skin, normal human epidermal keratinocytes (NHEK) and skin fibroblast of different ages by immunohistochemistry, immunocytochemistry, the reverse transcription-polymerase chain reaction (RT-PCR) and western blotting. The samples were derived from 60 patients of varying ages: <20 years of age, 30,45 years and >60 years of age. Twenty skin biopsies, 6 for keratinocyte/fibroblast cultures, were taken from each age group. Results:, AQP3 decreased with increasing age in both skin and NHEK samples. We demonstrated significant differences in AQP3 expression between the 3 age groups (P < 0.05). In fibroblasts, AQP3 expression levels were significantly lower in the >60 year olds compared to 30,45 year olds (P < 0.05) and <20 year olds (P < 0.05), there was no significant difference between the two younger groups (P > 0.05). Conlusions:, AQP3 may be involved in the intrinsic aging process of non sun-exposed human skin. [source]

Gambling and older people in Australia

John McCormack
Objectives: There is a dearth of studies on the gambling behaviour of older people in Australia. This study aims to address that gap in local knowledge by investigating the gambling activity of older people in the general community, as well as the situation of older gamblers who attend counselling services for people with problem gambling behaviour. Method: The study draws on a recent national gambling survey to review older peoples' gambling in the general community, and then uses data from Victorian Gamblers' Help counselling services to review the gambling problems and treatment needs of older problem gamblers. Results: Older people gamble at a slightly lower rate than younger groups in the general community. Older problem gamblers similarly appear to have less serious problems than younger groups although there is a small group with quite severe problems as a result of gambling. There are more older female problem gamblers in counselling than males, but older men present more serious problems. Treatment responses appear to be effective for this age group. Conclusion: As older age is currently characterised by a low fixed income and thus greater vulnerability to the adverse consequences of gambling, research should continue to monitor the gambling impact on older people as our population ages. [source]