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Benzoxazole Derivatives (benzoxazole + derivative)
Selected AbstractsSynthesis of Some Novel Benzoxazole Derivatives as Anticancer, Anti-HIV-1 and Antimicrobial Agents.CHEMINFORM, Issue 6 2006Samia M. Rida Abstract For Abstract see ChemInform Abstract in Full Text. [source] Syntheses and herbicidal activity of pyrazolyl benzoxazole derivativesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 1 2010Na Xue In recent years, protoporphyrinogen oxidase (Protox) inhibitor herbicides are developed rapidly, because of this type of herbicides shows high herbicidal activity and low toxicity. In this paper, we prepared a series of new substituted pyrazolyl benzoxazole derivative, which were synthesized from 4-fluorophenol, via a serial of reactions included chlorination, acylation, condensation, ring closure, methylation, nitration, and so on. All the structures are confirmed by 1H NMR, MS and element analysis. Preliminary bioassay shows that most substituted pyrazolyl benzoxazole derivatives exhibit high herbicidal activity to the tested gramineous weeds and latifoliate weeds. J. Heterocyclic Chem., (2010). [source] Novel probes for imaging amyloid- ,: F-18 and C-11 labeling of 2-(4-aminostyryl)benzoxazole derivativesJOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 3 2004Hiroshi Shimadzu Abstract 2-(4-Methylaminostyryl)-6-(2-[18F]fluoroethoxy)benzoxazole ([18F]BF-168) was prepared and found to be a potential probe for imaging amyloid- ,. The precursor, a 6-(2-tosyloxyethoxy)benzoxazole derivative, was fluorinated with [18F]KF and Kryptofix 222 in acetonitrile, and the crude product purified by semi-preparative HPLC to give [18F]BF-168. The radiochemical purity was >95% and the maximum specific activity was 106 TBq/mmol at the end of synthesis. The synthesis time was 110 min from the end of bombardment. 2-(4-[N -methyl- 11C]methylaminostyryl)-5-fluorobenzoxazole ([11C]BF-145) was also prepared from 2-(4-aminostyryl)-5-fluorobenzoxazole, [11C]MeI and 5 N NaOH in DMSO, and purified by semi-preparative HPLC. The radiochemical purity was >95% and the specific activity was 40,70 TBq/mmol at the end of synthesis. The synthesis time was 45 min from the end of bombardment. Copyright © 2004 John Wiley & Sons, Ltd. [source] Syntheses and herbicidal activity of pyrazolyl benzoxazole derivativesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 1 2010Na Xue In recent years, protoporphyrinogen oxidase (Protox) inhibitor herbicides are developed rapidly, because of this type of herbicides shows high herbicidal activity and low toxicity. In this paper, we prepared a series of new substituted pyrazolyl benzoxazole derivative, which were synthesized from 4-fluorophenol, via a serial of reactions included chlorination, acylation, condensation, ring closure, methylation, nitration, and so on. All the structures are confirmed by 1H NMR, MS and element analysis. Preliminary bioassay shows that most substituted pyrazolyl benzoxazole derivatives exhibit high herbicidal activity to the tested gramineous weeds and latifoliate weeds. J. Heterocyclic Chem., (2010). [source] Novel probes for imaging amyloid- ,: F-18 and C-11 labeling of 2-(4-aminostyryl)benzoxazole derivativesJOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 3 2004Hiroshi Shimadzu Abstract 2-(4-Methylaminostyryl)-6-(2-[18F]fluoroethoxy)benzoxazole ([18F]BF-168) was prepared and found to be a potential probe for imaging amyloid- ,. The precursor, a 6-(2-tosyloxyethoxy)benzoxazole derivative, was fluorinated with [18F]KF and Kryptofix 222 in acetonitrile, and the crude product purified by semi-preparative HPLC to give [18F]BF-168. The radiochemical purity was >95% and the maximum specific activity was 106 TBq/mmol at the end of synthesis. The synthesis time was 110 min from the end of bombardment. 2-(4-[N -methyl- 11C]methylaminostyryl)-5-fluorobenzoxazole ([11C]BF-145) was also prepared from 2-(4-aminostyryl)-5-fluorobenzoxazole, [11C]MeI and 5 N NaOH in DMSO, and purified by semi-preparative HPLC. The radiochemical purity was >95% and the specific activity was 40,70 TBq/mmol at the end of synthesis. The synthesis time was 45 min from the end of bombardment. Copyright © 2004 John Wiley & Sons, Ltd. [source] | ||||||||||