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Benzimidazole Derivatives (benzimidazole + derivative)
Selected AbstractsSynthesis of Benzoxazole and Benzimidazole Derivatives via Ligand-Free Copper(I)-Catalyzed Cross-Coupling Reaction of o -Halophenols or o -Haloanilines with CarbodiimidesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2010Guodong Shen Abstract A novel and efficient synthesis of benzoxazole and benzimidazole derivatives via a ligand-free, copper(I)-catalyzed, one-pot cascade process has been developed. A variety of carbodiimides coupled with o -halophenols or o -haloanilines to give the products in moderate to excellent yields under the mild conditions. [source] Synthesis, in-vitro Microbial and Cytotoxic Studies of New Benzimidazole DerivativesARCHIV DER PHARMAZIE, Issue 7 2009Reddy S. Harisha Abstract Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD50) at the concentration 1×10,3 M against Artemia salina. [source] ChemInform Abstract: The Synthesis of Benzimidazole Derivatives in the Absence of Solvent and Catalyst.CHEMINFORM, Issue 43 2009Chuanming Yu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Ytterbium Triflate Promoted Synthesis of Benzimidazole Derivatives.CHEMINFORM, Issue 51 2004Massimo Curini Abstract For Abstract see ChemInform Abstract in Full Text. [source] Immunomodulatory and Anticancer Activities of Some Novel 2-Substituted-6-bromo-3-methylthiazolo[3,2- a]benzimidazole DerivativesARCHIV DER PHARMAZIE, Issue 4 2009Hatem A. Abdel-Aziz Abstract Ethyl 6-bromo-3-methyl-1,3-thiazolo[3,2- a]benzimidazole-2-carboxylate 2 was prepared by the ambient temperature bromination of ethyl 3-methyl-1,3-thiazolo[3,2- a]benzimidazole-2-carboxylate 1. The acid hydrazide 4 was obtained by the reaction of ester 2 with hydrazine hydrate. Treatment of compound 4 with benzaldehyde or 2-thiophenaldehyde yielded the corresponding hydrazones 6a and 6b, respectively, while the reaction of acid hydrazide 4 with ethoxymethylene malononitrile (7a) or with ethyl ethoxymethylene cyanoacetate (7b) in refluxing ethanol afforded pyrazole derivatives 9a and 9b, respectively. Taken together, from the biological investigations compounds 9a and 9b were the most significant inhibitors of LPS-stimulated NO generation from Raw murine macrophage 264.7, and, as another result, compounds 2 and 4 had a weak radical scavenging activity against DPPH radicals. Moreover, 2, 4, and 9a had a concomitant strong cytotoxicity against both colon carcinoma cells (HCT-116) and hepatocellular carcinoma cells (Hep-G2) while 9b showed specific cytotoxicity only against colon carcinoma cells. [source] Synthesis and Antimicrobial Activity of Some Novel 2-[4-(Substituted Piperazin-/Piperidin-1-ylcarbonyl)phenyl]-1H -benzimidazole DerivativesARCHIV DER PHARMAZIE, Issue 1 2009Canan Kus Abstract In this study, we report the synthesis and antimicrobial evaluation of several new 4-(1H -benzimidazol-2-yl)benzamides (11,30) and 5-chloro-1-(p -fluorobenzyl)-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-1H -benzimidazole (33). Compound 20 exhibited the best antibacterial activity with MIC value of 6.25 ,g/mL against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Significant antifungal activities were obtained with the compounds 13, 14, 18, 19, and 33 with MIC values of 3.12 ,g/mL which are close to fluconazole. [source] ChemInform Abstract: An Efficient Single Step Synthesis of Pyridazine, Pyrazolo[5,1-c]-1,2,4-triazine, 1,2,4-Triazolo[5,1-c]-1,2,4-triazine and 1,2,4-Triazino[4,3-a]benzimidazole Derivatives.CHEMINFORM, Issue 29 2009Mohamed R. Shaaban Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis of 3,3,-Bi-1,2,4-triazolo[4,5-a]benzimidazole, 5,5,-Bi-1,3,4-thiadiazole, and Thiazolo[3,2-a]benzimidazole Derivatives.CHEMINFORM, Issue 13 2004Kamal M. Dawood Abstract For Abstract see ChemInform Abstract in Full Text. [source] 1,3-Bis(ethylamino)-2-nitrobenzene, 1,3-bis(n -octylamino)-2-nitrobenzene and 4-ethylamino-2-methyl-1H -benzimidazoleACTA CRYSTALLOGRAPHICA SECTION C, Issue 5 2008Christopher P. Walczak 1,3-Bis(ethylamino)-2-nitrobenzene, C10H15N3O2, (I), and 1,3-bis(n -octylamino)-2-nitrobenzene, C22H39N3O2, (II), are the first structurally characterized 1,3-bis(n -alkylamino)-2-nitrobenzenes. Both molecules are bisected though the nitro N atom and the 2-C and 5-C atoms of the ring by twofold rotation axes. Both display intramolecular N,H...O hydrogen bonds between the amine and nitro groups, but no intermolecular hydrogen bonding. The nearly planar molecules pack into flat layers ca 3.4,Å apart that interact by hydrophobic interactions involving the n -alkyl groups rather than by ,,, interactions between the rings. The intra- and intermolecular interactions in these molecules are of interest in understanding the physical properties of polymers made from them. Upon heating in the presence of anhydrous potassium carbonate in dimethylacetamide, (I) and (II) cyclize with formal loss of hydrogen peroxide to form substituted benzimidazoles. Thus, 4-ethylamino-2-methyl-1H -benzimidazole, C10H13N3, (III), was obtained from (I) under these reaction conditions. Compound (III) contains two independent molecules with no imposed internal symmetry. The molecules are linked into chains via N,H...N hydrogen bonds involving the imidazole rings, while the ethylamino groups do not participate in any hydrogen bonding. This is the first reported structure of a benzimidazole derivative with 4-amino and 2-alkyl substituents. [source] Synthesis of Benzoxazole and Benzimidazole Derivatives via Ligand-Free Copper(I)-Catalyzed Cross-Coupling Reaction of o -Halophenols or o -Haloanilines with CarbodiimidesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2010Guodong Shen Abstract A novel and efficient synthesis of benzoxazole and benzimidazole derivatives via a ligand-free, copper(I)-catalyzed, one-pot cascade process has been developed. A variety of carbodiimides coupled with o -halophenols or o -haloanilines to give the products in moderate to excellent yields under the mild conditions. [source] Synthesis, in-vitro Microbial and Cytotoxic Studies of New Benzimidazole DerivativesARCHIV DER PHARMAZIE, Issue 7 2009Reddy S. Harisha Abstract Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD50) at the concentration 1×10,3 M against Artemia salina. [source] | ||||||||||