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Wider Application (wider + application)
Selected AbstractsProtocol Biopsies in Renal Transplantation: Insights into Patient Management and PathogenesisAMERICAN JOURNAL OF TRANSPLANTATION, Issue 3 2007M. Mengel A 1-day symposium on the application of protocol biopsies in renal transplantation was held in Boston, 21 July 2006. Representatives from centers with extensive experience in the use of protocol biopsies for routine patient care and research reported results on the pathological findings and their value in patient management. The consensus was that protocol biopsies, in experienced hands, are a safe and valuable means of detecting subclinical disease that can benefit from modification of therapy. Furthermore, molecular studies reveal evidence of activity or progression not readily appreciated by histological techniques. Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention. [source] Regional industrial recycling network in energy supply,the case of Joensuu city, FinlandCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 3 2002Jouni Korhonen Industrial recycling networks offer an example of the practical application of some of the industrial ecology (IE) principles. In the industrial ecosystem and eco-industrial park approaches the material cycles and energy cascades in a natural ecosystem serve as the metaphoric vision for a local/regional industrial system in which waste material and waste (residual) energy are utilized through cooperation between the actors in the system. In this paper, a local/regional recycling network scenario is presented with the energy supply system of the city of Joensuu in Finland. The conditions of success include the co-production of heat and electricity (heat and power, CHP), waste energy utilization for industrial steam and renewable flow use as fuel. Some difficulties in the industrial ecosystem-type development of the system are discussed. Methodological suggestions for industrial ecosystem and eco-industrial park case studies are considered and the experience from this Finnish case is discussed in terms of wider application of IE in local/regional economic energy systems. For future research on the theme, it is suggested that regional industrial ecology may benefit from regional economics theory and, vice versa, regional economics theory may find a new area of application in regional industrial ecology. Copyright © 2002 John Wiley & Sons, Ltd. and ERP Environment. [source] Integrating physiology and life history to improve fisheries management and conservationFISH AND FISHERIES, Issue 4 2006Jeffery L. Young Abstract Knowledge of life-history traits is increasingly recognized as an important criterion for effective management and conservation. Understanding the link between physiology and life history is an important component of this knowledge and in our view is particularly relevant to understanding marine and freshwater fishes. Such linkages (i.e. the life-history/physiology nexus) have been recently advocated for avian systems and here we explore this concept for fish. This paper highlights the gap in fisheries literature with regard to understanding the relationship between physiology and life history, and proposes ways in which this integration could improve fisheries management and conservation. We use three case studies on different fishes (i.e. the Pacific salmon, the grouper complex and tuna) to explore these issues. The physiological structure and function of fish plays a central role in determining stock response to exploitation and changes in the environment. Physiological measures can provide simple indicators necessary for cost-effective monitoring in the evaluation of fisheries sustainability. The declining state of world fisheries and the need to develop and implement restoration strategies, such as hatchery production or protected areas, provides strong incentive to better understand the influence of physiology on population and reproductive dynamics and early life history. Physiology influences key population-level processes, particularly those dealing with reproduction, which must be incorporated into the design and successful implementation of specific and broadscale initiatives (e.g. aquatic protected areas and bycatch reduction). Suggestions are made for how to encourage wider application of the physiology/life-history link, in fisheries management and conservation, as well as more broadly in education and research. [source] Terrorism as a StrategyGOVERNMENT AND OPPOSITION, Issue 3 2007Lawrence Freedman In this article I discuss terrorism as a problem in the study of strategy rather than strategy as a problem in the study of terrorism. There is a developing literature now asserting that terrorist activity should be evaluated as strategy, so that dealing with the phenomenon requires not only denouncing it for its warped morality and inhumanity but also understanding motives and methods, treating it as purposive and instrumental and not just wicked. In this article I take it for granted that terrorism is strategic activity; my question is, what does this type of activity tell us about strategy? The case is interesting because terrorism is strategically generally demanding and prone to failure. Certainly when used on its own it is a poor support for political objectives, and may be counter-productive even when used with other methods. By looking at strategy at the fringes it is possible to illuminate aspects of strategic activity that have a wider application. [source] Hyperbaric oxygen therapy and liver transplantationHPB, Issue 3 2007VIJAYARAGAVAN MURALIDHARAN Abstract Liver transplantation is the treatment of choice for end stage liver disease and is often used for primary liver malignancies. The main limitation of its wider application is the availability of suitable donor organs. The use of marginal donor organs, split-liver transplantation and living-related liver transplantation techniques contribute to increase the donor pool. However, the use of these techniques is associated with a higher risk of post transplantation organ dysfunction, predominantly due to ischaemia, preservation and reperfusion injury (IPRI). A number of studies have demonstrated that hyperbaric oxygen (HBO) therapy influences IPRI and consequential acute cellular rejection. This article reviews the rationale of HBO therapy in the field of transplantation with particular emphasis on liver transplantation. [source] Beyond taxonomy: a review of macroinvertebrate trait-based community descriptors as tools for freshwater biomonitoringJOURNAL OF APPLIED ECOLOGY, Issue 4 2010Salomé Menezes Summary 1.,Species traits have been frequently used in ecological studies in an attempt to develop a general ecological framework linking biological communities to habitat pressures. The trait approach offers a mechanistic alternative to traditional taxonomy-based descriptors. This review focuses on research employing traits as biomonitoring tools for freshwater ecosystems, although the lessons learned have wider application in the assessment of other ecosystem types. 2.,We review the support from ecological theory to employ species traits for biomonitoring purposes (e.g. the habitat templet concept, landscape filtering hypothesis), and the subsequent studies that test the hypotheses arising from these theories, and apply this knowledge under real freshwater biomonitoring scenarios. We also include studies that deal with more specific issues such as trait trade-offs and trait syndromes. 3.,We highlight the functional trait approach as one of the most promising tools emerging for biomonitoring freshwater ecosystems. Several technical issues are addressed and solutions are proposed. We discuss the need for: a broader unified trait biomonitoring tool; a more accurate understanding of the natural variation of community patterns of trait expression; approaches to diminish the effects of trait trade-offs and trait syndromes; additional life history and ecological requirement studies; and the detection of specific impacts under multiple stressor scenarios. 4.,Synthesis and applications. This review provides biologists with the conceptual underpinning for the use of species traits as community descriptors and for freshwater biomonitoring and management. We expect that the functional trait approach will ultimately improve communication to managers and legislators of the importance of protecting freshwater ecosystem functions. [source] Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cellsJOURNAL OF CELLULAR PHYSIOLOGY, Issue 1 2001Toru Mizuguchi Liver transplantation is the only clinically effective method of treating acute liver failure. However, wider application of this therapeutic modality is restricted primarily by shortage of donor organs. In the search for alternative methods of liver replacement therapy, investigators have focused on transplantation of normal allogeneic hepatocytes and on the development of liver support systems utilizing isolated hepatocytes. Since all human livers suitable for cell harvest are being used for transplantation, hepatocyte therapy using human tissue would require growing of cells in vitro. Unfortunately, although hepatocytes have tremendous capacity to proliferate in vivo, their ability to grow in culture is severely limited. Stromal cells from bone marrow and other blood-forming organs have been found to support hematopoiesis. In this paper, we show that bone marrow-derived stromal cells (BMSCs) enhance proliferation and support differentiation of rat hepatocytes in culture. Further, we demonstrate that in hepatocyte/BMSC co-cultures, clonal expansion of small hepatocytes (SH) is increased. Using semipermeable membrane cultures, we established that direct cell,cell contact is necessary for stimulation of cell proliferation. We also show that BMSCs which are in direct contact with hepatocytes and SH colonies express Jagged1. This suggests a potential role for Notch signaling in the observed effects. Finally, we present evidence that the expression and activity of liver specific transcirption factors, CCAAT/enhancer binding proteins and liver specific key enzymes such as tryptophan 2,3-dioxygenase, are improved in hepatocyte/BMSC co-cultures. In conclusion, results of this study indicate that BMSCs could facilitate proliferation and differentiation of primary rat hepatocytes and their progenitors (SH) in vitro. © 2001 Wiley-Liss, Inc. [source] Improved design and optimization models for the fixed bed adsorption of acid dye and zinc ions from effluentsJOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 12 2002Danny C Abstract The bed depth service time (BDST) design model, which accounts for the change of bed adsorption capacity with service time, has been modified to expand its application and overcome the limiting assumptions of the original BDST analysis. Column experiments were undertaken to test the new model for two adsorption systems, namely zinc ion,bone char and Acid Blue 80 dye-activated carbon. It was found that the percentage of saturation capacity could be correlated using a square-root dependence on the service time and this correlation was incorporated into the original BDST analysis to replace the total sorption capacity term, giving the model a much wider application to real systems. The empty bed residence time optimization approach was modified using the same time-dependent capacity expression and was successfully applied to the metal ion,bone char and the dye-activated carbon system with the use of equilibrium saturated bed capacity. These modifications to the BDST design model and the EBRT optimization model will give more accurate scale-up data for the design of large-scale column adsorption systems. © 2002 Society of Chemical Industry [source] Embedding nursing and therapy consultantship: the case of stroke consultantsJOURNAL OF CLINICAL NURSING, Issue 2 2009Christopher R Burton Aims and objectives., As the basis for the design of career development opportunities for current and aspiring nursing and therapy consultants, we aimed to explore the factors that shape how these roles have embedded in UK stroke services. Background., The non-medical consultant role has been introduced into UK health care services to provide opportunities for experienced practitioners to progress their careers in clinical practice. Whilst there have been evaluations of the impact of the role on service delivery, little attention has been paid to the pathways towards consultantship. Design., An exploratory design, incorporating focus group discussions, was used to address the research questions. Participating consultants, both nurses and allied health professionals, worked in stroke services, although it is anticipated that the results will have wider application. Methods., Two focus groups were held with non-medical consultants in stroke from across the UK. Participants had the opportunity to comment on an interim paper prior to publication of the results. Thirteen consultants took part in the study. Results., A lack of consensus about the nature of clinical expertise and a diverse range of pathways towards consultantship were identified. Health care policy had presented the opportunity for consultants to be entrepreneurial in the development of stroke services, although this had limited the scope for the development of professional knowledge. Inflexible programmes to support aspiring consultants may limit the opportunities to develop these entrepreneurial skills. Conclusions., This study challenges health care organizations and the education and research departments that support them to think creatively in the way that the non-medical consultant role is embedded, and that this should draw on the commitment of existing consultants to support succession planning. Relevance to clinical practice., The identification of those aspects of career pathways that current consultants have found to be helpful will be useful in designing opportunities for aspiring consultants. [source] Applying the developmental perspective in the psychiatric assessment and diagnosis of persons with intellectual disability: part I , assessmentJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 1 2005A. Dosen Abstract Background In generic psychiatry there has been increasing interest among scientists for the developmental perspective. However, professionals active in the mental health care of people with intellectual disability (ID) have not shown the same degree of interest. The author of this article, who has had a liberal amount of rewarding experiences with the developmental approach in the field of ID, considers the developmental perspective to be innovative and very useful in psychiatric assessment, diagnosis and treatment of this population. The aim of the article is to stimulate a wider application of the developmental perspective as well as to challenge a professional discussion on this issue. Methods Basic assumptions of the developmental perspective are discussed and assessment tools and methods are described. Results In a case vignette, the advantages of developmentally based assessment are emphasized. Emotional development and personality development are viewed as the developmental components that play an important role in adaptive and maladaptive behaviour as well as in the onset and presentation of psychopathology. It is clear that interpretative insight into the totality of the psychosocial aspects of these individuals cannot only be obtained by measuring the level of cognitive development. A wider frame of mind is needed for unambiguous psychiatric diagnostics. Therefore, a replacement of the three dimensional paradigm (bio,psycho,social) by a four dimensional one (bio,psycho,socio,developmental) for the assessment and diagnosis of persons with ID is proposed. [source] Advances in Heart Valve SurgeryJOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 6 2003MATTHIAS AAZAMI Heart valve surgery continues to evolve in a dynamic fashion. While the exact role of minimally invasive approaches still needs to be defined, progress has been made in the development of new bioprostheses and their durability. Most importantly, valve repair has been standardized for the mitral and introduced for the aortic valve with results that have been superior to valve replacement. Selection of the optimal procedure for the individual patient is now facilitated. In the future, a wider application of repair procedures and further improvements of biologic valves can be anticipated not only to influence long-term results but also the decision-making process for conservative or surgical treatment. (J Interven Cardiol 2003;16:535,541) [source] Building the capacity for evidence-based clinical nursing leadership: the role of executive co-coaching and group clinical supervision for quality patient servicesJOURNAL OF NURSING MANAGEMENT, Issue 2 2007BA (Hons), JO ALLEYNE DProf Aim, The general aims of this article were to facilitate primary care nurses (District Nurse Team Leaders) to link management and leadership theories with clinical practice and to improve the quality of the service provided to their patients. The specific aim was to identify, create and evaluate effective processes for collaborative working so that the nurses' capacity for clinical decision-making could be improved. Background, This article, part of a doctoral study on Clinical Leadership in Nursing, has wider application in the workplace of the future where professional standards based on collaboration will be more critical in a world of work that will be increasingly complex and uncertain. This article heralds the type of research and development activities that the nursing and midwifery professions should give premier attention to, particularly given the recent developments within the National Health Service in the United Kingdom. The implications of: Agenda for Change, the Knowledge and Skills Framework, ,Our Health, Our Care, Our Say' and the recent proposals from the article Modernising Nursing Career, to name but a few, are the key influences impacting on and demanding new ways of clinical supervision for nurses and midwives to improve the quality of patient management and services. Method, The overall approach was based on an action research using a collaborative enquiry within a case study. This was facilitated by a process of executive co-coaching for focused group clinical supervision sessions involving six district nurses as co-researchers and two professional doctoral candidates as the main researchers. The enquiry conducted over a period of two and a half years used evidence-based management and leadership interventions to assist the participants to develop ,actionable knowledge'. Group clinical supervision was not practised in this study as a form of ,therapy' but as a focus for the development of actionable knowledge, knowledge needed for effective clinical management and leadership in the workplace. Findings, ,,Management and leadership interventions and approaches have significantly influenced the participants' capacity to improve the quality of services provided to their patients. ,,Using various techniques, tools, methods and frameworks presented at the sessions increased participants' confidence to perform. ,,A structured approach like the Clinical Nursing Leadership Learning and Action Process (CLINLAP) model makes implementing change more practical and manageable within a turbulent care environment. The process of Stakeholder Mapping and Management made getting agreement to do things differently much easier. Generally it is clear that many nurses and midwives, according to the participants, have to carry out management and leadership activities in their day-to-day practice. The traditional boundary between the private, the public and the voluntary sector management is increasingly becoming blurred. Conclusion, It is conclusive that the district nurses on this innovative programme demonstrated how they were making sense of patterns from the past, planning for the future and facilitating the clinical nursing leadership processes today to improve quality patient services tomorrow. Their improved capacity to manage change and lead people was demonstrated, for example, through their questioning attitudes about the dominance of general practitioners. They did this, for example, by initiating and leading case conferences with the multi-disciplinary teams. It became evident from this study that to use group clinical supervision with an executive co-coaching approach for the implementation and to sustain quality service demand that ,good nursing' is accepted as being synonymous with ,good management'. This is the future of ,new nursing'. [source] Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imagingJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 2 2007J. Axel Zeitler Abstract Three dimensional terahertz pulsed imaging (TPI) was evaluated as a novel tool for the nondestructive characterization of different solid oral dosage forms. The time-domain reflection signal of coherent pulsed light in the far infrared was used to investigate film-coated tablets, sugar-coated tablets, multilayered controlled release tablets, and soft gelatin capsules. It is possible to determine the spatial and statistical distribution of coating thickness in single and multiple coated products using 3D TPI. The measurements are nondestructive even for layers buried underneath other coating structures. The internal structure of coating materials can be analyzed. As the terahertz signal penetrates up to 3 mm into the dosage form interfaces between layers in multilayered tablets can be investigated. In soft gelatin capsules it is possible to measure the thickness of the gelatin layer and to characterize the seal between the gelatin layers for quality control. TPI is a unique approach for the nondestructive characterization and quality control of solid dosage forms. The measurements are fast and fully automated with the potential for much wider application of the technique in the process analytical technology scheme. ©2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:330,340, 2007 [source] Rhizocarpon calibration curve for the Aoraki/Mount Cook area of New Zealand,JOURNAL OF QUATERNARY SCIENCE, Issue 4 2005Thomas V. Lowell Abstract Development of Rhizocarpon growth curve from the Aoraki/Mount Cook area of New Zealand provides a means to assess Little Ice Age glacier behaviour and suggests approaches that have wider application. Employing a sampling strategy based on large populations affords the opportunity to assess which of various metrics (e.g. single largest, average of five largest, mean of an entire population) best characterise Rhizocarpon growth patterns. The 98% quantile from each population fitted with a quadric curve forms a reliable representation of the growth pattern. Since this metric does not depend on the original sample size, comparisons are valid where sample strategy must be adapted to local situations or where the original sample size differs. For the Aoraki/Mount Cook area a surface 100 years old will have a 98% quantile lichen diameter of 34.3,mm, whereas a 200-year-old surface will have a lichen diameter of 73.7,mm. In the Southern Alps, constraints from the age range of calibration points, the flattening of the quadric calibration curve and ecological factors limit the useful age range to approximately 250 years. Copyright © 2005 John Wiley & Sons, Ltd. [source] Surface-enhanced Raman spectroscopy: advancements and applicationsJOURNAL OF RAMAN SPECTROSCOPY, Issue 6-7 2005Z. Q. Tian Abstract Since the mid-1990s, surface-enhanced Raman scattering (SERS) has advanced greatly and gained wider application and a renewal of interest. There have been several new and creative developments, e.g. SERS of single molecules, nanostructures and transition metals, tip-enhanced Raman scattering (TERS), surface-enhanced hyper-Raman scattering (SEHRS), ultraviolet-excited SERS (UV-SERS) and surface-enhanced resonance Raman scattering (SERRS), and their wide applications in biology, medicine, materials science and electrochemistry. It is timely to publish a special issue reporting these initiatives and the progress made in the past 7 years. This issue consists of 30 invited articles that are roughly divided into three SERS research themes: theories, methods and applications. These up-to-date representatives of the research results clearly show that SERS is important not only for Raman spectroscopy and surface science but also for nanoscience. Copyright © 2005 John Wiley & Sons, Ltd. [source] Changing climate and historic-woodland structure interact to control species diversity of the ,Lobarion' epiphyte community in ScotlandJOURNAL OF VEGETATION SCIENCE, Issue 5 2007Christopher J. Ellis Abstract Question: How will changing climate and habitat structure interact to control the species diversity of lichen epiphytes? Location: Scotland. Method: Species richness (=diversity) of the epiphyte lichen community known as Lobarion (named after Lobaria pulmonaria) was quantified for 94 Populus tremula stands across Scotland, and compared in a predictive model to seven climate variables and eight measures of woodland structure. An optimum model was selected and used to project Lobarion diversity over the geographic range of the study area, based on IPCC climate change scenarios and hypothetical shifts in woodland structure. Results: Species diversity of the Lobarion community was best explained by three climate variables: (1) average annual temperature; (2) autumn and winter precipitation; in combination with (3) historic-woodland extent. Projections indicate a positive effect of predicted climate change on Lobarion diversity, consistent with the physiological traits of cyanobac-terial lichens comprising the Lobarion. However, the general response to climate is modified significantly by the effect on diversity of historic-woodland extent. Conclusions: Historic-woodland extent may exert an important control over local climate, as well as impacting upon the metapopulation dynamics of species in the Lobarion. In particular, a temporal delay in the response of Lobarion species to changed woodland structure is critical to our understanding of future climate change effects. Future Lobarion diversity (e.g. in the 2050s) may depend upon the interaction of contemporary climate (e.g. 2050s climate) and historic habitat structure (e.g. 1950s woodland extent). This is supported by previous observations for an extinction debt amongst lichen epiphytes, but suggests an extension of simple climate-response models is necessary, before their wider application to lichen epiphyte diversity. [source] Optimizing the use of donated cadaver livers: Analysis and policy development to increase the application of split-liver transplantationLIVER TRANSPLANTATION, Issue 10 2002Jean C. Emond MD The American Society of Transplant Surgeons and the American Society of Transplantation jointly sponsored a conference in Crystal City, Virginia, on March 28th and 29th, 2001, to explore mechanisms for maximizing the cadaver-organ donor pool. Participants from transplantation medicine, surgery, organ procurement organizations, the general public, and government convened to address expanding utilization of each organ type. The committee assigned to review liver organ utilization identified multiple practices that could expand the potential donor pool including non,heart beating donors, marginal grafts, efficient allocation of cadaver organs, and wider application of split-liver transplantation. This article details the data reviewed by the liver committee and their recommendations on policy development for the expanded application of split-liver transplantation. [source] ,2 -Agonists as analgesic agentsMEDICINAL RESEARCH REVIEWS, Issue 2 2009Maria Paola Giovannoni Abstract It is well known that norepinephrine is involved in the control of pain by modulating pain-related responses through various pathways. ,2 -Adrenergic agonists have a well-established analgesic profile and, in the recent years, have found a wider application, in particular as adjunct to anesthetics and analgesics in perioperative settings. This review analyzes the ,2 -agonists currently in clinical use, starting from the prototype Clonidine, as well as the most promising and studied molecules. In addition, an overview of the imidazoles, imidazolines, and hydroxyethyl-thioureas derivatives published in both the open and patented literature is presented, providing chemical description and pharmacological data. Finally, the most commonly ,2 -agonists used in veterinary medicine are described. © 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 2, 339,368, 2009 [source] Microsatellite markers in soil-feeding termites (Cubitermes subarquatus, Isoptera, Termitidae, Termitinae)MOLECULAR ECOLOGY RESOURCES, Issue 4 2001M. Harry Abstract Seven microsatellite markers were isolated from Cubitermes subarquatus belonging to the soil-feeding termite trophic group that plays a key role in tropical rain forests. A variability study performed by using a population of C. subarquatus (n = 73) sampled in the La Lopé forest reserve (Gabon) from 42 nests revealed from 4 to 12 alleles per locus and an heterozygosity from 0.28 to 0.84. Tests for cross-species amplification realized in the sympatric C. intercalatus and in eight other sympatric termite genera indicated a wider application of the primers isolated from Cubitermes in soil-feeding termites. [source] Multimodal management, including precisely targeted irradiation, in a severe refractory case of Evans syndromePEDIATRIC BLOOD & CANCER, Issue S5 2006Thomas D. Miale MD Abstract A challenging case of acute autoimmune thrombocytopenia (ITP) which evolved into a chronic refractory case of Evans syndrome over a period of more than 23 years is presented and may illustrate current therapeutic dilemmas now perplexing patients and clinicians. Newer modalities are being developed and their eventual role in the scheme of clinical management remains to be established. While this development unfolds, highly targeted radiotherapy was applied in this case to reduce platelet uptake by a refractory recurrent splenule with the goal of stabilizing the platelet count until promising investigational thrombopoietic agents or other newer, less toxic therapies might become available for wider application. Pediatr Blood Cancer 2006;47:726,728. © 2006 Wiley-Liss, Inc. [source] Towards minimizing immunosuppression in pediatric liver transplant recipientsPEDIATRIC TRANSPLANTATION, Issue 5 2009Yumirle P. Turmelle Abstract:, Immunosuppression regimens after liver transplantation focus mainly on preventing rejection and subsequent graft loss. However, in children, morbidity and mortality rates from infections exceed those from rejection after transplant, and immunosuppression can hinder growth, renal function, and graft tolerance. We hypothesized that early steroid withdrawal, with a primary aim of TAC monotherapy would yield no penalty in terms of rejection and graft loss, while reducing risks of infection and maximizing growth. We prospectively evaluated 64 consecutive pediatric liver transplant recipients. One yr patient/graft survival was 93/90%, respectively. At one yr post-transplant, 75.4% of patients were on TAC monotherapy. No deaths or graft losses were caused by infection. Sixty-one percent of patients had at least one episode of rejection, most within three months following transplant and 3.8% were treated for chronic rejection. One non-compliant adolescent died from chronic rejection. CMV, EBV, and lymphoproliferative disease rates were 3.1%, 5.3%, 1.8%, respectively. Pretransplant and one yr post-transplant glomerular filtration rates were unchanged. One yr improved catch-up growth was observed. We conclude that immunosuppression minimization after pediatric liver transplant yields no serious complications from rejection, and might confer advantages with respect to infection, renal function, growth, and is deserving of wider application and study. [source] History of pediatric stem cell transplantationPEDIATRIC TRANSPLANTATION, Issue 2004Rainer Storb Abstract:, During the past 50 yr, intensive studies into the use of hematopoietic cell transplantation (HCT) for therapy of cancer and non-malignant hematologic diseases have changed this treatment modality from one that was thought to be plagued by insurmountable complications to one that is now standard therapy for some diseases. Continued research by transplant teams worldwide is likely to allow continued progress toward developing novel and improved treatment modalities and even wider application of the use of pluripotent hematopoietic stem cells in the treatment of human diseases. [source] Synthesis of pH-responsive crosslinked poly[styrene- co -(maleic sodium anhydride)] and cellulose composite hydrogel nanofibers by electrospinningPOLYMER INTERNATIONAL, Issue 5 2009Shengguang Cao Abstract BACKGROUND: Stimuli-sensitive materials show enormous potential in the development of drug delivery systems. But the low response rate of most stimuli-sensitive materials limits their wider application. We propose that electrospinning, a technique for the preparation of ultrafine fibrous materials with ultrafine diameters, may be used to prepare materials with a fast response to stimuli. RESULTS: Poly[styrene- co -(maleic sodium anhydride)] and cellulose (SMA-Na/cellulose) hydrogel nanofibers were prepared through hydrolysis of precursor electrospun poly[styrene- co -(maleic anhydride)]/cellulose acetate (SMA/CA) nanofibers. In the presence of diethylene glycol, the SMA/CA composite nanofibers were crosslinked by esterification at 145 °C, and then hydrolyzed to yield crosslinked SMA-Na/cellulose hydrogel nanofibers. These nanofibers showed better mechanical strengths and were pH responsive. Their water swelling ratio showed a characteristic two-step increase at pH = 5.0 and 8.2, with the water swelling ratio reaching a maximum of 27.6 g g,1 at pH = 9.1. CONCLUSION: The crosslinked SMA-Na hydrogel nanofibers supported on cellulose showed improved dimensional stability upon immersion in aqueous solutions. They were pH responsive. This new type of hydrogel nanofiber is a potential material for biomedical applications. Copyright © 2009 Society of Chemical Industry [source] Mechanisms of Regulation of Litter Size in Pigs on the Genome LevelREPRODUCTION IN DOMESTIC ANIMALS, Issue 2007O Distl Contents Improvement in litter size has become of great interest in pig industry as good fecundity is directly related to a sow's productive life. Genetic regulation of litter size is complex and the main component traits so far defined are ovulation rate, embryonic survival, uterus capacity, foetal survival and pre-weaning losses. Improvements using concepts of the quantitative genetics let expect only slow genetic progress due to its low heritability of approximately 0.09 for number of piglets born alive. Marker assisted selection allows to dissect litter size in its component traits and using molecular genetic markers for the components of litter size traits promises more progress and advantages in optimum balancing of the different physiological mechanisms influencing litter size. In this review, efforts being made to unravel the genetic determinants of litter size are accounted and discussed. For litter size traits, more than 50 quantitative trait loci (QTL) were mapped and in more than 12 candidate genes associations confirmed. The number of useful candidate genes is much larger as shown by expression profiles and in addition, much more QTL can be assumed. These functional genomic approaches, both QTL mapping and candidate gene analysis, have to be merged for a better understanding of a wider application across different pig breeds and lines. Newly developed tools based on microarray techniques comprising DNA variants or expressed tags of many genes or even the whole genome appear useful for in depth understanding of the genetics of litter size in pigs. [source] ,Held in mind' or ,Hell in mind': group therapy in PolandTHE JOURNAL OF ANALYTICAL PSYCHOLOGY, Issue 2 2006Dale Mathers Abstract: This paper describes observations and experiences gathered whilst conducting group therapy with trainees in analytical psychology in Poland. The challenges and conflicts around language and translation reflect challenges common to analysis everywhere: accuracy of interpretation, agreements on permission to interpret and the acceptability of interpretation. The way in which archetypal patterns developed and matured suggests this approach to work with trainees may have wider application. [source] Laparoscopic-Assisted Right Lobe Donor HepatectomyAMERICAN JOURNAL OF TRANSPLANTATION, Issue 10 2006A.J. Koffron The major impediment to a wider application of living donor hepatectomy, particularly of the right lobe, is its associated morbidity. The recent interest in a minimally invasive approach to liver surgery has raised the possibility of applying these techniques to living donor right lobectomy. Herein, we report the first case of a laparoscopic, hand-assisted living donor right hepatic lobectomy. We describe the technical aspects of the procedure, and discuss the rationale for considering this option. We propose that the procedure, as described, did not increase the operative risks of the procedure; instead, it decreased potential morbidity. We caution that this procedure should only be considered for select donors, and that only surgical teams familiar with both living donor hepatectomy and laparoscopic liver surgery should entertain this possibility. [source] Using patterns of reef fish assemblages to refine a Habitat Classification System for marine parks in NSW, AustraliaAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 1 2010Hamish A. Malcolm Abstract 1.The Solitary Islands Marine Park (SIMP) in New South Wales (NSW), Australia, is located in a tropical-temperate biotone, with variable influence of the tropical East Australian Current (EAC) from inshore to offshore. Marine communities on the extensive, subtidal, rocky reefs are poorly described. As a result, the current Habitat Classification System (HCS) used as part of the process to determine the marine park zoning arrangements, which places all shallow reef (<25,m) in the same category, is unlikely to represent real biotic patterns. 2.To evaluate the influence of five key factors (distance from shore, reef type, dominant benthos, latitude, and depth range) fish assemblages were widely surveyed, using 30-minute timed counts, at 68 sites across the extent of shallow reef within the park. Relationships between assemblage patterns and levels of the different factors were subsequently examined using multivariate analyses. 3.Patterns of reef fish assemblages were most strongly correlated with distance from shore. Three distinct assemblages occurred on inshore (<1.5,km), mid-shelf (1.5,6,km), and offshore (>6,km) reefs. Differences in assemblage structure by reef type were also apparent on inshore and offshore reefs, but not on mid-shelf reefs. Correlations with the other factors were weak. The cross-shelf pattern was persistent over the scale of years. 4.The results of the study provide strong support for incorporating distance-from-shore categories into a refined HCS. This will improve its ability to represent biological diversity as reflected by patterns of reef fish assemblages. Further research is required to determine the wider application of the HCS to other marine parks in NSW and to determine if it also, effectively, represents other components of biodiversity. Copyright © 2009 John Wiley & Sons, Ltd. [source] Hydrothermal carbonization of biomass: A summary and discussion of chemical mechanisms for process engineeringBIOFUELS, BIOPRODUCTS AND BIOREFINING, Issue 2 2010Axel Funke Abstract Hydrothermal carbonization can be defined as combined dehydration and decarboxy lation of a fuel to raise its carbon content with the aim of achieving a higher calorific value. It is realized by applying elevated temperatures (180,220°C) to biomass in a suspension with water under saturated pressure for several hours. With this conversion process, a lignite-like, easy to handle fuel with well-defined properties can be created from biomass residues, even with high moisture content. Thus it may contribute to a wider application of biomass for energetic purposes. Although hydrothermal carbonization has been known for nearly a century, it has received little attention in current biomass conversion research. This review summarizes knowledge about the chemical nature of this process from a process design point of view. Reaction mechanisms of hydrolysis, dehydration, decarboxylation, aromatization, and condensation polymerization are discussed and evaluated to describe important operational parameters qualitatively. The results are used to derive fundamental process design improvements. Copyright © 2010 Society of Chemical Industry and John Wiley & Sons, Ltd [source] Use of real-time PCR to detect human papillomavirus-16 viral loads in vaginal and urine self-sampled specimensCLINICAL MICROBIOLOGY AND INFECTION, Issue 6 2008A. Daponte Abstract Increasing the accuracy of self-sampling methods to detect oncogenic human papillomavirus (HPV) infection would contribute to the wider application of these approaches. In this study, 120 women were tested for HPV-16 by conventional and quantitative real-time PCR (QRT-PCR) in cervical and self-sampled vaginal and urine specimens. QRT-PCR had a higher detection rate, and the HPV viral load in all three sampling sites correlated with the severity of disease, as determined by histology. The vaginal and urine viral loads correlated with HPV-16 positivity according to both conventional and QRT-PCR, and were proportional to the cervical viral load. [source] Surface Structures and Osteoblast Activity on Biomedical Polytetrafluoroethylene Treated by Long-Pulse, High-Frequency Oxygen Plasma Immersion Ion ImplantationADVANCED ENGINEERING MATERIALS, Issue 5 2010Liping Tong Abstract Polytetrafluoroethylene (PTFE) is a biologically safe polymer used widely in clinical medicine including oral and orthopedic surgery. However, the high bio-inertness of PTFE has hampered wider applications in the biomedical fields. In this work, we extend the treatment time in long-pulse, high-frequency oxygen plasma immersion ion implantation of PTFE and a more superhydrophobic surface with a water contact angle of 160° is created. X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) reveal that the optimized long-pulse, high-frequency oxygen plasma immersion ion implantation process induces a rougher surface and to a lesser extent alters the surface oxygen concentration on the PTFE. Our data, especially long-term contact angles, suggest that the superhydrophobility stems from surface roughness alteration. Furthermore, the activity of MC3T3-E1 osteoblasts cultured on the treated surfaces is promoted in terms of quantities and morphology. [source] | |||||||||||||||||||||||||||||||||||||