Home About us Contact
|
Home About us Contact | ||
|
|
||
White Hair (white + hair)
Selected AbstractsInfluence of prostaglandin F2, and its analogues on hair regrowth and follicular melanogenesis in a murine modelEXPERIMENTAL DERMATOLOGY, Issue 5 2005S. Sasaki Abstract:, Latanoprost and isopropyl unoprostone, which are analogues of prostaglandin F2, (PGF2,), are promising drugs for the reduction of intra-ocular pressure. However, they have been reported to have side effects, including hypertrichosis and hyperpigmentation of the eyelashes and periocular skin, and occasionally poliosis. In order to investigate these effects further, PGF2,, latanoprost and isopropyl unoprostone were applied to the dorsal skin of 7-week-old C57BL/6 mice, and hair length was measured during the treatment. The three molecules all showed stimulatory effects on the murine hair follicles and the follicular melanocytes in both the telogen and anagen stages, and stimulated conversion from the telogen to the anagen phase. PGE2 is known to act synergistically with PGF2,, and hence the influence of PGE2 was also examined. PGE2 did not induce distinct telogen-to-anagen conversion, but showed moderate growth stimulatory effects on early anagen hair follicles. In addition, we observed a case of hypertrichosis and trichomegaly with an excess of melanogenesis, leading to the emergence of white hair, suggesting that poliosis can occur as a side effect of eye treatment with solutions of PGF2, analogues. The stimulatory effects of PGF2,and PGE2 on hair growth have been discussed with regard to the role of protein kinase C and mast cells. [source] Poliosis as the First Clue of Tuberous SclerosisPEDIATRIC DERMATOLOGY, Issue 4 2008YINGLUCK APIBAL M.D. We reported herein a case of tuberous sclerosis presented with a tuft of white hair (poliosis) at birth for recommended poliosis as a useful earliest sign for detection of tuberous sclerosis in the newborn. [source] Repigmentation and curling of hair after acitretin therapyAUSTRALASIAN JOURNAL OF DERMATOLOGY, Issue 3 2009Dilek Seckin ABSTRACT Drug-induced hair colour and texture changes have been reported rarely. We describe a 70-year-old woman with psoriasis who noticed darkening of her previously white hair, which also gained a curly appearance after 6 months of acitretin treatment. We present this case to emphasize that acitretin can be added to the list of drugs that induce changes in hair colour and texture. [source] Poliosis circumscripta associated with neurofibromatosis 1AUSTRALASIAN JOURNAL OF DERMATOLOGY, Issue 3 2008Cecilia Sandoval-Tress SUMMARY A 38-year-old man presented with axillary freckling, multiple café au lait macules and neurofibromas on the scalp, trunk and extremities. In addition, he had a patch of white hair on the right parieto-occipital area overlying a scalp neurofibroma. He was diagnosed with poliosis circumscripta associated with neurofibromatosis 1. [source] The hair follicle melanocytes in vitiligo in relation to disease durationJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 8 2009T S Anbar Abstract Background and aims, Vitiligo is an acquired pigmentary disorder of skin and hair. Active melanocytes in hair follicles can be detected by DOPA and immunohistochemical staining, while amelanotic melanocytes can only be detected by the latter. None of the studies on hair melanocytes in vitiligo discussed the effect of disease duration on these melanocytes. Here, we study the presence of melanotic and amelanotic melanocytes in vitiligo hair follicles and statistically correlating their presence with the disease duration. Methods, This study was conducted on 30 patients with vitiligo and 10 normal volunteers. Three biopsies were taken from each patient: two from black and white hairs from vitiliginous areas and the third from apparently normal skin of the same patients. Sections were stained by DOPA reaction and NKI/beteb then examined for the presence of melanocytes. The presence of melanocytes and the disease duration were correlated statistically using the t -test. Results, Active melanocytes were detected in black hairs of 6.7% of vitiligo patients and in 100% of apparently normal skin of the same patients and controls. On examining black hairs of the 28 vitiligo patients with negative DOPA reaction, 19 of them (67.9%) showed positive NKI/beteb stain. Disease duration was inversely correlated with the melanocytes' presence within hair follicles. Melanocytes were absent from 100% of white hairs. Conclusions, The melanotic melanocytes were the first target of the disease process followed by the amelanotic melanocytes. Since the disappearance of the latter was inversely correlated with the disease duration, early treatment in vitiligo is advised. Conflicts of interest None declared. [source] The poor response of phototherapy in old lesions of vitiligo may be related to the presence of white hairs: a hypothesisPHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, Issue 4 2010Dong-Youn Lee No abstract is available for this article. [source] | ||||||||||