Web Servers (web + servers)

Distribution by Scientific Domains

Selected Abstracts

An adaptive load balancing scheme for web servers

Dr. James Aweya
This paper describes an overload control scheme for web servers which integrates admission control and load balancing. The admission control mechanism adaptively determines the client request acceptance rate to meet the web servers' performance requirements while the load balancing or client request distribution mechanism determines the fraction of requests to be assigned to each web server. The scheme requires no prior knowledge of the relative speeds of the web servers, nor the work required to process each incoming request. Copyright 2002 John Wiley & Sons, Ltd. [source]

Web server suite for complex mixture analysis by covariance NMR

Fengli Zhang
Abstract Elucidation of the chemical composition of biological samples is a main focus of systems biology and metabolomics. Their comprehensive study requires reliable, efficient, and automatable methods to identify and quantify the underlying metabolites. Because nuclear magnetic resonance (NMR) spectroscopy is a rich source of molecular information, it has a unique potential for this task. Here we present a suite of public web servers (http://spinportal.magnet.fsu.edu), termed COLMAR, which facilitates complex mixture analysis by NMR. The COLMAR web portal presently consists of three servers: COLMAR covariance calculates the covariance NMR spectrum from an NMR input dataset, such as a TOCSY spectrum; COLMAR DemixC method decomposes the 2D covariance TOCSY spectrum into a reduced set of nonredundant 1D cross sections or traces, which belong to individual mixture components; and COLMAR query screens the traces against a NMR spectral database to identify individual compounds. Examples are presented that illustrate the utility of this web server suite for complex mixture analysis. Copyright 2009 John Wiley & Sons, Ltd. [source]

Validation of crystallographic models containing TLS or other descriptions of anisotropy

Frank Zucker
The use of TLS (translation/libration/screw) models to describe anisotropic displacement of atoms within a protein crystal structure has become increasingly common. These models may be used purely as an improved methodology for crystallographic refinement or as the basis for analyzing inter-domain and other large-scale motions implied by the crystal structure. In either case it is desirable to validate that the crystallographic model, including the TLS description of anisotropy, conforms to our best understanding of protein structures and their modes of flexibility. A set of validation tests has been implemented that can be integrated into ongoing crystallographic refinement or run afterwards to evaluate a previously refined structure. In either case validation can serve to increase confidence that the model is correct, to highlight aspects of the model that may be improved or to strengthen the evidence supporting specific modes of flexibility inferred from the refined TLS model. Automated validation checks have been added to the PARVATI and TLSMD web servers and incorporated into the CCP4i user interface. [source]