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Wave Reflection (wave + reflection)
Selected AbstractsArterial stiffness in relation to subclinical atherosclerosisEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 1 2009A. Wykretowicz ABSTRACT Background, Increased arterial stiffness or arteriosclerosis, represents a physiological part of ageing. Atherosclerosis is a process that does not affect the arterial bed uniformly but has a variable local distribution and is frequently superimposed on stiffened vessels. We therefore addressed the question of whether any correlation exists between the general characteristics of arterial stiffness or wave reflection and subclinical atherosclerosis as assessed by carotid intima-media thickness (IMT) in a sample of healthy subjects. Methods, A total of 116 healthy subjects (mean age 55 years, 43 female) were evaluated. Arterial stiffness and wave reflection was assessed with the use of digital volume pulse analysis (DVP) and pulse wave analysis (PWA). Subclinical atherosclerosis was assessed by measurement of IMT. Results, Stiffness Index (SIDVP), the measure of general arterial stiffness correlated significantly with IMT (r = 0·37, P < 0·01). IMT correlated significantly with age (r = 0·5, P < 0·0001), waist to hip ratio (WHR) (r = 0·39, P < 0·0001) and mean blood pressure (BPmean) (r = 0·4, P < 0·0001). IMT did not correlate with measures of wave reflection. SIDVP correlated significantly with age (r = 0·32, P < 0·005), WHR (r = 0·36, P < 0·0001), BPmean (r = 0·36, P < 0·0001) and measurements of wave reflection. However analysis of a model which included variables that significantly influenced SIDVP and IMT, such as age, WHR and mean BP showed that arterial stiffness is not independently associated with subclinical atherosclerosis. Conclusions, The indices of subclinical atherosclerosis, arterial stiffness and wave reflection, indicate different aspects of vascular status in otherwise healthy subjects [source] Arterial stiffening and cardiac hypertrophy in a new rat model of type 2 diabetesEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 1 2006K.-C. Chang Abstract Background, We determined the effects of NIDDM on haemodynamic parameters describing arterial wall elasticity and cardiac hypertrophy in rats administered streptozotocin (STZ) and nicotinamide (NA), using the aortic impedance analysis. Methods, Male Wistar rats at 2 months were administered intraperitoneally 180 mg kg,1 of NA, 30 min before an intravenous injection of 50 mg kg,1 STZ, to induce type 2 diabetes. The STZ-NA rats were divided into two groups, 4 weeks and 8 weeks after induction of diabetes, and compared with untreated age-matched controls. Pulsatile aortic pressure and flow signals were measured by a high-fidelity pressure sensor and electromagnetic flow probe, respectively, and were then subjected to Fourier transformation for the analysis of aortic input impedance. Results, In each diabetic group, the experimental syndrome was characterized by a moderate and stable hyperglycaemia and a relative deficiency of insulin secretion. However, the 8-week but not the 4-week STZ-NA diabetic rats showed a decrease in cardiac output in the absence of any significant changes in mean aortic pressure, having increased total peripheral resistance. The diabetic syndrome at 8 weeks also contributed to an increase in aortic characteristic impedance, from 1·49 ± 0·33 (mean ± SD) to 1·95 ± 0·28 mmHg s mL,1 (P < 0·05), suggesting a detriment to the aortic distensibility in NIDDM. Meanwhile, the STZ-NA diabetic animals after 8 weeks had an increased wave reflection factor (0·46 ± 0·09 vs. 0·61 ± 0·13, P < 0·05) and decreased wave transit time (25·8 ± 3·8 vs. 20·6 ± 2·8 ms, P < 0·05). Ratio of the left ventricular weight to body weight was also enhanced in the 8-week STZ-NA diabetic rats. Conclusion, The heavy intensity with early return of the pulse wave reflection may augment systolic load of the left ventricle coupled to the arterial system, leading to cardiac hypertrophy in the rats at 8 weeks after following STZ and NA administration. [source] Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveformEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 1 2004J. Westerbacka Abstract Background, Individuals whose platelets are resistant to the antiaggregatory effects of insulin in vitro are also resistant to the antiaggregatory effects of nitroglycerin (GTN). We have previously shown that insulin acutely diminishes central wave reflection in large arteries and that this action of insulin is blunted in insulin-resistant subjects. However, as yet, no studies have compared the haemodynamic effects of insulin and GTN on large arterial function in the same group of subjects. The aim of this study was to determine whether resistance to the haemodynamic effects of insulin is a defect specific to insulin or whether individuals resistant to the vascular actions of insulin are also resistant to GTN. Design and results, Dose,response characteristics of insulin and GTN on the aortic waveform were determined using applanation tonometry and pulse wave analysis (PWA) in seven healthy men (age 26 ± 1 year, BMI 25 ± 2 kg m,2). Three doses of sublingual GTN (500 µg for 1, 3 or 5 min) and insulin (0·5, 1 or 2 mU kg,1 min,1 for 120 min) were administered on three separate occasions. Both agents dose-dependently decreased central pulse pressure and the augmentation index (AIx) without changing brachial artery blood pressure. We next compared responses to insulin (2 mU kg,1 min,1 for 120 min) and sublingual GTN (500 µg for 5 min) in 20 nondiabetic subjects (age 50 ± 2 year, BMI 21·0,36·3 kg m,2). Again, both agents significantly decreased AIx. Although the vascular effects of insulin and GTN vascular were positively correlated [Spearman's r = 0·92 (95% confidence interval 0·81,0·97), P < 0·0001], the time-course for the action GTN was faster than that of insulin. Brachial systolic blood pressure remained unchanged during the insulin infusion (122 ± 3 vs. 121 ± 3 mmHg, 0 vs. 120 min) but aortic systolic blood pressure decreased significantly by 30 min (111 ± 3 vs. 107 ± 3 mmHg, 0 vs. 30 min, P < 0·01). Similarly, GTN decreased aortic systolic blood pressure from 119 ± 4 to maximally 112 ± 3 mmHg (P < 0·001) without significantly decreasing systolic blood pressure in the brachial artery. Conclusions, The effects of insulin and GTN on large arterial haemodynamics are dose-dependent and significantly correlated. The exact mechanisms and sites of action of insulin and GTN in subjects with insulin resistance remain to be established. [source] Serroydyne modulator based on circularly polarized wave reflectionMICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 6 2005V. F. Fusco Abstract In this paper, a technique is described whereby we can directly Serrodyne a signal reflected from a rotating metal disk. This is achieved by placing a spinning circular-patch antenna (which has two short-circuiting pins at its periphery) in the path of an incident circularly polarized (CP) field. When excited by a circularly polarized signal, the rotating disk produces a re-reflected signal with a modulo 0° to 360° phase shift encoded onto it. The sense of the re-radiated signal is the same as that of the incident signal. The developed technique can be used as a mechanical Serrodyne modulator providing a small frequency offset in the return signal that is directly related to direction and rate of rotation. A mathematical rationale for the principal of operation of the device is given and experimental validation of the method is provided. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 45: 469,472, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.20855 [source] Interpretation of radial pulse contour during fentanyl/nitrous oxide anesthesia and mechanical ventilationACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 7 2002S. Söderström Background: Peripheral arterial blood pressure is not a reliable substitute for proximal aortic pressure. Recognition of this phenomenon is important for correct appreciation of cardiac afterload. Our aim was to evaluate the utility of the radial pulse wave to better understand ventriculo-vascular coupling during anesthesia. Methods: We observed the differences between aortic systolic pressure (AoSAP, tipmanometry) and radial systolic pressure in 15 patients, (including two women) aged 53,78 years, before coronary artery bypass surgery. We studied the induction of anesthesia with fentanyl (20 µg kg,1), moderate volume loading, and thereafter the addition of 70% nitrous oxide. The circulatory effects of mechanical ventilation were studied by doubling the tidal volumes. Pulse wave contours were assessed by calculation of radical and aortic augmentation indices (AI), which measure the second systolic pressure peak. Results: Radial systolic pressure was higher than AoSAP in the control situation (8±2 mmHg), and this SAP gradient increased further with fentanyl (12±2 mmHg). The gradient persisted throughout the study, but was partially reduced by volume loading and nitrous oxide, respectively. Radial augmentation index was the only parameter remaining in a stepwise multivariate model to explain the variance in the SAP gradient (r2=0.48). Radial augmentation index also correlated with aortic pulse pressure (r2=0.71). Mechanical ventilation had significant and similar effects on pulse wave augmentation both in the aorta and in the radial artery, and did not affect the radial to aortic SAP gradient. Conclusion: These elderly coronary patients had stiff vasculature (high aortic AI) and considerable pulse wave reflection, which was beneficially delayed by fentanyl. Changes in the radial pulse wave augmentation during mechanical ventilation were mainly a result of cyclic changes in the stroke volume, and were seldom associated with an increased systolic pressure gradient from the aorta to the radial artery. [source] Resonant gravity-wave drag enhancement in linear stratified flow over mountainsTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 609 2005M. A. C. Teixeira Abstract High-drag states produced in stratified flow over a 2D ridge and an axisymmetric mountain are investigated using a linear, hydrostatic, analytical model. A wind profile is assumed where the background velocity is constant up to a height z1 and then decreases linearly, and the internal gravity-wave solutions are calculated exactly. In flow over a 2D ridge, the normalized surface drag is given by a closed-form analytical expression, while in flow over an axisymmetric mountain it is given by an expression involving a simple 1D integral. The drag is found to depend on two dimensionless parameters: a dimensionless height formed with z1, and the Richardson number, Ri, in the shear layer. The drag oscillates as z1 increases, with a period of half the hydrostatic vertical wavelength of the gravity waves. The amplitude of this modulation increases as Ri decreases. This behaviour is due to wave reflection at z1. Drag maxima correspond to constructive interference of the upward- and downward-propagating waves in the region z Human skin permittivity determined by millimeter wave reflection measurementsBIOELECTROMAGNETICS, Issue 5 2007S.I. Alekseev Abstract Millimeter wave reflection from the human skin was studied in the frequency range of 37,74 GHz in steps of 1 GHz. The forearm and palm data were used to model the skin with thin and thick stratum corneum (SC), respectively. To fit the reflection data, a homogeneous unilayer and three multilayer skin models were tested. Skin permittivity in the mm-wave frequency range resulted from the permittivity of cutaneous free water which was described by the Debye equation. The permittivity increment found from fitting to the experimental data was used for determination of the complex permittivity and water content of skin layers. Our approach, first tested in pure water and gelatin gels with different water contents, gave good agreement with literature data. The homogeneous skin model fitted the forearm data well. Permittivity of the forearm skin obtained with this model was close to the skin permittivity reported by others. To fit reflection from the palmar skin with a thick SC, a skin model containing at least two layers was required. Multilayer models provided better fitting to both the forearm and palmar skin reflection data. The fitting parameters obtained with different models were consistent with each other. Bioelectromagnetics 28:331,339, 2007. © 2007 Wiley-Liss, Inc. [source] HEREDITARY AND ENVIRONMENTAL INFLUENCES ON ARTERIAL FUNCTIONCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 7 2007CS Hayward SUMMARY 1With the ageing population and increasing heart failure, arterial function has been shown to contribute to cardiovascular risk because of its adverse effects on ventriculovascular coupling. Population studies have confirmed independent prognostic information of arterial stiffening on cardiovascular survival. 2The term ,arterial function' encompasses a range of phenotypes, including measures of arterial structure/remodelling, measures of arterial wall mechanics, surrogate measures of stiffness and of wave reflection. There exists significant interaction between these measures and none is truly independent of the others. Added to this complexity is the recognition that, although arterial function has a strong genetic component, quantification requires a range of techniques from twin to family and population studies. 3The contribution of heritability is often derived from statistical models with input from genomic scanning and candidate gene studies. Studies to date confirm a significant heritable component for the majority of phenotypes examined. However, it has also been recognized that the factors involved in blood pressure maintenance are likely to be separate to those in arterial structural degeneration with ageing. Candidate genes for arterial function go beyond those of the sympathetic and renin,angiotensin systems and include genes involved in signalling pathways and extracellular matrix modulation. 4The present review examines the evidence for heritability of the major arterial function phenotypes with environmental and ageing modulation. A brief overview of the impact of atherosclerotic risk factors on arterial function is included. [source] Seismic evidence for a sharp lithospheric base persisting to the lowermost mantle beneath the CaribbeanGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2008Tadashi Kito SUMMARY Broad-band data from South American earthquakes recorded by Californian seismic networks are analysed using a newly developed seismic wave migration method,the slowness backazimuth weighted migration (SBWM). Using the SBWM, out-of-plane seismic P -wave reflections have been observed. The reflection locations extend throughout the Earth's lower mantle, down to the core,mantle boundary (CMB) and coincide with the edges of tomographically mapped high seismic velocities. Modelling using synthetic seismograms suggests that a narrow (10,15 km) low- or high-velocity lamella with about 2 per cent velocity contrast can reproduce the observed reflected waveforms, but other explanations may exist. Considering the reflection locations and synthetic modelling, the observed out-of-plane energy is well explained by underside reflections off a sharp reflector at the base of the subducted lithosphere. We also detect weaker reflections corresponding to the tomographically mapped top of the slab, which may arise from the boundary between the Nazca plate and the overlying former basaltic oceanic crust. The joint interpretation of the waveform modelling and geodynamic considerations indicate mass flux of the former oceanic lithosphere and basaltic crust across the 660 km discontinuity, linking processes and structure at the top and bottom of the Earth's mantle, supporting the idea of whole mantle convection. [source] Recovering acoustic reflectivity using Dirichlet-to-Neumann maps and left- and right-operating adjoint propagatorsGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 1 2005M. W. P. Dillen SUMMARY Constructing an image of the Earth subsurface from acoustic wave reflections has previously been described as a recursive downward redatuming of sources and receivers. Most of the methods that have been presented involve reflectivity and propagators associated with one-way wavefield components. In this paper, we consider the reflectivity relation between two-way wavefield components, each a solution of a Helmholtz equation. To construct forward and inverse propagators, and a reflection operator, the invariant-embedding technique is followed, using Dirichlet-to-Neumann maps. Employing bilinear and sesquilinear forms, the forward- and inverse-scattering problems, respectively, are treated analogously. Through these mathematical constructs, the relationship between a causality radiation condition and symmetry, with respect to a bilinear form, is associated with the requirement of an anticausality radiation condition with respect to a sesquilinear form. Using reciprocity, sources and receivers are redatumed recursively to the reflector, employing left- and right-operating adjoint propagators. The exposition of the proposed method is formal, that is numerical applications are not derived. The key to applications lies in the explicit representation, characterization and approximation of the relevant operators (symbols) and fundamental solutions (path integrals). Existing constructive work which could be applied to the proposed method are referred to in the text. [source] Nonreflecting boundary conditions based on nonlinear multidimensional characteristicsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 1 2010Qianlong Liu Abstract Nonlinear characteristic boundary conditions based on nonlinear multidimensional characteristics are proposed for 2- and 3-D compressible Navier,Stokes equations with/without scalar transport equations. This approach is consistent with the flow physics and transport properties. Based on the theory of characteristics, which is a rigorous mathematical technique, multidimensional flows can be decomposed into acoustic, entropy, and vorticity waves. Nonreflecting boundary conditions are derived by setting corresponding characteristic variables of incoming waves to zero and by partially damping the source terms of the incoming acoustic waves. In order to obtain the resulting optimal damping coefficient, analysis is performed for problems of pure acoustic plane wave propagation and arbitrary flows. The proposed boundary conditions are tested on two benchmark problems: cylindrical acoustic wave propagation and the wake flow behind a cylinder with strong periodic vortex convected out of the computational domain. This new approach substantially minimizes the spurious wave reflections of pressure, density, temperature, and velocity as well as vorticity from the artificial boundaries, where strong multidimensional flow effects exist. The numerical simulations yield accurate results, confirm the optimal damping coefficient obtained from analysis, and verify that the method substantially improves the 1-D characteristics-based nonreflecting boundary conditions for complex multidimensional flows. Copyright © 2009 John Wiley & Sons, Ltd. [source] Differential effects of sevoflurane and propofol anesthesia on left ventricular,arterial coupling in dogsACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 8 2010Y. L. J. M. DERYCK Background: General anesthetics interfere with arterial and ventricular mechanical properties, often altering left ventricular,arterial (LVA) coupling. We hypothesized that sevoflurane and propofol alter LVA coupling by different effects on arterial and ventricular properties. Methods: Experiments were conducted in six anesthetized open-chest dogs for the measurement of left ventricular pressure and aortic pressure and flow. Measurements were performed during anesthesia with 0.5, 1.0 and 1.5 minimum alveolar concentration sevoflurane and 12, 24 and 36 mg/kg/h propofol. LVA coupling was assessed as the ratio of ventricular end-systolic elastance (Ees, measuring ventricular contractility) to effective arterial elastance (Ea, measuring ventricular afterload). The steady component of afterload, arterial tone, was assessed by systemic vascular resistance and arterial pressure,flow curves. The pulsatile component of afterload was assessed by aortic impedance and compliance. Results: Sevoflurane decreased aortic pressure and cardiac output more than propofol. Sevoflurane reduced arterial tone, increased arterial stiffness and did not affect wave reflections. It increased Ea, decreased Ees and reduced LVA coupling. Propofol reduced arterial tone, did not affect arterial stiffness and decreased wave reflections. It did not affect Ea, Ees or LVA coupling. Conclusions: Sevoflurane increased ventricular afterload and decreased ventricular performance, thereby altering LVA coupling. Propofol did not affect ventricular afterload or ventricular performance, thereby preserving LVA coupling. Thus, propofol preserves LVA coupling in dogs better, and might be a better choice for patients with compromised left ventricular function. [source] ANALYSIS OF SHORT-TERM REPRODUCIBILITY OF ARTERIAL VASOREACTIVITY BY PULSE-WAVE ANALYSIS AFTER PHARMACOLOGICAL CHALLENGECLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 1 2009Biju Paul SUMMARY 1Pulse-wave analysis (PWA) is an established method to assess arterial wave reflections and arterial vasoreactivity in humans. A high short-term reproducibility of baseline augmentation index (AIx) has been reported. However, the short-term reproducibility of AIx changes following pharmacological challenge with either inhaled salbutamol (endothelium-dependent vasodilatation) or sublingual glyceryl trinitrate (GTN; endothelium-independent vasodilatation), using appropriate statistical methods, is largely unknown. 2Baseline AIx and GTN- and salbutamol-mediated changes in AIx (all corrected for a heart rate of 75 b.p.m.) were measured on two separate occasions, 1 h apart, in 22 healthy controls (mean (±SD) age 52.0 ± 13.4 years) and 11 elderly patients with chronic heart failure (CHF; 73.1 ± 8.7 years). Reproducibility was assessed by measuring intraclass correlation coefficients (ICC), coefficients of variation (CV) and Bland,Altman plots. 3Baseline AIx showed good short-term reproducibility with high ICC in both the control and CHF groups (0.90 and 0.87, respectively). In contrast, in the control and CHF groups, the ICC of GTN- (0.58 and 0.17, respectively) and salbutamol-mediated (0.18 and 0.04, respectively) changes in AIx were substantially low. The CV was relatively low for baseline AIx in control and CHF groups (25.0 and 22.5%, respectively), but not for GTN- (22.3 and 59.8%, respectively) or salbutamol-mediated (45.1 and 184.0%, respectively) changes in AIx. Bland,Altman analysis revealed poor reproducibility, with limits of agreement beyond either +15% or ,15% for changes in AIx after GTN and salbutamol for both control and CHF groups. The changes in blood pressure and heart rate following pharmacological challenge were similar between the two measurements. 4The poor reproducibility of changes in AIx following pharmacological challenge questions the use of this method in acute studies. [source] Experimental and clinical study of the combined effect of arterial stiffness and heart rate on pulse pressure: Differences between central and peripheral arteriesCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 3 2005Theodoros G Papaioannou SUMMARY 1.,Pulse pressure (PP) constitutes an independent predictor of cardiovascular events and mortality in various populations. Heart rate (HR) and arterial stiffness, in addition to their independent predictive value for cardiovascular complications, seem to interact with regard to the modification of PP. The aim of the present study was to investigate the association of PP with HR under different levels of arterial compliance (AC), revealing their synergistic effects. 2.,Seventy-one normotensive and untreated hypertensive subjects were examined. Arterial compliance was measured by the ,area' method, whereas central blood pressures and wave reflections were evaluated using the Sphygmocor® system (AtCor Medical, Sydney, NSW, Australia). A hydraulic Windkessel model was also used to evaluate the independent effect of HR and AC on PP. Peripheral PP was associated only with mean pressure and AC. In contrast, central PP was further related to HR (20 b.p.m. decrease in HR resulted in central PP augmentation by 5.6 mmHg) regardless of mean pressure, stroke volume, age and gender. However, this association was statistically significant only for subjects with lower AC (< 1.1 mL/mmHg) and not for those with more compliant arteries. These findings are also in accordance with the experimental data. 3.,Aortic PP is affected to a greater degree by HR changes compared with peripheral PP. This response was observed only at high levels of arterial stiffness. 4.,The present study provides the first evidence regarding the combined effect of AC and HR on aortic PP, which may lead to larger clinical or epidemiological studies aiming to optimization of drug treatment and to a possible reduction of cardiovascular risk. [source]
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