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Various Strategies (various + strategy)
Selected AbstractsPathogenesis of Helicobacter pylori infectionHELICOBACTER, Issue 2002Markus Gerhard Five years after publication of the complete genome sequence of Helicobacter pylori, research interest is shifting from the descriptive association of virulence factors with clinical outcome in infected patients to the molecular mechanisms of virulence factor action. This is particularly noticeable for VacA and CagA, for both of which detailed understanding of the interaction with host signalling pathways has accumulated over the last year. The role of H. pylori Lewis antigens for clinical outcome was further substantiated. Various strategies of H. pylori to fool or evade the human immune system are described, which all lead to the dysfunction of specific compartments of the host cellular immune system. Finally, a number of animal models indicate that inflammation is a key factor for gastric carcinogenesis, which is finally supported by a large prospective study identifying corpus atrophy and intestinal metaplasia as precancerous conditions. [source] Robustness analysis of flexible structures: practical algorithmsINTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 8 2003Gilles Ferreres Abstract When analysing the robustness properties of a flexible system, the classical solution, which consists of computing lower and upper bounds of the structured singular value (s.s.v.) at each point of a frequency gridding, appears unreliable. This paper describes two algorithms, based on the same technical result: the first one directly computes an upper bound of the maximal s.s.v. over a frequency interval, while the second one eliminates frequency intervals, inside which the s.s.v. is guaranteed to be below a given value. Various strategies are then proposed, which combine these two techniques, and also integrate methods for computing a lower bound of the s.s.v. The computational efficiency of the scheme is illustrated on a real-world application, namely a telescope mock-up which is significant of a high order flexible system. Copyright © 2003 John Wiley & Sons, Ltd. [source] Prediction of human pharmacokinetics , improving microsome-based predictions of hepatic metabolic clearanceJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 10 2007Urban Fagerholm Physiologically based methods generally perform poorly in predicting in-vivo hepatic CL (CLH) from intrinsic clearance (CLint) in microsomes in-vitro and unbound fraction in blood (fu,bl). Various strategies to improve the predictability have been developed, and inclusion of an empirical scaling factor (SF) seems to give the best results. This investigation was undertaken to evaluate this methodology and to find ways to improve it further. The work was based on a diverse data set taken from Ito and Houston (2005). Another objective was to evaluate whether rationalization of CLH predictions can be made by replacing blood/plasma-concentration ratio (Cbl/Cpl) measurements with SFs. There were apparently no or weak correlations between prediction errors and lipophilicity, permeability (compounds with low permeability missing in the data set) and main metabolizing CYP450s. The use of CLint class (high/low) and drug class (acid/base/neutral) SFs (the CD-SF method) gives improved and reasonable predictions: 1.3-fold median error (an accurate prediction has a 1-fold error), 76% within 2-fold-error, and a median absolute rank ordering error of 2 for CLH (n = 29). This approach is better than the method with a single SF. Mean (P < 0.05) and median errors, fraction within certain error ranges, higher percentage with most accurate predictions, and ranking were all better, and 76% of predictions were more accurate with this new method. Results are particularly good for bases, which generally have higher CLH and the potential to be incorrectly selected/rejected as candidate drugs. Reasonable predictions of fu,bl can be made from plasma fu (fu,pl) and empirical blood cell binding SFs (B-SFs; 1 for low fu,pl acids; 0.62 for other substances). Mean and median fu,bl prediction errors are negligible. The use of the CD-SF method with predicted fu,bl (the BCD-SF method) also gives improved and reasonable results (1.4-fold median error; 66% within 2-fold-error; median absolute rank ordering error = 1). This new empirical approach seems sufficiently good for use during the early screening; it gives reasonable estimates of CLH and good ranking, which allows replacement of Cbl/Cpl measurements by a simple equation. [source] DynaQoS© -RDF: a best effort for QoS-assurance of dynamic reconfiguration of dataflow systemsJOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 1 2009Wei Li Abstract The significance of QoS-assurance is being increasingly recognized by both the research and wider communities. In the latter case, this recognition is driven by the increasing adoption by business of 24/7 software systems and the QoS decline that end-users experience when these systems undergo dynamic reconfiguration. At the beginning of 2006, the author set up a project named DynaQoS© -RDF (QoS-assurance of Dynamic Reconfiguration on Reconfigurable Dataflow Model), which was then sponsored by the CQ University Australia. Over the last two years, the author has investigated QoS-assurance for dataflow systems, which are characterized by the pipe-and-filter architecture. The research has addressed issues such as: the global consistency of protocol transactions, the necessary and sufficient conditions for QoS-assurance, execution overhead control for reconfiguration, state transfer for stateful components, and the design of a QoS benchmark. This paper discusses these research issues. It also proposes various QoS strategies and presents a benchmark for evaluating QoS-assurance strategies for the dynamic reconfiguration of dataflow systems. This benchmark is implemented using the DynaQoS© -RDF v1.0 software platform. Various strategies, including those from the research literature are benchmarked, and the best efforts for QoS-assurance are identified. Copyright © 2008 John Wiley & Sons, Ltd. [source] Adherence to treatment in patients with psoriasisJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 4 2006HL Richards Abstract Non-adherence to medication is a chronic problem that impacts on healthcare professionals and patients alike. In psoriasis, a condition that presents patients with frequent and disabling physical, psychological and social effects, studies consistently suggest that up to 40% of patients do not use their medication as directed. Thus it is probable that poor adherence contaminates the clinical picture of response effectiveness in everyday practice. This educational paper reviews research that investigates adherence to medication in patients with psoriasis. It provides an overview of contributing factors and mediating variables. It is proposed that three specific facets appear to optimize patient adherence: an effective doctor,patient relationship; optimism with the treatment prescribed; and a limited ,nuisance' value of treatment in terms of side-effects and hassle of use. Various strategies to address adherence are suggested and it is argued that in order to enhance our understanding of adherence in patients with psoriasis, there needs to be an increasing focus on patients' beliefs about their condition and its management. [source] How international is Medical Education?MEDICAL EDUCATION, Issue 1 2004L J Brice Aims To consider Medical Education's claim to international status in terms of the extent of international authorship within published articles, the degree to which authors draw on the international literature to support their work, and its self-citation rates and publication decisions. Method We examined 6 journals' citation rates for the period 1997,2001 to see if there was evidence of national publication bias; we calculated their self-citation rates to see if this had any influence on impact factor, and we examined Medical Education's management files for trends which might indicate publication bias due to country of origin of authors. Results All 6 journals exhibited a bias in favour of citing journals from their own countries. The US journals were more likely to cite journals from their own country. Medical Education was most likely to cite journals from non-UK countries. Self-citation rates did not appear to affect impact factors. The ratio of UK to non-UK papers published in Medical Education has not changed significantly over the period studied although non-UK submissions increased sharply in 2002 and the number of North American submissions has doubled since 1998. Conclusion Medical Education is justified in calling itself an international journal to the extent that the majority of papers it publishes are from countries other than the UK, and it is more likely than other journals in the field to publish papers which cite work in journals published outside the UK. Nevertheless, there is some evidence of publication bias in the journal and more work is needed to discover why this is the case. Various strategies to address the issue of national bias in Medical Education are discussed. [source] Minimally Invasive Vein Surgery: Latest Options for Vein DiseaseMOUNT SINAI JOURNAL OF MEDICINE: A JOURNAL OF PERSONALIZED AND TRANSLATIONAL MEDICINE, Issue 3 2010FACPhArticle first published online: 20 MAY 2010, Steven Elias MD Abstract The goal of treatment for venous disease is to decrease ambulatory venous hypertension. Various strategies are employed. These can be divided into exogenous and endogenous treatments. Exogenous methods concern those employed from the outside of the limb, such as compression and elevation. Endogenous modalities treat from inside the limb the underlying venous pathology due to venous valvular dysfunction or venous obstruction. Traditional endogenous procedures include stripping, ligation, and phlebectomy. All these procedures require incisions, anesthesia, and perhaps hospitalization, and involve significant discomfort. Newer minimally invasive vein surgery procedures now exist. These are all same-day, outpatient procedures, usually involving local anesthesia. Most can be performed percutaneously without incisions. Patients ambulate the day of the procedure. Morbidity is less than 1%. This article summarizes the concept of minimally invasive vein surgery and summarizes new technologies to manage all forms of venous disease. Mt Sinai J Med 77:270,278, 2010. © 2010 Mount Sinai School of Medicine [source] The costing and funding of longitudinal birth cohort studiesPAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 2009Alan Doyle Key to the success of any longitudinal birth cohort study is the availability of appropriate and long-term levels of funding. The ease or difficulty of obtaining necessary funds to carry out data collection, preparation and documentation efficiently will determine the quality of data and the ease with which it is made available for collaborators. Various strategies for acquiring funding are outlined. [source] BARRIERS AND CHALLENGES IN CLINICAL ETHICS CONSULTATIONS: THE EXPERIENCES OF NINE CLINICAL ETHICS COMMITTEESBIOETHICS, Issue 8 2009REIDAR PEDERSEN ABSTRACT Clinical ethics committees have recently been established in nearly all Norwegian hospital trusts. One important task for these committees is clinical ethics consultations. This qualitative study explores significant barriers confronting the ethics committees in providing such consultation services. The interviews with the committees indicate that there is a substantial need for clinical ethics support services and, in general, the committee members expressed a great deal of enthusiasm for the committee work. They also reported, however, that tendencies to evade moral disagreement, conflict, and ,outsiders' are common in the hospitals. Sometimes even the committees comply with some of these tendencies. The committees agree that there is a need to improve their routines and procedures, clarify the committees' profile and field of responsibility, to make the committees well-known, to secure adequate operating conditions, and to develop organizational integration and support. Various strategies to meet these challenges on a local, regional or national level are also explored in this paper. [source] Comparison of Two Evolutionary Algorithms for Optimization of Bridge Deck RepairsCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 8 2006Hatem Elbehairy These decisions, however, represent complex optimization problems that traditional optimization techniques are often unable to solve. This article introduces an integrated model for bridge deck repairs with detailed life cycle costs of network-level and project-level decisions. Two evolutionary-based optimization techniques that are capable of handling large-size problems, namely Genetic Algorithms and Shuffled Frog Leaping, are then applied on the model to optimize maintenance and repair decisions. Results of both techniques are compared on case study problems with different numbers of bridges. Based on the results, the benefits of the bridge deck management system are illustrated along with various strategies to improve optimization performance. [source] Altering the surface properties of baculovirus Autographa californica NPV by insertional mutagenesis of the envelope protein gp64FEBS JOURNAL, Issue 18 2002Alexandra Spenger The envelope protein gp64 of the baculovirus Autographa californica nuclear polyhedrosis virus is essential for viral entry into insect cells, as the glycoprotein both mediates pH-dependent membrane fusion and binds to host cell receptors. Surface modification of baculovirus particles by genetic engineering of gp64 has been demonstrated by various strategies and thus has become an important and powerful tool in molecular biology. To improve further the presentation of peptides on the surface of baculovirus particles, several insertion sites within the gp64 envelope protein were selected by their theoretical maximum surface probability and investigated for efficient peptide presentation. The ELDKWA peptide of the gp41 of HIV-1, specific for the human mAb 2F5, was inserted into 17 different positions of the glycoprotein gp64. Propagation of viruses was successful in 13 cases, mutagenesis at four positions did not result in production of intact virus particles. Western blotting, FACS analysis and ELISA were used for characterization of the different binding properties of the mutants. Insertion of this peptide into the native envelope protein resulted in high avidity display on the surface of baculovirus particles. This approach offers the possibility of effective modification of surface properties in regard to host range specificity and antigen display. [source] Molecular Mimetic Self-Assembly of Colloidal ParticlesADVANCED FUNCTIONAL MATERIALS, Issue 7 2010Zhengwei Mao Abstract This article presents an overview of the current progress in molecular mimetic self-assembly of colloidal particles. Firstly, the recent study of colloidal particles at interfaces is highlighted, underlining the mesoscopic mimicry of the surface activity of amphiphilic molecules using colloidal particles. Secondly, various strategies developed thus far to impart colloidal particles with anisotropy in terms of chemical composition, surface chemistry and particle morphology, which are regarded as mesoscopic atoms and molecules, are reviewed. Thirdly, an overview of the current theoretical and experimental results of using the rules of molecular synthesis and self-assembly to direct self-assembly of colloidal particles is presented. Finally, the experimental challenges associated with molecular mimetic self-assembly of colloidal particles are outlined, giving a rather conservative conclusion of the status quo of this new research field with a very optimistic outlook. [source] Sodium Borohydride Hydrolysis as Hydrogen Generator: Issues, State of the Art and Applicability Upstream from a Fuel CellFUEL CELLS, Issue 3 2010U. B. Demirci Abstract Today there is a consensus regarding the potential of NaBH4 as a good candidate for hydrogen storage and release via hydrolysis reaction, especially for mobile, portable and niche applications. However as gone through in the present paper two main issues, which are the most investigated throughout the open literature, still avoid NaBH4 to be competitive. The first one is water handling. The second one is the catalytic material used to accelerate the hydrolysis reaction. Both issues are objects of great attentions as it can be noticed throughout the open literature. This review presents and discusses the various strategies which were considered until now by many studies to manage water and to improve catalysts performances (reactivity and durability). Published studies show real improvements and much more efforts might lead to significant overhangs. Nevertheless, the results show that we are still far from envisaging short-term commercialisation. [source] Complement and its implications in cardiac ischemia/reperfusion: strategies to inhibit complementFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 5 2001Tiphaine Monsinjon Although reperfusion of the ischemic myocardium is an absolute necessity to salvage tissue from eventual death, it is also associated with pathologic changes that represent either an acceleration of processes initiated during ischemia or new pathophysiological changes that were initiated after reperfusion. This so-called ,reperfusion injury' is accompanied by a marked inflammatory reaction, which contributes to tissue injury. In addition to the well known role of oxygen free radicals and white blood cells, activation of the complement system probably represents one of the major contributors of the inflammatory reaction upon reperfusion. The complement may be activated through three different pathways: the classical, the alternative, and the lectin pathway. During reperfusion, complement may be activated by exposure to intracellular components such as mitochondrial membranes or intermediate filaments. Two elements of the activated complement contribute directly or indirectly to damages: anaphylatoxins (C3a and C5a) and the membrane attack complex (MAC). C5a, the most potent chemotactic anaphylatoxin, may attract neutrophils to the site of inflammation, leading to superoxide production, while MAC is deposited over endothelial cells and smooth vessel cells, leading to cell injury. Experimental evidence suggests that tissue salvage may be achieved by inhibition of the complement pathway. As the complement is composed of a cascade of proteins, it provides numerous sites for pharmacological interventions during acute myocardial infarction. Although various strategies aimed at modulating the complement system have been tested, the ideal approach probably consists of maintaining the activity of C3 (a central protein of the complement cascade) and inhibiting the later events implicated in ischemia/reperfusion and also in targeting inhibition in a tissue-specific manner. [source] Redesigning mental health services: lessons on user involvement from the Mental Health CollaborativeHEALTH EXPECTATIONS, Issue 1 2003Glenn Robert PhD Abstract Objectives, To explore the involvement of mental health service users in the redesign of in-patient mental health services in six Trusts participating in a multi-regional NHS modernization programme. Design, Semi-structured interviews and observation of team meetings undertaken as part of an action research study. Participants and setting, Users, clinical, medical and managerial staff from six mental health trusts which participated in the Northern & Yorkshire and Trent regions' Mental Health Collaborative (MHC). Results and conclusions, Whilst there were some problems, user involvement was undoubtedly a strength of the MHC in comparison to other modernization programmes within the NHS we have studied. However, the particular challenges posed by the specific context of acute mental health services should not be overlooked. The initial approach taken in each of the sites was to simply invite a user or user representative to join the local project team. In the course of events, various changes were made to this initial mechanism for involving users in the ongoing work of the teams. These changes , and setbacks in some sites , make drawing firm conclusions as to the effectiveness of the various strategies employed problematic. However, our qualitative data suggest a number of broad lessons that will assist both those leading and participating in other redesign initiatives to maximize the benefits to be gained from service user involvement. [source] Human cytomegalovirus and natural killer-mediated surveillance of HLA class I expression: a paradigm of host,pathogen adaptationIMMUNOLOGICAL REVIEWS, Issue 1 2001Miguel López-Botet Summary: Among various strategies to evade the host immune response, some viruses like human cytomegalovirus (HCMV) interfere with surface MHC class I expression and antigen presentation to T lymphocytes. The ability of natural killer (NK) cells to detect MHC class I molecules through inhibitory receptors can be envisaged as an adaptation of the immune system for responding to such pathological alterations. To fulfil that role, rodents use members of the Ly49 C-type lectin superfamily, whereas primates employ killer immunoglobulin-like receptors and the immunoglobulin-like transcript 2/leucocyte immunoglobulin-like receptor-1 receptor. CD94/NKG2 lectin-like heterodimers represent the most conserved receptor system for MHC class I molecules; by interacting with human HLA-E or murine Qa-1b, CD94/NKG2A inhibitory receptors broadly probe the biosynthesis pathway of other class I molecules. Reciprocally, HCMV has developed mechanisms to evade the NK response while modulating HLA class Ia expression. The ability of HCMV to maintain surface levels of HLA-E and to express an HLA class I surrogate (UL18) are herein discussed in the context of the interplay with human NKR systems. This work was supported by grants FIS 00/0181 and SAF98-0006. We thank Dr A. Angulo for helpful discussion. [source] Parallel DSMC method using dynamic domain decompositionINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 1 2005J.-S. Wu Abstract A general parallel direct simulation Monte Carlo method using unstructured mesh is introduced, which incorporates a multi-level graph-partitioning technique to dynamically decompose the computational domain. The current DSMC method is implemented on an unstructured mesh using particle ray-tracing technique, which takes the advantages of the cell connectivity information. In addition, various strategies applying the stop at rise (SAR) (IEEE Trans Comput 1988; 39:1073,1087) scheme is studied to determine how frequent the domain should be re-decomposed. A high-speed, bottom-driven cavity flow, including small, medium and large problems, based on the number of particles and cells, are simulated. Corresponding analysis of parallel performance is reported on IBM-SP2 parallel machine up to 64 processors. Analysis shows that degree of imbalance among processors with dynamic load balancing is about ,,½ of that without dynamic load balancing. Detailed time analysis shows that degree of imbalance levels off very rapidly at a relatively low value with increasing number of processors when applying dynamic load balancing, which makes the large problem size fairly scalable for processors more than 64. In general, optimal frequency of activating SAR scheme decreases with problem size. At the end, the method is applied to compute two two-dimensional hypersonic flows, a three-dimensional hypersonic flow and a three-dimensional near-continuum twin-jet gas flow to demonstrate its superior computational capability and compare with experimental data and previous simulation data wherever available. Copyright © 2005 John Wiley & Sons, Ltd. [source] Robust and efficient quantization and coding for control of multidimensional linear systems under data rate constraintsINTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 10-11 2007K. Li Abstract Recently, we reported results on coding strategies for scalar feedback systems with data-rate-limited feedback channels in which the data-rate constraints are time varying. Such rate-varying channels are typically encountered in communication networks in which links between nodes are subject to noise, congestion, and intermittent disruption. The present paper describes results of extending this research into the multidimensional domain. An important consideration is that for systems of dimension greater than one, many classical feedback designs cannot be realized for operation near the theoretical minimum possible data rate. A novel control coding scheme will be presented, and in terms of this, it will be shown that the advantages of coarse signal quantization that had been reported earlier for scalar systems remain in the multidimensional case. The key is to allocate the communication bandwidth efficiently among faster and slower modes. We discuss various strategies that allocate bandwidth by scheduling the time slots assigned to each mode. In particular, we propose a ,robust attention varying' technique, whose merit will be discussed in terms of its robustness with respect to time-varying communication channel capacity and also in terms of how well it operates when the feedback channel capacity is near the theoretical minimum data rate. Copyright © 2006 John Wiley & Sons, Ltd. [source] From the defence of the nation to the consolidation of modernity: a genealogy of corruption in Bolivia (1982,1999)INTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 191 2008Sebastián Urioste Guglielmone The instruments and approach taken from the toolbox proposed by Michel Foucault are used in this first political and historical study of the constitution of knowledge relating to corruption in Bolivia between 1982 and 1999. By reflecting on the links between the discontinuity of knowledge in this phenomenon and the various strategies deployed to fight against it, a genealogy of corruption unveils the profound transformations in politics and policies that Bolivia experienced over two decades. [source] Strategies for Directing the Differentiation of Stem Cells Into the Osteogenic Lineage In Vitro,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 9 2004Boon Chin Heng Abstract A major area in regenerative medicine is the application of stem cells in bone reconstruction and bone tissue engineering. This will require well-defined and efficient protocols for directing the differentiation of stem cells into the osteogenic lineage, followed by their selective purification and proliferation in vitro. The development of such protocols would reduce the likelihood of spontaneous differentiation of stem cells into divergent lineages on transplantation, as well as reduce the risk of teratoma formation in the case of embryonic stem cells. Additionally, such protocols could provide useful in vitro models for studying osteogenesis and bone development, and facilitate the genetic manipulation of stem cells for therapeutic applications. The development of pharmokinetic and cytotoxicity/genotoxicity screening tests for bone-related biomaterials and drugs could also use protocols developed for the osteogenic differentiation of stem cells. This review critically examines the various strategies that could be used to direct the differentiation of stem cells into the osteogenic lineage in vitro. [source] Retrieval of spectral and dynamic properties from two-dimensional infrared pump-probe experimentsJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 9 2008Riccardo Chelli Abstract We have developed a fitting algorithm able to extract spectral and dynamic properties of a three level oscillator from a two-dimensional infrared spectrum (2D-IR) detected in time resolved nonlinear experiments. Such properties go from the frequencies of the ground-to-first and first-to-second vibrational transitions (and hence anharmonicity) to the frequency-fluctuation correlation function. This last is represented through a general expression that allows one to approach the various strategies of modeling proposed in the literature. The model is based on the Kubo picture of stochastic fluctuations of the transition frequency as a result of perturbations by a fluctuating surrounding. To account for the line-shape broadening due to pump pulse spectral width in double-resonance measurements, we supply the fitting algorithm with the option to perform the convolution of the spectral signal with a Lorentzian function in the pump-frequency dimension. The algorithm is tested here on 2D-IR pump-probe spectra of a Gly-Ala dipeptide recorded at various pump-probe delay times. Speedup benchmarks have been performed on a small Beowulf cluster. The program is written in FORTRAN language for both serial and parallel architectures and is available free of charge to the interested reader. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008 [source] The development of dentist practice profiles and managementJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 1 2009Chinho Lin PhD Abstract Rationale and objectives, With the current large computerized payment systems and increase in the number of claims, unusual dental practice patterns to cover up fraud are becoming widespread and sophisticated. Clustering the characteristic of dental practice patterns is an essential task for improving the quality of care and cost containment. This study aims at providing an easy, efficient and practical alternative approach to developing patterns of dental practice profiles. This will help the third-party payer to recognize and describe novel or unusual patterns of dental practice and thus adopt various strategies in order to prevent fraudulent claims and overcharges. Methodology, Knowledge discovery (or data mining) was used to cluster the dentists' profiles by carrying out clustering techniques based on the features of service rates. It is a hybrid of the knowledge discovery, statistical and artificial neural network methodologies that extracts knowledge from the dental claim database. Results, The results of clustering highlight characteristics related to dentists' practice patterns, and the detailed managerial guidance is illustrated to support the third-party payer in the management of various patterns of dentist practice. Conclusion, This study integrates the development of dentists' practice patterns with the knowledge discovery process. These findings will help the third-party payer to discriminate the patterns of practice, and also shed more light on the suspicious claims and practice patterns among dentists. [source] Combined strategies for enhancing the transdermal absorption of midazolam through human skinJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 9 2010Cristina Balaguer-Fernández Abstract Objectives, Midazolam administration by intravenous or intramuscular injection produces pain and stress. For this reason, alternative methods of administration have been proposed. The transdermal administration of midazolam could improve patient comfort, which is especially important for children in the pre-operative period. We aimed to assess the effect of iontophoresis and chemical percutaneous enhancers applied individually and together, to determine if a synergistic effect is achieved when both enhancement techniques are simultaneously employed. Methods, This work reports the characterization of the passive diffusion of midazolam hydrochloride through human skin in vitro and evaluates the effect of iontophoresis application and chemical percutaneous enhancers on said diffusion when employed both individually and in combination. Key findings, Percutaneous absorption assays demonstrated that the physical technique of iontophoresis, when applied alone, moderately increased midazolam hydrochloride permeation flux through human skin, producing a similar effect to that obtained with R -(+)-limonene chemical enhancer. Among the strategies assayed, it was observed that Azone produced the most pronounced enhancement effect when applied separately. The combination of pre-treatment with Azone and iontophoresis exhibited a higher capacity for enhancing the transdermal flux of midazolam through human skin than Azone alone. Conclusions, In conclusion, when applied individually, Azone exhibited the greatest enhancement effect on the transdermal diffusion of midazolam of the various strategies assayed. The combination of Azone and iontophoresis produce the highest transdermal steady-state flux of midazolam but no synergic effect was achieved when the two enhancement strategies were applied in combination, showing that although selecting the best conditions for iontophoresis application, it is less effective for augmenting the transdermal delivery of midazolam than the chemical enhancer Azone. [source] Supply Management Strategies for the Future: A Delphi StudyJOURNAL OF SUPPLY CHAIN MANAGEMENT, Issue 3 2005Jeffrey A. Ogden Summary As supply management becomes more involved in strategic decisions, an understanding of the various strategies that it can employ is crucial. This research uses a multiround Delphi study of key procurement and supply management executives to better understand which procurement and supply management strategies may lead to significant improvements over the next 5,10 years. The results indicate that strategies such as increased integration, information sharing and collaboration among supply chain members are most likely to be implemented and will have the largest impact on organizations. However, this integration will not include joint investment or asset sharing, will be limited to one tier in the supply chain, and will not heavily involve e-markets and electronic auctions. [source] Decreasing incidence of hepatocellular carcinoma among children following universal hepatitis B immunizationLIVER INTERNATIONAL, Issue 5 2003Mei-Hwei Chang Abstract: Hepatocellular carcinoma (HCC) is one of the 10 most common malignant tumors worldwide. Chronic infection with hepatitis B or C virus is closely related to hepatocarcinogenesis. The outcome of current therapies for HCC is not satisfactory. Prevention is the best way to control HCC. Among the various strategies of HCC prevention, immunization against hepatitis B virus infection is the most effective. Universal hepatitis B immunization has proved to be effective in reducing the incidence of HCC to 1/4,1/3 of that in children born before the hepatitis B vaccination era in Taiwan. The problems we face in achieving global control of hepatitis-related HCC include: (1) no effective vaccine for the prevention of hepatitis C and its related HCC; (2) no immunization program for hepatitis B in areas with inadequate resources; (3) poor compliance to the immunization program as a result of ignorance, anxiety, or poverty; and (4) vaccine failure. Integration of the hepatitis B vaccination program into the expanded program of immunization for all infants throughout the world will be most urgent and important for HCC control. The reduction of the incidence of HCC will be seen in adults 30,40 years of age after the launch of the universal hepatitis B vaccination program. This concept of cancer vaccine can be applied to other infectious agents and their related cancers. [source] Patterns of Development in Spanish L2 Pragmatic Acquisition: An Analysis of Novice Learners' Production of DirectivesMODERN LANGUAGE JOURNAL, Issue 4 2006LYNN PEARSON This article investigates from an acquisitional approach the development of pragmatic competence by novice learners of second language (L2) Spanish. Specifically, it examines the acquisition of various strategies (e.g., head acts, use of softeners, formality marking, and hearer-oriented directives) to realize Spanish directives. A quantitative and qualitative analysis of the data detected patterns in the learners' directive production. The analysis considered factors such as instruction, L2 grammatical competence, and the influence of the first language (L1) to illustrate the patterns of development of L2 pragmatics at lower proficiency levels. The results show (a) verb forms with increased morphological complexity replaced lower level directive strategies, possibly as a result of the expansion of L2 grammatical competence; (b) pragmatic competence seems to precede grammatical competence; and (c) the L1 pragmatic system appears to play a role in interpreting and processing new L2 data for use in production. [source] The Use of Reception Strategies by Learners of French as a Foreign LanguageMODERN LANGUAGE JOURNAL, Issue 3 2006THOMAS S. C. FARRELL Listening in a second or foreign language is a very demanding task because it involves both correctly interpreting incoming speech and responding appropriately to the speaker. This qualitative classroom-based investigation describes the types and frequency of reception strategies used by learners at three different proficiency levels in French while engaged in a two-way information-gap task. Results indicate that the learners used various strategies in order to achieve understanding while interacting with one another. These strategies were used either to obtain new information from interlocutors, to confirm information, or to repair comprehension problems. The results also suggest that learners at all proficiency levels were able to use these strategies when needed and evidently without prior training in strategy use. [source] The Off -Tonic Return in Beethoven's Piano Concerto No. 4 in G Major, Op.MUSIC ANALYSIS, Issue 3 2005Other Works ABSTRACT Various compositional problems and opportunities may accompany the return of a main theme that has a non-tonic opening. There are four overlapping strategies for approaching such ,off-tonic returns': (1) the thematic return may be preceded by V of the main key; (2) the returning theme may be preceded by an applied chord which points to the theme's opening, non-tonic harmony; (3) the theme may return in the middle of a larger progression; or (4) the theme may be recomposed so as to start on the tonic when it returns. In many compositions, these various strategies have deep harmonic, motivic, or narrative implications. Beethoven was particularly adept in handling off-tonic returns, as may be witnessed in works such as his Concerto for Piano and Orchestra in G Major, Op. 58. [source] Locational tying of complementary retail itemsNAVAL RESEARCH LOGISTICS: AN INTERNATIONAL JOURNAL, Issue 5 2009Bacel Maddah Abstract We study a selling practice that we refer to as locational tying (LT), which seems to be gaining wide popularity among retailers. Under this strategy, a retailer "locationally ties" two complementary items that we denote by "primary" and "secondary." The retailer sells the primary item in an appropriate "department" of his or her store. To stimulate demand, the secondary item is offered in the primary item's department, where it is displayed in very close proximity to the primary item. We consider two variations of LT: In the multilocation tying strategy (LT-M), the secondary item is offered in its appropriate department in addition to the primary item's department, whereas in the single-location tying strategy (LT-S), it is offered only in the primary item's location. We compare these LT strategies to the traditional independent components (IC) strategy, in which the two items are sold independently (each in its own department), but the pricing/inventory decisions can be centralized (IC-C) or decentralized (IC-D). Assuming ample inventory, we compare and provide a ranking of the optimal prices of the four strategies. The main insight from this comparison is that relative to IC-D, LT decreases the price of the primary item and adjusts the price of the secondary item up or down depending on its popularity in the primary item's department. We also perform a comparative statics analysis on the effect of demand and cost parameters on the optimal prices of various strategies, and identify the conditions that favor one strategy over others in terms of profitability. Then we study inventory decisions in LT under exogenous pricing by developing a model that accounts for the effect of the primary item's stock-outs on the secondary item's demand. We find that, relative to IC-D, LT increases the inventory level of the primary item. We also link the profitability of different strategies to the trade-off between the increase in demand volume of the secondary item as a result of LT and the potential increase in inventory costs due to decentralizing the inventory of the secondary item. © 2009 Wiley Periodicals, Inc. Naval Research Logistics 2009 [source] Disruption-management strategies for short life-cycle productsNAVAL RESEARCH LOGISTICS: AN INTERNATIONAL JOURNAL, Issue 4 2009Brian Tomlin Abstract Supplier diversification, contingent sourcing, and demand switching (whereby a firm shifts customers to a different product if their preferred product is unavailable), are key building blocks of a disruption-management strategy for firms that sell multiple products over a single season. In this article, we evaluate 12 possible disruption-management strategies (combinations of the basic building-block tactics) in the context of a two-product newsvendor. We investigate the influence of nine attributes of the firm, its supplier(s), and its products on the firs preference for the various strategies. These attributes include supplier reliability, supplier failure correlation, payment responsibility in the event of a supply failure, product contribution margin, product substitutability, demand uncertainties and correlation, and the decision makes risk aversion. Our results show that contingent sourcing is preferred to supplier diversification as the supply risk (failure probability) increases, but diversification is preferred to contingent sourcing as the demand risk (demand uncertainty) increases. We find that demand switching is not effective at managing supply risk if the products are sourced from the same set of suppliers. Demand switching is effective at managing demand risk and so can be preferred to the other tactics if supply risk is low. Risk aversion makes contingent sourcing preferable over a wider set of supply and demand-risk combinations. We also find a two-tactic strategy provides almost the same benefit as a three-tactic strategy for most reasonable supply and demand-risk combinations. © 2009 Wiley Periodicals, Inc. Naval Research Logistics, 2009 [source] | |||||||||||||||||||||||||||||||