Home About us Contact
|
Home About us Contact | ||
|
|
||
Various Numbers (various + number)
Selected AbstractsAcute viral lymphadenitis mimicking low-grade peripheral T-cell lymphoma A clinicopathological study of nine cases,APMIS, Issue 6 2001Masaru Kojima Acute viral lymphadenitis, especially infectious mononucleosis (IM), often shows the presence of Reed-Sternberg-like cells, resulting in confusion with Hodgkin's disease. However, acute viral lymphadenitis requiring differential diagnosis from non-Hodgkin's lymphoma is not widely recognized. We describe the clinicopathological and immunohistochemical features of lymph node lesions from nine such patients which pose serious problems of differential diagnosis from low-grade peripheral T-cell lymphoma. There were three males and six females with ages ranging from 21 to 44 years (median 25 years). All patients had "B" symptoms and multicentric lymphadenopathy. The clinical course was also self-limiting. Each lymph node specimen showed an obvious expansion of an interfollicular area by pleomorphic and polymorphous infiltration with an increased number of arborizing postcapillary venules. The infiltrate was composed of variable numbers of small and medium-sized lymphocytes, immunoblasts, plasma cells in various stage of maturation and occasional granulocytes. The small lymphocytes usually had regular round nuclei, whereas the medium-sized lymphocytes occasionally showed nuclear pleomorphism. Hyperreactivity of B-lymphocytes, including hyperplastic germinal centers and/or foci of monocytoid B-cells, was seen in parts of the lesion. The majority of the interfollicular T-lymphocytes, including T-immunoblasts, expressed CD8 antigen. Various numbers of TIA-1-positive small and medium-sized T-cells were observed in the paracortical area. Despite these findings, the overall histological picture of this series posed serious difficulties when differentially diagnosing this condition from low-grade peripheral T-cell lymphomas such as angioimmunoblastic T-cell (AILD) and T-zone types, indicating that viral lymphadenitis occasionally presents with histological features of AILD and T-zone lymphomas. To avoid overdiagnosis and overtreatment, we emphasize the need to pay careful attention to the clinical and laboratory findings as well as the morphological features. [source] Performance and scalability of MPI on PC clustersCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 1 2004Glenn R. Luecke Abstract The purpose of this paper is to compare the communication performance and scalability of MPI communication routines on a Windows Cluster, a Linux Cluster, a Cray T3E-600, and an SGI Origin 2000. All tests in this paper were run using various numbers of processors and two message sizes. In spite of the fact that the Cray T3E-600 is about 7 years old, it performed best of all machines for most of the tests. The Linux Cluster with the Myrinet interconnect and Myricom's MPI performed and scaled quite well and, in most cases, performed better than the Origin 2000, and in some cases better than the T3E. The Windows Cluster using the Giganet Full Interconnect and MPI/Pro's MPI performed and scaled poorly for small messages compared with all of the other machines. Copyright © 2004 John Wiley & Sons, Ltd. [source] Novel Brush Polymers with Phosphorylcholine Bristle Ends: Synthesis, Structure, Properties, and BiocompatibilityADVANCED FUNCTIONAL MATERIALS, Issue 10 2009Gahee Kim Abstract New brush polymers with various numbers of bristle ends incorporating phosphorylcholine (PC) moieties are synthesized. The polymers are thermally stable up to 175,°C and form good-quality films with conventional spin-, roll-, and dip-coating, and subsequent drying processes. Interestingly, all these brush polymers, as a PC-containing polymer, demonstrate a stable molecular multi-bilayer structure in thin films that arise due to the efficient self-assembly of the bristles for temperatures <55,°C and PC-rich surfaces, and therefore successfully mimic natural cell-membrane surfaces. These brush-polymer films exhibit excellent water wettability and water sorption whilst retaining the remarkable molecular multi-bilayer structure, and thus have hydrophilic surfaces. These novel multi-bilayer structured films repel fibrinogen molecules and platelets from their surfaces but also have bactericidal effects on bacteria. Moreover, the brush-polymer films are found to provide comfortable surface environments for the successful anchoring and growth of HEp-2 cells, and to exhibit excellent biocompatibility in mice. These newly developed brush polymers are suitable for use in biomedical applications including medical devices and biosensors that require biocompatibility and the reduced possibility of post-operative infection. [source] Cardiac Risk Factors and the Use of Triptans: A Survey StudyHEADACHE, Issue 7 2000William B. Young MD Objective.,To describe current practice in triptan use. Background.,Triptans are effective migraine treatments that cause chest symptoms in some patients. True cardiac ischemia is rare. Design.,Headache specialists and family practitioners completed questionnaires regarding the times when triptans are contraindicated, obtaining electrocardiograms (ECGs), and giving the first dose in the office. Results.,Sixty-five headache specialists and 67 family practitioners responded. Headache specialists saw an average of 36.3 patients with headache per week. Family practitioners saw an average of 7.2. Family practitioners and headache specialists had similar opinions regarding the age at which triptans were contraindicated with various numbers of risk factors. Sixty-one percent of headache specialists and 50% of family practitioners would not use a triptan at any age for patients with more than three risk factors (P = NS). Ten percent of headache specialists obtained an ECG for all patients being prescribed triptans, while no family practitioners did (P = .008). Ten percent of both family practitioners and headache specialists never obtained an ECG, even with multiple cardiac risk factors. Headache specialists obtained ECGs more often than family practitioners (P < .002 for one to three risk factors). Family practitioners were more likely to give the first dose of the triptan in the office regardless of cardiovascular risk (58% versus 20%, P < .001). Forty-five percent of headache specialists and 2% of family practitioners never gave the first dose in the office (P < .001). Family practitioners gave the first dose in the office more readily than headache specialists in patients with no risk factors (P = .001), but not for one or more risk factors. Conclusions.,No consensus exists among family practitioners or headache specialists about when to avoid using a triptan due to excessive cardiac risk factors, when to obtain an ECG prior to using a triptan, and when to give the first dose of a triptan in the office. Headache specialists are more likely to obtain ECGs, whereas family practitioners are more likely to give the first dose of a triptan in the office. [source] Contingent approaches to making likelihood judgments about polychotomous cases: the influence of task factorsJOURNAL OF BEHAVIORAL DECISION MAKING, Issue 4 2005Paul D. Windschitl Abstract Two experiments tested the influence of three task factors on respondents' tendency to use normative, heuristic, and random approaches to making likelihood judgments about polychotomous cases (i.e., cases in which there is more than one alternative to a focal hypothesis). Participants estimated their likelihood of winning hypothetical raffles in which they and other players held various numbers of tickets. Responding on non-numeric scales (vs. numeric ones) and responding under time pressure (vs. self-paced) increased participants' use of a comparison-heuristic approach, resulting in non-normative judgment patterns. A manipulation of evidence representation (whether ticket quantities were represented by numbers or more graphically by bars) did not have reliably detectable effects on processing approaches to likelihood judgment. The authors discuss the implications of these findings for the further development of likelihood judgment theories, and they discuss parallels between contingent processing in choice and contingent processing in likelihood judgment. Copyright © 2005 John Wiley & Sons, Ltd. [source] Accessible proteomics space and its implications for peak capacity for zero-, one- and two-dimensional separations coupled with FT-ICR and TOF mass spectrometryJOURNAL OF MASS SPECTROMETRY (INCORP BIOLOGICAL MASS SPECTROMETRY), Issue 3 2006Jennifer L. Frahm The number and wide dynamic range of components found in biological matrixes present several challenges for global proteomics. In this perspective, we will examine the potential of zero-dimensional (0D), one-dimensional (1D), and two-dimensional (2D) separations coupled with Fourier-transform ion cyclotron resonance (FT-ICR) and time-of-flight (TOF) mass spectrometry (MS) for the analysis of complex mixtures. We describe and further develop previous reports on the space occupied by peptides, to calculate the theoretical peak capacity available to each separations-mass spectrometry method examined. Briefly, the peak capacity attainable by each of the mass analyzers was determined from the mass resolving power (RP) and the m/z space occupied by peptides considered from the mass distribution of tryptic peptides from National Center for Biotechnology Information's (NCBI's) nonredundant database. Our results indicate that reverse-phase-nanoHPLC (RP-nHPLC) separation coupled with FT-ICR MS offers an order of magnitude improvement in peak capacity over RP-nHPLC separation coupled with TOF MS. The addition of an orthogonal separation method, strong cation exchange (SCX), for 2D LC-MS demonstrates an additional 10-fold improvement in peak capacity over 1D LC-MS methods. Peak capacity calculations for 0D LC, two different 1D RP-HPLC methods, and 2D LC (with various numbers of SCX fractions) for both RP-HPLC methods coupled to FT-ICR and TOF MS are examined in detail. Peak capacity production rates, which take into account the total analysis time, are also considered for each of the methods. Furthermore, the significance of the space occupied by peptides is discussed. Copyright © 2006 John Wiley & Sons, Ltd. [source] Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activityJOURNAL OF NEUROSCIENCE RESEARCH, Issue 6 2002Asuka Morizane Abstract A method of inducing dopamine (DA) neurons from mouse embryonic stem (ES) cells by stromal cell-derived inducing activity (SDIA) was previously reported. When transplanted, SDIA-induced DA neurons integrate into the mouse striatum and remain positive for tyrosine hydroxylase (TH) expression. In the present study, to optimize the transplantation efficiency, we treated mouse ES cells with SDIA for various numbers of days (8,14 days). SDIA-treated ES cell colonies were isolated by papain treatment and then grafted into the 6-hydroxydopamine (6-OHDA)-lesioned mouse striatum. The ratio of the number of surviving TH-positive cells to the total number of grafted cells was highest when ES cells were treated with SDIA for 12 days before transplantation. This ratio revealed that grafting cell colonies was more efficient for obtaining TH-positive cells in vivo than grafting cell suspensions. When we grafted a cell suspension of 2 × 105, 2 × 104, or 2 × 103 cells into the 6-OHDA-lesioned mouse striatum, we observed only a few surviving TH-positive cells. In conclusion, inducing DA neurons from mouse ES cells by SDIA for 12 days and grafting cell colonies into mouse striatum was the most effective method for the survival of TH-positive neurons in vivo. © 2002 Wiley-Liss, Inc. [source] An analysis of the neighborhood impacts of a mortgage assistance program: A spatial hedonic modelJOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 4 2010Wenhua Di Down payment or closing cost assistance is an effective program in addressing the wealth constraints of low-and moderate-income homebuyers. However, the spillover effect of such programs on the neighborhood is unknown. This paper estimates the impact of the City of Dallas Mortgage Assistance Program (MAP) on nearby home values using a hedonic model of home sales from 1990 to 2006. We define neighborhoods of 1,000 feet around each sale and estimate the average differences in sales prices between neighborhoods with various numbers of MAP properties before and after their appearance. We find that MAP properties tend to locate in neighborhoods with lower property values; however, unless a concentration of MAP properties forms, the infusion of MAP properties has little detrimental impact on neighboring property values. Moreover, low concentration of MAP properties has a modest positive impact on surrounding property values. © 2010 by the Association for Public Policy Analysis and Management. [source] Use of microbeads for the detection of binding sites on the human zona pellucida: a scanning electron microscopy (SEM) assayANDROLOGIA, Issue 5 2001Prof. Dr H. W. Michelmann Summary One prerequisite for fertilization is the specific binding of spermatozoa to the zona pellucida. However, the factors and mechanisms involved in this gamete contact are not well understood. Gamete recognition and binding are species-specific and are controlled by oligosaccharides of the zona and their corresponding carbohydrates on the spermatozoon. By using a specific lectin we developed a technique to detect those oligosaccharides on the human zona pellucida that might be involved in the binding process. Microbeads (Ø = 2.8 ,m), used as artificial spermatozoa, were coated with lectin Con A and cultured together with 75 unfertilized oocytes (group A) remaining after intracytoplasmic sperm injection. Con A binds specifically to ,-D-mannose and ,-D-glucose. As a control, 75 unfertilized oocytes after intracytoplasmic sperm injection (group B) were also cultured together with Con A-covered microbeads, but in a medium containing a binding inhibiting sugar (,-methyl-mannopyrasosid). The number and distribution of the microbeads on human oocytes of both groups were analysed on scanning electron microscopy images. Beads on oocytes of group A had binding patterns similar to those of spermatozoa. They were distributed in an extremely heterogeneous way with various numbers of bound beads both on individual and different oocytes. Most of the group A oocytes (85%) had more than 50 beads bound to the zona, in contrast to the control oocytes of group B, where 68% had less than 10 bound beads. The use of an inhibiting sugar abolished the binding capacity of the microbeads nearly completely. This technique is a powerful tool for the detection of binding sites on the zona pellucida, i.e. those sugars that are responsible for contact between spermatozoa and the zona pellucida. [source] Analysis of Al2O3 Atomic Layer Deposition on ZrO2 Nanoparticles in a Rotary Reactor,CHEMICAL VAPOR DEPOSITION, Issue 9 2007A. McCormick Abstract Al2O3 atomic layer deposition (ALD) is analyzed on ZrO2 nanoparticles in a rotary reactor. This rotary reactor allows for static exposures and efficiently utilizes the reactants for ALD on high surface area nanoparticles. The Al2O3 ALD is performed using exposures to Al(CH3)3 and H2O reactants. The pressure transients during these exposures are examined using a sequence of reactant micropulses. These micropulses are less than the required exposures for the ALD surface chemistry to reach completion. The pressure transients during identical sequential Al(CH3)3 and H2O micropulses change as the surface chemistry progresses to completion. These pressure transients allow the required saturation reactant exposure to be determined to maximize reactant usage. The ZrO2 nanoparticles are coated using various numbers of Al(CH3)3 and H2O reactant exposures. The Al2O3 ALD-coated ZrO2 nanoparticles are subsequently analyzed using a number of techniques including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Auger electron spectroscopy (AES), scanning AES (SAES), and X-ray photoelectron spectroscopy (XPS). The TEM images reveal very conformal Al2O3 ALD on the ZrO2 nanoparticles. The Al2O3 ALD thicknesses versus number of Al(CH3)3 and H2O reactant exposures yielded an Al2O3 ALD growth rate of 2.0,Å per reactant cycle. The AES and XPS results are consistent with an Al2O3 ALD film that completely and conformally covered the underlying ZrO2 nanoparticle. The SAES measurements show that the Al2O3 ALD films are continuous and homogeneous on the ZrO2 nanoparticles. These results demonstrate that a rotary reactor can successfully perform ALD with high reactant efficiency on high surface area nanoparticles. [source] | ||||||||||||||||