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Selected AbstractsGuillain,Barré syndrome in southern Taiwan: clinical features, prognostic factors and therapeutic outcomesEUROPEAN JOURNAL OF NEUROLOGY, Issue 6 2003B.-C. Cheng To determine the clinical features, prognostic factors, and therapeutic results of Guillain,Barré syndrome (GBS) in order to improve the therapeutic strategy for this disease. We retrospectively reviewed the electrodiagnostic study and medical records of patients with GBS admitted to Chang Gung Memorial Hospital, Kaohsiung, between January 1986 and December 2000. Outcomes and prognosis were followed-up after 1 year. Ninety-six patients were enrolled in this study. According to the clinical and electrophysiological findings, 77 patients were acute inflammatory demyelinating polyradiculoneuropathy, seven were Miller Fisher syndrome, and six were axonal forms, and six were unclassified. At a follow-up of 1 year, 61 patients (64%) recovered, 30 (31%) had residua and five (5%) died. Amongst these 30 had residua, including unassisted gait in 19, assisted gait in four, and wheel/bed bound in seven. According to the statistical analysis, disabilities at the nadir (P < 0.0001) and at admission (P = 0.014) were significant prognostic factors. Variables used for the stepwise logistic regression, and the results revealed that after analysis for all the above variables, only disability at the nadir (P < 0.0001) was independently associated with the treatment failure rate. Our study revealed 27% of cases in need of respiratory support during hospitalization, and 5% of hospital-treated patients die from the complications. Furthermore, 31% had residua at a follow-up of 1 year or more. If prognostic factors are considered, disability at the nadir during hospitalization demonstrates consistently poor therapeutic outcomes. Therefore, early diagnosis, choice of appropriate treatment, and preventing complications during acute stages are essential to maximize the potential for survival. [source] A typology of community opportunity and vulnerability in metropolitan Australia,PAPERS IN REGIONAL SCIENCE, Issue 1 2001Robert Stimson Socio-economic performance; community opportunity and vulnerability; metropolitan regions Abstract. A multivariate model using hierarchical clustering and discriminant analysis is used to identify clusters of community opportunity and community vulnerability across Australia's mega metropolitan regions. Variables used in the model measure aspects of structural economic change, occupational change, human capital, income, unemployment, family/household disadvantage, and housing stress. A nine-cluster solution is used to categorise communities across metropolitan space. Significant between-city variations in the incidence of these clusters of opportunity and vulnerability are apparent, suggesting the emergence of marked differentiation between Australia's mega metropolitan regions in their adjustments to changing economic and social conditions. [source] Family migration and physical growth in Merida, Yucatan, MexicoAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 3 2009Hugo Azcorra Merida city in Yucatan, Mexico, has received rural-to-urban migration for decades, with most immigrants settling in the city's southern neighborhoods. Exposure of immigrants to new environmental and sociocultural conditions can generate biological responses, including changes in physical growth pattern at early age. We performed a study to identify and measure the effects of family migration into south Merida on growth in 4- to 6-year-old children, measuring weight, height, sitting height, and calculated arm muscle and fat areas of 445 children: 228 natives (116 females) and 217 immigrants (118 females) and collecting family social and demographic data. Statistical analysis focused on determining differences in growth, socioeconomic, and biological variables by migratory condition and generating multiple regression models for each growth measurement. No univariate statistical differences (P > 0.05, Student's t- test) were observed in growth between studied children. Multiple regression analyses showed age, sex, mother's height, birth order, birth weight, family income, zone of residence, diet, and febrile episodes had an effect on growth. Neither the migration variable used above nor any other definition of migrant had a significant effect on growth. The lack of differences in growth between immigrant and native children is probably due to similarity in socioeconomic conditions of their families. Am. J. Hum. Biol., 2009. © 2009 Wiley-Liss, Inc. [source] RIGHT-TO-CARRY CONCEALED HANDGUNS AND VIOLENT CRIME: CRIME CONTROL THROUGH GUN DECONTROL?,CRIMINOLOGY AND PUBLIC POLICY, Issue 3 2003TOMISLAV V. KOVANDZIC Research Summary: "Right-to-Carry" (RTC) concealed-handgun laws mandate that authorities issue concealed handgun permits to qualified applicants. The supposition by those supporting the laws is that allowing private citizens to carry concealed handguns in public can reduce violent crime by deterring prospective criminals afraid of encountering armed civilians. Critics of the laws argue that violent altercations are more likely to turn deadly when more people carry guns. Whether the laws cause violent crime to increase or to decrease has become an important public policy question, as most states have now adopted such legislation. The present study evaluates Florida's 1987 RTC law, which prior research suggests plays a key role in the RTC debate. Specifically, we use panel data for 58 Florida counties from 1980 to 2000 to examine the effects on violent crime from increases in the number of people with concealed-carry permits, rather than before-after dummy and time-trend variables used in prior research. We also address many of the methodological problems encountered in earlier RTC studies. We present numerous model specifications, and we find little evidence that increases in the number of citizens with concealed-handgun permits reduce or increase rates of violent crime. Policy Implications: The main policy implication of this research is that there appears to be little gained in the way of crime prevention by converting restrictive gun carrying laws to "shall-issue" laws, although the laws might still prove beneficial by (1) eliminating arbitrary decisions on gun permit applications, (2) encouraging gun safety, (3) making permit holders feel safer when out in public, (4) providing permit holders with a more effective means of self-defense, and (5) reducing the costs to police departments of enforcing laws prohibiting unlicensed gun carrying. [source] Grinnellian and Eltonian niches and geographic distributions of speciesECOLOGY LETTERS, Issue 12 2007Jorge Soberón Abstract In the recent past, availability of large data sets of species presences has increased by orders of magnitude. This, together with developments in geographical information systems and statistical methods, has enabled scientists to calculate, for thousands of species, the environmental conditions of their distributional areas. The profiles thus obtained are obviously related to niche concepts in the Grinnell tradition, and separated from those in Elton's tradition. I argue that it is useful to define Grinnellian and Eltonian niches on the basis of the types of variables used to calculate them, the natural spatial scale at which they can be measured, and the dispersal of the individuals over the environment. I use set theory notation and analogies derived from population ecology theory to obtain formal definitions of areas of distribution and several types of niches. This brings clarity to several practical and fundamental questions in macroecology and biogeography. [source] Explaining stunting in nineteenth-century FranceECONOMIC HISTORY REVIEW, Issue 2 2010GILLES POSTEL-VINAY We examine the share of French men with stunted growth during the nineteenth century using data on potential army conscripts. The share of stunted men (those whose height was below 1.62 metres) in France's 82 departments declined dramatically across the century, especially in the south and west. Our models examine the role of education expenditure, health care personnel, local wages, asset distribution, and a dummy variable for Paris as determinants of stunting, decomposing changes over time into the effects of levels and returns to the various explanatory variables used in the model of heights. All covariates are strongly significant, with education spending being particularly important. Our evidence clearly indicates that living in congested Paris contributed to poor health. [source] State-dependent fertility in pinnipeds: contrasting capital and income breedersFUNCTIONAL ECOLOGY, Issue 5 2000I. L. Boyd Abstract 1.,The study tested the hypothesis that the occurrence of pregnancy in mammals that are capital breeders will be most closely related to state variables that are indices of food stores. Income breeders would not be expected to have the same relationship. 2.,The study examined the relationships between mass, time of year, age and body length with the occurrence of pregnancy in three species of pinniped. This included two capital breeders (Crabeater Seal, Lobodon carcinophagus Hombron & Jacquinot, and Grey Seal, Halichoerus grypus Fabricius) and one income breeder (Antarctic Fur Seal, Arctocephalus gazella Peters). Multiple logistic regression analysis was used to examine the relationships and the interactions between the different state variables. 3.,In both the capital breeders the state variables used in the study explained approximately twice the amount of variability (55% compared with 25%) in the occurrence of pregnancy than in the income breeder. Mass was the dominant state variable among both the capital breeders whereas in the income breeder mass was less important both relative to other state variables and in absolute terms. The results support the conclusion that the occurrence of pregnancy in capital breeders is more sensitive to body reserves than it is in income breeders. 4.,The results also support the conclusion that life histories are the end result of a variety of functional responses to different state variables that have differing degrees of influence. In particular a size-structured approach to studies of population dynamics in pinnipeds may be a more informative way of predicting population responses to environmental variability than the more traditional age-structured approach. [source] Vector Autoregression (Var) , An Approach to Dynamic analysis of Geographic ProcessesGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 2 2001Max Lu Vector autoregression (VAR) is a widely used econometric technique for multivariate time series modelling. This paper shows that with several very attractive features, VAR may also provide a valuable tool for analysing the dynamics among geographic processes and for spatial autoregressive modelling. After a brief discussion of the VAR approach, a VAR model for the dynamics of the US population between 1910 and 1990 is estimated and interpreted to illustrate the techniques. The VAR makes it possible to view the interactions among the four variables used in the model (total population, birth rate, immigration and per capita GNP) more adequately. The paper then discusses recent developments in the VAR methodology such as Bayesian vector autoregression (BVAR), spatial prior for regional modelling and cointegration, as well as the limitations and problems that arise from the application of VARs. [source] Least-square support vector machine applied to settlement of shallow foundations on cohesionless soilsINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 17 2008Pijush Samui Abstract This paper examines the potential of least-square support vector machine (LSVVM) in the prediction of settlement of shallow foundation on cohesionless soil. In LSSVM, Vapnik's ,-insensitive loss function has been replaced by a cost function that corresponds to a form of ridge regression. The LSSVM involves equality instead of inequality constraints and works with a least-squares cost function. The five input variables used for the LSSVM for the prediction of settlement are footing width (B), footing length (L), footing net applied pressure (P), average standard penetration test value (N) and footing embedment depth (d). Comparison between LSSVM and some of the traditional interpretation methods are also presented. LSSVM has been used to compute error bar. The results presented in this paper clearly highlight that the LSSVM is a robust tool for prediction of settlement of shallow foundation on cohesionless soil. Copyright © 2008 John Wiley & Sons, Ltd. [source] Global formulation of 3D magnetostatics using flux and gauged potentialsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 4 2004M. Repetto Abstract The use of algebraic formulation for the solution of electromagnetic fields is becoming more and more widespread. This paper presents the theoretical development of two algebraic formulations of the magneto-static problem and their implementation in a three dimensional computational procedure based on an unstructured tetrahedral mesh. A complete description of the variables used and of the solution algorithm is provided together with a discussion about the performances of the method. The performances of the two procedures are tested and assessed versus cases with known solutions. Copyright © 2004 John Wiley & Sons, Ltd. [source] The development of a new set of long-term climate averages for the UKINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 8 2005Matthew Perry Abstract Monthly and annual long-term average datasets of 13 climate variables are generated for the periods 1961,90 and 1971,2000 using a consistent analysis method. Values are produced for each station in the Met Office's observing network and for a rectangular grid of points covering the UK at a horizontal spacing of 1 km. The variables covered are mean, maximum, minimum, grass minimum and soil temperature, days of air and ground frost, precipitation, days with rain exceeding 0.2 and 1 mm, sunshine, and days with thunder and snow cover. Gaps in the monthly station data are filled with estimates obtained via regression relationships with a number of well-correlated neighbours, and long-term averages are then calculated for each site. Gridded datasets are created by inverse-distance-weighted interpolation of regression residuals obtained from the station averages. This method does not work well for days of frost, thunder and snow, so an alternative approach is used. This involves first producing a grid of values for each month from the available station data. The gridded long-term average datasets are then obtained by averaging the monthly grids. The errors associated with each stage in the process are assessed, including verification of the gridding stage by leaving out a set of stations. The estimation of missing values allows a dense network of stations to be used, and this, along with the range of independent variables used in the regression, allows detailed and accurate climate datasets and maps to be produced. The datasets have a range of applications, and the maps are freely available through the Met Office Website. © Crown Copyright 2005. Reproduced with the permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd. [source] Sexual dimorphism in limb bones of ibex (Capra ibex L.): mixture analysis applied to modern and fossil dataINTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 5 2007H. Fernández Abstract Estimating sex ratios of fossil bone assemblages is an important step in the determination of demographic profiles, which are essential for understanding the palaeobiology and palaeoethology of any particular species, as well as its exploitation patterns by humans. This is especially true for ibex (Capra ibex), which was a main source of food for hominids during Pleistocene times. Classical methods for determining sexual dimorphism and sex ratio, such as analyses using uni- and bivariate plots, are based on an arbitrary fixing of limits between sexes. Here we use a more robust statistical method termed mixture analysis (MA) to determine the sex of postcranial remains (long bones, metapodials and tarsals) from ibex. For the first time, we apply MA to both a modern and a fossil sample of one species, by using metric data taken from (i) a collection of present-day ibex skeletons and (ii) a Palaeolithic sample of the same species. Our results clearly show that the forelimb (humerus and radius) is more dimorphic than the hindlimb (femur and tibia) and is therefore better suited for sexing ibex. It also appears that metapodials should be used carefully for estimating sex ratios. On the basis of these results, we propose a classification of bone measurements that are more or less reliable for sexing ibex. The results of MA applied to the ibex fossil bones from the Upper Palaeolithic site of the Observatoire (Monaco) lead us to the conclusion that this assemblage consists of a majority of males. The quantitative estimations calculated by the MA make it possible to compare the size of Pleistocene and modern ibex for the whole set of variables used in this study. Copyright © 2006 John Wiley & Sons, Ltd. [source] Bioclimatic perspectives in the distribution of Quercus ithaburensis Decne. subspecies in Turkey and in the LevantJOURNAL OF BIOGEOGRAPHY, Issue 3 2004Jean-Marc Dufour-Dror Abstract Aim, To define the bioclimatic tolerance ranges of the two Tabor oak subspecies. Prior to this definition, and considering the confusion in the literature regarding the Tabor oak subspecies geography, a reassessment of their present distribution is proposed. Location, Turkey and the Levant. Methods, The bioclimatic tolerance range of each subspecies was characterized by four parameters: (1) the humidity category (Q2), (2) the winter variant (m) , the two basic variables used in Emberger's method for the definition of Mediterranean bioclimates, (3) the length of the dry season (LDS) and (4) its severity, expressed by the dry season water deficit (DSWD). The reference to the last two variables in the definition of bioclimatic tolerance ranges of Mediterranean species has so far never been considered. The concept of bioclimatic niche, based on the reference to these four parameters, is proposed and discussed. Results, The reassessment of the Tabor oak subspecies distribution shows that their extents of occurrence do not overlap and are significantly distant. The comparison between the characteristics of each subspecies bioclimatic niche has highlighted three major differences: (1) The bioclimatic niche of the subspecies macrolepis is characterized by a great heterogeneity as it includes up to 10 distinct bioclimate types, whereas only four types have been found in the bioclimatic niche of the subspecies ithaburensis. (2) A 10 °C gap has been found between the winter variants of both bioclimatic niches. (3) The third major difference relates to the dry season characteristics: the bioclimatic niche of the subspecies ithaburensis is characterized by an LDS 40,75% longer than it is in the bioclimatic niche of the subspecies macrolepis. Moreover, and surprisingly, although the most arid humidity categories are found in the bioclimatic niche of the subspecies macrolepis, the bioclimatic niche of the subspecies ithaburensis is characterized by a significantly more severe dry season as the DSWD is 36,180% greater than in the bioclimatic niche of the subspecies macrolepis. It is suggested that the duration and the severity of the dry season is a major limiting factor in the spatial distribution of the subspecies macrolepis. Main conclusions, The reference to the duration (LDS) and severity (DSWS) of the dry season is essential when defining the bioclimatic niche of Mediterranean species. [source] International Experts' Perspectives on the State of the Nurse Staffing and Patient Outcomes LiteratureJOURNAL OF NURSING SCHOLARSHIP, Issue 4 2007Koen Van den Heede Purpose: To assess the key variables used in research on nurse staffing and patient outcomes from the perspective of an international panel. Design: A Delphi survey (November 2005-February 2006) of a purposively-selected expert panel from 10 countries consisting of 24 researchers specializing in nurse staffing and quality of health care and 8 nurse administrators. Methods: Each participant was sent by e-mail an up-to-date review of all evidence related to 39 patient-outcome, 14 nurse-staffing and 31 background variables and asked to rate the importance/usefulness of each variable for research on nurse staffing and patient outcomes. In two subsequent rounds the group median, mode, frequencies, and earlier responses were sent to each respondent. Findings: Twenty-nine participants responded to the first round (90.6%), of whom 28 (87.5%) responded to the second round. The Delphi panel generated 7 patient-outcome, 2 nurse-staffing and 12 background variables in the first round, not well-investigated in previous research, to be added to the list. At the end of the second round the predefined level of consensus (85%) was reached for 32 patient outcomes, 10 nurse staffing measures and 29 background variables. The highest consensus levels regarding measure sensitivity to nurse staffing were found for nurse perceived quality of care, patient satisfaction and pain, and the lowest for renal failure, cardiac failure, and central nervous system complications. Nursing Hours per Patient Day received the highest consensus score as a valid measure of the number of nursing staff. As a skill mix variable the proportion of RNs to total nursing staff achieved the highest consensus level. Both age and comorbidities were rated as important background variables by all the respondents. Conclusions: These results provide a snapshot of the state of the science on nurse-staffing and patient-outcomes research as of 2005. The results portray an area of nursing science in evolution and an understanding of the connections between human resource issues and healthcare quality based on both empirical findings and opinion. [source] Urban, Suburban, and Exurban Sprawl in the Rocky Mountain West: Evidence from Regional Adjustment Models,JOURNAL OF REGIONAL SCIENCE, Issue 1 2005John I. Carruthers Three interrelated questions motivate the research. How does the proliferation of urban, suburban, and exurban sprawl in the Rocky Mountain West relate to the population and employment growth process? Are population and employment endogenously determined there? And what does this imply for the sustainability of economic development in the region? Through a series of regional adjustment models, the empirical analysis links population and employment growth in the Rocky Mountain West to explicit spatial outcomes and delivers substantive evidence of endogeneity between the two. The results suggest that the long-term prosperity of the region depends on the preservation of the high quality of life it offers, and that greater intergovernmental coordination, careful infrastructure planning, and attention to the character of its economic structure may help to accomplish this. Future research should focus on looking deeper into certain explanatory variables used in this analysis and on developing a better picture of what the spatial equilibrium that regional adjustment models emulate may look like. [source] Modelling fault-proneness statistically over a sequence of releases: a case studyJOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 3 2001Magnus C. Ohlsson Abstract Many of today's software systems evolve through a series of releases that add new functionality and features, in addition to the results of corrective maintenance. As the systems evolve over time it is necessary to keep track of and manage their problematic components. Our focus is to track system evolution and to react before the systems become difficult to maintain. To do the tracking, we use a method based on a selection of statistical techniques. In the case study we report here that had historical data available primarily on corrective maintenance, we apply the method to four releases of a system consisting of 130 components. In each release, components are classified as fault-prone if the number of defect reports written against them are above a certain threshold. The outcome from the case study shows stabilizing principal components over the releases, and classification trees with lower thresholds in their decision nodes. Also, the variables used in the classification trees' decision nodes are related to changes in the same files. The discriminant functions use more variables than the classification trees and are more difficult to interpret. Box plots highlight the findings from the other analyses. The results show that for a context of corrective maintenance, principal components analysis together with classification trees are good descriptors for tracking software evolution. Copyright © 2001 John Wiley & Sons, Ltd. [source] Resource abundance vs. resource dependence in cross-country growth regressionsOPEC ENERGY REVIEW, Issue 2 2010Annika Kropf Having analysed the macroeconomic performance of large oil exporters, I found that, in many cases, rents from natural resources have been successfully used to enhance economic growth. Nevertheless, adherents of the ,resource curse' seem to have found ample evidence suggesting that resource-abundant countries grow slower than resource-poor countries. A review of empirical research on the ,resource curse' reveals that the variables used were usually proxies for resource dependence. These variables introduce a bias, making less developed economies per se more resource ,abundant' than developed economies. As a consequence, a new variable, not containing any information on a country's stage of development, was introduced. Comparing the variables on resource dependence and resource abundance in a model by Sachs and Warner, resource abundance was not significant. In a new model, resource abundance was even positively correlated with growth. [source] Nurse dose: What's in a concept?,RESEARCH IN NURSING & HEALTH, Issue 4 2008Milisa Manojlovich Abstract Many researchers have sought to address the relationship between nursing care and patient outcomes, with inconsistent and contradictory findings. We conducted a concept analysis and concept derivation, basing our work on theoretical and empirical literature, to derive nurse dose as a concept that pulls into a coherent whole disparate variables used in staffing studies. We defined nurse dose as the level of nursing reflected in the purity, amount, frequency, and duration of nursing care needed to produce favorable outcomes. All four parameters of nurse dose used together can facilitate our understanding of how nursing contributes to patient outcomes. Ongoing investigation will help to identify the parameters of nurse dose that have the greatest effect on outcomes. © 2008 Wiley Periodicals, Inc. Res Nurs Health 31:310,319, 2008 [source] Finding Commercially Attractive User Innovations: A Test of Lead-User Theory,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 4 2006Nikolaus Franke Firms and governments are increasingly interested in learning to exploit the value of lead-user innovations for commercial advantage. Improvements to lead-user theory are needed to inform and to guide these efforts. The present study empirically tests and confirms the basic tenets of lead-user theory. It also uncovers some new refinements and related practical applications. Using a sample of users and user,innovators drawn from the extreme sport of kite surfing, an analysis was made of the relationship between the commercial attractiveness of innovations developed by users and the intensity of the lead-user characteristics those users display. A first empirical analysis is provided of the independent effects of its two key component variables. In the empirical study of user modifications to kite-surfing equipment, it was found that both components independently contribute to identifying commercially attractive user innovations. Component 1, the high expected-benefits dimension, predicts innovation likelihood, and component 2, the ahead of the trend dimension, predicts both the commercial attractiveness of a given set of user-developed innovations and innovation likelihood due to a newly proposed innovation supply side effect. It was concluded that the component variables in the lead-user definition are indeed independent dimensions, so neither can be dropped without loss of information,an important matter for lead-user theory. It also was found that adding measures of users' local resources can improve the ability of the lead-user construct to identify commercially attractive innovations under some conditions. The findings reported here have practical as well as theoretical import. Product modification and development has been found to be a relatively common user behavior in many fields. Thus, from 10 to nearly 40 percent of users report having modified or developed a product for in-house use in the case of industrial products or for personal use in the case of consumer products in fields sampled to date. As a practical matter, therefore, it is important to find ways to selectively identify the user innovations that manufacturers will find to be the basis for commercially attractive products in the collectivity of user-developed innovations. The implications of these findings for theory as well as for practical applications of the lead-user construct are discussed,that is, how variables used in lead-user studies can profitably be adapted to fit specific study contexts and purposes. [source] Habitat indices for rivers: derivation and applicationsAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue S1 2010Ian P. Vaughan Abstract 1.River Habitat Survey (RHS) is the standard riverine hydromorphology survey in the UK and modified versions have been adopted in several other European Countries. It aims to broadly characterize physical features over 500,m reaches, but in so doing records more than 100 variables, often making interpretation and data analysis challenging. In such instances, synoptic treatment of the data, creating simple indices such as Habitat Modification and Habitat Quality Assessment scores, can prove beneficial. 2.The derivation of seven new indices is described, summarizing nearly half of the variables used by RHS and providing a quantitative overall summary of river reaches. 3.Derived using an objective analysis of the RHS database (cf expert judgement), one index describes bedrock/boulder channels, two indices describe bank and riparian vegetation and a further two describe aspects of sediment transport and deposition. Two distinct types of modification,,,bank reinforcement and channel re-sectioning,,,are also quantified. 4.Rigorous testing indicates that the indices are reliable across the complete range of conditions and countries in the UK. 5.The new indices are readily interpreted and while providing a simple overview of a river reach, they are objective and quantitative, lending themselves to a range of management and research applications. They have already been used successfully in quantifying riverine bird habitats and this, along with other applications, is discussed. Copyright © 2009 John Wiley & Sons, Ltd. [source] Functioning and disability in bipolar disorders: a systematic review of literature using the ICF as a referenceBIPOLAR DISORDERS, Issue 5 2010Carolina C Ávila Ávila CC, Cabello M, Cieza A, Vieta E, Ayuso-Mateos JL. Functioning and disability in bipolar disorders: a systematic review of literature using the ICF as a reference. Bipolar Disord 2010: 12: 473,482. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objectives:, To systematically identify and examine the frequency of use of concepts contained in outcome variables across bipolar disorder (BD) studies using the International Classification of Functioning, Disability and Health (ICF) as a reference. Methods:, Original studies published between 2000 and 2006 were located on the MEDLINE and PsycINFO databases and selected according to predetermined criteria. Outcome variables were extracted, and concepts contained therein were linked to the ICF. Results:, A total of 109 final studies were included. The concepts contained in these studies were linked to 145 different ICF categories. ICF category b152, emotional functions, was the most frequently represented category, appearing in 94% of the publications, followed by b126, temperament and personality functions (73%). E110, products or substances for personal consumption, and e580, health services, systems, and policies, appeared in 68% of the studies. Conclusions:, The present systematic review reflects the research focus of the literature on BD in recent years. Most of the studies performed concentrate on body functions rather than activities and participation domains. Experimental studies are mostly pharmacological, reflecting the need to study nonpharmacological interventions. Furthermore, our study shows that outcome variables used in studies with persons with BD can, to a large extent, be mapped to the ICF. [source] Validation of a nomogram to predict disease progression following salvage radiotherapy after radical prostatectomy: results from the SEARCH databaseBJU INTERNATIONAL, Issue 10 2009Daniel M. Moreira OBJECTIVE To externally validate the nomogram published by Stephenson et al. (termed the ,Stephenson nomogram') to predict disease progression after salvage radiotherapy (SRT) among patients with prostate cancer from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. PATIENTS AND METHODS We analysed data from 102 men treated with SRT for prostate-specific antigen (PSA) failure after prostatectomy, of whom 30 (29%) developed disease progression after SRT during a median follow-up of 50 months. The predicted 6-year progression-free survival (PFS) was compared to the actuarial PFS using calibration plots. The accuracy of the nomogram to risk-stratify men for progression was assessed by the concordance index. RESULTS The median PSA and PSA doubling time before SRT was 0.6 ng/mL and 10.3 months, respectively. The 6-year actuarial disease-free progression after SRT was 57% (95% confidence interval 42,69%). The overall concordance index of the Stephenson nomogram was 0.65. The nomogram predicted failure more accurately at the extremes of risk (lowest and highest) but in intermediate groups, the accuracy was less precise. Of the 11 variables used in the nomogram, only negative margins and high PSA level before SRT were significantly associated with increased disease progression. CONCLUSION The Stephenson nomogram is an important tool to predict disease progression after SRT following radical prostatectomy. It adequately predicted progression in SEARCH with reasonable accuracy. Also, in SEARCH, disease progression was predicted by similar disease characteristics. However, the overall modest performance of the model in our validation cohort indicates there is still room for improvement in predictive models for disease progression after SRT. [source] An interinstitutional and interspecialty comparison of treatment outcome data for patients with prostate carcinoma based on predefined prognostic categories and minimum follow-up,CANCER, Issue 10 2002Frank A. Vicini M.D. Abstract BACKGROUND The optimal management of patients with clinically localized prostate carcinoma remains undefined due in part to the absence of well-designed, prospective, randomized trials. The current study was conducted to compare and contrast outcomes with different forms of therapy for patients with prostate carcinoma who were treated at several institutions using predefined prognostic categories. METHODS A retrospective study of 6877 men with prostate carcinoma who were treated between 1989 and 1998 at 7 different institutions with 6 different types of therapy was conducted. Five-year actuarial rates of prostate specific antigen (PSA) failure were calculated based on predefined prognostic categories, which included combinations of pretreatment PSA level, tumor stage, and Gleason score. In addition, outcome was calculated using consistent biochemical failure definitions and a minimum, median length of follow-up. RESULTS Substantial differences in outcome were observed for the same type of treatment and at the same institution, depending on the number of prognostic variables used to define treatment groups. However, estimates of 5-year PSA outcomes after all forms of therapy for low-risk and intermediate-risk patient groups were remarkably similar (regardless of the type of treatment) when all three pretreatment variables were used to define prognostic categories. For patients in high-risk groups, the 5-year PSA outcomes were suboptimal, regardless of the treatment technique used. CONCLUSIONS The current data suggest that interinstitutional and interspecialty comparisons of treatment outcome for patients with prostate carcinoma are possible but that results must be based on all major prognostic variables to be meaningful. Analyzed in this fashion, 5-year PSA results were similar for patients in low-risk and intermediate-risk groups, regardless of the form of therapy. Findings from prospective, randomized trials using survival (cause specific and overall) as the end point for judging treatment efficacy and longer follow-up will be needed to validate these findings and to identify the most appropriate management option for patients with all stages of disease. Cancer 2002;95:2126,35. © 2002 American Cancer Society. DOI 10.1002/cncr.10919 [source] | |||||||||||||||||||||||||