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Vascular Fractal Dimension (vascular + fractal_dimension)
Selected AbstractsVascular fractal dimension and total vascular area in the study of oral cancerHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 3 2009Lampros P. Goutzanis DDS Abstract Background Microvessel quantification has been studied extensively as a factor reflecting angiogenesis in various malignant tumors. The aim of our study was to evaluate the vascular fractal dimension and the immunohistochemically positive total vascular area in oral cavity carcinomas in order to assess their potential value as factors reflecting angiogenesis. Methods Histologic sections from 48 carcinomas and 17 nonmalignant mucosa specimens were evaluated by image analysis using fractal analysis software. Total vascular area was also quantified. Results Carcinomas presented higher mean values of vascular fractal dimension and total vascular area compared to normal mucosa. The difference for the vascular fractal dimension was statistically significant. Conclusions This study provides evidence that vascular fractal dimension could be used as a reliable factor reflecting angiogenesis in oral squamous cell carcinoma and that there are several statistically significant correlations among total vascular area, vascular fractal dimension, nuclear size, and clinicopathologic factors. © 2008 Wiley Periodicals, Inc. Head Neck, 2009 [source] Lens opacity and refractive influences on the measurement of retinal vascular fractal dimensionACTA OPHTHALMOLOGICA, Issue 6 2010Haitao Li Acta Ophthalmol. 2010: 88: e234,e240 Abstract. Purpose:, To examine the influence of lens opacity and refraction on the measurement of retinal vascular fractal dimension (Df). Methods:, Optic disc photographs (right eyes) of 3654 baseline Blue Mountains Eye Study participants (aged 49,97 ) were digitized. Retinal vascular Df was quantified using a computer-based program. Summated severity scores for nuclear, cortical and posterior subcapsular (PSC) cataract were assessed from lens photographs. Refraction data were converted to spherical equivalent refraction (SER), as sum spherical plus 0.5 cylinder power. Axial length was measured at 10-year follow-up examinations using an IOL master. Results:, Mean Df of the retinal vasculature was 1.444 ± 0.023 for 2859 eligible participants. Increasing lens opacity scores were associated with significant reduction in Df (, = ,0.0030, p < 0.0001). Both cortical and PSC cataract involving central lens area were associated with reduced Df, after controlling for confounding factors (ptrend , 0.0105). Increasing myopia severity was associated with reduced Df after adjusting for lens opacity scores and other confounders (ptrend < 0.0001). The slope of Df decrease per SER reduction was 0.0040 in eyes with SER , ,4D, compared to ,0.0016 in eyes with SER > ,4D. For axial length quintiles, there were no significant differences in mean Df in all groups except a reduction in the fifth quintile (axial length ,24.15 mm) (all p < 0.05). Conclusion:, Ocular media opacity independently influenced retinal vascular Df measurement, but we found no evidence supporting any refractive axial magnification effect on this measure. Myopic refraction ,,4D was associated with a reduction in Df, suggesting rarefaction of retinal vasculature associated with high myopia. [source] | ||||||||||