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Kinds of Unrelated Terms modified by Unrelated Selected AbstractsFactors associated with treatment nonadherence among US bipolar disorder patients,HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 2 2008Ross J. Baldessarini Abstract Objective Since sustained treatment-adherence is often problematic and may limit clinical outcomes among bipolar disorder (BPD) patients, we sought risk factors to guide clinical prediction of nonadherence. Methods Data were from a 2005 US national sample providing questionnaire responses by 131 randomly selected prescribing psychiatrists and their adult BPD patients. We contrasted demographic and clinical factors in treatment-adherent versus nonadherent patients (strictly defined as missing ,1 dose within 10 days) in univariate analyses followed by multivariate logistic-regression modeling. Results Of 429 DSM-IV BPD patients (79% type-I; 62% women; 17% minorities), 34% reported missing,,,1 dose of psychotropic medication within 10 days, 20% missed entire daily doses at least once, and only 2.5% missed all doses for 10 days. However, their prescribing psychiatrists considered only 6% as treatment-nonadherent. Factors significantly associated with nonadherence in multivariate modeling ranked: alcohol-dependence,>,youth,>,greater affective morbidity,>,various side effects,,,comorbid obsessive-compulsive disorder,,,recovering from mania-hypomania. Unrelated were sex, diagnostic subtype, and other comorbidities. Since most patients received,,,2 psychotropics, potential relationships between treatment-complexity and adherence were obscured. Conclusions Prevalent treatment-nonadherence among American BPD patients, and striking underestimation of the problem by prescribing clinicians may encourage increasingly complex treatment-regimens of untested value, but added expense, risk of adverse effects, and uncertain impact on treatment-adherence itself. Copyright © 2007 John Wiley & Sons, Ltd. [source] Ecological Traits Predicting Amphibian Population Declines in Central AmericaCONSERVATION BIOLOGY, Issue 4 2003Karen R. Lips Populations of some species are extirpated, others have declined but survive, some have not obviously declined, and some are increasing. If amphibian populations at multiple sites were affected by the same factors, then surviving species should share traits that promote persistence, whereas declining species should share traits that promote susceptibility. Identifying these traits can help diagnose potential causes and thus help to direct conservation actions. Using logistic regression, we quantified the vulnerability of amphibian populations in four areas in Central America. We analyzed a species-specific database of taxonomic identity, geographic and elevational range, elevational distribution, adult and larval habitat, activity period, and maximum adult body size. We found that ( 1 ) all four sites exhibited the same pattern of decline ( there were no interactions between site and other variables ); ( 2 ) declining populations shared aquatic habitats, restricted elevational ranges, and large body sizes; and ( 3 ) there was an interaction between body size and elevational range. The most significant variable in the model was lifetime aquatic index, a factor unrelated to demographic vulnerability and one that therefore might indicate the potential causative agent( s ). Our results provide a predictive model with which to assess potential causes of population declines in other areas, and we generated a list of 52 species predicted to decline at a currently unaffected site in central Panama. Resumen: Las poblaciones de anfibios están declinando en todos los continentes donde ocurren, pero no todas las especies han sido afectadas por igual. Algunas especies han sido extirpadas, otras han declinado pero sobreviven, algunas no han declinado notablemente y otras están aumentando. Si las poblaciones de anfibios en varios sitios fueran afectadas por los mismos factores, las especies sobrevivientes deberían compartir características que promuevan la persistencia mientras que las especies en declinación deberían compartir características que promuevan la susceptibilidad. La identificación de estas características puede ayudar a diagnosticar las causas potenciales y así ayudar a dirigir medidas de conservación. Utilizando regresión logística, cuantificamos la vulnerabilidad de las poblaciones de anfibios en cuatro áreas de Centro América. Analizamos una base de datos de identidad taxonómica de especies, rango geográfico y altitudinal, distribución altitudinal, hábitat de larvas y adultos, período de actividad y máxima talla corporal de adultos. Encontramos que ( 1 ) los cuatro sitios presentaron el mismo patrón de declinación ( no hubo interacciones entre el sitio y otras variables ), ( 2 ) las poblaciones en declinación compartieron hábitats acuáticos, rangos altitudinales restringidos y tamaño corporal grande y ( 3 ) hubo interacción entre el tamaño corporal y el rango altitudinal. La variable más significativa del modelo fue el índice de vida acuática, un factor no relacionado con la vulnerabilidad demográfica y que, por lo tanto, podría indicar el agente causal potencial. Nuestros resultados proporcionan un modelo predictivo para evaluar las causas potenciales de declinación poblacional en otras áreas, y generamos una lista de 52 especies de declinación prevista en un sitio actualmente no afectado del centro de Panamá. [source] Local Gradients of Cowbird Abundance and Parasitism Relative to Livestock Grazing in a Western LandscapeCONSERVATION BIOLOGY, Issue 6 2000Christopher B. Goguen We predicted that both cowbird abundance and parasitism rates of vireo nests would decrease with increasing distance from active livestock grazing, and that the nesting success of vireos would increase. We measured cowbird abundance and host density and located and monitored vireo nests in pinyon-juniper and mixed-conifer habitats that ranged from actively grazed to isolated from livestock grazing by up to 12 km. Cowbird abundance declined with distance from active livestock grazing and was not related to host density or habitat type. Brood parasitism levels of vireo nests (n = 182) decreased from> 80% in actively grazed habitats to 33% in habitats that were 8,12 km from active grazing but did not vary by habitat type or distance to forest edge. Vireo nesting success was higher in mixed-conifer habitat than in pinyon-juniper but was unrelated to distance from active livestock grazing. Nest losses due to parasitism declined with distance from active livestock grazing. Our results suggest that cowbird abundance and parasitism rates of hosts may be distributed as a declining gradient based on distance from cowbird feeding sites and that isolation from feeding sites can reduce the effects of parasitism on host populations. These findings provide support for management techniques that propose to reduce local cowbird numbers and parasitism levels by manipulating the distribution of cowbird feeding sites. The presence of parasitized nests> 8 km from active livestock grazing suggests that, in some regions, management efforts may need to occur at larger scales than previously realized. Resumen: Estudiamos patrones locales de abundancia del tordo cabeza café (Molothrus ater), las tasas de parasitismo y el éxito de nidada de un hospedero común, el vireo (Vireo plumbeus), en relación con la distribución del pastoreo en una región poco desarrollada del noreste de Nuevo México, entre 1992 y 1997. Pronosticamos que tanto la abundancia del tordo, como las tasas de parasitismo de nidos de vireo disminuirían con un incremento en la distancia a las zonas de pastoreo activo de ganado y el éxito de nidada de vireos incrementaría. Medimos la abundancia de tordos y la densidad de hospederos y localizamos y monitoreamos los nidos de vireos en hábitats de pino-cedro y de coníferas mixtas que variaron desde activamente pastoreadas hasta sitios distanciados del pastoreo hasta por 12 km. La abundancia de los tordos disminuyó con la distancia de las zonas de pastoreo activo de ganado y no estuvo relacionada con la densidad de hospederos o el tipo de hábitat. Los niveles de parasitismo de las nidadas del vireo (n = 182) disminuyeron de> 80% en hábitats activamente pastoreados a 33% en hábitats que estuvieron de 8 a 12 km de distancia de los sitios de pastoreo activo, pero no variaron con el tipo de hábitat ni la distancia al borde del bosque. El éxito de nidada de vireos fue mayor en el hábitat mixto de coníferas que en el hábitat de pino-cedro, pero no estuvo relacionado con la distancia al sitio de pastoreo. Las pérdidas debidas al parasitismo disminuyeron con la distancia al sitio activo de pastoreo. Nuestros resultados sugieren que la abundancia de tordos y las tasas de parasitismo de hospederos podría estar distribuida en forma de un gradiente en descenso basado en la distancia a los sitios de alimentación de los tordos y a que el aislamiento de los sitios de alimentación puede reducir los efectos del parasitismo de las poblaciones de hospederos. Estos resultados apoyan las técnicas de manejo que proponen la reducción local de números de tordos y los niveles de parasitismo al manipular la distribución de sitios de alimentación de tordos. La presencia de nidos parasitados> 8 km de sitios con pastoreo activo sugiere que, en algunas regiones, los esfuerzos de manejo deben ocurrir a escalas mayores a lo que anteriormente se pensaba. [source] Antecedents of Shareholder Activism in Target Firms: Evidence from a Multi-Country StudyCORPORATE GOVERNANCE, Issue 4 2010William Q. Judge ABSTRACT Manuscript Type: Empirical Research Question/Issue: This study seeks to better understand the antecedents of shareholder activism targeted at firms located in three common law countries (i.e., USA, UK, and Australia) and three civil law countries (Japan, Germany, and South Korea) during the 2003,07 time period. Research Findings/Insights: Our findings suggest that the antecedents of shareholder activism vary by the motivation of the activist. We demonstrate that activists target firms with two motives (a) to improve the financial performance, and (b) to improve the social performance of the firm. With respect to the target firm level antecedents, we find that firm size is unrelated to financial activism, but positively related to social activism; ownership concentration is negatively related to both financial and social activism; and prior profitability is negatively related to financial activism, but positively related to social activism. Further, these relationships in the case of financial activism are generally stronger in common law legal systems, whereas those in the case of social activism are generally stronger in environments with a greater level of income inequality. Theoretical/Academic Implications: Our findings suggest that future research should differentiate between the motivations of the activism event. Further, we find that while agency logic works well for financial activism, institutional theory provides stronger explanations for social activism. Overall, we demonstrate the complementary nature of these two theories in explaining shareholder activism. Practitioner/Policy Implications: We found that the "exposure" to shareholder activism varies by the motivation of the activist, and the nature of the firm and its national context. An understanding of these issues would help firms develop proper response strategies to activism events. [source] ECONOMIC DEPRIVATION AND CHANGES IN HOMICIDE ARREST RATES FOR WHITE AND BLACK YOUTHS, 1967,1998: A NATIONAL TIME-SERIES ANALYSIS,CRIMINOLOGY, Issue 3 2001STEVEN F. MESSNER Using time-series techniques with national data for 1967,98, we model the effects on changes in age-race-specific arrest rates of changes in indicators of economic deprivation. A measure of child poverty is positively related to juvenile arrest rates for both races, whereas changing unemployment (lagged) yields a surprising negative effect on youth offending. Measures of intraracial income inequality are also associated with changes in juvenile arrest rates, but the effects differ by race. Between-race inequality is unrelated to changes in arrest rates for both races. Our general conclusion is that fluctuations in juvenile homicide offending over recent decades can be understood, at least in part, with reference to the macro-economic environment confronting young people and their families. [source] EXAMINING THE "CRIMINAL CAREERS" OF PROSTITUTES WITHIN THE NEXUS OF DRUG USE, DRUG SELLING, AND OTHER ILLICIT ACTIVITIES,CRIMINOLOGY, Issue 3 2000SHEILA ROYO MAXWELL This paper examines the co-occurrence of prostitution, drug use, drug selling, and involvement in non-drug crimes among women who have used serious drugs (e.g., crack, heroin). Existing perspectives on the drug use-prostitution nexus are re-examined using three dimensions of the criminal career paradigm: prevalence, lambda, and age of onset. Results show that approximately one-half of the women who reported regular drug use never prostituted, and that, except for use of crack cocaine, use of other drugs was unrelated to the prevalence, frequency, or age of onset into prostitution. The results also show that committing property crime was associated with an increased prevalence and early onset into prostitution, while selling drugs coincided with a decreased prevalence and delayed onset into prostitution. [source] A CROSS-CULTURAL EXAMINATION OF THE LINK BETWEEN CORPORAL PUNISHMENT AND ADOLESCENT ANTISOCIAL BEHAVIOR,CRIMINOLOGY, Issue 1 2000RONALD L. SIMONS Several studies with older children have reported a positive relationship between parental use of corporal punishment and child conduct problems. This has lead some social scientists to conclude that physical discipline fosters antisocial behavior. In an attempt to avoid the methodological difficulties that have plagued past research on this issue, the present study used a proportional measure of corporal punishment, controlled for earlier behavior problems and other dimensions of parenting, and tested for interaction and curvilinear effects. The analyses were performed using a sample of Iowa families that displayed moderate use of corporal punishment and a Taiwanese sample that demonstrated more frequent and severe use of physical discipline, especially by fathers. For both samples, level of parental warmth/control (i.e., support, monitoring, and inductive reasoning) was the strongest predictor of adolescent conduct problems. There was little evidence of a relationship between corporal punishment and conduct problems for the Iowa sample. For the Taiwanese families, corporal punishment was unrelated to conduct problems when mothers were high on warmth/control, but positively associated with conduct problems when they were low on warmtwcontrol, An interaction between corporal punishment and warmth/Wcontro1 was found for Taiwanese fathers as well. For these fathers, there was also evidence of a curvilinear relationship, with the association between corporal punishment and conduct problems becoming much stronger at extreme levels of corporal punishment. Overall, the results are consistent with the hypothesis that it is when parents engage in severe forms of corporal punishment, or administer physical discipline in the absence of parental warmth and involvement, that children feel angry and unjustly treated, defy parental authority, and engage in antisocial behavior. [source] P-11 THE IMPACT OF INTRODUCING LIQUID BASED CYTOLOGY INTO A ROUTINE SCREENING LABORATORYCYTOPATHOLOGY, Issue 2006L. Gregory With the exception of information from the liquid based cytology (LBC) pilot site there has been limited data to date on the impact of the introduction of SurePathÔ LBC in the NHSCSP. We will present data to show the impact on a medium sized laboratory (42 000 requests per annum) over the first phases of rollout. Data from before, during and post conversion, a period of 28 months, shows the following trends: (1) A significant fall in the inadequate rate (2) A slight decrease in the borderline / mild dyskaryosis rate (3) A small increase in the high-grade squamous dyskaryosis reporting rate (4) An increase in both the number and specificity of glandular lesions reported (5) A largely unchanged positive predictive value for high-grade abnormalities (6) A significant increase in laboratory productivity, unrelated to inadequate rate but through increased speed of screening. Although our experience is not directly comparable to the experience of the LBC pilot, our observations may well reflect that we were fortunate to be trained by staff from one of the LBC sites and thereby benefited directly from their experience. [source] Mood states, sympathetic activity, and in vivo ,-adrenergic receptor function in a normal populationDEPRESSION AND ANXIETY, Issue 7 2008Bum-Hee Yu M.D. Ph.D. Abstract The purpose of this study was to examine the relationship between mood states and ,-adrenergic receptor function in a normal population. We also examined if sympathetic nervous system activity is related to mood states or ,-adrenergic receptor function. Sixty-two participants aged 25,50 years were enrolled in this study. Mood states were assessed using the Profile of Mood States (POMS). ,-adrenergic receptor function was determined using the chronotropic 25 dose isoproterenol infusion test. Level of sympathetic nervous system activity was estimated from 24-hr urine norepinephrine excretion. Higher tension-anxiety, depression-dejection, and anger-hostility were related to decreased ,-adrenergic receptor sensitivity (i.e., higher chronotropic 25 dose values), but tension-anxiety was the only remaining independent predictor of ,-adrenergic receptor function after controlling for age, gender, ethnicity, and body mass index (BMI). Urinary norepinephrine excretion was unrelated to either mood states or ,-adrenergic receptor function. These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) ,-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index. Depression and Anxiety 0:1,6, 2007. © 2007 Wiley-Liss, Inc. [source] Patients Spend More Time With the Physician for Excision of a Malignant Skin Lesion Than for Excision of a Benign Skin LesionDERMATOLOGIC SURGERY, Issue 3 2004Steven R. Feldman MD Background. Currently, there is a difference in reimbursement between excision of malignant and benign lesions. There is concern that there is not sufficient rationale for differential reimbursement for these two procedures. Objective. To assess whether there is a difference in physician work involved with excision of benign versus malignant skin tumors. Method. We searched National Ambulatory Medical Care Survey data for visits at which excision of benign and malignant skin lesions was performed. We compared the time spent with the physician at these two types of visits. To exclude confounding issues unrelated to the excision that would affect the time of visit, we excluded visits at which multiple diagnoses were addressed. Results. The mean time spent with the physician at visits for excision of benign lesions was 22.9±1.0 minutes. The mean time spent with the physician at visits for excision of malignant lesions was 30.0±1.7, 30% longer (p < 0.001). The longer time for excision of malignant lesions remained significant after controlling for age, gender, and race. Conclusion. Excision of malignant lesions involves more physician work than does excision of benign lesions. Elimination of differential compensation for benign versus malignant skin lesion procedures would not enhance the accuracy of reimbursement. In the absence of any compelling rationale to change the existing differential reimbursement, the proposals to do so are not warranted. [source] Use of Alternative Therapies by Patients Undergoing Surgery for Nonmelanoma Skin CancerDERMATOLOGIC SURGERY, Issue 6 2002Scott M. Dinehart MD background. The use of alternative therapies is becoming increasingly common and may result in unwanted side effects and drug interactions. objective. To determine the frequency of alternative medicine use by patients undergoing Mohs surgery for nonmelanoma skin cancer. methods. A written survey concerning use of alternative therapies was given to patients undergoing Mohs surgery for nonmelanoma skin cancer. A follow-up telephone survey was used to clarify positive responses. results. Thirty-six of 192 (18.8%) patients with nonmelanoma skin cancer reported using some type of alternative therapy. Almost all patients were using these therapies for conditions unrelated to their nonmelanoma skin cancer. Herbs and botanicals were the most common type of alternative therapy utilized. conclusion. Physicians performing Mohs surgery should be aware that a significant number of their patients use alternative therapies. Since most patients do not readily volunteer information about alternative medicine usage, specific steps should be taken to obtain this information. [source] Cancer incidence in patients with schizophrenia and their first-degree relatives , a meta-analysisACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2008V. S. Catts Objective:, Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings. Method:, A meta-analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first-degree relatives and compared with general population samples. Results:, The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95,1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01,1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84,0.94) and parents (SIR = 0.90, CI 0.88,0.93) was significantly reduced. A meta-regression detected a significant relationship between cancer risk in the general population and relative risk in patients. Conclusion:, The meta-analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect. [source] Nipple preference and contests in suckling kittens of the domestic cat are unrelated to presumed nipple qualityDEVELOPMENTAL PSYCHOBIOLOGY, Issue 4 2009Robyn Hudson Abstract We studied the development of suckling behavior and weight gain in 11 litters (52 kittens) of free-ranging domestic cats until postnatal day 28 just before the start of weaning. In six of these litters, we also recorded milk intake and contests for access to nipples. Already within 12 hr of birth kittens showed a preference for posterior nipples, and by postnatal day 3 each had developed a preference for particular nipples. In fact, 86% of kittens used one particular nipple most often, and even when the mother changed the side she lay on to nurse. Contests for access to nipples occurred throughout the study period at an average rate of one to two contests per kitten per hour of nursing. Contrary to suggestions in the literature that kittens compete for more productive nipples, we found no relation between kittens' use of particular nipples and their weight gain, milk intake, or involvement in contests during suckling. We suggest that kittens' preference for posterior nipples as well as their establishment of an individual "teat order" might function to optimize the number of nipples remaining productive across lactation, and to reduce energetically costly scrambles and potentially injurious contests among littermates. © 2009 Wiley Periodicals, Inc. Dev. Psychobiol 51: 322,332, 2009. [source] Fetal cyclic motor activity in diabetic pregnancies: Sensitivity to maternal blood glucoseDEVELOPMENTAL PSYCHOBIOLOGY, Issue 1 2003Steven S. Robertson Abstract Spontaneous fetal movement in the last third of human gestation is dominated by irregular oscillations on a scale of minutes (cyclic motility, CM). The core properties of these oscillations are stable during the third trimester of gestation in normal fetuses, but disrupted by poorly controlled maternal diabetes. Here we investigated whether fetal CM is linked to short-term instabilities in maternal glucose metabolism. The fetuses of 40 mothers with type I (n,=,28) or gestational (n,=,12) diabetes were studied one to six times between 27 and 40 postmenstrual weeks of gestation. Fetal movement and maternal blood glucose concentration were measured during two separate periods of fetal activity in each session. Fetal CM was quantified with spectral analysis. Early in the third trimester, changes in the rate of oscillation in fetal CM between the two periods of activity were inversely related to changes in maternal blood glucose levels. Fetal CM was unrelated to concurrent maternal blood glucose levels at any point in the third trimester. The pattern of results suggests that disruption of the temporal organization of spontaneous fetal motor activity in pregnancies complicated by maternal diabetes represents an acute response to fluctuations in the metabolic environment rather than an alteration of CM development. © 2003 Wiley Periodicals, Inc. Dev Psychobiol 42: 9,16, 2003. [source] In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1DIABETES OBESITY & METABOLISM, Issue 4 2010K. Kos In this study, the regional adipose tissue-adiponectin (AT-ADN) and adiponectin receptor (R1 and R2) expression and their relation with metabolic parameters, circulating and AT-derived cytokine expressions were compared. Paired subcutaneous adipose tissue (SCAT) and visceral adipose tissue (VAT) were taken from 18 lean and 39 obese humans, AT-mRNA expression of adipokines analysed by RT-PCR and corresponding serum levels by enzyme-linked immunosorbent assay (ELISA). R1 and R2 adipocyte expression was compared with 17 other human tissues. ADN-gene expression was lower in VAT than SCAT [mean (SD) 1.54 (1.1) vs. 2.84 (0.87); p < 0.001], and lower in obese subjects (VAT : p = 0.01;SCAT : p < 0.001). SCAT-ADN correlated positively with serum ADN (r = 0.33;p = 0.036) but not VAT-ADN. AT expressions of ADN and macrophage migration inhibiting factor (MMIF), IL18 and cluster of differentiation factor 14 (CD14) in both depots showed inverse correlations. R1 and R2 were expressed ubiquitously and R2 highest in SCAT, and this is much higher (×100) than R1 (×100). R expression was similar in lean and obese subjects and unrelated to the metabolic syndrome, however, receptors correlated with VAT-MMIF (R 1: r = 0.4;p = 0.008;R 2: r = 0.35,p = 0.02) and SCAT-MMIF expression (R 2: r = 0.43;p = 0.004). Unlike ADN, its receptors are expressed in many human tissues. Human R2 expression is not highest in the liver but in AT where it is associated with MMIF expression. The adiponectin-dependent insulin-sensitizing action of thiazolidinediones is thus probably to differ amongst species with weaker effects on the human liver. [source] Evidence for distinct effects of GH and IGF-I in the metabolic syndromeDIABETIC MEDICINE, Issue 9 2007P. Maison Abstract Aims, The metabolic syndrome is a cluster of cardiovascular risk factors which include central obesity, dyslipidaemia, glucose intolerance and hypertension. These risk factors are common in patients with growth hormone (GH) deficiency, suggesting a role for the somatotropic axis in the development of metabolic syndrome. Methods, We used factor analysis to investigate the relationships linking serum levels of GH and insulin-like growth factor I (IGF-I) to metabolic syndrome variables (high-density lipoprotein cholesterol, triglycerides, fasting glucose, blood pressure and waist circumference). We studied 359 men and 388 women from the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR). Their age range was 30,64 years. Results, Three independent latent factors explained 61% of the total variance in women and four factors explained 73% in men. In both men and women, IGF-I showed a strong positive correlation with the lipid factor and a negative correlation with the obesity/glucose factor. In women, GH showed a strong negative correlation with the obesity/glucose factor but not the lipid factor. In men, GH was unrelated to the lipid and obesity/glucose factors. The blood pressure factor was not related to GH or IGF-I. In contrast with IGF-I, GH was significantly lower in women with metabolic syndrome (1575 ± 449 pg/ml) than in the other women (2121 ± 520 pg/ml, P = 0.002). No significant difference was observed in men for GH or IGF-I. Conclusion, Our results support a link between the somatotropic axis and several features of the metabolic syndrome, and suggest distinct effects of GH and IGF-I on these parameters. [source] Screening for gestational diabetes; past, present and futureDIABETIC MEDICINE, Issue 5 2002F. W. F. Hanna Abstract Gestational diabetes is carbohydrate intolerance, with onset or first recognition of hyperglycaemia during pregnancy. Several studies have suggested that gestational hyperglycaemia is associated with adverse maternal and fetal outcomes, promoting the case for screening. Conversely, others argue that screening for gestational diabetes may colour the clinical judgement, influencing further management, e.g. more ,unjustified' caesarean sections. Additionally, the lack of definitive data either on a clear-cut glycaemic threshold for the development of adverse outcomes or on the impact of intervention is emphasized by opponents of screening. This review attempts to evaluate the available data on screening for gestational diabetes. Oral glucose tolerance test is promoted on the basis that the diabetogenic stress of pregnancy is encountered during late gestation and is best recognized in the fed state. There are different tests, including the 1 h/50-g, 2 h/75-g and 3 h/100-g tests, with practical limitations, including the time and cost involved and the unpleasant supra-physiological glucose load that is unrelated to body weight, and issues of reproducibility and sensitivity/specificity profiles. Despite its convenience, the poor sensitivity of random glucose has precluded its routine use for screening. Fasting glucose appears to be promising but further testing is required to ensure satisfactory sensitivity/specificity in different populations. Despite its limitations, the oral glucose tolerance test has become established as the ,most acceptable' diagnostic test for gestational diabetes. More convenient methods, e.g. fasting or random or post-load glucose, have to be validated therefore against the oral glucose tolerance test to gain acceptance for routine screening. Diabet. Med 19, 351,358 (2002) [source] Cervical cytology reading times: A comparison between thinprep imager and conventional methodsDIAGNOSTIC CYTOPATHOLOGY, Issue 9 2007Elizabeth Davey MBBS Abstract We aimed to compare the times cytologists spend reviewing cervical cytology slides processed by the ThinPrep Imager® (TPI) with times they spend examining conventional cytology (CC) slides. We also aimed to examine the effect of cytologists' experience on reading times. Using a cross-sectional analytical design, we analyzed routine laboratory data, collected retrospectively over 7 months, for 41 cytologists, including paired data for 20 who read both TPI and CC slides. For the 20 cytologists who read both types of cytology, the mean reading rate was 13.3 slides per hour for TPI slides and 6.1 slides per hour for CC slides. The mean within-reader difference between TPI and CC rates was 7.2 slides per hour (P < 0.001). For CC reading, mean times did not differ between those who were additionally trained to read TPI slides and those who only read CC. Slower readers had greater increases in speed when using the TPI compared with CC reading than did faster readers (P < 0.001). More experienced cytologists tended to read CC slides more quickly than did those less experienced, but experience did not affect TPI reading times or within-reader differences in reading times between cytology types. The TPI significantly reduced reading times compared with CC. This reduction was greater amongst slower readers, and was unrelated to experience. Diagn. Cytopathol. 2007;35:550,554. © 2007 Wiley-Liss, Inc. [source] Urban disaster recovery: a measurement framework and its application to the 1995 Kobe earthquakeDISASTERS, Issue 2 2010Stephanie E. Chang This paper provides a framework for assessing empirical patterns of urban disaster recovery through the use of statistical indicators. Such a framework is needed to develop systematic knowledge on how cities recover from disasters. The proposed framework addresses such issues as defining recovery, filtering out exogenous influences unrelated to the disaster, and making comparisons across disparate areas or events. It is applied to document how Kobe City, Japan, recovered from the catastrophic 1995 earthquake. Findings indicate that while aggregate population regained pre-disaster levels in ten years, population had shifted away from the older urban core. Economic recovery was characterised by a three to four year temporary boost in reconstruction activities, followed by settlement at a level some ten per cent below pre-disaster levels. Other long-term effects included substantial losses of port activity and sectoral shifts toward services and large businesses. These patterns of change and disparity generally accelerated pre-disaster trends. [source] The role of surveillance endoscopy and endosonography after endoscopic ablation of high-grade dysplasia and carcinoma of the esophagusDISEASES OF THE ESOPHAGUS, Issue 2 2008A. D. Savoy SUMMARY., Barrett's esophagus (BE) with high-grade dysplasia (HGD) or early carcinoma treated with surgery or photodynamic therapy (PDT) is at risk of recurrence. The efficacy of endoscopic ultrasound (EUS) for surveillance after PDT is unknown. Our objective was to determine if EUS is superior to esophagogastroduodenoscopy (EGD) and/or CT scan for surveillance of BE neoplasia after PDT. The study was designed as a retrospective review with the setting as a tertiary referral center. Consecutive patients with BE with HGD or carcinoma in situ treated with PDT were followed with EUS, CT scan and EGD with jumbo biopsies every 1 cm at 3, 4, or 6-month intervals. Exclusion criteria was < 6 months of follow up and/or < 2 EUS procedures. Main outcome measurements were residual or recurrent disease discovered by any method. Results showed that 67/97 patients met the inclusion criteria (56 men and 11 women). Median follow-up was 16 months. Recurrent or residual adenocarcinoma (ACA) was detected in four patients during follow-up. EGD with random biopsies or targeted nodule biopsies detected three patients. EUS with endoscopic mucosal resection of the nodule confirmed T1 recurrence in one of these three. In the fourth patient, CT scan revealed perigastric lymphadenopathy and EUS-FNA (fine needle aspiration) confirmed adenocarcinoma. There were two deaths, one related to disease progression and one unrelated. The rate of recurrent/persistent ACA after PDT was 4/67 = 6%. EUS did not detect disease when EGD and CT were normal. Limitations of this study include non-blinding of results and preferential status of non-invasive imaging (CT) over EUS. Our experience suggests that EUS has little role in the surveillance of these patients, unless discrete abnormalities are found on EGD or cross-sectional imaging. [source] Psychiatric morbidity among patients with cancer of the esophagus or the gastro-esophageal junction: a prospective, longitudinal evaluationDISEASES OF THE ESOPHAGUS, Issue 6 2007H. Bergquist SUMMARY., Cancer of the esophagus is often diagnosed at a late stage and is related to severe morbidity and a low 5-year survival rate. Previous studies have reported low health-related quality of life and high suicide rates for these patients. The occurrence of psychiatric morbidity and thus the potential need for psychological support may vary over time after diagnosis. This has not been adequately studied in patients with newly diagnosed cancer of the esophagus or gastro-esophageal junction. The present study therefore aimed to prospectively evaluate the prevalence of psychiatric morbidity in 94 consecutive patients (median age 66, range 45,88 years) with all stages of disease. Psychiatric morbidity was evaluated with the Hospital Anxiety and Depression Scale (HADS) questionnaire at inclusion and 1, 2, 3, 6 and 12 months later. At inclusion, 42% of the patients had HADS scores indicating possible or probable anxiety disorder and/or depression. At all follow-ups except at 3 months, proportions of patients with possible/probable anxiety disorder were significantly lower than at inclusion. Among patients with a duration of tumor-specific symptoms exceeding 6 months pre-diagnosis, larger proportions of patients with a possible/probable anxiety disorder were found at the 1- and 6-month follow ups. The prevalence of possible/probable depression was greater among patients treated with a palliative intent than among those with a curative intent at inclusion. Patients who died during the study period scored worse for depression compared to the survivors. Apart from this, the proportion of patients with possible/probable psychiatric morbidity (anxiety and/or depression) was relatively stable over time and was unrelated to patient characteristics or clinical background, including the treatment regime. In conclusion, psychiatric morbidity is common among esophageal cancer patients, both at inclusion and over time, regardless of the cancer therapy given. The findings stress the importance of monitoring the patients' mental health and of offering adequate psychological care when needed. [source] Using multi-scale species distribution data to infer drivers of biological invasion in riparian wetlandsDIVERSITY AND DISTRIBUTIONS, Issue 1 2010Jane A. Catford Abstract Aim, Biological invasion is a major conservation problem that is of interest to ecological science. Understanding mechanisms of invasion is a high priority, heightened by the management imperative of acting quickly after species introduction. While information about invading species' ecology is often unavailable, species distribution data can be collected near the onset of invasion. By examining distribution patterns of exotic and native plant species at multiple spatial scales, we aim to identify the scale (of those studied) that accounts for most variability in exotic species abundance, and infer likely drivers of invasion. Location, River Murray wetlands, south-eastern Australia. Methods, A nested, crossed survey design was used to determine the extent of variation in wetland plant abundance, grazing intensity and water depth at four spatial scales (reaches, wetland clumps, wetlands, wetland sections), and among three Depth-strata. We examined responses of exotic and native species groups (grouped into terrestrial and amphibious taxa), native weeds and 10 individual species using hierarchical ANOVA. Results, As a group dominated by terrestrial taxa, exotic species cover varied at reach-, wetland- and section-scales. This likely reflects differences in abiotic characteristics and propagule pressure at these scales. Groups based on native species did not vary at any scale examined. Cover of 10 species mostly varied among and within wetlands (patterns unrelated to species' origin or functional group), but species' responses differed, despite individual plants being similar in size. While flora mostly varied among wetlands, exotic cover varied most among reaches (26%), which was attributed to hydrological modification and human activities. Main conclusions, Multi-scale surveys can rapidly identify factors likely to affect species' distributions and can indicate where future research should be directed. By highlighting disproportionate variation in exotic cover among reaches, this study suggests that flow regulation and human-mediated dispersal facilitate exotic plant invasion in River Murray wetlands. [source] Genetic diversity of endangered brown bear (Ursus arctos) populations at the crossroads of Europe, Asia and AfricaDIVERSITY AND DISTRIBUTIONS, Issue 5 2009Sébastien Calvignac Abstract Aim, Middle East brown bears (Ursus arctos syriacus Hemprich and Ehrenberg, 1828) are presently on the edge of extinction. However, little is known of their genetic diversity. This study investigates that question as well as that of Middle East brown bear relationships to surrounding populations of the species. Location, Middle East region of south-western Asia. Methods, We performed DNA analyses on 27 brown bear individuals. Twenty ancient bone samples (Late Pleistocene to 20th century) from natural populations and seven present-day samples obtained from captive individuals were analysed. Results, Phylogenetic analyses of the mitochondrial sequences obtained from seven ancient specimens identify three distinct maternal clades, all unrelated to one recently described from North Africa. Brown bears from Iran exhibit striking diversity (three individuals, three haplotypes) and form a unique clade that cannot be linked to any extant one. Individuals from Syria belong to the Holarctic clade now observed in Eastern Europe, Turkey, Japan and North America. Specimens from Lebanon surprisingly appear as tightly linked to the clade of brown bears now in Western Europe. Moreover, we show that U. a. syriacus in captivity still harbour haplotypes closely linked to those found in ancient individuals. Main conclusion, This study brings important new information on the genetic diversity of brown bear populations at the crossroads of Europe, Asia and Africa. It reveals a high level of diversity in Middle East brown bears and extends the historical distribution of the Western European clade to the East. Our analyses also suggest the value of a specific breeding programme for captive populations. [source] A multi-scale test for dispersal filters in an island plant communityECOGRAPHY, Issue 4 2005Kevin C. Burns Constraints on plant distributions resulting from seed limitation (i.e. dispersal filters) were evaluated on two scales of ecological organization on islands off the coast of British Columbia, Canada. First, island plant communities were separated into groups based on fruit morphology, and patterns in species diversity were compared between fruit-type groups. Second, abundance patterns in several common fleshy-fruited, woody angiosperm species were compared to species-specific patterns in seed dispersal by birds. Results from community-level analyses showed evidence for dispersal filters. Dry-fruited species were rare on islands, despite being common on the mainland. Island plant communities were instead dominated by fleshy-fruited species. Patterns in seed dispersal were consistent with differences in diversity, as birds dispersed thousands of fleshy-fruited seeds out to islands, while dry fruited species showed no evidence of mainland-island dispersal. Results from population-level analyses showed no evidence for dispersal filters. Population sizes of common fleshy-fruited species were unrelated to island isolation, as were rates of seed dispersal. Therefore, island isolation distances were not large enough to impose constraints on species' distributions resulting from seed limitation. Rates of seed dispersal were also unrelated to island area. However, several species increased in abundance with island area, indicating post-dispersal processes also help to shape species distributions. Overall results suggest that seed dispersal processes play an important role in determining the diversity and distribution of plants on islands. At the community-level, dry-fruited species were seed limited and island communities were instead dominated by fleshy-fruited species. At the population-level, common fleshy-fruited species were not seed limited and showed few differences in distribution among islands. Therefore, although evidence for dispersal filters was observed, their effects on plant distributions were scale-dependent. [source] The community-wide and guild-specific effects of pubescence on the folivorous insects of manzanitas Arctostaphylos spp.ECOLOGICAL ENTOMOLOGY, Issue 4 2003Melissa R. Andres Abstract., 1.,Insect communities on 26 species of manzanita Arctostaphylos spp. (Ericaceae) were sampled in order to examine the effects of variation in foliar pubescence traits on a community of folivorous insects. Manzanitas vary widely in pubescence density, length, and glandularity both within and between species. 2.,Linear models were fitted and evaluated to determine whether pubescence traits are associated with the species richness and abundance of folivorous insects after accounting for the effects of other relevant habitat and host-plant related characteristics. 3.,Pubescence traits were clearly associated with both community-wide and guild-specific variation in the structure of the folivorous insect community of manzanitas, however the effects of pubescence were manifested primarily as effects on the abundance of folivores not on species richness. The species richness of folivorous insects on manzanitas was not associated with pubescence density or length but was associated positively with glandularity. 4.,The abundance of all guilds except leaf-mining insects was lower on manzanitas having longer pubescence. In contrast, the abundance of external-chewing insects was higher on plants having denser pubescence and on plants having glandular pubescence. 5.,Overall, the results suggest that both longer pubescence and the amount of contact between an insect and pubescence act quantitatively to decrease the abundance of external-feeding guilds of folivorous insects. The abundance of species in internal-feeding guilds that oviposit directly on leaves is unrelated to foliar pubescence traits in the host plant. [source] Lifespan is unrelated to investment in reproduction in populations of mammals and birds in captivityECOLOGY LETTERS, Issue 10 2007Robert E. Ricklefs Abstract We examined the relationship between number of offspring produced to a certain age and subsequent longevity in captive zoo populations of 18 species of mammal and 12 species of bird. The age cut-offs in each analysis were set to include 50%, 75% and 90% of the offspring produced in each of the population samples. Only one of 68 regressions was significant, and its slope was positive. In addition, we examined the relationship between age at first reproduction up to a certain age and longevity after that age, generally 5 years (3,8), among 17 species of mammal and 12 species of bird. Only one of these regressions had a significantly positive slope, indicating that early reproduction rarely reduces lifespan. Overall, we found no evidence that producing offspring in a zoo environment influences the age at death. Thus, although trade-offs might apply in natural populations under resource limitation, neither pregnancy, growth of the foetus and lactation in mammals, nor egg production in birds, reduces lifespan in the absence of such stress. If genetically based or other intrinsic antagonistic pleiotropy underlies the evolution of senescence, it was not evident in our analyses. [source] Minimum viable population sizes and global extinction risk are unrelatedECOLOGY LETTERS, Issue 4 2006Barry W. Brook Abstract Theoretical and empirical work has shown that once reduced in size and geographical range, species face a considerably elevated risk of extinction. We predict minimum viable population sizes (MVP) for 1198 species based on long-term time-series data and model-averaged population dynamics simulations. The median MVP estimate was 1377 individuals (90% probability of persistence over 100 years) but the overall distribution was wide and strongly positively skewed. Factors commonly cited as correlating with extinction risk failed to predict MVP but were able to predict successfully the probability of World Conservation Union Listing. MVPs were most strongly related to local environmental variation rather than a species' intrinsic ecological and life history attributes. Further, the large variation in MVP across species is unrelated to (or at least dwarfed by) the anthropogenic threats that drive the global biodiversity crisis by causing once-abundant species to decline. [source] Population ecology and prey consumption by fathead minnows in prairie wetlands: importance of detritus and larval fishECOLOGY OF FRESHWATER FISH, Issue 3 2007B. R. Herwig Abstract,,, The fathead minnow Pimephales promelas occurs in high densities in wetlands of the prairie pothole region (PPR) of North America, but food resources sustaining these populations are poorly known. We assessed population dynamics and prey consumption of fathead minnow populations in three PPR wetlands for 2 years. Fish density peaked at 107 fish per m2 for all age classes combined. Larval and juvenile fish dominated these populations in terms of abundance and accounted for 83% of total prey consumption. Detritus dominated fish diets, representing 53%, 40% and 79% of diet mass for larval, juvenile and adult fish respectively. Detritus consumption was positively related to minnow density and negatively related to invertebrate abundance, but only for adult fish. Seasonal production:biomass ratios were unrelated to proportions of detritus in the diet for all ages of fish, indicating that detritus is an important food resource capable of meeting metabolic demands and sustaining fish growth in high-density populations. Detritus consumption may also weaken links between abundance of invertebrate prey and minnows, promoting dense fish populations with strong, consistent influences on wetland ecosystems. [source] Identification and Estimation of Regression Models with MisclassificationECONOMETRICA, Issue 3 2006Aprajit Mahajan This paper studies the problem of identification and estimation in nonparametric regression models with a misclassified binary regressor where the measurement error may be correlated with the regressors. We show that the regression function is nonparametrically identified in the presence of an additional random variable that is correlated with the unobserved true underlying variable but unrelated to the measurement error. Identification for semiparametric and parametric regression functions follows straightforwardly from the basic identification result. We propose a kernel estimator based on the identification strategy, derive its large sample properties, and discuss alternative estimation procedures. We also propose a test for misclassification in the model based on an exclusion restriction that is straightforward to implement. [source] Predictors of smoking relapse by duration of abstinence: findings from the International Tobacco Control (ITC) Four Country SurveyADDICTION, Issue 12 2009Natalie Herd ABSTRACT Aim To explore predictors of smoking relapse and how predictors vary according to duration of abstinence. Design, setting and participants A longitudinal survey of 1296 ex-smokers recruited as part of the International Tobacco Control (ITC) Four Country Survey (Australia, Canada, United Kingdom and United States). Measurements Quitters were interviewed by telephone at varying durations of abstinence (from 1 day to approximately 3 years) and then followed-up approximately 1 year later. Theorized predictors of relapse (i.e. urges to smoke; outcome expectancies of smoking and quitting; and abstinence self-efficacy) and nicotine dependence were measured in the survey. Findings Relapse was associated with lower abstinence self-efficacy and a higher frequency of urges to smoke, but only after the first month or so of quitting. Both these measures mediated relationships between perceived benefits of smoking and relapse. Perceived costs of smoking and benefits of quitting were unrelated to relapse. Conclusions Challenging perceived benefits of smoking may be an effective way to increase abstinence self-efficacy and reduce frequency of urges to smoke (particularly after the initial weeks of quitting), in order to reduce subsequent relapse risk. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||