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Unsaturated Nitriles (unsaturated + nitrile)

Distribution by Scientific Domains
Chemistry88%

Selected Abstracts

Diastereoselective and Enantiospecific Synthesis of ,-Substituted ,,,-Unsaturated Nitriles from O-Protected Allylic Cyanohydrins.

CHEMINFORM, Issue 40 2006
Alejandro Baeza
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Enantioselective Hydrogenation of Diaryl-Substituted ,,,-Unsaturated Nitriles.

CHEMINFORM, Issue 37 2006
Tobias C. Wabnitz
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Silylcupration of Allene with the Lower Order Cuprate (t-BuPh2Si)CuCNLi and Reaction with ,,,-Unsaturated Nitriles.

CHEMINFORM, Issue 20 2005
An Unusual Diaddition Process Leading to Disilyl Functionalized Ketones.
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Titanium-Mediated Synthesis of Bicyclic Cyclopropylamines from Unsaturated Nitriles.

CHEMINFORM, Issue 26 2003
Christophe Laroche
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Convenient Procedure of Horner,Wadsworth,Emmons Olefination for the Synthesis of Simple and Functionalized ,,,-Unsaturated Nitriles.

CHEMINFORM, Issue 19 2003
Alessandra Lattanzi
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

ChemInform Abstract: ,,,-Unsaturated Nitriles: Preparative MgO Elimination.

CHEMINFORM, Issue 9 2001
Fraser F. Fleming
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

A Facile Synthesis of ,-Phenylseleno-,,,-unsaturated Nitriles via ,-Phenylselenenyl Cyanomethylene Triphenylarsorane.

CHEMINFORM, Issue 44 2002
Gui-Sheng Deng
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Addition of Me3SiCN to trifluoromethyl derivates of N -(pyridylmethylidene) anilines catalyzed by Lewis acids

APPLIED ORGANOMETALLIC CHEMISTRY, Issue 9 2001
Irina Iovel
Abstract A series of novel Shiff bases (1a,h) was synthesized by condensation of pyridinecarboxaldehydes (1,4) with 3- and 4-trifluoromethylanilines (5, 6) in the presence of molecular sieves (4 Å). It was found that AlCl3 and AlBr3 catalyzed the addition of Me3SiCN to the CN bond of the imines obtained, whereas the other Lewis acids studied (YCl3, LaCl3, ZnI2) were not active. The reactivity of the imines in the title reaction, on the whole, correlated with their basicity. Besides the addition giving the expected ,-amino nitriles (2a,b,d,f,h), an unusual reaction leading to unsaturated nitriles (3a,h) was observed. The structures of saturated and unsaturated products 2d and 3c were determined by X-ray diffraction. Copyright © 2001 John Wiley & Sons, Ltd. [source]

The Ototoxic Effects Induced in Rats by Treatment for 12 Weeks with 2-Butenenitrile, 3-Butenenitrile and cis-2-Pentenenitrile

BASIC AND CLINICAL PHARMACOLOGY & TOXICOLOGY, Issue 3 2001
François Gagnaire
The rats were given, by gastric intubation, doses of 10, 20 and 40 mg ,· ,kg,1 3-butenenitrile (allyl cyanide) and 25, 50 and 100 mg ,· ,kg,1 of either cis/trans-2-butenenitrile (crotononitrile) or cis-2-pentenenitrile once a day, 5 days per week for 12 weeks. Oral administration of the three unsaturated nitriles produced deafness and absence of reaction when the animals were subject to droptest. Rats in the high dosage groups exhibited a complete disappearance of the five waves of the auditory evoked-potentials. There was a decrease in the amplitudes of the 2nd component of the auditory evoked-potentials. Those changes were not reversible at the 8th week of the recovery period. A dose-dependent effect on inner and outer hair cells was observed in the organ of Corti. The basal part of the cochlea was the most affected. Though no measurements were made of systemic exposure, a tentative ranking of decreasing ototoxicity of these three unsaturated nitriles might be proposed based on the electrophysiological deficiencies and histological losses observed: 3-butenenitrile >cis-2-pentenenitrile >cis/trans-2-butenenitrile. Moreover, rats treated with those nitriles showed a corneal opacity as well as a decrease in the amplitude and lengthening of the peak latencies of the visual evoked-potentials. These latter changes were reversible by the end of the 8th week of the recovery period and appeared to be related to the opacity of the cornea. [source]