Unsatisfactory State (unsatisfactory + state)

Distribution by Scientific Domains

Selected Abstracts

Solving the surgical waiting list problem?

New Zealand's, booking system'
Abstract This article discusses the development and implementation of New Zealand's booking system for publicly funded non-urgent surgical and medical procedures. The ,booking system' emerged out of New Zealand's core services debate and the government's desire to remove waiting lists. It was targeted for implementation by mid-1998. However, the booking system remains in an unsatisfactory state and a variety of problems have plagued its introduction. These include a lack of national consistency in the priority access criteria, failure to pilot the system and a shortfall in the levels of funding available to treat the numbers of patients whose priority criteria ,scores' deem them clinically eligible for surgery. The article discusses endeavours to address these problems. In conclusion, based on the New Zealand experience, the article provides lessons for policy-makers interested in introducing surgical booking systems. Copyright 2000 John Wiley & Sons, Ltd. [source]

Three-Dimensional Pharmacology, a Subject Ranging from Ignorance to Overstatements

Bertil Waldeck
Nevertheless, chiral drugs have been developed and used as racemates, neglecting the fact that they comprise mixtures of two or more compounds which may have quite different pharmacological properties. A very limited access to pure enantiomers in the past has been responsible for this unsatisfactory state of affairs. During the last 20 years, significant achievements have made it possible to perform stereoselective synthesis and analysis. Today, novel chiral drugs are as a rule developed as single enantiomers. Yet, studies of old racaemic drugs are still designed, performed and published without mention of the fact that two or more compounds are involved. In recent years, a number of old racaemic drugs have been re-evaluated and re-introduced into the clinical area as the pure, active enantiomer (the eutomer). While in principle correct, the clinical benefit of this shift from a well established racaemate to a pure enantiomer often seems to be limited and sometimes exaggerated. Racaemic drugs with a deleterious enantiomer that does not contribute to the therapeutic effect (the distomer), may have been sorted out in the safety evaluation process. However, in the future any pharmacological study of racaemic drugs must include the pure enantiomers. This will generate new, valuable information on stereoselectivity in drug action and interaction. [source]

Color difference formulas: An unsatisfactory state of affairs

Rolf G. Kuehni
Abstract Color difference formulas are of considerable importance in production control of colored materials, as they offer a kind of quantitative numerical method to predict perceived differences. Current formulas are based on various sets of empirical difference perception data established with different kinds of materials, under different evaluation conditions, and with different observer panels. The best current formulas predict the average of these perceptual data only with an accuracy of about 65%, a PF/3 value of about 35 (zero being optimal). This article argues that this is an unsatisfactory state of affairs and proposes the development of new uniformly established perceptual data and a new formula/system that predicts the visual results, statistically verified to represent the world-average observer, with an accuracy of 95%, a PF/3 value (or appropriate improved measure) of 5 or lower. Such a multiyear effort requires a solid experimental plan and a consortium supported by Government and industry to achieve its goal. 2008 Wiley Periodicals, Inc. Col Res Appl, 33, 324,329, 2008. [source]