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UVA Protection (uva + protection)
Selected AbstractsSunscreens and UVA Protection: A Major Issue of Minor Importance,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 1 2001Brian L. Diffey ABSTRACT The ultraviolet A (320,400 nm) (UVA) exposure of sunscreen-protected skin depends not just on the absorption characteristics of the product but also on a number of other factors. These include the amount of sunscreen applied and how it is spread over the skin. The importance of the spectral absorption of a sunscreen compared with these other two variables in controlling cutaneous UVA exposure is examined here using an analysis of variance approach. The results demonstrate that by far the most important factor is the application of a liberal quantity of sunscreen. Less important is to spread it uniformly, and least important is the precise shape of the sunscreen-absorption spectrum, providing, of course, the spectrum extends into the UVA region. [source] Relationship between UVA protection and skin response to UV light: proposal for labelling UVA protectionINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 4 2004M. Jean-Louis Refrégier Synopsis Definition and validation of a most relevant method to assess ultravoilet A (UVA) protection is a major concern for industry, authorities and consumers. However, due to the lack of knowledge about all the biological phenomena involved, the level of UVA protection needed, the ways to assess and label it, remain controversial. In order to overcome this situation, the paper deals with the outcomes of a mathematical model to calculate the distribution between ultravoilet B (UVB) and UVA components of skin responses to UV light. Mathematical calculations of UVB and UVA erythemal components of skin response to sunlight are developed from the well-known determination procedure to calculate the sunburn protection factor (SPF) of sunscreens. The model establishes the relationship between the UVA component of skin erythemal response to overall UV radiation received from sunlight and the ratio SPF/PFAe (erythemal protection factor) where SPF is the product and PFAe is related to the UVA part of the sunlight. Depending on the efficacy profile of sunscreens, the skin erythemal response may be mainly promoted by UVB rays as it normally occurs in unprotected skin or on contrary by UVA rays. Therefore, the efficacy profile of sunscreens defines the deepness where biological events induced by sunlight take place. This new relationship pinpoints the tremendous importance of the protection afforded by sunscreen products in the UVA range when erythema is taken as biological response. By extrapolation of the model to any other biological skin response it becomes possible to predict how to improve the efficiency of sunscreen products in the future. UVA protection afforded by sunscreens should be improved until reaching the same level as the SPF protection factor so that all UV-induced biological responses could be prevented or lowered at the same extend. To enforce this improvement, a proposal to classify sunscreen products in relation with their UVA protection is made. Résumé Bien que les méfaits du rayonnement UVA soient à présent reconnus et l'importance de s'en protéger au même titre que ceux du rayonnement UVB totalement admise, l'obtention d'un consensus au niveau international, sur les méthodes pour mesurer l'efficacité des produits solaires vis-à-vis des UVA et sur les niveaux d'efficacité souhaitables, semble impossible à atteindre. Afin de tenter de surmonter les obstacles actuels, nous présentons un modèle mathématique qui permet d'établir la relation qui dèfinit le poids relatif des rayonnements UVB et UVA dans l'initiation des phénomènes biologiques engendrés par le rayonnement solaire, en fonction des caractéristiques du produit solaire utilisé et en particulier de son efficacité protectrice vis-à-vis des UVA. Dans le cas de l'érythème nous établissons ainsi que la proportion des effets engendrés par le rayonnement UVA est définie par le rapport SPF/PFAe: le SPF étant le facteur de protection contre l'érythème vis-à-vis de l,ensemble du rayonnement UV, c'est l'indice de protection affiché sur les produits; et, PFAe étant le facteur de protection du produit vis-à-vis du seul rayonnement UVA. L'extrapolation possible de ce modèle à l'ensemble des phénomènes biologiques met en évidence que le facteur de proportionnalité entre la protection globale et celle apportée vis-à-vis des UVA (SPF/PFAe) permet d'établir une classification de la qualité des systèmes filtrants en fonction de leur aptitude à prèvenir l'ensemble des méfaits du rayonnement solaire. Ce modèle démontre l'importance d'évaluer l,efficacité protectrice des produits solaires vis-à-vis du rayonnement UVA et son enseignement plus pertinent que celle de seulement évaluer l'allure des spectres d'absorption. Nous jugeons que l'application directe de ce modèle, au même titre que les méthodes d'évaluation de l,allure des spectres d'absorption, n'est aujourd'hui pas souhaitable en raison des connaissances et donc de la validation insuffisantes des méthodes in vitro en particulier pour évaluer les produits non parfaitement photostables. En conséquence, nous proposons de mettre en place une qualification qui repose sur l'évaluation de la protection UVA par les mèthodes in vivo dûment étudiées et validées telles que les méthodes PPD ou PFA. La mise en place du système proposé de qualification des produits solaires, permettrait d'apporter rapidement aux consommateurs une meilleure information sur la qualité des produits et permettrait de créer une dynamique d'amélioration de la qualité de l'ensemble des produits commercialisés. [source] In vitro testing to assess the UVA protection performance of sun care productsINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 1 2001Applied Cosmetics) Task Force, Members of the DGK (German Society for Scientific, Sun Protection'. Synopsis The UVA protection delivered by sunscreens is an issue of increasing importance due to the increasing knowledge about UVA-induced skin damage. In Europe there is no officially accepted method available to determine the degree of UVA protection. Therefore, the objective of the present study was to design a protocol combining the merits of an in vitro model, which are simple and reproducible, with aspects known to be relevant from in vivo studies. The principle is: an UV-transparent support to which the test product is applied, a (pre)irradiation and a transmission measurement. Transpore® tape (standard support for SPF determinations) was found to be incompatible with many preparations on prolonged contact times. Roughened quartz was adopted as a suitable alternative. Transmission measurements on this support are not reliable with a layer of 2 mg cm,2 (standard for SPF) due to detection limitations of spectrophotometers, hence a reduced layer of 0.75 mg cm,2 was adopted. Overall, it is very difficult to apply products in a reproducible thin layer on appropriate substrates. As a consequence, absolute parameters derived from the transmission profile show relatively large dispersion, whereas relative parameters, such as critical wavelength ,c[1] or UVA/UVB ratio are much less sensitive to unavoidable variations in layer thickness. An increase in deviations was observed when the samples were irradiated before measurement. It is crucial to control the output carefully (spectral distribution and even more importantly, irradiance and dose delivered) of the light source. By doing so and also taking into account the previous learning steps, a protocol was drafted and tested in a ringtest (four samples in six laboratories). The results are encouraging and show that if relative parameters (e.g. ,c, UVA/UVB ratio) are considered, the intra- as well as interlaboratory reproducibility is clearly better than can be obtained in vivo. In general, we describe a suitable method, which can be considered in any future official discussions about the methodology to determine UVA protection. Résumé La protection contre les UVA apportée par les écrans solaires est un sujet d'importance croissante en raison de la progression des connaissances concernant les dommages à la peau causés par les UVA. En Europe il n'existe pas de méthode disponible officiellement reconnue pour déterminer le degré de protection contre les UVA. Par conséquent, l'objectif de la présente étude est de concevoir un protocole associant les avantages d'un modèle in vitro, qui est simple et reproductible, avec des aspects connus comme appartenant aux études in vivo. Le principe est le suivant: un support transparent aux UV auquel le produit testé est appliqué, une (pré)irradiation et une mesure de transmission. Le ruban Transpore® (support standard pour la détermination des SPF) se révèle incompatible avec de nombreuses préparations lors de temps de contact prolongés. Le quartz rugueux est adopté comme alternative appropriée. Les mesures de transmission sur ce support ne sont pas fiables avec une couche de 2 mg/cm2 (norme pour les SPF) en raison des limites de détection des spectrophotomètres, et on adopte donc une couche réduite de 0,75 mg/cm2. Il est surtout très difficile d'appliquer des produits en une couche fine reproductible sur des substrats appropriés. En conséquence, les paramètres absolus tirés du profil de transmission montrent une assez grande dispersion, tandis que les paramètres relatifs, tels que la longueur d'onde critique ,c[l] ou le rapport UVA/UVB sont beaucoup moins sensibles aux variations inévitables de l'épaisseur de la couche. On observe une augmentation des écarts lorsque les échantillons sont irradiés avant la mesure. Il est crucial de contrôler soigneusement la sortie (distribution spectrale et encore plus important, irradiation et dose délivrée) de la source lumineuse. Dans ces conditions, et en tenant aussi compte des enseignements des étapes précédentes, un protocole a étéébauché et testé lors d'un essai tournant (quatre échantillons dans six laboratoires). Les résultats sont encourageants et montrent que si on considère les paramètres relatifs (par exemple ,c, rapport UVA/UVB), la reproductibilité intra et interlaboratoires est clairement meilleures que ce qu'on peut obtenir in vivo. D'une façon générale, nous décrivons une méthode appropriée, qui peut être considérée dans tout échange officiel futur concernant la méthodologie pour déterminer la protection contre les UVA. [source] Photostability of UV Absorber Systems in Sunscreens,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 4 2009Bernd Herzog Sunscreens are used to protect the human skin against harmful UV radiation. Today there is a trend toward higher sun protection factors (SPF) and better UVA protection. Methods for the assessment of SPF and UVA protection involve irradiation of the product, and the photostability properties of the sunscreen have an influence on its performance. Sunscreens often contain more than one UV filter. Thus it is important to understand the photostability properties of the complete system. The filter combinations used may exhibit destabilizing, stabilizing or inert interactions. For that reason, besides assessment of the properties of the single filters, photostabilities of binary filter combinations are investigated. Destabilization occurs when two UV absorbers undergo a chemical reaction after absorption of UV radiation. Stabilization may be achieved when the optical density of the system is very high, giving rise to a self-protection effect of the sunscreen film. Photounstable UV absorbers may be additionally stabilized by employing triplet quenchers. Being aware of these mechanisms and applying them for specific UV filter combinations can help in designing efficient sunscreens. [source] Determination of Wavelength-Specific UV Protection Factors of Sunscreens in Intact Skin by EPR Measurement of UV-Induced Reactive Melanin RadicalPHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 4 2007Leslie Lund ABSTRACT There remains an unmet need for skin tissue-based assays for the measurement of the UVA protection and efficacy of sunscreens. Here we describe development of a novel electron paramagnetic resonance assay that uses the photogeneration of reactive melanin radical as a measure of UV light penetration to melanocytes in situ in skin. We have used areas of focal melanocytic hyperplasia in the skin of Monodelphis domestica to model the human nevus. We show that we are able to use this assay to determine the monochromatic protection factors (mPF) of research and commercial sunscreens at specific narrow wavebands of UVB, UVA and blue visible light. Both commercial sunscreens, a sun protection factor (SPF) 4 and an SPF 30 product, had mPFs in the UVB range that correlated well with their claimed SPF. However, their mPF in the UVA ranges were only about one-third of claimed SPF. This technique can be used to design and assay sunscreens with optimally balanced UVA and UVB protection. [source] Sunscreens containing the broad-spectrum UVA absorber, Mexoryl® SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study resultsPHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, Issue 4 2008Anny Fourtanier Background: UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage. It alters immune function, pigmentation and it is certainly responsible for a large part of photoaging changes. Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones. Aim: To assess the efficacy of sunscreens containing a broad-spectrum UVA absorber the Mexoryl® SX or ecamsule and to compare formulations with and without it through a large number of clinical studies in human volunteers and patients. Methods: The following assessments were conducted: ,Prevention of excessive pigmentation induced by UV exposure in Caucasian and Asian skins using a method that measures pigmentation protection factors (PPF). ,Efficacy against DNA damage by measurement of pyrimidine dimer formation and p53 protein accumulation. ,Protection of immune system using delayed type hypersensitivity (DTH) reactions to recall antigens, isomerization of urocanic acid (UCA), alteration of Langerhans cells (LC) density, morphology and function. ,Reduction of epidermal and dermal alterations induced by repeated UVA or UV solar simulated radiation (SSR) using histology or immunohistology. ,Prevention of the polymorphous light eruption (PMLE) in patients prone to develop this disease. Results: Mexoryl® SX-containing formulations showed a dose-dependent level of protection against pigmentation. For a same sun protection factor (SPF) the higher the UVA protection was, the higher was the PPF. Pyrimidine dimer formation and p53 accumulation were significantly reduced by formulations with Mexoryl® SX. In the studies looking at the suppression of DTH reactions to recall antigens by the different UV spectra, the LC alterations and the cis UCA formation, Mexoryl® SX formulations always showed a higher protective potency than sunscreen without it even when the protection against erythema was similar (products with same SPF). Mexoryl® SX formulations also prevented or significantly decreased to minimal, ferritin, tenascin and lysozyme expression induced by repeated UVA or SSR exposure. It also reduced the enhancement of collagenase 2 mRNA expression induced by SSR exposure. Finally PMLE study demonstrated that UVA protection was essential for the prevention of this photodermatose. Conclusion: Mexoryl® SX formulated in sunscreens or daily use products have been shown to be an effective UV absorber, leading to an increased efficacy of these products against a large number of biological damage induced by UVA, SSR or sun exposure. [source] Sunscreen protection in the ultraviolet A region: how to measure the effectivenessPHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, Issue 1 2001C. Cole Products containing ultraviolet (UV) radiation absorbing or scattering ingredients provide varying degrees of protection from sunlight (or other UV sources), thus minimizing the deleterious effects on the skin. The "sun protection factor" (SPF) of sunscreen products has become a well recognized indicator of protection against sunburn induced predominantly by ultraviolet B radiation (UVB: 290,320 nm). A similar system of denoting sunscreen protection from ultraviolet A (UVA: 320,400 nm) radiation has not been universally recognized. A variety of test methods have been proposed, both in vitro and in vivo, each with specific virtues and shortcomings. Regulatory agencies and industry have been reviewing the available methods over the past decade in an effort to develop consumer meaningful claims and appropriate substantiation methods. This article reviews these test methodologies, in vitro and in vivo, as well as the biological background that establishes the need for UVA protection, and the UVA content of solar radiation and its variability. [source] Sunscreen ingredients and labelling: a survey of products available in the UKCLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 4 2007S. Wahie Summary Background., In Europe, where sunscreens are classified as cosmetics, products may contain one or several of 27 permitted ,ultraviolet filters'. We were unable to find published data on the frequency of usage of individual ultraviolet (UV)-absorbing chemicals in currently available sunscreens. Aim., To record the active ingredients and labelling characteristics of sunscreens available in the UK. Methods., In 2005, two dermatologists visited seven retail outlets, which stocked a large range of sunscreens. Manufacturers were also contacted. For each product, the names of UV-protective ingredients and the labelling information, including sun protection factor (SPF), UVA protection and age group for which the product was marketed were recorded. Results., Data on 308 skin sunscreen products and 21 lip sunscreens were recorded. For skin products, the SPF ranged from 2 to 60. In total, 23 different UV-absorbing ingredients were found, 4 of which were found in >,25% of products. The child and baby skin sunscreens (n = 52) had a significantly higher median SPF of 40, compared with 15 for the remaining 256 adult products (P < 0.001). The number of UV-absorbing chemicals and the frequency of those commonly used did not differ substantially between child and adult products. Of skin sunscreens marketed for babies, 60% contained 2,6 UV-absorbing chemicals. Nearly half of the skin sunscreens contained at least one of nine UV-absorbing chemicals not available in patch testing formulations from commercial suppliers. Conclusions., The results of this survey indicate current sunscreen content and labelling, and are a benchmark from which new developments can be tracked. More standard sunscreen labelling, particularly separate listing of active ingredients, would be helpful. It was surprising to find UV-absorbing chemicals in products sold for use on babies. [source] | ||||||||||