Home About us Contact
|
Home About us Contact | ||
|
|
||
Triggering Mechanism (triggering + mechanism)
Selected AbstractsLandslide inventories and their statistical propertiesEARTH SURFACE PROCESSES AND LANDFORMS, Issue 6 2004Bruce D. Malamud Abstract Landslides are generally associated with a trigger, such as an earthquake, a rapid snowmelt or a large storm. The landslide event can include a single landslide or many thousands. The frequency,area (or volume) distribution of a landslide event quanti,es the number of landslides that occur at different sizes. We examine three well-documented landslide events, from Italy, Guatemala and the USA, each with a different triggering mechanism, and ,nd that the landslide areas for all three are well approximated by the same three-parameter inverse-gamma distribution. For small landslide areas this distribution has an exponential ,roll-over' and for medium and large landslide areas decays as a power-law with exponent -2·40. One implication of this landslide distribution is that the mean area of landslides in the distribution is independent of the size of the event. We also introduce a landslide-event magnitude scale mL = log(NLT), with NLT the total number of landslides associated with a trigger. If a landslide-event inventory is incomplete (i.e. smaller landslides are not included), the partial inventory can be compared with our landslide probability distribution, and the corresponding landslide-event magnitude inferred. This technique can be applied to inventories of historical landslides, inferring the total number of landslides that occurred over geologic time, and how many of these have been erased by erosion, vegetation, and human activity. We have also considered three rockfall-dominated inventories, and ,nd that the frequency,size distributions differ substantially from those associated with other landslide types. We suggest that our proposed frequency,size distribution for landslides (excluding rockfalls) will be useful in quantifying the severity of landslide events and the contribution of landslides to erosion. Copyright © 2004 John Wiley & Sons, Ltd. [source] Initiation of TCR signaling: regulation within CD3 dimersIMMUNOLOGICAL REVIEWS, Issue 1 2003Balbino Alarcón Summary: The number of possible T cell activation outcomes resulting from T cell receptor (TCR) engagement suggests that the TCR is able to differentially activate a myriad of signaling pathways depending on the nature of the stimulus. The complex structural organization of the TCR itself could underlie this diversity of responses. Assembly and stoichiometric studies have helped us to shed some light on the initiation of TCR signaling. The TCR is composed of TCR and CD3 dimers. Changes in the interaction between CD3 subunits within the CD3 dimers and in the interaction of these dimers with the TCR heterodimer could be the triggering mechanism that initiates the first activation events. One of the hallmarks of these early changes in TCR conformation is the induced recruitment of the adapter protein Nck to a proline-rich sequence of the cytoplasmic tail of CD3,, but there may be others. According to our most recent observations, the TCR is organized in pre-existing clusters within plasma membrane microdomains, exhibiting a complexity above and beyond that of dimer composition complexity. How the presence of TCR in clusters influences TCR avidity and propagation of TCR signals is something that has yet to be investigated. [source] Is AGN feedback necessary to form red elliptical galaxies?MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 1 2008A. Khalatyan ABSTRACT We have used the smoothed particle hydrodynamics (SPH) code gadget-2 to simulate the formation of an elliptical galaxy in a group-size cosmological dark matter halo with mass Mhalo, 3 × 1012 h,1 M, at z= 0. The use of a stellar population synthesis model has allowed us to compute magnitudes, colours and surface brightness profiles. We have included a model to follow the growth of a central black hole and we have compared the results of simulations with and without feedback from active galactic nuclei (AGN). We have studied the interplay between cold gas accretion and merging in the development of galactic morphologies, the link between colour and morphology evolution, the effect of AGN feedback on the photometry of early-type galaxies, the redshift evolution in the properties of quasar hosts, and the impact of AGN winds on the chemical enrichment of the intergalactic medium (IGM). We have found that the early phases of galaxy formation are driven by the accretion of cold filamentary flows, which form a disc galaxy at the centre of the dark matter halo. Disc star formation rates in this mode of galaxy growth are about as high as the peak star formation rates attained at a later epoch in galaxy mergers. When the dark matter halo is sufficiently massive to support the propagation of a stable shock, the gas in the filaments is heated to the virial temperature, cold accretion is shut down, and the star formation rate begins to decline. Mergers transform the spiral galaxy into an elliptical one, but they also reactivate star formation by bringing gas into the galaxy. Without a mechanism that removes gas from the merger remnants, the galaxy ends up with blue colours, which are atypical for its elliptical morphology. We have demonstrated that AGN feedback can solve this problem even with a fairly low heating efficiency. Our simulations support a picture where AGN feedback is important for quenching star formation in the remnant of wet mergers and for moving them to the red sequence. This picture is consistent with recent observational results, which suggest that AGN hosts are galaxies in migration from the blue cloud to the red sequence on the colour,magnitude diagram. However, we have also seen a transition in the properties of AGN hosts from blue and star forming at z, 2 to mainly red and dead at z, 0. Ongoing merging is the primary but not the only triggering mechanism for luminous AGN activity. Quenching by AGN is only effective after the cold filaments have dried out, since otherwise the galaxy is constantly replenished with gas. AGN feedback also contributes to raising the entropy of the hot IGM by removing low-entropy tails vulnerable to developing cooling flows. We have also demonstrated that AGN winds are potentially important for the metal enrichment of the IGM a high redshift. [source] Deep spectroscopy of 9C J1503+4528: a very young compact steep spectrum radio source at z= 0.521MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2006K. J. Inskip ABSTRACT 9C J1503+4528 is a very young compact steep spectrum radio galaxy, with an age of the order of 104 yr. This source is therefore an ideal laboratory for the study of the intrinsic host galaxy/intergalactic medium properties, interactions between the radio source and surrounding interstellar medium, links between star formation and active galactic nucleus (AGN) activity and the radio source triggering mechanism. Here we present the results of a spectroscopic analysis of this source, considering each of these aspects of radio source physics. We find that shock ionization by the young radio source is important in the central regions of the galaxy on scales similar to that of the radio source itself, whilst evidence for an AGN ionization cone is observed at greater distances. Line and continuum features require the presence of a young stellar population (YSP), the best-fitting model for which implies an age of 5 × 106 yr, significantly older than the radio source. Most interestingly, the relative sizes of radio source and extended emission-line region suggest that both AGN and radio source are triggered at approximately the same time. If both the triggering of the radio source activity and the formation of the YSP had the same underlying cause, this source provides a sequence for the events surrounding the triggering process. We propose that the AGN activity in 9C J1503+4528 was caused by a relatively minor interaction, and that a supermassive black hole powering the radio jets must have been in place before the AGN was triggered. [source] Localization and gestation-dependent pattern of corticotrophin-releasing factor receptor subtypes in ovine fetal distal colonNEUROGASTROENTEROLOGY & MOTILITY, Issue 12 2008J. Lakshmanan Abstract, Meconium passage is frequently observed in association with feto-maternal stress factors such as hypoxia and infection, but the triggering mechanism is unknown. We hypothesize that differential regulation of corticotrophin-releasing factor (CRF) receptors during gestation play an important role in determining the susceptibilities of the fetus to stress-induced in utero meconium passage at term. We examined the innervation patterns of CRF-receptor type 1 (CRF-R1), a stimulator of gastrointestinal motility and CRF-receptor type II (CRF-R2), an inhibitor of gastrointestinal motility in ovine fetal distal colonic segments from very preterm to term gestation. Both CRF-R1 and CRF-R2 receptors were present in muscularis mucosa as well as in longitudinal and circular smooth muscle layers in fetal distal colonic segments at all gestational ages. Quantitative image analysis indicated a 42% increase in CRF-R1 receptor immunoreactivity in muscularis mucosa and a 30% in longitudinal smooth muscle layers from very preterm to term. In contrast, CRF-R2 receptor immunoreactivity in muscularis mucosa as well as in longitudinal and circular smooth muscle layers decreased by 38%, 55% and 51%, respectively, at term. The percentage of enteric ganglia and the number of enteric neurons expressing CRF-R1 receptors were high at term. Western blot analysis identified 235 and 50 kDa molecular species of CRF-R1 receptors and 37 and 28 kDa molecular species of CRF-R2 receptors. In summary, we speculate that downregulation of CRF-R2 receptor abundance with concurrent increases in CRF-R1 receptor levels in myenteric-smooth muscle unit with advancing gestation sensitizes the colonic motility responses to stressors. [source] Microemboli may link spreading depression, migraine aura, and patent foramen ovaleANNALS OF NEUROLOGY, Issue 2 2010Ala Nozari MD Objective Patent foramen ovale and pulmonary arteriovenous shunts are associated with serious complications such as cerebral emboli, stroke, and migraine with aura. The pathophysiological mechanisms that link these conditions are unknown. We aimed to establish a mechanism linking microembolization to migraine aura in an experimental animal model. Methods We introduced particulate or air microemboli into the carotid circulation in mice to determine whether transient microvascular occlusion, insufficient to cause infarcts, triggered cortical spreading depression (CSD), a propagating slow depolarization that underlies migraine aura. Results Air microemboli reliably triggered CSD without causing infarction. Polystyrene microspheres (10,m) or cholesterol crystals (<70,m) triggered CSD in 16 of 28 mice, with 60% of the mice (40% of those with CSD) showing no infarcts or inflammation on detailed histological analysis of serial brain sections. No evidence of injury was detected on magnetic resonance imaging examination (9.4T; T2 weighted) in 14 of 15 selected animals. The occurrence of CSD appeared to be related to the magnitude and duration of flow reduction, with a triggering mechanism that depended on decreased brain perfusion but not sustained tissue damage. Interpretation In a mouse model, microemboli triggered CSD, often without causing microinfarction. Paradoxical embolization then may link cardiac and extracardiac right-to-left shunts to migraine aura. If translatable to humans, a subset of migraine auras may belong to a spectrum of hypoperfusion disorders along with transient ischemic attacks and silent infarcts. ANN NEUROL 2010;67:221,229 [source] Optical flares from the faint mid-dM star 2MASS J00453912+4140395ASTRONOMISCHE NACHRICHTEN, Issue 9 2007Zs. K Abstract We present B and V light curves of a large stellar flare obtained with the Wide Field Camera at the Isaac Newton 2.5-m telescope (La Palma). The source object is a faint (mV = 21.38) foreground star in the field of the Andromeda galaxy, with its most probable spectral type being dM4. We provide an estimate of the total flare energy in the optical range and find it to be of the order of 1035 erg. The cooling phase of the large flare shows three additional weak flare-like events, which we interpret as results of a triggering mechanism also observed on the Sun during large coronal mass ejections. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Morphology of Younger Dryas subglacial and ice-proximal submarine landforms, inner Vestfjorden, northern NorwayBOREAS, Issue 3 2009KAI ROGER FLØISTAD The sea-floor morphology of two pronounced across-fjord bedrock thresholds located at the mouths of Ofotfjorden and Tysfjorden, northern Norway, has been analysed based on swath bathymetry and seismic data. The Younger Dryas ice front was located here during the recession of one of the large palaeo-ice streams of the Fennoscandian Ice Sheet. The thresholds are several kilometres long and wide, rising to several hundred metres above the adjacent sea floor, and the slopes are steep, up to 25°. The Ofotfjorden threshold is draped by acoustically discontinuous to chaotic sediments partly infilling the bedrock relief. A pattern of well-developed, subglacial bedforms (e.g. crag-and-tail formations, drumlins and glacial lineations) on top of both thresholds suggests fast-flowing ice. A series of smaller transverse ridges is identified on both thresholds and probably records ice-front oscillations during the final deglaciation. The distal parts of the sediments have been remobilized by slides that occurred after glacial retreat from the thresholds. Earthquake activity due to the isostatic rebound following ice retreat from this area was the most likely triggering mechanism for the slides. The location of the ice front on a prominent bedrock threshold indicates that the basin configuration was important in locating the maximum position of the climatically induced re-advance, i.e. a topographic control on the maximum Younger Dryas position in the Ofotfjorden and Tysfjorden area is suggested. [source] Myocardial Contractility and Cardiac Filling Measured by Impedance Cardiography in Patients with Nitroglycerine-Induced Vasovagal SyncopePACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 1 2006PETER MITRO Objective: Increased myocardial contractility and inadequate cardiac filling leading to activation of the Bezold-Jarisch reflex were proposed as possible triggering mechanisms of vasovagal syncope (VVS). In the present study noninvasive hemodynamic measurements were performed in order to examine the role of myocardial contractility and cardiac filling in pathogenesis of VVS. Methods: Hemodynamic parameters were measured during head-up tilt test (HUT) by impedance cardiography in 46 patients with unexplained syncope. Myocardial contractility was measured as index of contractility (IC), acceleration index (ACI), and ejection fraction (EF). Afterload was measured as systemic vascular resistance index (SVRI) and preload was expressed as end-diastolic index (EDI). Serial measurements were done 1 minute before HUT, during HUT at 1-minute intervals, and 1 minute after completion of HUT. Results: HUT was positive in 30 patients (10 men, 20 women, mean age 36 ± 16 years) and negative in 16 patients (8 men, 8 women, mean age 31 ± 14 years). No significant differences were observed between HUT(+) and HUT(,) groups in hemodynamic parameters at supine rest and during HUT until the development of syncope. SVRI was lower in HUT(+) than in HUT(,) group at syncope (122.7 + 66.3 vs 185.6 + 51.4 dyn sec cm,5/m2, P = 0.002) and after syncope (117.0 + 61.1 vs 198.0 + 95.7 dyn sec cm,5/m2, P = 0.007). ACI, IC, EF, and EDI did not differ between groups at syncope. After syncope EF was higher in HUT(+) group compared to HUT(,) group (59.2 + 6.1 vs 52.7 + 9.4%, P = 0.02). Conclusion: The role of increased myocardial contractility and decreased cardiac filling is not confirmed in the present study. [source] Increases in core body temperature precede hot flashes in a prostate cancer patientPSYCHO-ONCOLOGY, Issue 5 2009Laura J. Hanisch Abstract Objective: An effective and safe alternative treatment to hormone replacement therapy for hot flashes is needed for cancer patients. Interventions targeting the triggering mechanisms of hot flashes hold promise. Increases in core body temperature are a precursor of most hot flashes in women, and similar findings in prostate cancer patients undergoing androgen deprivation therapy would support further research in this area. We present preliminary findings of physiological changes in a prostate cancer patient with frequent hot flashes. Methods: Physiological changes in sternal skin conductance, heart rate, and core body temperature were continuously measured during two 3.5,h laboratory sessions. Perceived characteristics of hot flashes were recorded in a diary. Results: Five hot flashes were reported during laboratory sessions. Severity and bother ratings were low. All hot flashes were accompanied by large increases in sternal skin conductance and moderate increases in heart rate. Core body temperature increased 0.11,0.32°C prior to and fell 0.23,0.44°C following the peak increase in skin conductance. Conclusions: This case study suggests that hot flashes in men may be preceded by increases in core body temperature. Identification of behavioral factors that raise core body temperature may lead to specific treatment strategies to reduce the frequency of hot flashes. Copyright © 2008 John Wiley & Sons, Ltd. [source] | ||||||||||||||||