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Trifluoromethyl Ketones (trifluoromethyl + ketone)

Distribution by Scientific Domains

Chemistry	95%

Selected Abstracts

ChemInform Abstract: Synthesis and Properties of ,-Iodo-,-ethoxyvinyl Trifluoromethyl Ketone.

CHEMINFORM, Issue 19 2002
Liliya M. Kacharova
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Synthesis and Properties of 2,2-Dichlorovinyl Trifluoromethyl Ketone.

CHEMINFORM, Issue 51 2001
G. G. Levkovskaya
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

A Direct Intermolecular Cross-Benzoin Type Reaction: N-Heterocyclic Carbene-Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2009
Dieter Enders
Abstract A direct intermolecular cross-benzoin-type condensation catalyzed by an N-heterocyclic carbene has been developed. The cross-coupling of commercially available aromatic aldehydes and trifluoromethyl ketones results in ,-hydroxy-,-trifluoromethyl ketones bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields. [source]

Synthesis of N-Heteroaryl(trifluoromethyl)hydroxyalkanoic Acid Esters by Highly Efficient Solid Acid-Catalyzed Hydroxyalkylation of Indoles and Pyrroles with Activated Trifluoromethyl Ketones

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 14 2005
Mohammed Abid
Abstract The synthesis of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters by solid acid-catalyzed Friedel,Crafts hydroxyalkylation of indoles and pyrroles with ethyl 3,3,3-trifluoropyruvate and ethyl 4,4,4-trifluoroacetoacetate is described. The inexpensive and readily available K-10 montmorillonite is found to be an efficient catalyst for the synthesis of a wide variety of trifluoromethylated indol-3-yl- and pyrrol-2-yl-hydroxypropionic and -butanoic acid esters. Using a series of substituted indoles and pyrroles the corresponding products were isolated in excellent yield (up to 98%) and 100% selectivity under mild experimental conditions, during very short reaction times. Beyond these, the ease of product isolation, catalyst stability and handling make this process an attractive, environmentally benign alternative for the synthesis of the target compounds. [source]

ChemInform Abstract: Dy(OTf)3/Pybox-Catalyzed Enantioselective Friedel,Crafts Alkylation of Indoles with ,,,-Unsaturated Trifluoromethyl Ketones.

CHEMINFORM, Issue 33 2010
Shigeru Sasaki
Abstract In most cases, good yields and enantioselectivities are obtained. [source]

ChemInform Abstract: Enantioselective Zirconium-Catalyzed Friedel,Crafts Alkylation of Pyrrole with Trifluoromethyl Ketones.

CHEMINFORM, Issue 24 2009
Gonzalo Blay
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: One-Pot Synthesis of Functionalized Indenols from 2-Bromoalkenyl Trifluoromethyl Ketones.

CHEMINFORM, Issue 50 2008
Alexander Yu.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Organocatalyzed Asymmetric Inverse-Electron-Demand Hetero-Diels,Alder Reaction of ,,,-Unsaturated Trifluoromethyl Ketones and Aldehydes.

CHEMINFORM, Issue 36 2008
Yan Zhao
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and ,-Amino Esters.

CHEMINFORM, Issue 27 2007
Greg Hughes
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Enantioselective Rhodium-Catalyzed Addition of Arylboronic Acids to Trifluoromethyl Ketones.

CHEMINFORM, Issue 8 2007
Sebastien L. X. Martina
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Synthesis of N-(5-Pyrazolyl) Schiff Bases Derived from Aryl Trifluoromethyl Ketones.

CHEMINFORM, Issue 37 2004
M. V. Vovk
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

A General Method of Halogenation for Synthesis of ,-Halodifluoromethyl Ketones and [18F]-Labeled Trifluoromethyl Ketones.

CHEMINFORM, Issue 36 2003
G. K. Surya Prakash
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Regioselective Reactions of ,-Aminovinyl Trifluoromethyl Ketones with Tosyl Isocyanate.

CHEMINFORM, Issue 26 2003
Natalie V. Lyutenko
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Enantioselective Reduction of Trifluoromethyl Ketones with Chiral Organomagnesium Amides (COMAs).

CHEMINFORM, Issue 13 2003
Kelvin H. Yong
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

ChemInform Abstract: Enantioselective Rhodium(I)-Catalyzed Hydrogenation of Trifluoromethyl Ketones.

CHEMINFORM, Issue 20 2001
Yoshichika Kuroki
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: A New and Facile Stereocontrolled Synthesis of Conjugated Dienyl Trifluoromethyl Ketones.

CHEMINFORM, Issue 18 2001
Jingbo Xiao
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

The Use of Trifluoroacetaldehyde Ethyl Hemiacetal or Hydrate in a Simple and Practical Regioselective Synthesis of ,-Hydroxy-,-trifluoromethyl Ketones from Enamines and Imines.

CHEMINFORM, Issue 32 2003
Kazumasa Funabiki
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test

EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2003
Mehmet Ates
Abstract It is generally accepted that the phospholipase-A2 -cyclooxygenase-prostanoids-cascade mediates spinal sensitization and hyperalgesia. However, some observations are not in line with this hypothesis. The aim of the present work was to investigate whether different components of this cascade exhibit nociceptive or antinociceptive effects in the rat formalin test. Intrathecal (i.th.) injection of prostaglandin E2 (PGE2) induced a dose-dependent antinociceptive effect on the formalin-induced nociception. Furthermore, thimerosal, which inhibits the reacylation of arachidonic acid thereby enhancing arachidonic acid levels, had an antinociceptive effect rather than the expected pronociceptive effect when given i.th. While the phospholipase A2 inhibitor methyl arachidonyl fluorophosphonate (MAFP; i.th.) had a significant antinociceptive effect, its analogue palmitoyl trifluoromethyl ketone (PTFMK; i.th.) had no significant effect on the formalin-induced nociception. However, MAFP, but not PTFMK, showed a cannabinoid CB1 agonistic effect as shown by the inhibition of electrically evoked contractions of the vas deferens isolated from CB1 wild-type mice but not of that from CB1 knockout mice. The antinociceptive effect of MAFP was completely reversed by the CB1 receptor antagonist AM-251 (i.th.), thus attributing such effect to its CB1 agonistic effect. Moreover, the antinociceptive effect of the cyclooxygenase inhibitor, flurbiprofen (i.th.) was reversed by the co-administration of AM-251, but not by PGE2. Finally. the combination of phenylmethylsulfonyl fluoride (PMSF; intraperitoneal), which inhibits the degradation of anandamide through the inhibition of fatty acid amidohydrolase, with thimerosal (i.th.) produced a profound CB1 -dependent antinociception. The present results show that endocannabinoids play a major role in mediating flurbiprofen-induced antinociception at the spinal level. [source]

Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils

FEBS JOURNAL, Issue 15 2002
Evidence for different arachidonate pools
The goal of this study was to determine the effects of a putative specific cytosolic phospholipase A2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3), on arachidonic acid (AA) release and lipid mediator biosynthesis by ionophore-stimulated human neutrophils. Initial studies indicated that AACOCF3 at concentrations 0,10 µm did not affect AA release from neutrophils. In contrast, AACOCF3 potently inhibited leukotriene B4 formation by ionophore-stimulated neutrophils (IC50 , 2.5 µm). Likewise, AACOCF3 significantly inhibited the biosynthesis of platelet activating factor. In cell-free assay systems, 10 µm AACOCF3 inhibited 5-lipoxygenase and CoA-independent transacylase activities. [3H]AA labeling studies indicated thatthe specific activities of cell-associated AA mimicked that of leukotriene B4 and PtdCho/PtdIns, while the specific activities of AA released into the supernatant fluid closely mimicked that of PtdEtn. Taken together, these data argue for the existence of segregated pools of arachidonate in human neutrophils. One pool of AA is linked to lipid mediator biosynthesis while another pool provides free AA that is released from cells. Additionally, the data suggest that AACOCF3 is also an inhibitor of CoA-independent transacylase and 5-lipoxygenase. Thus, caution should be exercised in using AACOCF3 as an inhibitor of cytosolic phospholipase A2 in whole cell assays because of the complexity of AA metabolism. [source]

Disruption of responses to pheromone by (Z)-11-hexadecenyl trifluoromethyl ketone, an analogue of the pheromone, in the cabbage armyworm Mamestra brassicae

PEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 8 2002
Michel Renou
Abstract The effects of (Z)-11-hexadecenyl trifluoromethyl ketone (Z11-16:TFMK) a fluorinated pheromone analogue, on the responses to sex pheromone of the male cabbage armyworm, Mamestra brassicae, have been investigated in an actograph and by electroantennography (EAG). In spite of its structural proximity with the natural pheromone, Z11-16:TFMK was poorly active in EAG, and not active on male behaviour. When permeated in the air, Z11-16:TFMK reversibly inhibited the electroantennographic responses to (Z)-11-hexadecenyl acetate (Z11-16:Ac), the main component of the sex pheromone. In the actograph, the latency of the activation was increased and the intensity of the behavioural activity of males in response to Z11-16:Ac was significantly reduced in the presence of Z11-16:TFMK. These results, along with others previously reported by us, provide new pointers to the possible use of Z11-16:TFMK in pest-control strategies. © 2002 Society of Chemical Industry [source]

Efficient Catalytic Corey,Chaykovsky Reactions Involving Ketone Substrates

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010
Sarah
Abstract It has been demonstrated for the first time that a sulfide catalyst, utilised at 20,mol% loading, can promote methylene transfer to ketones in the presence of methyl triflate and an organic base. This metal-free methodology is of broad scope , both aliphatic and aromatic ketones (including trifluoromethyl ketones) can be converted to synthetically useful terminal epoxides in excellent yields at room temperature. [source]