Tricyclic Compounds (tricyclic + compound)

Distribution by Scientific Domains
Distribution within Chemistry


Selected Abstracts


An Efficient Synthesis of Tricyclic Compounds, (.+-.),-(4a,,8a,,10a,) -1,2,3,4,4a,6,7,8,8a,9,10,10a-Dodecahydro-1,1,4a-trimethyl-2-oxophenanth rene-8a-carboxylic Acid, Its Methyl Ester, and (.+-.)-(4a,,8a,,10a,) -3,4,4a,6,7,8,8a,9,10,10a-Decahydro-8a-hydroxymethyl-1,1,4a-trimethylphe nanthren-2(1H)-one.

CHEMINFORM, Issue 15 2006
Tadashi Honda
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


Synthesis of Aza Mono, Bi and Tricyclic Compounds.

CHEMINFORM, Issue 29 2003
Evaluation of Their anti MDR Activity.
Abstract For Abstract see ChemInform Abstract in Full Text. [source]


ChemInform Abstract: Investigation of the Synthesis of Angular Tricyclic Compounds by Intramolecular Pauson,Khand Reaction of exo- and endo-Cyclic Enynes.

CHEMINFORM, Issue 31 2001
Miyuki Ishizaki
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


Molecular docking studies of selected tricyclic and quinone derivatives on trypanothione reductase of Leishmania infantum

JOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 13 2010
Santhosh Kannan Venkatesan
Abstract Visceral leishmaniasis, most lethal form of Leishmaniasis, is caused by Leishmania infantum in the Old world. Current therapeutics for the disease is associated with a risk of high toxicity and development of drug resistant strains. Thiol-redox metabolism involving trypanothione and trypanothione reductase, key for survival of Leishmania, is a validated target for rational drug design. Recently published structure of trypanothione reductase (TryR) from L. infantum, in oxidized and reduced form along with Sb(III), provides vital clues on active site of the enzyme. In continuation with our attempts to identify potent inhibitors of TryR, we have modeled binding modes of selected tricyclic compounds and quinone derivatives, using AutoDock4. Here, we report a unique binding mode for quinone derivatives and 9-aminoacridine derivatives, at the FAD binding domain. A conserved hydrogen bonding pattern was observed in all these compounds with residues Thr335, Lys60, His461. With the fact that these residues aid in the orientation of FAD towards the active site forming the core of the FAD binding domain, designing selective and potent compounds that could replace FAD in vivo during the synthesis of Trypanothione reductase can be deployed as an effective strategy in designing new drugs towards Leishmaniasis. We also report the binding of Phenothiazine and 9-aminoacridine derivatives at the Z site of the protein. The biological significance and possible mode of inhibition by quinone derivatives, which binds to FAD binding domain, along with other compounds are discussed. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010 [source]


Stereoselective synthesis of conformationally constrained tropane analogues: 6-Chloro-2,5-diazatetracyclo[8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one and 6-chloro-2,7-diazatetracyclo-[8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 4 2004
Jie Cheng
Two conformationally constrained tropane derivatives were prepared as rigid nicotinic acetylcholine receptor ligands. A palladium catalyzed intramolecular ,-arylation reaction was employed to generate the tricyclic compounds in good yields from N -(bromo-chloropyridylmethyl)-8-azabicyclo[3.2.1]octan-3-ones. [source]


Acid-catalyzed hydrolysis of bridged bi- and tricyclic compounds.

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 9 2002
3-acetylnortricyclanes, Kinetics, XXXIX, mechanisms of the hydration reactions of 1-
Abstract The disappearance of 1- and 3-acetylnortricyclanes (1-Ac and 2-Ac) in aqueous perchloric acid was followed by capillary gas chromatography at different temperatures and acid concentrations. 1-Ac is much less reactive than 2-Ac. The activation parameters, solvent deuterium isotope effects and parameters of excess acidity equations were measured and the products studied. 1-Acetylnortricyclane is hydrated according to the A -2 mechanism, i.e. the carbonyl oxygen is protonated in the fast pre-equilibrium and one water molecule attacks at the rate-limiting stage the partially open cyclopropane ring, producing 6-acetyl-2-norborneols. 3-Acetylnortricyclane is hydrated according to the AdE2 mechanism, i.e. the cyclopropane ring is slowly protonated and opened, with subsequent fast attack of water producing 3-, 5- and 7-acetyl-2-norborneols. Copyright © 2002 John Wiley & Sons, Ltd. [source]


Acid-catalyzed hydrolysis of bridged bi- and tricyclic compounds.

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 12 2001
3-nortricyclanols, Kinetics, XXXVIII, mechanisms of 1-
Abstract The disappearance of 1- and 3-nortricyclanols (1-OH and 2-OH) in aqueous perchloric acid was followed by capillary GC at different temperatures and acid concentrations. 1-OH is ca 1000 times more reactive than 2-OH. The activation parameters, solvent deuterium isotope effects and parameters of excess acidity equations were measured and the products were studied. Both isomeric nortricyclanols react according to the AdE2 mechanism, i.e. the cyclopropane ring is protonated at the rate-determining stage of the reaction. The protonation causes, in the case of 1-OH, an isomerization called homoketonization with 2-norbornanone as the only product and, in the case of 2-OH, hydration, i.e. the formation of hydroxyl-substituted norbornyl cations, the fast attack of which by water produces several norbornanediols. Copyright © 2001 John Wiley & Sons, Ltd. [source]