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Tissue Engineering Materials (tissue + engineering_material)
Selected AbstractsPreparation of Cross-Linked Poly[(, -caprolactone)- co -lactide] and Biocompatibility Studies for Tissue Engineering MaterialsMACROMOLECULAR BIOSCIENCE, Issue 1 2007Hiroshi Miyasako Abstract In this study, cross-linked materials were prepared using the branched macromonomer with different CL/LA molar ratios, and feasibility studies for tissue engineering were carried out. The thermal and mechanical properties of these materials depended on the CL/LA compositions; however, there was no change in the wettability of each material. The HeLa cells adhesion and growth on the CL-LA7030c were equal to that on the commercially available polystyrene dish. The protein absorption experiment using the FBS proteins revealed that the materials with well-grown cells showed better adhesion of the proteins. [source] Self-hardening calcium phosphate composite scaffold for bone tissue engineering,JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 3 2004Hockin H. K. Xu Abstract Calcium phosphate cement (CPC) sets in situ to form solid hydroxyapatite, can conform to complex cavity shapes without machining, has excellent osteoconductivity, and is able to be resorbed and replaced by new bone. Therefore, CPC is promising for craniofacial and orthopaedic repairs. However, its low strength and lack of macroporosity limit its use. This study investigated CPC reinforcement with absorbable fibers, the effects of fiber volume fraction on mechanical properties and macroporosity, and the cytotoxicity of CPC,fiber composite. The rationale was that large-diameter absorbable fibers would initially strengthen the CPC graft, then dissolve to form long cylindrical macropores for colonization by osteoblasts. Flexural strength, work-of-fracture (toughness), and elastic modulus were measured vs. fiber volume fraction from 0% (CPC Control without fibers) to 60%. Cell culture was performed with osteoblast-like cells, and cell viability was quantified using an enzymatic assay. Flexural strength (mean ± SD; n == 6) of CPC with 60% fibers was 13.5 ± 4.4 MPa, three times higher than 3.9 ± 0.5 MPa of CPC Control. Work-of-fracture was increased by 182 times. Long cylindrical macropores 293 ± 46 ,m in diameter were created in CPC after fiber dissolution, and the CPC,fiber scaffold reached a macroporosity of 55% and a total porosity of 81%. The new CPC,fiber formulation supported cell adhesion, proliferation and viability. The method of using large-diameter absorbable fibers in bone graft for mechanical properties and formation of long cylindrical macropores for bone ingrowth may be applicable to other tissue engineering materials. Published by Elsevier Ltd. on behalf of Orthopuedic Research Society. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved. [source] Preparation and characterization of novel poly[cyclotriphosphazene- co -(4,4,-sulfonyldiphenol)] nanofiber matricesPOLYMER INTERNATIONAL, Issue 12 2006Zhu Lu Abstract Novel poly[cyclotriphosphazene- co -(4,4,-sulfonyldiphenol)] nanofiber matrices were synthesized via a facile one-pot polymerization. The fibers are 20,50 nm in diameter and 500 nm or more in length. Uniform nanoscale fibers linked covalently with each other and formed three-dimensional matrices. The highly cross-linked chemical structure of the nanofiber matrices was measured by means of Fourier transform infrared and quantitative solid-state NMR spectroscopy. Experiments show the pH had an effect on the hydrolytic degradation of the polymer. The hydrolysis of the matrices could be accelerated by alkaline conditions. The as-synthesized nanofiber matrices have potential applications in tissue engineering materials. Copyright © 2006 Society of Chemical Industry [source] Tissue Engineering Research in Oral Implant SurgeryARTIFICIAL ORGANS, Issue 3 2001Minoru Ueda Abstract: In this article, we introduce some of the more extensively evaluated technologies using concepts of tissue engineering. We report on hard tissue engineering and soft tissue engineering and their utility for dental implant therapy. For hard tissue engineering, we evaluated human recombinant bone morphogenetic protein-2 and marrow mesenchymal stem cells using a model of sinus augmentation procedure in rabbit. We also describe distraction osteogenesis as another category for hard tissue engineering. In addition, we evaluate soft tissue management using cultured epithelial grafting for soft tissue engineering. The results of our tissue regeneration materials and methods in this study are positive. When the tissue engineering materials are used in clinics in the future, implant surgery could be the leading field. [source] | ||||||||||