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Tissue Adhesion (tissue + adhesion)
Selected AbstractsFree-Standing Biodegradable Poly(lactic acid) Nanosheet for Sealing Operations in SurgeryADVANCED MATERIALS, Issue 43 2009Yosuke Okamura A free-standing biodegradable nanosheet composed of poly(L -lactic acid) (PLLA) was shown to have excellent sealing efficacy for a gastric incision as a novel wound dressing material that did not require adhesive agents, and the PLLA nanosheet-induced wound repair showed neither scars nor tissue adhesion. This material may, therefore, be an ideal alternative to conventional tissue repairing procedures using suture/ligation in surgery. [source] Fibrin Sealants and GluesJOURNAL OF CARDIAC SURGERY, Issue 6 2003Thomas E. MacGillivray M.D. They have been used as an adjunct to hemostasis, wound healing, tissue adhesion, and drug delivery. In cardiac surgery, fibrin glues have emerged as valuable tools to improve hemostasis, decreased blood transfusions, improve tissue handling, and pretreat vascular grafts. Fibrin glues and sealants are now available commercially in the United States. This article will review the history, pharmacology, uses, and toxicity of fibrin sealants and fibrin glues. (J Card Surg 2003;18:480-485) [source] Thermogelling behaviors of poly(caprolactone- b -ethylene glycol- b -caprolactone) triblock copolymer in the presence of hyaluronic acidJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 11 2008In Yong Kim Abstract In this article, we studied the effect of hyaluronic acid (HA) on thermogelation of poly(caprolactone- b -ethylene glycol- b -caprolactone) (PCL-PEG-PCL) aqueous solution designed as an injectable system for prevention of postsurgical tissue adhesion. The PCL-PEG-PCL triblock copolymers were simply synthesized by ring-opening polymerization of ,-caprolactone (CL) in the presence of PEG as a polymeric initiator. The synthesized copolymers were confirmed by proton nuclear magnetic resonance (1H-NMR) spectroscopy. Possible interactions between HA and PCL-PEG-PCL triblock copolymers in the blend were evaluated by Fourier-transform infrared spectroscopy (FTIR). The effect of HA on the micellization of PCL-PEG-PCL aqueous solution was investigated by dye solubilization method and electrophoretic lighting scattering (ELS) spectrophotometer. Also, the thermogelling behaviors of the PCL-PEG-PCL triblock copolymers in the presence of HA and their mechanism were investigated by test tube inverting method, 13C-NMR, 1H-NMR, Advanced Rheometic Expansion System (ARES), and differential scanning calorimetry (DSC). The PCL-PEG-PCL/HA blend aqueous solutions undergo the sol-gel-sol transition in response to an increase in temperature (10,60 °C) and the gelation of the PCL-PEG-PCL was rather accelerated by HA. Presumably, this accelerated gelation seems to arise from the attractive interactions between them and the effect of chain confinement in the micelle corona region. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 3629,3637, 2008 [source] Thrombin induces neoangiogenesis in the chick chorioallantoic membraneJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 10 2003M. Caunt Summary., Most tumors have constitutively active tissue factor on their surface, capable of generating thrombin in the surrounding environment, and thrombosis is associated with cancer. Thrombin is known to induce a malignant phenotype by enhancing tissue adhesion and cell growth in vitro and in vivo in mice. Because tumors require angiogenesis for growth, we examined whether thrombin induces neoangiogenesis in a physiologically intact in vivo model. Thrombin (0.1 U mL,1) induced neoangiogenesis in the chick chorioallantoic membrane over a 24,72-h period by approximately 2,3-fold. This was inhibited by the potent thrombin inhibitor, hirudin and shown to have its mode of action by ligation of the thrombin protease-activated receptor, PAR-1. The thrombin receptor activation peptide, SFLLRNPNDKYEPF (200 µm) also enhanced neoangiogenesis c. 2,3-fold. Thrombin-induced neoangiogenesis was accompanied by the induction of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) mRNA at 24,48 h (approximately 2-fold) as determined by semi-quantitative reverse transcriptase-polymerase chain reaction. Thrombin-induced neoangiogenesis was inhibited to baseline level by the specific angiogenesis receptor inhibitors KDR-Fc (vs. VEGF) and Tie-2-Fc (vs. Ang-1 and Ang-2), as well as the non-specific angiogenesis inhibitor thrombospondin-1. Thrombin-induced neoangiogenesis was also inhibited to baseline level by agents known to inhibit thrombin receptor signaling in other cells: G-coupled protein receptor inhibitor, pertussis toxin (40 pg per egg), protein kinase C inhibitor, bisindolylmaleimide (1 µm per egg), MAP kinase inhibitor, PD980598 (10 µm per egg) and PI3 kinase inhibitor, LY294002 (0.25 µm per egg). Thus angiogenesis is stimulated by thrombosis, which could help explain the enhancement of experimental tumorigenesis by thrombin. [source] Late Results of Gelatin,Resorcin,Formalin Glue-aided Repair in Acute Type A Aortic DissectionARTIFICIAL ORGANS, Issue 12 2006Motomi Shiono Abstract:, Gelatin,resorcin,formalin (GRF) glue has been used to obliterate the false lumen of dissected aortas, resulting in reduced mortality. However, because of the cytotoxicity of formalin, the application of GRF remains controversial. In this study, a total of 138 consecutive patients with acute type A dissection since 1995, who underwent emergency graft replacement, were reviewed. The mean age was 65.5 years. The hospital mortality rate was 6.5%. In-hospital re-exploration rate and patency rate of the false lumen were 6.5% and 24.7%, respectively. The actuarial survival rates were 81.5% after 5 years and 54.8% after 10 years. Reoperation-free rates were 87.9% after 5 years and 72.3% after 10 years. Tissue necrosis or aneurismal degeneration was not demonstrated at reoperation. In conclusion, GRF glue demonstrats excellent tissue adhesion and hemostasis capability, and contributes to improve surgical results. [source] | |||||||||||||