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Third Site (third + site)
Selected AbstractsMore Difficult to Believe?INTERNATIONAL JOURNAL OF SYSTEMATIC THEOLOGY, Issue 1 2001Luther on Divine Omnipotence This article considers Luther's statement in thesis 21 of the 1545 doctoral disputation of Petrus Hegemon (1545) concerning the difficulty of belief in creatio ex nihilo, and suggests that this difficulty shapes the later Luther's theology in significant ways. The difficulty is reconstructed as a gradual movement into the mystery of the creatio ex nihilo. The first site of difficulty correlates the knowledge of creatures as particulars with the knowledge of the Creator as the source of existence. The move towards a second site is propelled by the question of inevitable death, which Luther answers by moving from material and natural generation to the resurrection and then to the creatio ex nihilo. At the third site, Luther addresses such disturbing questions as the suffering of the righteous, the historical cycle of political power, and the harshness of reprobation. He answers these questions by integrating the symmetrical biblical statements of the annihilatio and the creatio with a theological theory of divine omnipotence. God's hiddenness is understood as God's omnipotence working at the specific locations of self-negation, as well as behind the ebb and flow of historical-political contingency. Faith presses into the hidden mystery, grounded in the certainty that all things are effected by the Creator whose nature is self-giving goodness, and established by the hope that the light of glory will determine more fully the God who is to be honored above all. [source] Application of ground-penetrating radar imagery for three-dimensional visualisation of near-surface structures in ice-rich permafrost, Barrow, AlaskaPERMAFROST AND PERIGLACIAL PROCESSES, Issue 4 2007Jeffrey S. Munroe Abstract Three-dimensional ground-penetrating radar (3D GPR) was used to investigate the subsurface structure of ice-wedge polygons and other features of the frozen active layer and near-surface permafrost near Barrow, Alaska. Surveys were conducted at three sites located on landscapes of different geomorphic age. At each site, sediment cores were collected and characterised to aid interpretation of GPR data. At two sites, 3D GPR was able to delineate subsurface ice-wedge networks with high fidelity. Three-dimensional GPR data also revealed a fundamental difference in ice-wedge morphology between these two sites that is consistent with differences in landscape age. At a third site, the combination of two-dimensional and 3D GPR revealed the location of an active frost boil with ataxitic cryostructure. When supplemented by analysis of soil cores, 3D GPR offers considerable potential for imaging, interpreting and 3D mapping of near-surface soil and ice structures in permafrost environments. Copyright © 2007 John Wiley & Sons, Ltd. [source] The influence of a topical corticosteroid on short-contact high-dose dithranol therapyBRITISH JOURNAL OF DERMATOLOGY, Issue 1 2001O.Q.J. Swinkels Background Dithranol (anthralin) has been known to be effective in the treatment of psoriasis for more than 80 years. However, perilesional and uninvolved skin often show irritation during dithranol treatment, which limits its use. As the relapse rate of psoriasis is worsened by adding corticosteroids to a dithranol regimen, the use of topical corticosteroids to reduce dithranol irritation is controversial. Objectives The aim of the present study was to investigate the clinical and cell biological effect of clobetasol-17-propionate 0·05% ointment on dithranol-treated lesional and perilesional skin. Methods For 17 consecutive days, 2% dithranol cream was applied on two test sites. A third site was left untreated on all participating patients (n = 8). All sites consisted of a psoriasis lesion as well as a 3-cm zone of perilesional skin localized on the back. After 1 h, the cream was washed off, and subsequently one of the dithranol-treated sites was treated once a day with clobetasol-17-propionate 0·05% ointment. The second site was treated once daily with the vehicle. On day 17, punch biopsies were taken from all three lesions and from the perilesional zone of all test sites in order to perform an immunohistochemical investigation, using markers to assess proliferation, differentiation and inflammation. Results The SUM score (erythema + induration + scaling) of the lesion treated with dithranol/clobetasol showed a pronounced reduction, which was significantly greater than the SUM score of the lesion treated with dithranol/vehicle. However, the scores of both sites were equal by 6 weeks of follow-up. Comparing the two treated lesions, we observed a lower number of cycling epidermal cells in the dithranol/clobetasol lesion and a significantly lower perivascular dermal score of T lymphocytes. Comparing the perilesional skin of the two treated sites we observed less cycling epidermal cells in the dithranol/clobetasol-treated site. Regarding perilesional differentiation, the interpapillary involucrin expression was higher in the dithranol/clobetasol-treated site. With respect to perilesional inflammation the expression of dermal polymorphonuclear leucocytes, monocytes, macrophages and T lymphocytes in the dermal infiltrate were significantly lower in the dithranol/clobetasol-treated site. Conclusions The addition of clobetasol-17-propionate enhanced the antipsoriatic efficacy of dithranol by interfering with T-cell accumulation and epidermal proliferation. The addition of a corticosteroid reduced perilesional dithranol inflammation at the cellular level, although clinically detectable dithranol erythema was not reduced. [source] Alkali Metal Complexes of the Dipeptides PheAla and AlaPhe: IRMPD Spectroscopy,CHEMPHYSCHEM, Issue 4 2008Nick C. Polfer, Prof. Abstract Complexes of PheAla and AlaPhe with alkali metal ions Na+ and K+ are generated by electrospray ionization, isolated in the Fourier-transform ion cyclotron resonance (FT,ICR) ion trapping mass spectrometer, and investigated by infrared multiple-photon dissociation (IRMPD) using light from the FELIX free electron laser over the mid-infrared range from 500 to 1900 cm,1. Insight into structural features of the complexes is gained by comparing the obtained spectra with predicted spectra and relative free energies obtained from DFT calculations for candidate conformers. Combining spectroscopic and energetic results establishes that the metal ion is always chelated by the amide carbonyl oxygen, whilst the C-terminal hydroxyl does not complex the metal ion and is in the endo conformation. It is also likely that the aromatic ring of Phe always chelates the metal ion in a cation-, binding configuration. Along with the amide CO and ring chelation sites, a third Lewis-basic group almost certainly chelates the metal ion, giving a threefold chelation geometry. This third site may be either the C-terminal carbonyl oxygen, or the N-terminal amino nitrogen. From the spectroscopic and computational evidence, a slight preference is given to the carbonyl group, in an ROaOt chelation pattern, but coordination by the amino group is almost equally likely (particularly for K+PheAla) in an ROaNt chelation pattern, and either of these conformations, or a mixture of them, would be consistent with the present evidence. (R represents the , ring site, Oa the amide oxygen, Ot the terminal carbonyl oxygen, and Nt the terminal nitrogen.) The spectroscopic findings are in better agreement with the MPW1PW91 DFT functional calculations of the thermochemistry compared with the B3LYP functional, which seems to underestimate the importance of the cation,, interaction. [source] | ||||||||||