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Kinds of Third Terms modified by Third Selected AbstractsFROM SUSA TO ANURADHAPURA: RECONSTRUCTING ASPECTS OF TRADE AND EXCHANGE IN BITUMEN-COATED CERAMIC VESSELS BETWEEN IRAN AND SRI LANKA FROM THE THIRD TO THE NINTH CENTURIES AD*ARCHAEOMETRY, Issue 3 2008B. STERN In contrast with artefactual studies of long-distance trade and exchange in South Asia during the Prehistoric and Early Historic periods (Ardika et al. 1993; Gogte 1997; Krishnan and Coningham 1997; Tomber 2000; Gupta et al. 2001; Ford et al. 2005), few scientifically orientated analyses have focused on artefacts from the region's Historic period. During excavations at the ancient city of Anuradhapura, Sri Lanka, a number of buff ware ceramics with a putative organic coating on the interior were recovered (Coningham 2006). Dated stylistically to between the third and ninth centuries ad, analysis of the coatings using gas chromatography,mass spectrometry (GC,MS) and stable isotope analysis (carbon and deuterium) confirmed that the coatings are bitumen,an organic product associated with petroleum deposits. There are no known bitumen sources in Sri Lanka, and biomarker distributions and isotopic signatures suggest that the majority of the samples appear to have come from a single bitumen source near Susa in Iran. The relationship between the bitumen coatings and the vessels is discussed, and it is suggested that the coatings were used to seal permeable ceramic containers to allow them to transport liquid commodities. This study enhances our knowledge of networks of trade and exchange between Sri Lanka and western Asia during Historic times. [source] FEATURE-BASED KOREAN GRAMMAR UTILIZING LEARNED CONSTRAINT RULESCOMPUTATIONAL INTELLIGENCE, Issue 1 2005So-Young Park In this paper, we propose a feature-based Korean grammar utilizing the learned constraint rules in order to improve parsing efficiency. The proposed grammar consists of feature structures, feature operations, and constraint rules; and it has the following characteristics. First, a feature structure includes several features to express useful linguistic information for Korean parsing. Second, a feature operation generating a new feature structure is restricted to the binary-branching form which can deal with Korean properties such as variable word order and constituent ellipsis. Third, constraint rules improve efficiency by preventing feature operations from generating spurious feature structures. Moreover, these rules are learned from a Korean treebank by a decision tree learning algorithm. The experimental results show that the feature-based Korean grammar can reduce the number of candidates by a third of candidates at most and it runs 1.5 , 2 times faster than a CFG on a statistical parser. [source] HIGH-DIMENSIONAL LEARNING FRAMEWORK FOR ADAPTIVE DOCUMENT FILTERING,COMPUTATIONAL INTELLIGENCE, Issue 1 2003Wai Lam We investigate the unique requirements of the adaptive textual document filtering problem and propose a new high-dimensional on-line learning framework, known as the REPGER (relevant feature pool with good training example retrieval rule) algorithm to tackle this problem. Our algorithm possesses three characteristics. First, it maintains a pool of selective features with potentially high predictive power to predict document relevance. Second, besides retrieving documents according to their predicted relevance, it also retrieves incoming documents that are considered good training examples. Third, it can dynamically adjust the dissemination threshold throughout the filtering process so as to maintain a good filtering performance in a fully interactive environment. We have conducted experiments on three document corpora, namely, Associated Press, Foreign Broadcast Information Service, and Wall Street Journal to compare the performance of our REPGER algorithm with two existing on-line learning algorithms. The results demonstrate that our REPGER algorithm gives better performance most of the time. Comparison with the TREC (Text Retrieval Conference) adaptive text filtering track participants was also made. The result shows that our REPGER algorithm is comparable to them. [source] Automated Negotiation from Declarative Contract DescriptionsCOMPUTATIONAL INTELLIGENCE, Issue 4 2002Daniel M. Reeves Our approach for automating the negotiation of business contracts proceeds in three broad steps. First, determine the structure of the negotiation process by applying general knowledge about auctions and domain,specific knowledge about the contract subject along with preferences from potential buyers and sellers. Second, translate the determined negotiation structure into an operational specification for an auction platform. Third, after the negotiation has completed, map the negotiation results to a final contract. We have implemented a prototype which supports these steps by employing a declarative specification (in courteous logic programs) of (1) high,level knowledge about alternative negotiation structures, (2) general,case rules about auction parameters, (3) rules to map the auction parameters to a specific auction platform, and (4) special,case rules for subject domains. We demonstrate the flexibility of this approach by automatically generating several alternative negotiation structures for the domain of travel shopping in a trading agent competition. [source] A Polymorphic Dynamic Network Loading ModelCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 2 2008Nie Yu (Marco) The polymorphism, realized through a general node-link interface and proper discretization, offers several prominent advantages. First of all, PDNL allows road facilities in the same network to be represented by different traffic flow models based on the tradeoff of efficiency and realism and/or the characteristics of the targeted problem. Second, new macroscopic link/node models can be easily plugged into the framework and compared against existing ones. Third, PDNL decouples links and nodes in network loading, and thus opens the door to parallel computing. Finally, PDNL keeps track of individual vehicular quanta of arbitrary size, which makes it possible to replicate analytical loading results as closely as desired. PDNL, thus, offers an ideal platform for studying both analytical dynamic traffic assignment problems of different kinds and macroscopic traffic simulation. [source] Toward replication in grids for digital libraries with freshness and correctness guaranteesCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 17 2008Fuat Akal Abstract Building digital libraries (DLs) on top of data grids while facilitating data access and minimizing access overheads is challenging. To achieve this, replication in a Grid has to provide dedicated features that are only partly supported by existing Grid environments. First, it must provide transparent and consistent access to distributed data. Second, it must dynamically control the creation and maintenance of replicas. Third, it should allow higher replication granularities, i.e. beyond individual files. Fourth, users should be able to specify their freshness demands, i.e. whether they need most recent data or are satisfied with slightly outdated data. Finally, all these tasks must be performed efficiently. This paper presents an approach that will finally allow one to build a fully integrated and self-managing replication subsystem for data grids that will provide all the above features. Our approach is to start with an accepted replication protocol for database clusters, namely PDBREP, and to adapt it to the grid. Copyright © 2008 John Wiley & Sons, Ltd. [source] Towards a framework and a benchmark for testing tools for multi-threaded programsCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 3 2007Yaniv Eytani Abstract Multi-threaded code is becoming very common, both on the server side, and very recently for personal computers as well. Consequently, looking for intermittent bugs is a problem that is receiving more and more attention. As there is no silver bullet, research focuses on a variety of partial solutions. We outline a road map for combining the research within the different disciplines of testing multi-threaded programs and for evaluating the quality of this research. We have three main goals. First, to create a benchmark that can be used to evaluate different solutions. Second, to create a framework with open application programming interfaces that enables the combination of techniques in the multi-threading domain. Third, to create a focus for the research in this area around which a community of people who try to solve similar problems with different techniques can congregate. We have started creating such a benchmark and describe the lessons learned in the process. The framework will enable technology developers, for example, developers of race detection algorithms, to concentrate on their components and use other ready made components (e.g. an instrumentor) to create a testing solution. Copyright © 2006 John Wiley & Sons, Ltd. [source] Prevalence of the Third and Fourth Heart Sound in Asymptomatic AdultsCONGESTIVE HEART FAILURE, Issue 5 2005Sean P. Collins MD The prevalence of abnormal diastolic heart sounds in asymptomatic adults has been the subject of great debate. The authors determined the prevalence of an electronically detected S3 and S4 in 1329 asymptomatic adults between the ages of 18 and 94. The authors also investigated the relationship between abnormal diastolic heart sounds, age, and electrocardiography. The overall prevalence of S3 was 10.0% (95% confidence interval [Cl], 8.1%,12.2%), S4 was 15.6% (95% Cl, 13.2%,18.2%), and both S3 and S4 were 3.5% (95% Cl, 2.4%,5.0%). Using multinomial logistic regression, increasing age was found to decrease the odds of an S3 being heard (odds ratio, 0.96; 95% Cl, 0.95,0.96) and increase the odds of an S4 being heard (odds ratio, 1.04; 95% Cl, 1.03,1.05). We conclude that the prevalence of an S3 is increased earlier in life, that an S4 is less common than previous studies suggest, and that its detection, even in the elderly, should not be ignored. [source] An Emerging Market's Reaction to Initial Modified Audit Opinions: Evidence from the Shanghai Stock Exchange,CONTEMPORARY ACCOUNTING RESEARCH, Issue 3 2000CHARLES J. P. CHEN Abstract This study investigates the valuation effect of modified audit opinions (MAOs) on the emerging Chinese stock market. Here, the term MAO refers to both qualified opinions and unqualified opinions with explanatory notes. The latter can be considered an alternative form of a qualified opinion in China. The institutional setting in China enables us to find compelling evidence in support of the monitoring role of independent auditing as an institution. First, we find a significantly negative association between MAOs and cumulative abnormal returns after controlling for effects of other concurrent announcements. Further, results from a by-year analysis suggest that investors did not reach negative consensus about MAOs' valuation effect until the second year, exhibiting the learning process of a market without prior exposure to MAOs. Second, we do not observe significant differences between market reaction to non-GAAP- and GAAP-violation-related MAOs. Third, no significant difference is found between market reaction to qualified opinions and market reaction to unqualified opinions with explanatory notes. [source] MAY ISSUE VERSUS SHALL ISSUE: EXPLAINING THE PATTERN OF CONCEALED-CARRY HANDGUN LAWS, 1960,2001CONTEMPORARY ECONOMIC POLICY, Issue 2 2008RICHARD S. GROSSMAN We analyze the timing and pattern of adoption of "shall issue" concealed-carry handgun laws. "Shall issue" laws require the authorities to issue permits to qualified applicants; "may issue" laws give the authorities more latitude to reject applications. We find three factors influence the shift from "may issue" to "shall issue." First, more urban states are less likely to shift to "shall issue," although the size of this effect is quantitatively small. Second, the switch is influenced by the decisions taken by neighboring states. Third, we find evidence that increases in the crime rate accelerated the switch to "shall issue."(JEL K40) [source] Labor productivity of small and large manufacturing firms: the case of TaiwanCONTEMPORARY ECONOMIC POLICY, Issue 3 2000M. Hsu This work studies the factors influencing the labor productivity of small and medium-sized enterprises (SMEs) and large firms using Taiwan as a case study. A special emphasis is placed on two possible international channels: exports and foreign direct investment (FDI). Different from conventional studies, we employ the two-stage switching regressions to correct the firm-size effect on labor productivity and estimate labor productivity for SMEs and large firms. The main findings are as follows. First, the estimates of the selectivity variable are statistically significant for both SMEs and large firms, supporting the hypothesis of correcting the effect of firm-size truncation. Second, while a larger trade intensity significantly increases the labor productivity of SMEs, it deteriorates significantly that of large firms. Third, FDI enhances the labor productivity of SMEs internally, whereas it has a negative spillover on that of other small and large firms in the industry. While the first outcome lends supports to the role of self-selection, the remaining stands in sharp contrast to conventional wisdom. [source] Earnings Management and Corporate Governance in Asia's Emerging MarketsCORPORATE GOVERNANCE, Issue 5 2007Chung-Hua Shen This paper studies the impacts of corporate governance on earnings management. We use firm-level governance data, taken from Credit Lyonnais Security Asia (CLSA), of nine Asian countries, in addition to the country-level governance data used in past studies. Our conclusion is as follows. First, firms with good corporate governance tend to conduct less earnings management. Second, there is a size effect for earnings smoothing, that is, large size firms are prone to conduct earnings smoothing, but good corporate governance can mitigate the effect on average. Third, there is a turning point for leverage effect, i.e. when the governance index is large, leverage effect exists, otherwise reverse leverage effect exists. It shows that a highly leveraged firm with poor governance is prone to be scrutinised closely and thus finds it harder to fool the market by manipulating earnings. Fourth, firms with higher growth (lower earnings yield) are prone to engage in earnings smoothing and earnings aggressiveness, but good corporate governance can mitigate the effect. Finally, firms in stronger anti-director rights countries tend to exhibit stronger earnings smoothing. This counter-intuitive result is different from Leuz et al. (2003). [source] Should we measure corporate social responsibility?CORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 1 2003Dr Jouni Korhonen This paper is critical towards efforts that try and measure corporate social responsibility (CSR). A critical approach can be important for the development of the theory of the emerging field of corporate social responsibility. A critical and provocative approach can generate discussion and debate. Three main points of critique are presented toward the current efforts in the literature to measure corporate contributions to economic, social and ecological sustainability. First, the use of the concepts of eco-efficiency and eco-efficacy in measuring corporate contributions to sustainability are criticized from the viewpoint of the complementarity relation of human-manufactured capital, natural capital and social sustaining functions. Second, the use of measures that focus on an individual process or an individual company are reconsidered with an approach to industrial and firm networks. Third, the use of the monetary value is reconsidered, e.g. by suggesting an approach based on physical material and energy flows and on a new paradigmatic foundation for social responsibility. The social and ecological indicators illustrating the social and environmental impacts of economic activity and of firms can be combined with economic indicators, but not expressed in monetary terms. Copyright © 2003 John Wiley & Sons, Ltd. and ERP Environment. [source] THE CONTEXT OF MARRIAGE AND CRIME: GENDER, THE PROPENSITY TO MARRY, AND OFFENDING IN EARLY ADULTHOOD,CRIMINOLOGY, Issue 1 2007RYAN D. KING Marriage is central to theoretical debates over stability and change in criminal offending over the life course. Yet, unlike other social ties such as employment, marriage is distinct in that it cannot be randomly assigned in survey research to more definitively assess causal effects of marriage on offending. As a result, key questions remain as to whether different individual propensities toward marriage shape its salience as a deterrent institution. Building on these issues, the current research has three objectives. First, we use a propensity score matching approach to estimate causal effects of marriage on crime in early adulthood. Second, we assess sex differences in the effects of marriage on offending. Although both marriage and offending are highly gendered phenomena, prior work typically focuses on males. Third, we examine whether one's propensity to marry conditions the deterrent capacity of marriage. Results show that marriage suppresses offending for males, even when accounting for their likelihood to marry. Furthermore, males who are least likely to marry seem to benefit most from this institution. The influence of marriage on crime is less robust for females, where marriage reduces crime only for those with moderate propensities to marry. We discuss these findings in the context of recent debates concerning gender, criminal offending, and the life course. [source] INVESTIGATING RACIAL PROFILING BY THE MIAMI-DADE POLICE DEPARTMENT: A MULTIMETHOD APPROACHCRIMINOLOGY AND PUBLIC POLICY, Issue 1 2007GEOFFREY P. ALPERT Research Summary The perception and existence of biased policing or racial profiling is one of the most difficult issues facing contemporary American society. Citizens from minority communities have focused their concerns on the improper use of race by law enforcement officers. The current research uses a complex methodological approach to investigate claims that the Miami-Dade, Florida Police Department uses race improperly for the purposes of making traffic stops and conducting post-stop activities. The results are mixed in that the officer's aggregate actions do not show a pattern of discriminatory actions toward minority citizens when making a traffic stop, but results of post-stop activities do show some disparate treatment of minorities. Policy Implications Five specific policy recommendations are made to reduce the perception or reality of racial profiling by the police. First, police departments must have clear policies and directives explaining the proper use of race in decision making. Second, officers must be trained and educated in the overall impact of using race as a factor in deciding how to respond to a citizen. Third, the department must maintain a data-collection and analytic system to monitor the activities of their officers as it pertains to the race of the citizen. The fourth police recommendation involves the use of record checks in the field that can set in motion a process that results in the detention and arrest of citizens. Fifth, the completion of a record of interrogation for later intelligence has implications for the citizen. The use of this intelligence tool must depend on suspicion rather than on the race of the citizen. [source] RUNAWAY STORIES: The Underground Micromovements of Filipina Oyomesan in Rural JapanCULTURAL ANTHROPOLOGY, Issue 4 2008LIEBA FAIER ABSTRACT During fieldwork among Filipina migrants married to Japanese men in rural Nagano, stories about Filipina women who had "run away" from Japanese husbands and families in the region regularly surfaced in casual conversations. This essay focuses on both running away and stories about it as interconnected means through which these women negotiated their dissatisfactions with their lives abroad. I suggest that through such practices, these women's dissatisfactions assumed a "runaway agency" that created unsettling and, sometimes, unexpected social effects. First, insofar as running away involved "underground micromovements," it enabled Filipina women to craft spaces in Japan outside the domestic boundaries of both the home and the nation. These "extradomestic spaces" offered at once hopeful and dangerous possibilities for building alternative lives in Japan. Second, as Filipina women who remained in rural Nagano gossiped about those who had run away, they pressured some Filipina wives into staying while encouraging others to leave. Third, running away became an unexpected leveraging tool through which some Filipina women negotiated the conditions of their domestic situations to unpredictable effect. [source] Animal Magnetism and Curriculum HistoryCURRICULUM INQUIRY, Issue 2 2007BERNADETTE BAKER ABSTRACT This article elaborates the impact that crises of authority provoked by animal magnetism, mesmerism, and hypnosis in the 19th century had for field formation in American education. Four layers of analysis elucidate how curriculum history's repetitive focus on public school policy and classroom practice became possible. First, the article surveys external conditions of possibility for the enactment of compulsory public schooling. Second, "internal" conditions of possibility for the formation of educational objects (e.g., types of children) are documented via the processes of différance that were generated from within the experiences of confinement. Third, the article maps how these were interpenetrated by animal magnetic debates that were lustered and planished in education's emerging field, including impact upon behavior management practices, the contouring of expertise and authority, the role of Will in intelligence testing and child development theories, and the redefinition of public and private. Last, the article examines implications for curriculum history, whether policy- or practice-oriented, especially around the question of influence, the theorization of child mind, and philosophies of Being. [source] Women's Careers Beyond the Classroom: Changing Roles in a Changing WorldCURRICULUM INQUIRY, Issue 3 2001Nina Bascia Drawing from our own and others' research over the past decade and a half, we present four "readings," each illuminating a different dimension of women educators' career development, particularly their movement into work beyond the classroom. The majority of the participants in our studies are women who work for change in their classrooms, schools, and district organizations, using the opportunities, vehicles, and channels available,or apparent,to them. They do this work in professional and personal contexts that are continually changing, sometimes as a result of their own choices and actions and sometimes not. While there is a growing body of literature on women's movement into, and their lives in, educational administration, we are concerned here with the broader and more varied manifestations of leadership beyond the classroom. In the four readings, we bring together several strands in the literature on women educators' lives and careers. We first lay out the taken-for-granted oppositional contrasts in the educational discourses that have tended to obscure more complex understandings of work lives and careers. Next, we explore how the particular kinds of work available to women actually encourage some to move beyond narrow conceptions of the distinctions between classroom and nonclassroom work. Third, we discuss the developmental nature of individual career paths. Fourth, we note the spatial and temporal nature of leadership work by showing how it is influenced and changed by greater economic, social, and political forces. We believe that these multiple interpretations are required to understand the range and combination of influences that propel and compel women educators to take up various forms of leadership work beyond the classroom. [source] Critical Thoughts on Teaching Standard EnglishCURRICULUM INQUIRY, Issue 2 2000Barbara L. Speicher This article exposes four assumptions that underlie most discussions of Standard English. First, spoken English equates to written English. Substantial evidence demonstrates that this equation is both misleading and false. Second, spoken and written English are equally amenable to standardization. This is also fallacious. We will use Prototype Theory (Rosch et al., 1976) and Standard Ideology (Milroy and Milroy, 1991) to explore how broadly shared notions about standard language have led to this belief. Third, Standard English is the language of the workplace and essential for social mobility. While we do not refute this assumption, we do explore the discrimination that stems from it. Fourth, Standard English is the language of the classroom. This assumption has never been systematically tested in the literature by examining the language that teachers use. Nor is it clear that teachers believe they do or should impose an idealized spoken form on their students. [source] Difficulties in diagnosing small round cell tumours of childhood from fine needle aspiration cytology samplesCYTOPATHOLOGY, Issue 2 2008ekArticle first published online: 18 MAR 200, iva Pohar-Marin There are four basic reasons for the difficulties in diagnosing small round cell tumours (SRCT) in childhood from fine needle aspiration cytology (FNAC) samples. First, SRCTs are rare and it is difficult for cytopathologists to obtain enough experience for rendering reliable diagnoses. Second, SRCTs are morphologically very similar. Third, many SRCTs do not have specific antigens which could be demonstrated with immunocytochemistry (ICC) or they lose them when poorly differentiated. In addition, cross reactivity exists between some SRCTs. Unstandardized performance of ICC also contributes to the difficulties due to unreliable results. Fourth, suboptimal FNAC samples add additional pitfalls. The latter may be due to partly degenerate samples or to unrepresentative ones in cases where a SRCT is a heterologous component of another nosological entity. Lymphoma, neuroblastoma, nephroblastoma, Ewing's tumour/primitive neuroendocrine tumours and rhabdomyosarcoma are discussed in detail, while other less common SRCTs are mentioned as differential diagnoses when appropriate. The use of cytogenetic and molecular techniques for differentiating between certain SRCTs is helpful in some doubtful cases. However, there are still problems in the use of these techniques, especially their cost which may delay their being introduced in every cytopathology laboratory. [source] Agoraphobia: a review of the diagnostic classificatory position and criteria,,DEPRESSION AND ANXIETY, Issue 2 2010Hans-Ulrich Wittchen Ph.D. Abstract The status of agoraphobia (AG) as an independent diagnostic category is reviewed and preliminary options and recommendations for the fifth edition of The Diagnostic and Statistical Manual (DSM-V) are presented. The review concentrates on epidemiology, psychopathology, neurobiology, vulnerability and risk factors, clinical course and outcome, and correlates and consequences of AG since 1990. Differences and similarities across conventions and criteria of DSM and ICD-10 are considered. Three core questions are addressed. First, what is the evidence for AG as a diagnosis independent of panic disorder? Second, should AG be conceptualized as a subordinate form of panic disorder (PD) as currently stipulated in DSM-IV-TR? Third, is there evidence for modifying or changing the current diagnostic criteria? We come to the conclusion that AG should be conceptualized as an independent disorder with more specific criteria rather than a subordinate, residual form of PD as currently stipulated in DSM-IV-TR. Among other issues, this conclusion was based on psychometric evaluations of the construct, epidemiological investigations which show that AG can exist independently of panic disorder, and the impact of agoraphobic avoidance upon clinical course and outcome. However, evidence from basic and clinic validation studies remains incomplete and partly contradictory. The apparent advantages of a more straightforward, simpler classification without implicit hierarchies and insufficiently supported differential diagnostic considerations, plus the option for improved further research, led to favoring the separate diagnostic criteria for AG as a diagnosis independent of panic disorder. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source] Tophaceous Lesion of the Middle Third of the NoseDERMATOLOGIC SURGERY, Issue 4 2006PIER C. PARODI MD No abstract is available for this article. [source] Utility of a Bilayered Banner Transposition Flap in Reconstruction of the Lower Third of the PinnaDERMATOLOGIC SURGERY, Issue 7 2000Dania Tannir MD Background. Reconstruction of the entire ear lobule is challenging and complex. We present a case in which a banner transposition flap from the preauricular and mandibular area of the cheek resulted in an excellent cosmetic outcome. Objective. To demonstrate the utility of a bilayered banner transposition flap to reconstruct a full-thickness defect of the inferior one-third of the pinna. Methods., The technique employed in this reconstruction is described and previously reported techniques are reviewed. Results., A symmetrical earlobe with normal tissue consistency was created, as noted at 4 months postoperatively. Conclusion. Utilization of a banner transposition flap should be considered as an excellent method for reconstruction of full-thickness defects of the lower one-third of the ear. [source] ,Salience syndrome' replaces ,schizophrenia' in DSM-V and ICD-11: psychiatry's evidence-based entry into the 21st century?ACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2009J. Van Os Objective:, Japan was the first country to abandon the 19th century term of ,mind-splitting disease' (schizophrenia). Revisions of DSM and ICD are forthcoming. Should the rest of the world follow Japan's example? Method:, A comprehensive literature search was carried out in order to review the scientific evidence for the validity, usefulness and acceptability of current concepts of psychotic disorder. Results:, The discussion about re-classifying and renaming schizophrenia and other psychotic disorders is clouded by conceptual confusion. First, it is often misunderstood as a misguided attempt to change societal stigma instead of an attempt to change iatrogenic stigma occasioned by the use of misleading and mystifying terminology. Second, the debate is misunderstood as purely semantic, whereas in actual fact it is about the core concepts underlying psychiatric nosology. Third, it has been suggested that the debate is political. However, solid scientific evidence pointing to the absence of nosological validity of diagnostic categories lies at the heart of the argument. Fourth, there is confusion about what constitutes a syndrome (a group of symptom dimensions that cluster in different combinations in different people and for which one or more underlying diseases may or may not be found) and a disease (a nosologically valid entity with specific causes, symptoms, treatment and course). Conclusion:, Scientific evidence favours a syndromal system of classification combining categorical and dimensional representations of psychosis. The concept of ,salience' has the potential to make the public recognize psychosis as relating to an aspect of human mentation and experience that is universal. It is proposed to introduce, analogous to the functional-descriptive term ,Metabolic syndrome', the diagnosis of ,Salience syndrome' to replace all current diagnostic categories of psychotic disorders. Within Salience syndrome, three subcategories may be identified, based on scientific evidence of relatively valid and specific contrasts, named Salience syndrome with affective expression, Salience syndrome with developmental expression and Salience syndrome not otherwise specified. [source] Ethnic Inequalities in the Public Sector: A Comparative AnalysisDEVELOPMENT AND CHANGE, Issue 2 2006Yusuf Bangura This article uses empirical data to discuss the links between ethnicity, inequality and governance in a framework that divides countries according to their levels of ethnic polarization. It makes three main arguments. First, types of diversity, not the existence of diversity per se, explain potentials for conflict or cohesion in multiethnic societies. Ethnic cleavages are configured differently in different social structures and are less conflictual in some countries than in others. Second, relative balance has been achieved in the public sectors of countries that are highly fragmented or those with ethnicity-sensitive policies, but not in those with ethnicity-blind policies. Third, the article is critical of institutional approaches to conflict management that underplay background conditions in shaping choices. Consociational arrangements may not be relevant in unipolar ethnic settings or fragmented multiethnic societies, where governments may be ethnically inclusive under democratic conditions. They seem unavoidable in ethnic settings with two or three main groups or in settings with strong ethnic/regional clusters. [source] Gastrulation in the sea urchin embryo: A model system for analyzing the morphogenesis of a monolayered epitheliumDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 4 2004Tetsuya Kominami Processes of gastrulation in the sea urchin embryo have been intensively studied to reveal the mechanisms involved in the invagination of a monolayered epithelium. It is widely accepted that the invagination proceeds in two steps (primary and secondary invagination) until the archenteron reaches the apical plate, and that the constituent cells of the resulting archenteron are exclusively derived from the veg2 tier of blastomeres formed at the 60-cell stage. However, recent studies have shown that the recruitment of the archenteron cells lasts as late as the late prism stage, and some descendants of veg1 blastomeres are also recruited into the archenteron. In this review, we first illustrate the current outline of sea urchin gastrulation. Second, several factors, such as cytoskeletons, cell contact and extracellular matrix, will be discussed in relation to the cellular and mechanical basis of gastrulation. Third, differences in the manner of gastrulation among sea urchin species will be described; in some species, the archenteron does not elongate stepwise but continuously. In those embryos, bottle cells are scarcely observed, and the archenteron cells are not rearranged during invagination unlike in typical sea urchins. Attention will be also paid to some other factors, such as the turgor pressure of blastocoele and the force generated by blastocoele wall. These factors, in spite of their significance, have been neglected in the analysis of sea urchin gastrulation. Lastly, we will discuss how behavior of pigment cells defines the manner of gastrulation, because pigment cells recently turned out to be the bottle cells that trigger the initial inward bending of the vegetal plate. [source] Potential roles for BMP and Pax genes in the development of iris smooth muscleDEVELOPMENTAL DYNAMICS, Issue 2 2005Abbie M. Jensen Abstract The embryonic optic cup generates four types of tissue: neural retina, pigmented epithelium, ciliary epithelium, and iris smooth muscle. Remarkably little attention has focused on the development of the iris smooth muscle since Lewis ([1903] J. Am. Anat. 2:405,416) described its origins from the anterior rim of the optic cup neuroepithelium. As an initial step toward understanding iris smooth muscle development, I first determined the spatial and temporal pattern of the development of the iris smooth muscle in the chick by using the HNK1 antibody, which labels developing iris smooth muscle. HNK1 labeling shows that iris smooth muscle development is correlated in time and space with the development of the ciliary epithelial folds. Second, because neural crest is the only other neural tissue that has been shown to generate smooth muscle (Le Lievre and Le Douarin [1975] J. Embryo. Exp. Morphol. 34:125,154), I sought to determine whether iris smooth muscle development shares similarities with neural crest development. Two members of the BMP superfamily, BMP4 and BMP7, which may regulate neural crest development, are highly expressed by cells at the site of iris smooth muscle generation. Third, because humans and mice that are heterozygous for Pax6 mutations have no irides (Hill et al. [1991] Nature 354:522,525; Hanson et al. [1994] Nat. Genet. 6:168,173), I determined the expression of Pax6. I also examined the expression of Pax3 in the developing anterior optic cup. The developing iris smooth muscle coexpresses Pax6 and Pax3. I suggest that some of the eye defects caused by mutations in Pax6, BMP4, and BMP7 may be due to abnormal iris smooth muscle. Developmental Dynamics 232:385,392, 2005. © 2004 Wiley-Liss, Inc. [source] Characterization of dendritic spines in the Drosophila central nervous systemDEVELOPMENTAL NEUROBIOLOGY, Issue 4 2009Florian Leiss Abstract Dendritic spines are a characteristic feature of a number of neurons in the vertebrate nervous system and have been implicated in processes that include learning and memory. In spite of this, there has been no comprehensive analysis of the presence of spines in a classical genetic system, such as Drosophila, so far. Here, we demonstrate that a subset of processes along the dendrites of visual system interneurons in the adult fly central nervous system, called LPTCs, closely resemble vertebrate spines, based on a number of criteria. First, the morphology, size, and density of these processes are very similar to those of vertebrate spines. Second, they are enriched in actin and devoid of tubulin. Third, they are sites of synaptic connections based on confocal and electron microscopy. Importantly, they represent a preferential site of localization of an acetylcholine receptor subunit, suggesting that they are sites of excitatory synaptic input. Finally, their number is modulated by the level of the small GTPase dRac1. Our results provide a basis to dissect the genetics of dendritic spine formation and maintenance and the functional role of spines. © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2009 [source] Initial stages of neural regeneration in Helisoma trivolvis are dependent upon PLA2 activityDEVELOPMENTAL NEUROBIOLOGY, Issue 4 2003Matthew S. Geddis Abstract Neuronal regeneration after damage to an axon tract requires the rapid sealing of the injured plasma membrane and the subsequent formation of growth cones that can lead regenerating processes to their appropriate target. Membrane sealing and growth cone formation are Ca2+ -dependent processes, but the signaling pathways activated by Ca2+ to bring about these effects remain poorly understood. An in vitro injury model was employed in which neurites from identified snail neurons (Helisoma trivolvis) were transected with a glass microknife, and the formation of new growth cones from the distal portions of transected neurites was recorded at defined times after transection. This study presents three main results. First, phospholipase A2 (PLA2), a calcium-activated enzyme, is necessary for membrane sealing in vitro. Second, PLA2 activity is also required for the formation of a new growth cone after the membrane has sealed successfully. Thus, PLA2 plays a dual role by affecting both growth cone formation and membrane sealing. Third, the injury-induced activation of PLA2 by Ca2+ controls growth cone formation through the production of leukotrienes, secondary metabolites of PLA2 activity. Taken together, these results suggest that the injury-induced Ca2+ influx acts via PLA2 and leukotriene production to assure growth cone formation. These findings indicate that events that cause an inhibition of PLA2 or lipoxygenases, enzymes that produce leukotrienes, could result in the inability of neurites to regenerate. © 2003 Wiley Periodicals, Inc. J Neurobiol 54: 555,565, 2003 [source] Predictive tracking over occlusions by 4-month-old infantsDEVELOPMENTAL SCIENCE, Issue 5 2007Claes Von Hofsten Two experiments investigated how 16,20-week-old infants visually tracked an object that oscillated on a horizontal trajectory with a centrally placed occluder. To determine the principles underlying infants' tendency to shift gaze to the exiting side before the object arrives, occluder width, oscillation frequency, and motion amplitude were manipulated resulting in occlusion durations between 0.20 and 1.66 s. Through these manipulations, we were able to distinguish between several possible modes of behavior underlying ,predictive' actions at occluders. Four such modes were tested. First, if passage-of-time determines when saccades are made, the tendency to shift gaze over the occluder is expected to be a function of time since disappearance. Second, if visual salience of the exiting occluder edge determines when saccades are made, occluder width would determine the pre-reappearance gaze shifts but not oscillation frequency, amplitude, or velocity. Third, if memory of the duration of the previous occlusion determines when the subjects shift gaze over the occluder, it is expected that the gaze will shift after the same latency at the next occlusion irrespective of whether occlusion duration is changed or not. Finally, if infants base their pre-reapperance gaze shifts on their ability to represent object motion (cognitive mode), it is expected that the latency of the gaze shifts over the occluder is scaled to occlusion duration. Eye and head movements as well as object motion were measured at 240 Hz. In 49% of the passages, the infants shifted gaze to the opposite side of the occluder before the object arrived there. The tendency to make such gaze shifts could not be explained by the passage of time since disappearance. Neither could it be fully explained in terms of visual information present during occlusion, i.e. occluder width. On the contrary, it was found that the latency of the pre-reappearance gaze shifts was determined by the time of object reappearance and that it was a function of all three factors manipulated. The results suggest that object velocity is represented during occlusion and that infants track the object behind the occluder in their ,mind's eye'. [source] | ||||||||||||||||||||||||||||||||||||||||||||||