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Thiourea Derivatives (thiourea + derivative)
Selected AbstractsChemInform Abstract: A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium.CHEMINFORM, Issue 30 2010Mahagundappa R. Maddani Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Facile Synthesis of Thiourea Derivatives in Ionic Liquid.CHEMINFORM, Issue 18 2008Min Liang Xiao Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] A New Synthesis Method for Benzo[f]quinolin-3-carbonyl Urea and Thiourea Derivatives in Aqueous Media Catalyzed by TEBAC.CHEMINFORM, Issue 31 2007Xiang-Shan Wang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] ChemInform Abstract: Synthesis and Biological Activity of N-Aroyl-N,-Substituted Thiourea Derivatives.CHEMINFORM, Issue 4 2002You-Ming Zhang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and Antiviral Activities of Chiral Thiourea DerivativesCHINESE JOURNAL OF CHEMISTRY, Issue 3 2009Zhikun YAN Abstract An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF6. The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, 1H NMR and 13C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC50=50.8 µg/mL) than Ningnanmycin (EC50=60.2 µg/mL). [source] Synthesis and reactions of 3-amino-2-methyl-3H -[1,2,4]triazolo[5,1- b]-quinazolin-9-one and 2-hydrazino-3-phenylamino-3H -quinazolin-4-oneJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 6 2003Mohamed A. Saleh The reaction of 3- N -(2-mercapto-4-oxo-4H -quinazolin-3-yl)acetamide (1) with hydrazine hydrate yielded 3-amino-2-methyl-3H -[1,2,4]triazolo[5,1- b]quinazolin-9-one (2). The reaction of 2 with o -chlorobenzaldehyde and 2-hydroxy-naphthaldehyde gave the corresponding 3-arylidene amino derivatives 3 and 4, respectively. Condensation of 2 with 1-nitroso-2-naphthol afforded the corresponding 3-(2-hydroxy-naphthalen-1-yl-diazenyl)-2-methyl-3H -[1,2,4]triazolo[5,1- b]quinazolin-9-one (5), which on subsequent reduction by SnCl2 and HCl gave the hydrazino derivative 6. Reaction of 2 with phenyl isothiocyanate in refluxing ethanol yielded thiourea derivative 7. Ring closure of 7 subsequently cyclized on refluxing with phencyl bromide, oxalyl dichloride and chloroacetic acid afforded the corresponding thiazolidine derivatives 8, 9 and 10, respectively. Reaction of 2-mercapto-3-phenylamino-3H -quinazolin-4-one (11) with hydrazine hydrate afforded 2-hydrazino-3-phenylamino-3H -quinazolin-4-one (12). The reactivity 12 towards carbon disulphide, acetyl acetone and ethyl acetoacetate gave 13, 14 and 15, respectively. Condensation of 12 with isatin afforded 2-[N -(2-oxo-1,2-dihydroindol-3-ylidene)hydrazino]-3-phenylamino-3H -quinazolin-4-one (16). 2-(4-Oxo-3-phenylamino-3,4-dihydroquinazolin-2-ylamino)isoindole-1,3-dione (17) was synthesized by the reaction of 12 with phthalic anhydride. All isolated products were confirmed by their ir, 1H nmr, 13C nmr and mass spectra. [source] A study to assess the cross-reactivity of cellulose membrane-bound peptides with detection systems: an analysis at the amino acid levelJOURNAL OF PEPTIDE SCIENCE, Issue 6 2010Carsten C. Mahrenholz Abstract The growing demand for binding assays to study protein,protein interaction can be addressed by peptide array-based methods. The SPOT technique is a widespread peptide-array technology, which is able to distinguish semi-quantitatively the binding affinities of peptides to defined protein targets within one array. The quality of an assay system used for probing peptide arrays depends on the well-balanced combination of screening and read-out methods. The former address the steady-state of analyte capture, whereas the latter provide the means to detect captured analyte. In all cases, however, false-positive results can occur when challenging a peptide array with analyte or detecting captured analyte with label conjugates. Little is known about the cross-reactivity of peptides with the detection agents. Here, we describe at the amino acid level the potential of (i) 5-(and 6)-carboxytetramethylrhodamine (5(6)-TAMRA), (ii) fluoresceinisothiocyanate in form of the peptide-bound fluorescein-substituted thiourea derivative (FITC), and (iii) biotin/streptavidin-POD to cross-react with individual amino acids in a peptide sequence. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd. [source] Synthesis and Anticonvulsant Activity of New N -(Alkyl/Sub-stituted aryl)- N,-[4-(5-cyclohexylamino)-1,3,4-thiadiazole-2-yl)phenyl]thioureasARCHIV DER PHARMAZIE, Issue 1 2009Sevgi Karakus Abstract A series of novel thiourea derivatives carrying the 5-cylohexylamino-1,3,4-thiadiazole moiety was synthesized and their anticonvulsant activity was evaluated. Structures of the synthesized compounds have been confirmed by IR, 1H-NMR, and elemental analysis. All of the compounds were administered at a dose of 50 mg/kg. Some of the active compounds have different effects in pentylenetetrazole (PTZ) and maximal electroshock (MES) tests, indicating the therapeutical potential in petit mal seizures, but not in grand mal seizures. Compounds 10, 11, 13, and 14 carrying 2-methylphenyl, 4-chlorophenyl, allyl, and 4-methylphenyl on the thiourea pharmacophore, increased the survival rate in the PTZ model. The ED50 values of the active compounds 10, 11, 13, and 14 were found 68.42, 43.75, 18.75 and 25 mg/kg, respectively. [source] ChemInform Abstract: Highly Asymmetric Michael Additions of ,,,-Disubstituted Aldehydes to ,-Nitroalkenes Promoted by Chiral Pyrrolidine,Thiourea Bifunctional Catalysts.CHEMINFORM, Issue 37 2010Jian-Fei Bai Abstract Four bifunctional amine,thiourea derivatives bearing 2 catalytic sites are tested and ATC is found to be most efficient one for the asymmetric Michael addition of secondary alkyl aldehydes to (het)aryl nitroalkenes. [source] Synthesis and Antiviral Activities of Chiral Thiourea DerivativesCHINESE JOURNAL OF CHEMISTRY, Issue 3 2009Zhikun YAN Abstract An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF6. The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, 1H NMR and 13C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC50=50.8 µg/mL) than Ningnanmycin (EC50=60.2 µg/mL). [source] | ||||||||||