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Term Safety (term + safety)

Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

Ethical aspects of technical safety

HUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 3 2003
Carl Friedrich Gethmann
Uncertainty and inequality are the most important phenomena that lead to the situation in which the modern technical age, in contrast to the premodern technical phase, gives rise to specifically moral problems which in the premodern era played only a marginal role or no role at all. So modern, technically constituted societies must learn to develop from the initial perception of dangers to a rational risk assessment. To justify this ethical obligation, the first section discusses the relation between danger and risk. The problem of weighing risks is analyzed in the second section; in this context the concept of pragmatic consistency is introduced. In the third section, the term safety is explicated as a comparative concept by means of the principle of pragmatic consistency. © 2003 Wiley Periodicals, Inc. Hum Factors Man 13: 243,252, 2003. [source]

Long term safety and efficacy of donepezil in the treatment of dementia in Alzheimer's disease in adults with Down syndrome: open label study

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 6 2003
V. P. Prasher
No abstract is available for this article. [source]

CASE REPORT: Efficacy of Hoodia for weight loss: is there evidence to support the efficacy claims?

JOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 5 2010
A. M. Whelan PharmD
Summary Increasing rates of adult obesity and its negative health consequences are likely to become an increasing burden to the Canadian health care system. Consumers are looking for treatment options and often try the natural health products that are heavily promoted as safe, fast and effective. In this case report, MH, a 57-year-old overweight female wanted advice regarding whether she should use the natural product Hoodia to help her attain her weight loss goals. A literature search was conducted using Medline, EMBASE, the Cochrane Library, Natural Medicines Comprehensive Database and IPA from inception to March 2009. The internet, files of the authors and bibliographies of articles were searched for additional references. No published, peer-reviewed randomized controlled trials examining efficacy of Hoodia were found. Unpublished data from two small trials reported promising results with no adverse events. However, this leaves many unanswered questions regarding the use of Hoodia for weight loss such as the appropriate dose and duration, short and long term safety and use in patients with concomitant diseases. Literature suggests that some commercial products may not actually contain Hoodia at all. Additionally, Hoodia is not yet listed in the Canadian Licensed Natural Health Products Database meaning products sold in Canada may not meet Canadian regulatory standards. Upon discussing this information, MH decided not to use Hoodia, and other evidence-based recommendations were discussed. [source]

Effect of Long-Term Testosterone Administration on the Endometrium of Female-to-Male (FtM) Transsexuals

THE JOURNAL OF SEXUAL MEDICINE, Issue 11 2009
Anna Myriam Perrone MD
ABSTRACT Introduction., Long term safety of testosterone (T) administration in women is still unknown. In particular few and discordant data exists on the effects of T on the endometrium. Aim., The aim of this study was to investigate the effects of long-term T treatment on endometrium histology and proliferation in female to male transsexual subjects (FtM). We compared these endometria with those of young women in the proliferative phase (PM) of the cycle and with those of post menopausal women (M). Method., Endometrial samples from 27 FtM treated with T (intramuscular injection of 100 mg Testoviron Depot /10 days for at least one year), 30 M undergoing vaginal hysterectomy, and 13 PM undergoing hysteroscopy for infertility problems were collected. Endometrial proliferation was evaluated on the basis of histopathology and expression of the proliferation marker Ki-67. Both M and PM women had not received any hormonal treatment for at least one year. Main Outcome Measure., Circulating total testosterone (TT), estradiol (E), progesterone (P), insulin and glucose levels were measured in FtM and PM subjects. Results., FtM had received T for 33.6 ± 21.3 months (mean ± SD). In FtM subjects, histological analysis found inactive endometrium similar to the atrophic menopausal endometrium. The expression of Ki-67 in the glands, stroma and glands and stroma together was significantly (p < 0.0005) lower in FtM than in PM women and was similar in the FtM and M groups. Small polyps were detected in 5 of the 27 FtM subjects. Conclusions., In conclusion our data suggest that exogenous T administration does not stimulate endometrial proliferation in FtM transsexuals and indeed may have atrophic effects. Perrone AM, Cerpolini S, Salfi NCM, Ceccarelli C, Badiali De Giorgi L, Formelli G, Casadio P, Ghi T, Pelusi G, Pelusi C, and Meriggiola MC. Effect of long-term testosterone administration on the endometrium of female-to-male (FtM) transsexuals. J Sex Med 2009;6:3193,3200. [source]