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Term Consequences (term + consequence)
Selected AbstractsOngoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities,THE JOURNAL OF PATHOLOGY, Issue 5 2008PJ Coates Abstract The major adverse consequences of radiation exposure, including the initiation of leukaemia and other malignancies, are generally attributed to effects in the cell nucleus at the time of irradiation. However, genomic damage as a longer term consequence of radiation exposure has more recently been demonstrated due to untargeted radiation effects including delayed chromosomal instability and bystander effects. These processes, mainly studied in vitro, are characterized by un-irradiated cells demonstrating effects as though they themselves had been irradiated and have been associated with altered oxidative processes. To investigate the potential for these untargeted effects of radiation to produce delayed damaging events in vivo, we studied a well-characterized model of radiation-induced acute myeloid leukaemia in CBA/Ca mice. Haemopoietic tissues of irradiated CBA/Ca mice exhibit enhanced levels of p53 stabilization, increased levels of p21waf1, and increased amounts of apoptosis, as expected, in the first few hours post-irradiation, but also at much later times: weeks and months after the initial exposure. Because these responses are seen in cells that were not themselves directly irradiated but are the descendants of irradiated cells, the data are consistent with an initial radiation exposure leading to persistently increased levels of ongoing DNA damage, analogous to radiation-induced chromosomal instability. To investigate the potential source of ongoing oxidative processes, we show increased levels of 3-nitrotyrosine, a marker of damaging nitrogen/oxygen species in macrophages. Not all animals show increased oxidative activity or p53 responses as long-term consequences of irradiation, but increased levels of p53, p21, and apoptosis are directly correlated with increased 3-nitrotyrosine in individual mice post-irradiation. The data implicate persistent activation of inflammatory-type responses in irradiated tissues as a contributory bystander mechanism for causing delayed DNA damage. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [source] Short and long term consequences of increases in exotic species richness on water filtration by marine invertebratesECOLOGY LETTERS, Issue 8 2009Jarrett Byrnes Abstract Although recent research has considered the consequences of global declines in the number of species, less attention has focused on the aggregate effects of regional increases in species richness as a result of human-mediated introductions. Here we examine several potential ecosystem consequences of increasing exotic species diversity of suspension feeding marine invertebrates. First, we experimentally manipulated native and non-native suspension feeder richness and measured its effect on short-term phytoplankton clearance rates. Multispecies communities all performed similarly, regardless of whether they were dominated by natives, exotics, or an even mix of the two. Individual species varied considerably in filtration rates, but non-native species often filtered less than the most similar native. Second, we determined potential changes in integrated function over time by comparing seasonal patterns of recruitment as a proxy for the ability to quickly recover filtration capacity after a disturbance. We found that exotic species have complementary seasonal phenologies both to native species and each other. Our results suggest that the consequences of local increases in species richness due to invasions may be manifest over long (annual to interannual) time scales, even when short term changes in ecosystem function are negligible. [source] Long term consequences of the 1944,1945 Dutch famine on the insulin-like growth factor axisINTERNATIONAL JOURNAL OF CANCER, Issue 4 2004Sjoerd G. Elias Abstract The insulin-like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin-like growth factor (IGF)-I, or IGF-I relative to IGF binding protein (IGFBP)-3 have been related to various human cancer types. In a group of 87 postmenopausal women, we found that childhood exposure to the 1944,1945 Dutch famine was associated with increased plasma levels of IGF-I and IGFBP-3, whereas IGFBP-1 and -2 levels were weakly decreased. These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine. © 2003 Wiley-Liss, Inc. [source] An exploratory study of the influences that compromise the sun protection of young adultsINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 6 2008Ngaia Calder Abstract This paper reports on an exploratory research project designed to gain a deeper understanding of the influences on ultraviolet radiation (UVR) behaviours among high-risk young adults to determine what compromises the adoption of protection measures for this group. A dual approach using focus groups and the Zaltman Metaphor Elicitation Technique was used to provide personal narratives related to UVR behaviour for tertiary education students. Results from both ,conversations' were content-analysed using an iterative ,bootstrapping' technique to identify key themes and issues. This exploratory research identified a number of key themes including effect on mood, influence of culture, the value of tans, unrealistic optimism, risk-orientation, and the role of experience. This group felt that they not been targeted effectively by public health campaigns and did not fully understand the dangers of high-risk UVR behaviours. Although a number of previous studies have investigated the relationship between knowledge and behaviour, and largely concluded that increases in knowledge do not lead to increases in adoption of protection practices, the preliminary findings of this study reveal that the knowledge and perceived self efficacy of protective practices is extremely high, what is lacking is the perceived threat and thus the motivations to adopt such behaviours. The conclusions drawn from this research indicate that there are a variety of important influencing factors that compromise UVR behaviours, in particular, the lack of perceived seriousness and severity towards long term consequences such as skin cancer. The recommendation to address the imbalance of ,perceived threat' and ,outcome expectations' is to focus on increasing knowledge of skin cancer, particularly susceptibility to skin cancer and the severity of the condition. [source] Attacking Poverty,a strategic dilemma for the World BankJOURNAL OF INTERNATIONAL DEVELOPMENT, Issue 3 2001Michael Hubbard Attacking Poverty has attracted more than the usual interest in World Development Reports mainly because it reflects the dilemma in future strategy for the World Bank. Its basis in a widely welcomed consultation with the poor, its transparent process and new conceptual framework contrast with limited development of the new themes , equality, security, empowerment of the poor , and of issues to do with aid: resources and rights. Contributors to this special issue discuss the dilemma reflected in Attacking Poverty from a number of angles: critical self-awareness by World Bank, promoting equality, shifting from the Washington Consensus, limits to the Bank's role, and enabling collective action by the poor. Other contributions discuss how the analysis in Attacking Poverty should be strengthened: inclusion of urban poverty and urbanisation's role in political development, promoting informal means of reducing vulnerability, and investigation of the long term consequences of the HIV/AIDS pandemic. Priorities for the next poverty-focused World Development Report (2010?) should include a more disaggregated and complete view of who is poor, why and where, and analysis of progress in political development. The World Bank may be best able to contribute to political development by extending to the subnational and public services level its main achievement of recent decades: the gathering, analysis and dissemination of comparative development data, to help move the focus of politics towards improving services and living standards. Copyright © 2001 John Wiley & Sons, Ltd. [source] Relative importance of stakeholders: analysing speech acts in a layoffJOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 7 2002Wendy L. Guild Grounded in a participant observation study of a ski resort, this paper explores the (re)production of legitimate discourses through speech acts pertaining to an organizational event, a layoff. Manager's justifications and employees' reactions and critiques put sanctioned discourses into play. And while the stated organizational values include shareholder, customer, and employee concerns, the relative importance of these stakeholders is only made clear through the conversation of the speech acts and their reception. The shape of the conversation, in locution, illocution and perlocution, shifts the relations between managers and the employees and creates longer term consequences for the organization. This focus on language use serves as a micro-foundation for the study of legitimation processes and its consequences within organizations. Copyright © 2002 John Wiley & Sons, Ltd. [source] | |||||||||||||