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Technical
Terms modified by Technical Selected AbstractsIMPOVERISHING TECHNICAL AND PREFERENTIAL IMPROVEMENTSPACIFIC ECONOMIC REVIEW, Issue 2 2007Geoffrey Fishburn More recently it has been shown that improvements confined to the country's import competing industry can never be impoverishing if, in that country, no commodity is inferior in consumption. However, in all available proofs of these propositions, it has been assumed that for each country there exists an autarkic equilibrium. It will be shown that, without that assumption, the second proposition must be severely qualified. [source] DUNG BY PREFERENCE: THE CHOICE OF FUEL AS AN EXAMPLE OF HOW ANDEAN POTTERY PRODUCTION IS EMBEDDED WITHIN WIDER TECHNICAL, SOCIAL, AND ECONOMIC PRACTICES,ARCHAEOMETRY, Issue 1 2000B. SILLAR A discussion of how Andean potters acquire and use their fuels is used to demonstrate the ,embedded'nature of ceramic technology. The most common choice of fuel in the highlands of Peru and Bolivia is animal dung (mainly cow, sheep, and llama). This technological choice is related to wider social and economic practices (particularly in relation to animal husbandry) which has further repercussions that affect other technologies (such as agriculture practices). Such a succession of interrelated activities is not unique to pottery; it is fundamental to all technologies and should be considered within archaeological analysis. [source] Management Strategies and Improvement of Performance of Sewer NetworksCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 7 2007Denys Breysse Even when they are conscious about the needs of maintenance to keep the system in a good condition, they lack efficient methods and tools that may help them in taking appropriate decisions. One can say that no really satisfactory and efficient tool exists, enabling the optimization of Inspection, Maintenance, or Rehabilitation (IMR) strategies on such systems. Sewer managers and researchers have been involved for many years in the French National Research Project for Renewal of Non Man Entry Sewer System (RERAU,Réhabilitation des Réseaux d'Assainissement Urbains, in French) to improve their knowledge of these systems and the management policies. During the RERAU project, a specific action has been dedicated to the modeling of asset ageing and maintenance. A special attention has been dedicated to the description of defects and dysfunctions, to the evaluation of performances and its modeling, accounting for its various dimensions (from the point of view of the manager, of the user, of the environment,). After having defined an Index of Technical Performance (ITp), we will introduce the Index of Technical and Economic Performance (ITEp) that is a combined measure of performance (including social costs) and technical costs. This index provides an objective standard tool for managers to compare different alternatives. It is used in the article to compare some simple IMR strategies. It sets the basis of a new method for no-man entry sewer system management, enabling us to analyze the profitableness of investment in terms of both technical and economic performance. [source] Providing operators and technicians for the ecological restoration industryECOLOGICAL MANAGEMENT & RESTORATION, Issue 1 2007Robin Buchanan In 1986, it took little effort from bush regenerators to persuade the New South Wales Department of Technical and Further Education (TAFE) to set up a new course specifically for the bush regeneration industry, but the unique nature of training for ecological restoration and management was threatened in late 2006. [source] How necessary are universities?ECONOMIC AFFAIRS, Issue 3 2001Sir Alan Peacock The paper discusses whether universities can continue to be the ,template for the extension and transmission of knowledge.' Technical and social changes are already undermining the universities' previous near-monopoly of delivery of higher education. Alternative delivery methods ought to be considered on their own merits and barriers to entry should be removed. The ideal form of higher education is not necessarily residence combined with traditional teaching and associated research. [source] Technical and economical analysis of 3-LIMB and 4-LIMB three phase transformers in YN/YN networkEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 6 2002M. Elleuch This paper deals with the behaviour of the three phase three limb transformer (with or without tertiary winding) as well as the four limb transformer under unbalanced steady states in a YN/yn network. Technical and economical comparative analysis has been established among the different configurations of the transformers. The opportunity of the replacement of the four limb transformer, currently used in the Tunisian distribution network, by a three limb transformer equipped by a tertiary winding has been discussed. During the analysis, the example of a 20 KVA transformer with a tertiary winding and a fourth limb (which could be removed) has been tested. A satisfactory concurrent is obtained between theoretical and experimental results. [source] Exploring the mismatch between skills and jobs for women in Saudi Arabia in technical and vocational areas: the views of Saudi Arabian private sector business managersINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 2 2002John R. Calvert Saudi Arabia's rapid development has highlighted the shortage of national technical manpower and the subsequent need to recruit non-Saudi technical workers, on the one hand, and the difficulty of replacing these workers with qualified Saudis, on the other. Therefore successive Development Plans have tried to raise the quality and quantity of technical and vocational education for both men and women. In 1995/96 only 5 per cent of Technical and Vocational Education (TEVT) enrolled students were female. This compares with an average of 29 per cent in other Islamic countries and 45 per cent in Japan (UNESCO, 1997, 1999). Part of this may be due to the preferences of female students in education, part due to the structure of TEVT in Saudi Arabia, part due to the availability of technical and vocational jobs available for women after completing their training and part due to the natural place of women in Saudi society. The Seventh Development Plan (2000,2004) assumes that the private sector will play a very significant role in employing a Saudi labour force including both men and women. As part of a comprehensive study concerning the factors affecting women's employment in the Saudi private sector private sector business managers in four large cities were surveyed to see what factors they felt were important. The main factors affecting employment of women in technical and vocational education were seen by the managers as those relating to the structure of TEVT education in Saudi Arabia rather than preferences of women or pressures from society. [source] Technical and non-technical skills can be reliably assessed during paramedic simulation trainingACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 1 2009T. VON WYL Background: Medical teams depend on technical skills (TS) as well as non-technical skills (NTS) for successful management of critical events. Simulated scenarios are an opportunity for presentation of similar crisis situations. The aim of this study was to test whether TS and NTS are assessable with satisfactory interrater reliability (IRR) during a regular paramedic training. Methods: Thirty paramedics were rated by two independent observers using video-recording and previously validated checklists while managing two simulated emergency scenarios as a team of two. The observed items of the team's TS included type, order, and time of adequate medical care. The NTS were restricted to six team-oriented dimensions. The IRR was quantified by calculating the intraclass correlation coefficient (ICC). The z -transformed values of the TS and NTS were correlated by Pearson's correlation. Internal consistency was controlled using Cronbach's ,. Results: The average measures ICC for the IRR was between 0.97 [95% confidence interval (CI) 0.91,0.99] and 0.98 (95% CI 0.94,0.99) for the TS sum-score, and was 0.94 (95% CI 0.87,0.97) for the NTS sum-score; the Cronbach's , of this NTS sum-score was 0.86. There is a positive correlation between the normalised TS and NTS sum-scores (r=0.53; P<0.05). Conclusion: Assessment of TS and NTS is feasible and reliable during paramedic training in emergency scenarios. TS can be reliably assessed by one trained observer; for NTS, two trained raters provide a suitable condition for excellent observations. There is a significant positive correlation between TS and NTS. [source] The Role of Formal Education, Technical and Management Training on Information Systems (IS) Managers' Managerial Effectiveness as Perceived by Their SubordinatesPERFORMANCE IMPROVEMENT QUARTERLY, Issue 1 2007Jerry Ligon This study examined the relationship between Information Systems (IS) managers' formal education, level of technical and managerial training and their managerial effectiveness as perceived by their subordinates. The study finds that there is a strong positive relationship between the amount of technical training IS managers have received and their managerial effectiveness as perceived by their subordinates. There is also a significant relationship between IS managers' level of managerial training and their subordinates' perception of their managerial effectiveness. The managers' level of formal education was not found to have a significant relationship to the subordinates' perceived level of (their) managerial effectiveness. Finally, a regression model has been proposed to measure Information System managers'managerial effectiveness. [source] Prenatal diagnosis of citrullinemia and argininosuccinic aciduria: evidence for a transmission ratio distortion in citrullinemiaPRENATAL DIAGNOSIS, Issue 3 2006Wim J. Kleijer Abstract Background In the course of 25 years, we have experienced a high rate of affected fetuses in the prenatal diagnosis of citrullinemia. Methods and Results Ninety-one pregnancies at 1 in 4 risk were tested; 36 were diagnosed as affected (39.5%; P = 0.0015). The high rate of positive diagnoses was found both after chorionic villus sampling (24/68 = 35.3%) and amniocentesis (12/23 = 52.2%) despite the completely different and independent techniques used. Using exactly the same (indirect) enzyme assay for argininosuccinic aciduria on chorionic villi and a similar method on amniotic fluid, the expected rate of affected fetuses was found: 13/53 = 24.5%. Technical and genetic causes for the unexpected results were excluded by confirmatory studies performed on independent fetal material, which was available for 27 of the 36 fetuses affected with citrullinemia. Biochemical confirmation was obtained in the 27 cases, whereas in 18 fetuses homozygosity or compound heterozygosity for disease-causing mutations were retrospectively demonstrated in the stored fetal cells. Conclusion The results suggest the occurrence of preferential transmission of the mutant allele. An explanation for this phenomenon may be found in a protective role of argininosuccinic acid synthetase deficiency in mutant sperm cells against the possibly detrimental or apoptotic effect of nitric oxide produced normally from arginine by nitric oxide synthase. Copyright © 2006 John Wiley & Sons, Ltd. [source] Remediation process optimization: A status reportREMEDIATION, Issue 3 2007Sriram Madabhushi There are hundreds of contaminated sites with remediation systems that require evaluation and modification to accomplish cleanup goals. These systems are operating well past projected cleanup schedules, cost more than projected to operate, and may not be as protective of human health and the environment as planned. Remediation process optimization (RPO) is an effective method to assess the progress of a system toward achieving cleanup goals within desired time frames and to make the necessary changes in order to reach those goals. Eight main components to the RPO process are evaluated during a review and an implementation plan of recommended changes to the system is developed. Follow-up and tracking are essential to successful RPO programs. In this article, the authors present a summary of a recent Technical and Regulatory (TechReg) Guidance Document (Interstate Technology and Regulatory Council [ITRC], 2004) and related Technology Overview Series on Advanced Topics in RPO (ITRC, 2006) in a distilled form. © 2007 Wiley Periodicals, Inc. [source] Perception Versus Reality?: Virtual Crossmatch,How to Overcome Some of the Technical and Logistic LimitationsAMERICAN JOURNAL OF TRANSPLANTATION, Issue 8 2009A. R. Tambur The goal of this work was to evaluate concordance between (a) actual flow cytometric crossmatch (FCXM) that is performed by the OPO laboratory servicing our transplant center and (b) virtual XM (vXM) prediction based on antibody identification by solid-phase methods performed in our laboratory. A total of 1586 FCXM, performed between June 2007 and September 2008, between all potential deceased donors in our region and sera from patients awaiting kidney or kidney,pancreas transplant, listed at Northwestern Memorial Hospital were evaluated. A key finding of this analysis was the understanding that a thorough vXM cannot be performed in some donor/recipient pairs due to the lack of certain antibody profile data specific to the donor in question. Obtaining more in depth and stringent information regarding antibody specificities, we demonstrate an excellent sensitivity and specificity of the vXM assays, 86.1% and 96.8%, respectively, with a positive likelihood ratio and negative likelihood ratios of 26.9 and 0.14, respectively. The vXM can serve as an outstanding tool to predict HLA compatibility between donor and recipient, with the caveat that the presence/absence of all antibodies against the potential donor and their strength have been thoroughly investigated. [source] The relationship between guardian certification requirements and guardian sanctioning: a research issue in elder law and policyBEHAVIORAL SCIENCES & THE LAW, Issue 5 2007LL.M., Winsor C. Schmidt J.D. This study investigated the relationship between guardian certification requirements and guardian sanctioning in the state of Washington. A total of 377 files were examined. Findings show that 52.4% of guardians with an undergraduate degree or higher education are likely to be sanctioned compared with 42.2% with an Associate of Arts (AA) or Technical (Tech) degree, and 36.9% with a high school diploma (HS) or equivalency (GED). Guardians with an undergraduate or higher education are 1.88 times more likely to be sanctioned compared with GED or HS graduates (p,<,0.05). However, 83.3% of GED or HS graduates are likely to have more severe sanctions compared with 76.4% undergraduate or higher education, and 47.7% with an AA or Tech degree, respectively. Guardians with an AA or Tech degree are 0.28 times less likely to have more severe sanctions than guardians with an undergraduate degree or higher education (p,<,0.01). The results are discussed with respect to guardian registration, licensing, certification and quality; licensing and regulation of other professions; the limitations of the study; and the need for further research. Copyright © 2007 John Wiley & Sons, Ltd. [source] Procedural results and acute complications in stenting native and recurrent coarctation of the aorta in patients over 4 years of age: A multi-institutional studyCATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 2 2007Thomas J. Forbes MD Abstract Background: We report a multi-institutional experience with intravascular stenting (IS) for treatment of coarctation of the aorta. Methods and Results: Data was collected retrospectively by review of medical records from 17 institutions. The data was broken down to prior to 2002 and after 2002 for further analysis. A total of 565 procedures were performed with a median age of 15 years (mean = 18.1 years). Successful reduction in the post stent gradient (<20 mm Hg) or increase in post stent coarctation to descending aorta (DAo) ratio of >0.8 was achieved in 97.9% of procedures. There was significant improvement (P < 0.01) in pre versus post stent coarctation dimensions (7.4 mm ± 3.0 mm vs. 14.3 ± 3.2mm), systolic gradient (31.6 mm Hg ± 16.0 mm Hg vs. 2.7 mm Hg ± 4.2 mm Hg) and ratio of the coarctation segment to the DAo (0.43 ± 0.17 vs. 0.85 ± 0.15). Acute complications were encountered in 81/565 (14.3%) procedures. There were two procedure related deaths. Aortic wall complications included: aneurysm formation (n = 6), intimal tears (n = 8), and dissections (n = 9). The risk of aortic dissection increased significantly in patients over the age of 40 years. Technical complications included stent migration (n = 28), and balloon rupture (n = 13). Peripheral vascular complications included cerebral vascular accidents (CVA) (n = 4), peripheral emboli (n = 1), and significant access arterial injury (n = 13). Older age was significantly associated with occurrence of CVAs. A significant decrease in the technical complication rate from 16.3% to 6.1% (P < 0.001) was observed in procedures performed after January 2002. Conclusions: Stent placement for coarctation of aorta is an effective treatment option, though it remains a technically challenging procedure. Technical and aortic complications have decreased over the past 3 years due to, in part, improvement in balloon and stent design. Improvement in our ability to assess aortic wall compliance is essential prior to placement of ISs in older patients with coarctation of the aorta. © 2007 Wiley-Liss, Inc. [source] Transradial intervention for native fistula failureCATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 4 2006Osami Kawarada MD Abstract The native radiocephalic (Brescia-Cimino) fistula is usually constructed with an anastomosis of the cephalic vein and radial artery. Catheter interventions for native fistula failure have until now been performed via the transcephalic or transbrachial approach. Transradial intervention for native fistula failure was prospectively evaluated for a selected consecutive 11 patients. Six patients had a single lesion and 5 patients had double lesions. Twelve lesions were stenotic and 4 were occlusive with thrombus. Balloon angioplasty alone was successful in 10 lesions. In thrombosed fistulas, 2 lesions underwent manual catheter-directed thrombo-aspiration and 2 further lesions underwent a combination of catheter-directed thrombo-aspiration and mechanical thrombectomy. Cutting Balloon angioplasty was performed for 3 resistant venous stenoses and for 1 radial artery stenosis. Technical and clinical success were achieved in all patients. No vessel rupture or perforation was observed in this study, nor was distal embolization in the radial artery or symptomatic pulmonary embolism. No radial artery occlusion or fistula infection was seen during the follow-up. The primary patency rates were 82% at 3 months and 64% at 6 months. Transradial intervention for native fistula failure is considered safe and feasible in a selected population; yet requires further validation. © 2006 Wiley-Liss., Inc. [source] The use of models for synthesizing knowledge for integrated lake basin management, and facilitating implementation of the World Lake VisionLAKES & RESERVOIRS: RESEARCH AND MANAGEMENT, Issue 1 2007Sven E. Jorgensen Abstract Integrated water resources management (IWRM) is becoming increasingly accepted as the most logical and effective means of managing aquatic ecosystems for their sustainable use. Despite efforts to provide practical examples of the application of IWRM, we still lack knowledge on how to best consider and integrate the potentially large quantity of data and information, both scientific and socioeconomic, which must be considered in pursuit of the goal of sustainable water resources. The unique features of (i) an integrating nature; (ii) long water retention time, and (iii) complex response dynamics make the management of lakes and reservoirs particularly difficult to achieve. Although the World Lake Vision has provided substantial management guidance to address some of the complex issues facing lake and reservoir management, additional work directed to analysing the interactions and linkages between the scientific/technical and the socioeconomic components of the sustainability ,equation' is needed. This report examines the use of mathematical models as a synthesizing tool in developing and applying management strategies for lakes and reservoirs. The different types of available models, and the criteria that can be used to select the ,best' model for a given situation, also are discussed, as is the important role of environmental indicators in the process. A case study focusing on the restoration of Lake Fure in Denmark provides an illustrative example of the application of the approach discussed in this report. [source] Management Strategies and Improvement of Performance of Sewer NetworksCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 7 2007Denys Breysse Even when they are conscious about the needs of maintenance to keep the system in a good condition, they lack efficient methods and tools that may help them in taking appropriate decisions. One can say that no really satisfactory and efficient tool exists, enabling the optimization of Inspection, Maintenance, or Rehabilitation (IMR) strategies on such systems. Sewer managers and researchers have been involved for many years in the French National Research Project for Renewal of Non Man Entry Sewer System (RERAU,Réhabilitation des Réseaux d'Assainissement Urbains, in French) to improve their knowledge of these systems and the management policies. During the RERAU project, a specific action has been dedicated to the modeling of asset ageing and maintenance. A special attention has been dedicated to the description of defects and dysfunctions, to the evaluation of performances and its modeling, accounting for its various dimensions (from the point of view of the manager, of the user, of the environment,). After having defined an Index of Technical Performance (ITp), we will introduce the Index of Technical and Economic Performance (ITEp) that is a combined measure of performance (including social costs) and technical costs. This index provides an objective standard tool for managers to compare different alternatives. It is used in the article to compare some simple IMR strategies. It sets the basis of a new method for no-man entry sewer system management, enabling us to analyze the profitableness of investment in terms of both technical and economic performance. [source] Opening up the Solution Space: The Role of Analogical Thinking for Breakthrough Product InnovationCREATIVITY AND INNOVATION MANAGEMENT, Issue 2 2008Oliver Gassmann The purpose of this paper is to investigate the approach of analogical thinking for product innovation. We collected data on projects from four engineering firms where analogical thinking was successfully applied for the development of breakthrough innovations. Results show that abstracting the problem by in-depth technical and contextual analysis is pivotal when searching for analogical solutions. Furthermore, the chances of identifying highly novel analogous solutions are increased if the problem is abstracted to the level of its structural similarities to other settings. We also found that the identification of structural similarities is supported when firms not only rely on the cognitive abilities of the individual but also employ an active search based on abstract search terms. Based on these insights, we propose a process model for the development of product innovations by means of analogical thinking. [source] The Art and Science of Surge: Experience from Israel and the U.S. MilitaryACADEMIC EMERGENCY MEDICINE, Issue 11 2006Boaz Tadmor MD In a disaster or mass casualty incident, health care resources may be exceeded and systems may be challenged by unusual requirements. These resources may include pharmaceuticals, supplies, and equipment as well as certain types of academic and administrative expertise. New agencies and decision makers may need to work together in an unfamiliar environment. Furthermore, large numbers of casualties needing treatment, newer therapies required to care for these casualties, and increased workforce and space available for these casualties all contribute to what is often referred to as "surge." Surge capacity in emergency care can be described in technical, scientific terms that are measured by numbers and benchmarks (e.g., beds, patients, and medications) or can take on a more conceptual and abstract form (e.g., decisions, authority, and responsibility). The former may be referred to as the "science" of surge, whereas the latter, an equal if not more important component of surge systems that is more conceptual and abstract, can be considered the "art" of surge. The experiences from Israel and the U.S. military may serve to educate colleagues who may be required to respond or react to an event that taxes the current health care system. This report presents concrete examples of surge capacity strategies used by both Israel and the U.S. military and provides solutions that may be applied to other health care systems when faced with similar situations. [source] Geeks, Social Imaginaries, and Recursive PublicsCULTURAL ANTHROPOLOGY, Issue 2 2005Christopher Kelty This article investigates the social, technical, and legal affiliations among "geeks" (hackers, lawyers, activists, and IT entrepreneurs) on the Internet. The mode of association specific to this group is that of a "recursive public sphere" constituted by a shared imaginary of the technical and legal conditions of possibility for their own association. On the basis of fieldwork conducted in the United States, Europe, and India, I argue that geeks imagine their social existence and relations as much through technical practices (hacking, networking, and code writing) as through discursive argument (rights, identities, and relations). In addition, they consider a "right to tinker" a form of free speech that takes the form of creating, implementing, modifying, or using specific kinds of software (especially Free Software) rather than verbal discourse. [source] Guidelines for improving the reproducibility of quantitative multiparameter immunofluorescence measurements by laser scanning cytometry on fixed cell suspensions from human solid tumorsCYTOMETRY, Issue 1 2006Stanley Shackney Abstract Background: Laser scanning Cytometry (LSC) is a versatile technology that makes it possible to perform multiple measurements on individual cells and correlate them cell by cell with other cellular features. It would be highly desirable to be able to perform reproducible, quantitative, correlated cell-based immunofluorescence studies on individual cells from human solid tumors. However, such studies can be challenging because of the presence of large numbers of cell aggregates and other confounding factors. Techniques have been developed to deal with cell aggregates in data sets collected by LSC. Experience has also been gained in addressing other key technical and methodological issues that can affect the reproducibility of such cell-based immunofluorescence measurements. Methods and results: We describe practical aspects of cell sample collection, cell fixation and staining, protocols for performing multiparameter immunofluorescence measurements by LSC, use of controls and reference samples, and approaches to data analysis that we have found useful in improving the accuracy and reproducibility of LSC data obtained in human tumor samples. We provide examples of the potential advantages of LSC in examining quantitative aspects of cell-based analysis. Improvements in the quality of cell-based multiparameter immunofluorescence measurements make it possible to extract useful information from relatively small numbers of cells. This, in turn, permits the performance of multiple multicolor panels on each tumor sample. With links among the different panels that are provided by overlapping measurements, it is possible to develop increasingly more extensive profiles of intracellular expression of multiple proteins in clinical samples of human solid tumors. Examples of such linked panels of measurements are provided. Conclusions: Advances in methodology can improve cell-based multiparameter immunofluorescence measurements on cell suspensions from human solid tumors by LSC for use in prognostic and predictive clinical applications. © 2005 Wiley-Liss, Inc. [source] Applications of cone-beam computed tomography in fractures of the maxillofacial complexDENTAL TRAUMATOLOGY, Issue 4 2009Werner H. Shintaku Several studies support the use of conventional two-dimensional imaging for traumas involving mainly the mandible, but for more complex situations advanced imaging modalities such as computed tomography (CT) and magnetic resonance imaging have higher indication. Nowadays, besides CT, cone-beam computed tomography (CBCT) has appeared as a reasonable and reliable alternative considering radiation dosage, image quality and comfort for the patient. The purpose of this study was to review the fracture patterns involving the maxillofacial complex, provide a technical and practical comparison between CT and CBCT, and finally present the potential applications of CBCT illustrated with clinical examples. [source] Nonprofit organizations and pharmaceutical research and developmentDRUG DEVELOPMENT RESEARCH, Issue 7 2009Walter H. Moos Abstract Not-for-profit or nonprofit organizations (NPOs) are playing an increasingly important role in providing solutions to the significant challenges faced by both large pharmaceutical and smaller biotechnology companies in today's world. NPOs chartered for the public benefit are common in the United States and in selected other parts of the world. The largest NPOs in the U.S. with bioscience programs include Battelle, the Midwest Research Institute, the Research Triangle Institute, Southern Research, and SRI International. To provide a perspective on NPO business models, 10 SRI case studies spanning a broad range of technical and business initiatives are summarized herein, including basic and contract research, discovery of new drugs and biologics, pharmaceutical and biotech R&D services, technology pivots, company spin-ins and spin-outs, and the creation of new NPOs. The article concludes with lessons learned and food for thought for both pharmaceutical companies and outsourcing participants. Drug Dev Res 70: 461,471, 2009. © 2009 Wiley-Liss, Inc. [source] Accelerating botulism therapeutic product development in the Department of Defense,DRUG DEVELOPMENT RESEARCH, Issue 4 2009Andrea M. Stahl Abstract Coordinated small-molecule drug discovery research efforts for the treatment of botulism by the public sector, especially the U.S. Department of Defense (DoD) and Department of Health and Human Services (DHHS), began in the 1990s and represent a significant resource investment. Organization of an effective botulism therapeutic drug program, however, presents formidable technical and logistical challenges. Seven distinct BoNT serotypes are known, each representing a different target. Moreover, BoNT exerts its action inside peripheral cholinergic neurons, and some serotypes may persist functionally within nerve cells for weeks or months. Clinical botulism occurs infrequently, and the effectiveness of prolonged mechanical ventilation to treat poisoning further limits experimental drug testing. The efficacy of experimental compounds must be extrapolated from disparate cell- or tissue-based or rodent models. Numerous compounds with moderate efficacy in experimental laboratory assays have been reported, but may not possess the necessary safety, efficacy, and pharmacokinetic profile to support therapeutic development. To mitigate these challenges, we propose product development tools to assist in management of the BoNT portfolio and to clearly define the desired therapeutic product. Establishing a target product profile (TPP) is proposed to guide public sector managers toward critical aspects of the desired therapeutic product. Additional product development tools to assist in shaping research portfolios and to inform decisions regarding lead candidates to pursue are also discussed. Product development tools that facilitate the characterization of the ideal therapeutic product, and assist in the maintenance of a robust portfolio, will ameliorate the inherent financial risk in drug development for treating BoNT intoxication. Drug Dev Res 70:303,326, 2009. Published 2009 Wiley-Liss, Inc. [source] Discrepancies Between Score Trends from NAEP and State Tests: A Scale-Invariant PerspectiveEDUCATIONAL MEASUREMENT: ISSUES AND PRACTICE, Issue 4 2007Andrew D. Ho State test score trends are widely interpreted as indicators of educational improvement. To validate these interpretations, state test score trends are often compared to trends on other tests such as the National Assessment of Educational Progress (NAEP). These comparisons raise serious technical and substantive concerns. Technically, the most commonly used trend statistics,for example, the change in the percent of proficient students,are misleading in the context of cross-test comparisons. Substantively, it may not be reasonable to expect that NAEP and state test score trends should be similar. This paper motivates then applies a "scale-invariant" framework for cross-test trend comparisons to compare "high-stakes" state test score trends from 2003 to 2005 to NAEP trends over the same period. Results show that state trends are significantly more positive than NAEP trends. The paper concludes with cautions against the positioning of trend discrepancies in a framework where only one trend is considered "true." [source] Cover Picture: Electrophoresis 7'2010ELECTROPHORESIS, Issue 7 2010Article first published online: 26 MAR 2010 Issue no. 7 is a special issue on CE-MS consisting of "19 manuscripts subdivided into three major categories: one devoted to instrumental and methodical advances, two providing an insight into up-to-date applications from the fields of technical and natural products, food and environmental analysis on the one hand and biomedical and pharmaceutical analysis on the other hand. Diverse approaches how CE-MS can be employed for the solution of various analytical problems can be found in these papers. Different modes of electroseparation techniques in the capillary format such as CZE, CEC or MEEKC are coupled to various MS instruments ranging from simple quadrupole MS instruments to state of the art QTOF's, using a range of interfaces such as ESI, ICP or APPI. So this special issue will again try to present an overview of current trends and developments in the fields of CE-MS" [source] Cover Picture: Electrophoresis 7'09ELECTROPHORESIS, Issue 10 2009Article first published online: 13 MAY 200 Issue no. 10 is a special issue on CE-MS edited by Phillipe Schmitt-Kopplin. It has three review articles describing recent advances in fundamental concepts, instrumentation, food safety, food quality, trace analysis of environmental pollutants and food contaminants, as well as many other applications. In addition, the special issue consists of 22 research articles on various topics of CE-MS, including technical and method developments, residue analysis in food and environmental applications and applications in diagnostic and life sciences. [source] Materials used for root canal obturation: technical, biological and clinical testingENDODONTIC TOPICS, Issue 1 2005DAG ØRSTAVIK First page of article [source] Does sports participation during adolescence prevent later alcohol, tobacco and cannabis use?ADDICTION, Issue 1 2009Tove Wichstrøm ABSTRACT Aims To study whether participation in organized sports during adolescence predicts increased smoking of tobacco, alcohol intoxication and cannabis use from late adolescence to adulthood when controlling for potential confounders. Moreover, to study whether such increased drug use varies according to type of sport (team versus individual), main skills needed (endurance, strength or technical) and level of competition. Design, setting and participants Survey of national sample of Norwegian high school students (aged 13,19 years) in 1992 (T1) followed-up in 1994 (T2), 1999 (T3) and 2006 (T4) (n = 3251). Measurements Outcome measures included smoking of tobacco and 12-month prevalences of alcohol intoxication and cannabis use, respectively. Confounders included pubertal timing, friends' drug use, perceived social acceptance, grades and parental socio-economic status. Findings Latent growth curve analyses showed that initial level of participation in organized sports predicted growth in alcohol intoxication. Those involved initially in team sports had greater growth in alcohol intoxication, but lower growth in tobacco use and cannabis use, during the adolescent and early adult years compared to those involved in technical or strength sports. Practising endurance sports, as opposed to technical or strength sports, predicted reduced growth in alcohol intoxication and tobacco use. Conclusions Sports participation in adolescence, and participation in team sports in particular, may increase the growth in alcohol intoxication during late adolescent and early adult years, whereas participation in team sports and endurance sports may reduce later increase in tobacco and cannabis use. [source] Hydrophobic pervaporation for environmental applications: Process optimization and integrationENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 4 2002Frank Lipnizki The focus of this paper is on the design of pervaporation units for wastewater treatment taking into account technical, economic, and environmental aspects. Two different sized industrial wastewater streams of water-chloroform, and of water-methyl-isobutylketone (MIBK) are considered. Based on a wastewater stream of 1,500 kg/d, a semi-batch process combining pervaporation with a decanter recycle loop is developed. Using this process, it is possible to recover over 99% of the organic components at concentrations of more than 98 wt. %. The treatment costs are between 0.11 to 0.16 $/kg wastewater. For the treatment of a wastewater stream of 1,000 kg/h, pervaporation combined with a decanter and recycling loop, as well as integrated in a hybrid process with adsorption, is considered. For MIBK, pervaporation with a decanter is the most attractive option taking economic and environmental aspects into account, while, for chloroform, the hybrid process is the better option. Treatment costs in all cases are about 0.03 $/kg wastewater. The recovery rate of the organic compounds is over 99% at concentrations over 98 wt. %. The authors concluded that pervaporation as a stand-alone unit, or integrated into hybrid processes, offers significant advantages over conventional alternatives. [source] | |||||||||||||||||||||||||||||||||||||||||||