Home About us Contact
|
Home About us Contact | ||
|
|
||
Targeted Drug Delivery (targeted + drug_delivery)
Selected AbstractsInnentitelbild: Facile, Template-Free Synthesis of Stimuli-Responsive Polymer Nanocapsules for Targeted Drug Delivery (Angew. Chem.ANGEWANDTE CHEMIE, Issue 26 201026/2010) Sesam öffne Dich! Eine templatfreie Synthese auf Stimuli reagierender Polymernanokapseln, die für die gezielte Wirkstoff-Freisetzung nützlich sein könnten, stellen K. Kim et,al. in der Zuschrift auf S.,4507,ff. vor. Es wird gezeigt, dass reduktionslabile Polymernanokapseln aus CB[6] und Disulfidbrücken nicht nur eine einfache, nichtkovalente Oberflächenmodifikation für die zielspezifische Anlieferung, sondern auch die Freisetzung eingeschlossener Ladung in intrazellulärer Umgebung als Reaktion auf ein vorgegebenes Redoxstimulans ermöglichen. [source] Facile, Template-Free Synthesis of Stimuli-Responsive Polymer Nanocapsules for Targeted Drug Delivery,ANGEWANDTE CHEMIE, Issue 26 2010Eunju Kim Dr. Sesam öffne Dich! Die Synthese stimuliresponsiver Polymernanokapseln wird beschrieben. Die reduktionslabile Polymernanokapsel ermöglicht eine einfache, nichtkovalente Oberflächenmodifikation und die Freisetzung eingeschlossener Ladung in intrazellulärer Umgebung als Reaktion auf ein vorgegebenes Redoxstimulans. [source] Asymmetric bolaamphiphiles from vernonia oil designed for drug deliveryEUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, Issue 1 2010Sarina Grinberg Abstract Throughout the ages, fats, oils and their chemical derivatives have been used in a variety of medical applications, but currently they are becoming important as components in drug delivery systems. Liposomes (vesicles from phospholipids) are among the lipid-based delivery systems that have been most extensively studied. However, targeting of liposomes to specific tissues is still problematic, and attempts to overcome these limitations include developments in nano-sized monolayer vesicles made of bolaamphiphiles (compounds containing two hydrophilic headgroups at each end of an alkyl chain). This paper describes bolaamphiphile synthesis and characterization of the nano-sized vesicles formed from the bolaamphiphiles with potential application for targeted drug delivery to the brain. The starting material for the synthesis is vernonia oil (or its fatty acids or methyl esters), which is a naturally epoxidized triacylglycerol obtained from the seeds of Vernonia galamensis. The targeting mechanism is based on the hydrolysis of the amphiphile's headgroup by an enzyme abundant in the target tissue, with subsequent release of the encapsulated drug at the target site. Preliminary experiments in mice demonstrated that the marker FITC-dextran, which normally does not penetrate the blood brain barrier, is delivered into the brain when encapsulated in these vesicles. [source] Design of Multiresponsive Hydrogel Particles and AssembliesADVANCED FUNCTIONAL MATERIALS, Issue 11 2010Grant R. Hendrickson Abstract In the realm of soft nanotechnology, hydrogel micro- and nanoparticles represent a versatile class of responsive materials. Over the last decade, our group has investigated the synthesis and physicochemical properties of a variety of synthetic hydrogel particles. From these efforts, several particle types have emerged with potentially enabling features for biological applications, including nanogels for targeted drug delivery, microlenses for biosensing, and coatings for biomedical devices. For example, core/shell nanogels have been used to encapsulate and deliver small interfering RNA to ovarian cancer cells; nanogels used in this fashion may improve therapeutic outcomes for a variety of macromolecular therapeutics. Microgels arranged as multilayers on implantable biomaterials greatly minimize the host inflammatory response to the material. Furthermore, the triggered release of drugs (i.e., insulin) has been demonstrated from similar assemblies. The goal of this feature article is to highlight developments in the design of responsive microgels and nanogels in the context of our recent efforts and in relation to the community that has grown up around this fascinating class of materials. [source] Cell adhesion molecules for targeted drug deliveryJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 9 2006Alison L. Dunehoo Abstract Rapid advancement of the understanding of the structure and function of cell adhesion molecules (i.e., integrins, cadherins) has impacted the design and development of drugs (i.e., peptide, proteins) with the potential to treat cancer and heart and autoimmune diseases. For example, RGD peptides/peptidomimetics have been marketed as anti-thrombic agents and are being investigated for inhibiting tumor angiogenesis. Other cell adhesion peptides derived from ICAM-1 and LFA-1 sequences were found to block T-cell adhesion to vascular endothelial cells and epithelial cells; these peptides are being investigated for treating autoimmune diseases. Recent findings suggest that cell adhesion receptors such as integrins can internalize their peptide ligands into the intracellular space. Thus, many cell adhesion peptides (i.e., RGD peptide) were used to target drugs, particles, and diagnostic agents to a specific cell that has increased expression of cell adhesion receptors. This review is focused on the utilization of cell adhesion peptides and receptors in specific targeted drug delivery, diagnostics, and tissue engineering. In the future, more information on the mechanism of internalization and intracellular trafficking of cell adhesion molecules will be exploited for delivering drug molecules to a specific type of cell or for diagnosis of cancer and heart and autoimmune diseases. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1856,1872, 2006 [source] Cyclodextrin polyrotaxanes assembled from a molecular construction kit in aqueous solutionJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 23 2009Gerhard Wenz Abstract We describe a molecular construction kit in which amphiphilic polymers and functionalized cyclodextrins are arranged into sophisticated molecular architectures in aqueous solution without the need to perform chemical reactions. Therefore, these systems are highly biocompatible and show programmable lifetimes. The kinetic stabilities of our polyrotaxane structures are tunable using sterically demanding groups that hinder dissociation. These cyclodextrin-based polymer systems are applicable in principle for the detection of analytes at the level of single molecules. These systems may also serve well in targeted drug delivery and gene transfection. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6333,6341, 2009 [source] Perfluorocarbons: Life sciences and biomedical uses Dedicated to the memory of Professor Guy Ourisson, a true RENAISSANCE man.JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 7 2007Marie Pierre Krafft Abstract Perfluorocarbons are primarily characterized by outstanding chemical and biological inertness, and intense hydrophobic and lipophobic effects. The latter effects provide a powerful noncovalent, labile binding interaction that can promote selective self- assembly. Perfluoro compounds do not mimic nature, yet they can offer abiotic building blocks for the de novo design of functional biopolymers and alternative solutions to physiologically vital issues. They offer new tags useful for molecular recognition, selective sorting, and templated binding (e.g., selective peptide and nucleic acid pairing). They also stabilize membranes and provide micro- and nanocompartmented fluorous environments. Perfluorocarbons provide inert, apolar carrier fluids for lab-on-a-chip experiments and assays using microfluidic technologies. Low water solubility, combined with high vapor pressure, allows stabilization of injectable microbubbles that serve as contrast agents for diagnostic ultrasound imaging. High gas solubilities are the basis for an abiotic means for intravascular oxygen delivery. Other biomedical applications of fluorocarbons include lung surfactant replacement and ophthalmologic aids. Diverse colloids with fluorocarbon phases and/or shells are being investigated for molecular imaging using ultrasound or magnetic resonance, and for targeted drug delivery. Highly fluorinated polymers provide a range of inert materials (e.g., fluorosilicons, expanded polytetrafluoroethylene) for contact lenses, reconstructive surgery (e.g., vascular grafts), and other devices. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1185,1198, 2007. [source] Synthesis of Folic Acid Functionalized PLLA- b -PPEGMA Nanoparticles for Cancer Cell TargetingMACROMOLECULAR RAPID COMMUNICATIONS, Issue 8 2009Feixiong Hu Abstract Poly(L -lactic acid)- block -poly(poly(ethylene glycol) monomethacrylate) (PLLA- b -PPEGMA) has been prepared by the ring-opening polymerization of lactide with a double-headed initiator, 2-hydroxyethyl 2,-methyl-2,-bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA). PLLA- b -PPEGMA nanoparticles with encapsulated Fe3O4 are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA- b -PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment. [source] Nanotechnology advances in controlled drug delivery systemsPHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 12 2008C. Kiparissides Abstract Nanotechnology advances in drug delivery deal with the development of synthetic nanometer sized targeted delivery systems for therapeutic agents of increased complexity, and biologically active drug products. Therapeutic systems in this class are up to a million times larger than classical drugs like aspirin. Being larger there is more scope for diversity and complexity, which makes their protection much more challenging and their delivery more difficult. Their increased complexity however, gives these systems the unique power to tackle more challenging diseases. Targeted delivery systems can have multiple functions, a key one being their ability to recognize specific molecules which can be located either on the membrane of target cells, or in specific compartments within the cell. A challenging objective of targeted drug delivery is the development of innovative multidisciplinary approaches for the design, synthesis and functionalization of novel nanocarriers for targeted delivery of protein/peptide (P/P) drugs via oral, pulmonary and nasal administration routes as well as the fabrication of "smart" miniaturized drug delivery devices able to release a variety of drugs on demand. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Iron oxide-based magnetic nanostructures bearing cytotoxic organosilicon molecules for drug delivery and therapyAPPLIED ORGANOMETALLIC CHEMISTRY, Issue 3 2010Alla Zablotskaya Abstract The results of our own investigation on synthesis, physico-chemical and biological study of iron oxide based magnetic nanoparticles bearing cytotoxic organosilicon molecules of choline and colamine analogues, as potential agents for antitumor therapy, are summarized. These molecules contain hydrophilic head and long lipophilic tails, which are able to deepen inside the first surfactant shell (oleic acid), forming bilayer membrane like structures. Such compositions have a great privilege possessing magnetic properties, which in some cases could be essential moment in targeted drug delivery. The methodological approach has been developed and applied to the preparation of water soluble single or mixed coated biologically active nanoparticles of different types. Copyright © 2010 John Wiley & Sons, Ltd. [source] | |||||||||||||