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Systemic Malignancies (systemic + malignancy)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

The therapeutic benefits of heme oxygenase (HO-1) inhibition in the management of systemic malignancies besides hepatocellular carcinomas

INTERNATIONAL JOURNAL OF CANCER, Issue 3 2009
Shailendra Kapoor
No abstract is available for this article. [source]

Assessment of sperm quality, DNA integrity and cryopreservation protocols in men diagnosed with testicular and systemic malignancies

ANDROLOGIA, Issue 6 2009
T. M. Said
Summary Men diagnosed with malignancy are often referred for semen banking to preserve their fertility prior to cancer treatment. The chances of cancer patients for achieving future fecundity will be determined by the sperm quality including the integrity of the genomic material in the frozen samples. The objectives of this study were to compare the sperm quality and DNA integrity in men diagnosed with testicular and systemic malignancies before receiving treatment and to identify the optimum cryopreservation protocol for their samples including a remote semen collection option. In comparison with fertile donors, patients with testicular malignancies had significantly lower sperm concentration, while both testicular and systemic malignancy patients had significantly lower sperm motility and cryosurvival rates. In addition, the SCSA defined DNA fragmentation index was significantly higher in patients with testicular and systemic malignancies compared with fertile donors. It was noted that the extent of deterioration in sperm quality and DNA integrity seen in cancer patients did not reach the previously defined statistical threshold for impaired fertility. Freezing spermatozoa with the seminal plasma offers the highest protection against cryo-injury. Nevertheless, remote semen collection can still be used as it yields adequate results. [source]

Dermatological features of inherited cancer syndromes in adults

CLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 5 2010
A. Al Fares
Summary Many syndromes predisposing to cancer have dermatological features, which, although often subtle, will alert the clinician to the possibility of systemic malignancy. Many of these conditions are hereditary and are therefore also of relevance to the families of these patients. Early detection and appropriate genetic counselling is vital, as this will allow the patient and their relatives to be screened appropriately. This review will provide an overview of dermatological features of several cancer-predisposing syndromes divided according to organ system, describing the main clinical features and presentation of the selected syndromes. [source]