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Synthetic Tool (synthetic + tool)

Distribution by Scientific Domains

Chemistry	85%

Selected Abstracts

ChemInform Abstract: CuX2 -Mediated [4 + 2] Benzannulation as a New Synthetic Tool for Stereoselective Construction of Haloaromatic Compounds.

CHEMINFORM, Issue 6 2010
Yukie Isogai
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: The Bergman Reaction as a Synthetic Tool: Advantages and Restrictions.

CHEMINFORM, Issue 33 2001
Daniel M. Bowles
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Macromolecular design via reversible addition,fragmentation chain transfer (RAFT)/xanthates (MADIX) polymerization

JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 22 2005
Sébastien Perrier
Abstract Among the living radical polymerization techniques, reversible addition,fragmentation chain transfer (RAFT) and macromolecular design via the interchange of xanthates (MADIX) polymerizations appear to be the most versatile processes in terms of the reaction conditions, the variety of monomers for which polymerization can be controlled, tolerance to functionalities, and the range of polymeric architectures that can be produced. This review highlights the progress made in RAFT/MADIX polymerization since the first report in 1998. It addresses, in turn, the mechanism and kinetics of the process, examines the various components of the system, including the synthesis paths of the thiocarbonyl-thio compounds used as chain-transfer agents, and the conditions of polymerization, and gives an account of the wide range of monomers that have been successfully polymerized to date, as well as the various polymeric architectures that have been produced. In the last section, this review describes the future challenges that the process will face and shows its opening to a wider scientific community as a synthetic tool for the production of functional macromolecules and materials. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43:5347,5393, 2005 [source]

Diels,Alder "Click" Chemistry in Designing Dendritic Macromolecules

CHEMISTRY - A EUROPEAN JOURNAL, Issue 23 2009
Grégory Franc Dr.
Abstract Simple, versatile and green: Diels,Alder "click" chemistry is a simple, versatile and "greener" approach in the design of a diverse range of dendritic macromolecules (see scheme). In the current decade, design of dendritic macromolecules including dendrimers and polymers has reached a new era, mainly due to the remarkably successful and elegant synthetic routes that have been developed recently. This survey aims at demonstrating the potential of the Diels,Alder "click" chemistry, a very effective, simple and versatile synthetic tool in the formation of complex and functional nanometer-sized assemblies. The role of retro Diels-Alder reaction is also explored to highlight the increasing competitive potential of this strategy in the design of dendritic macromolecules of topical interest. The potential "green" nature of this methodology in constructing macromolecular assemblies is also evaluated. [source]

Selective Iridium-Catalyzed Alkylation of (Hetero)Aromatic Amines and Diamines with Alcohols under Mild Reaction Conditions

CHEMISTRY - A EUROPEAN JOURNAL, Issue 15 2009
Benoît Blank
Abstract Selective amine alkylation: A P,N-ligand-stabilized iridium complex has been used as an efficient catalyst for the alkylation of (hetero)aromatic amines with alcohols at mild reaction temperatures and catalyst loadings as low as 0.1,mol,% Ir (see scheme). The excellent selectivity of the catalyst for monoalkylation of the amine function has also been exploited for the N,N,-dialkylation of diamines in both symmetric and nonsymmetric fashions. A P,N-ligand-coordinated iridium complex has been employed as an efficient catalyst for the selective monoalkylation of (hetero)aromatic amines with alcohols. A significant improvement of this alkylation method has been achieved, such that it can be performed at a temperature of 70,°C and with catalyst loadings as low as 0.1,mol,% Ir, while still affording excellent yields of secondary amines. Furthermore, the high selectivity of this catalyst for the monoalkylation of aromatic amino functions has been successfully exploited for the alkylation of diamines in both symmetric and nonsymmetric fashions, providing a novel and very efficient synthetic tool for the preparation of N,N,-dialkylated aromatic diamines. Ein P,N-Ligand-koordinierter Iridiumkomplex wird als ein effizienter Katalysator für die selektive Monoalkylierung von (hetero)aromatischen Aminen mit Alkoholen beschrieben. Eine signifikante Verbesserung dieser Alkylierungsmethode wurde erreicht. Bei Temperaturen von 70,°C und mit Katalysatorbeladungen von bis zu 0.1,mol,% Ir konnten exzellente Ausbeuten für sekundäre Amine erhalten werden. Weiterhin konnte die hohe Selektivität des Katalysators hinsichtlich der Monoalkylierung von aromatischen Aminogruppen genutzt werden, um Diamine symmetrisch und unsymmetrisch zu alkylieren. Damit steht ein neues sehr effizientes Synthesewerkzeug zur Darstellung von N,N, -alkylierten aromatischen Diaminen zur Verfügung. [source]

Synthesis of azirines containing aldehyde functionality and their utilization as synthetic tools for five membered oxazoles and isoxazoles

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2008
Sulagna Brahma
A simple and useful procedure for the synthesis of azirines containing aldehyde functionality from open chain bromo/chloro-aldehydes at room temperature is reported. The scope of the ring expansion reaction of a number of 3-substituted-2-formyl-azirines has been examined using different oraganometallic catalysts and a variety of Lewis acids. [source]

Glycosyltransferases and their Assays

CHEMBIOCHEM, Issue 14 2010
Dr. Gerd K. Wagner
Abstract Glycosyltransferases (GTs) are a large family of enzymes that are essential in all domains of life for the biosynthesis of complex carbohydrates and glycoconjugates. GTs catalyse the transfer of a sugar from a glycosyl donor to a variety of acceptor molecules, for example, oligosaccharides, peptides, lipids or small molecules. Such glycosylation reactions are central to many fundamental biological processes, including cellular adhesion, cell signalling and bacterial- and plant-cell-wall biosynthesis. GTs are therefore of significant interest as molecular targets in chemical biology and drug discovery. In addition, GTs have found wide application as synthetic tools for the preparation of complex carbohydrates and glycoconjugates. In order to exploit the potential of GTs both as molecular targets and synthetic tools, robust and operationally simple bioassays are essential, especially as more and more protein sequences with putative GT activity but unknown biochemical function are being identified. In this minireview, we give a brief introduction to GT biochemistry and biology. We outline the relevance of GTs for medicinal chemistry and chemical biology, and describe selected examples for recently developed GT bioassays, with a particular emphasis on fluorescence-based formats. [source]