			Home About us Contact

Synthetic Multifunctional Pores (synthetic + multifunctional_pore)

Distribution by Scientific Domains

Chemistry	50%

Selected Abstracts

Molecular Recognition by Synthetic Multifunctional Pores in Practice: Are Structural Studies Really Helpful?,

ADVANCED FUNCTIONAL MATERIALS, Issue 2 2006
Y. Baudry
Abstract This account summarizes five years of research devoted to the development of the concept of synthetic multifunctional pores. The objective is to complement a comprehensive graphical summary of molecular recognition with a survey of structural studies on the same topic. The relevance of the latter for research focusing on creation and application of supramolecular functional materials is discussed briefly in a subjective manner. [source]

Contributions of Lipid Bilayer Hosts to Structure and Activity of Multifunctional Supramolecular Guests

CHEMISTRY & BIODIVERSITY, Issue 6 2005
Abhigyan Som
The question of whether or not the surrounding lipid bilayer host contributes to structure and activity of included functional guests is a general topic of current scientific concern. We report that synthetic multifunctional pores are of use to address this elusive question, because the detection of their catalytic activity is membrane independent. According to their salt-rate profiles, unstable multifunctional supramolecules with permanent internal charges show highest membrane sensitivity, and the dependence of membrane sensitivity on the acidity of internal cations exceeds that on supramolecule stability. These results can, with all appropriate caution, be interpreted as indications for the existence of long-range EMP,ICR interactions (EMP: external membrane pressure, ICR: internal charge repulsion) between membrane hosts and functional guests that can, for instance, prevent the ,explosion' and promote the ,implosion' of over- and undercharged transmembrane barrel-stave supramolecules, respectively. [source]

Chirality sensing with synthetic pores,

CHIRALITY, Issue 3-4 2008
Hiroyuki Tanaka
Abstract A concept to determine enantiomeric excess with synthetic multifunctional pores is introduced. To do so, the poor stereoselectivity of molecular recognition by stimuli-responsive pores is coupled with the stereospecificity of enzymes. With substrates as good and products as poor pore blockers, enzymatic conversion of one enantiomer is shown to readily reveal the concentration of the other one. Calculations suggest that high substrate/product discrimination by the synthetic pores may provide access to the accurate detection of the extreme enantiomeric excess that is of interest in chemistry, pharmacology, and medicine, but otherwise possibly problematic to detect. Validity of the introduced concept is experimentally confirmed with poly- L -glutamate and poly- D -glutamate as enantiomeric substrates with high blockage efficiency, L -glutamate and D -glutamate as enantiomeric products with poor blockage efficiency, subtilisin A as enzyme, and a classical rigid-rod ,-barrel as synthetic pore. Chirality, 2008. © 2007 Wiley-Liss, Inc. [source]