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Substances
Kinds of Substances Terms modified by Substances Selected Abstracts[Commentary] META-ANALYSES AND THE SEARCH FOR SPECIFIC AND COMMON MEDIATORS OF SUBSTANCE MISUSE INTERVENTION EFFECTSADDICTION, Issue 5 2009JOHN W. FINNEY No abstract is available for this article. [source] THE SUBSTANCE AND SIGNIFICANCE OF THE DISPUTE OVER TWO-DIMENSIONALISMANALYTIC PHILOSOPHY, Issue 1 2007Scott Soames First page of article [source] SUBSTANCE: THINGS AND STUFFSARISTOTELIAN SOCIETY SUPPLEMENTARY VOLUME, Issue 1 2004Peter Hacker The categorial concepts of substance (thing) and substance (stuff) are described, and the conceptual relationships between things and their constitutive stuff delineated. The relationship between substance concepts, expressed by other count-nouns, and natural kind concepts is examined. Artefacts and their parts are argued to be substances, whereas parts of organisms are not. The confusions of seventeenth- and eighteenth-century philosophers who invoked the concept of substance are adumbrated. [source] A VANADIUM BROMOPEROXIDASE CATALYZES THE FORMATION OF HIGH-MOLECULAR-WEIGHT COMPLEXES BETWEEN BROWN ALGAL PHENOLIC SUBSTANCES AND ALGINATES,JOURNAL OF PHYCOLOGY, Issue 1 2009Leonardo Tavares Salgado The interaction between phenolic substances (PS) and alginates (ALG) has been suggested to play a role in the structure of the cell walls of brown seaweeds. However, no clear evidence for this interaction was reported. Vanadium bromoperoxidase (VBPO) has been proposed as a possible catalyst for the binding of PS to ALG. In this work, we studied the interaction between PS and ALG from brown algae using size exclusion chromatography (SEC) and optical tweezers microscopy. The analysis by SEC revealed that ALG forms a high-molecular-weight complex with PS. To study the formation of this molecular complex, we investigated the in vitro interaction of purified ALG from Fucus vesiculosus L. with purified PS from Padina gymnospora (Kütz.) Sond., in the presence or absence of VBPO. The interaction between PS and ALG only occurred when VBPO was added, indicating that the enzyme is essential for the binding process. The interaction of these molecules led to a reduction in ALG viscosity. We propose that VBPO promotes the binding of PS molecules to the ALG uronic acids residues, and we also suggest that PS are components of the brown algal cell walls. [source] Form before Substance: Eisenhower's Commitment to Psychological Warfare and Negotiations with the EnemyDIPLOMATIC HISTORY, Issue 3 2000Kenneth A. Osgood [source] Substance misuse over the first 18 months of specialized intervention for first episode psychosisEARLY INTERVENTION IN PSYCHIATRY, Issue 3 2009Jason A. R. Carr Abstract Aim: Examine substance misuse over the first 18 months of first-episode psychosis treatment. Method: Clinicians rated alcohol and drug (mostly cannabis) misuse for 243 individuals followed prospectively. Assessments were completed at baseline and after 3, 6 and 18 months. Interventions relating to substance misuse included ongoing assessment of use, education and counselling to avoid. Results: Alcohol and drug misuse declined significantly between baseline and 3 months, especially among patients with a substance abuse or dependence diagnosis at baseline. Overall, these reductions were maintained over the 18-month follow-up period. The exception was worsening alcohol misuse over time among patients with alcohol abuse or dependence on entry. Conclusions: With good usual care, education and support, alcohol and drug misuse declined significantly during the first months of psychosis treatment. The improvements in drug misuse were generally maintained over the 18-month follow-up, and worsening alcohol misuse over time may be the greater issue. [source] Substance misuse among older adults: a neglected but treatable problemADDICTION, Issue 3 2008MICHAEL GOSSOP No abstract is available for this article. [source] The role of alcohol and drugs in homicides in England and WalesADDICTION, Issue 8 2006Jenny Shaw SUMMARY Background The annual number of homicide convictions in England and Wales is increasing. Previous studies have highlighted the aetiological role of alcohol and drugs in homicide. Aims To examine rates of alcohol and drug misuse and dependence in people convicted of homicide; the role of alcohol and drugs in the offence; the social and clinical characteristics of alcohol- and drug-related homicides; and the social and clinical characteristics of patients with dual diagnosis who commit homicide. Methods A national clinical survey based on a 3-year (1996,9) consecutive sample of people convicted of homicide in England and Wales. Information on rates of alcohol and drug misuse/dependence, the role of alcohol and drugs in the offence and social and clinical characteristics of perpetrators were collected from psychiatric reports prepared for the court in homicide convictions. Detailed clinical information was gathered from questionnaires completed by mental health teams for those in contact with mental health services. Results Of the 1594 homicide perpetrators, more than one-third (42%) occurred in people with a history of alcohol misuse or dependence and 40% in people with a history of drug misuse or dependence. Alcohol or drug misuse played a contributory role in two-fifths of homicides. Alcohol played a major role in 52 (6%) and a minor role in 364 (39%) homicides. Drugs played a major role in six (1%) and a minor role in 138 (14%) homicides. Forty-two homicides (17%) were committed by patients with severe mental illness and substance misuse. Alcohol- and drug-related homicides were generally associated with male perpetrators who had a history of violence, personality disorders, mental health service contact and with stranger victims. Conclusions Substance misuse contributes to the majority of homicides in England and Wales. A public health approach to homicide would highlight alcohol and drugs before severe mental illness. [source] GENETIC STUDY: 5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up studyADDICTION BIOLOGY, Issue 1 2010Rocío Martín-Santos ABSTRACT A 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD) among ecstasy users and two control groups: one of cannabis users and the other of non-drug users. The 5-HTTLPR polymorphism related to NSUD was also studied. A total of 94 subjects were included: 37 ecstasy users, 23 cannabis users and 34 non-drug users. SUD and NSUD disorders were diagnosed according to the fourth edition of the Diagnostic and Statistical Manual of Mental Health Disorders criteria using the Psychiatric Research Interview for Substance and Mental Disorders. Incidence Rates (IR) are presented. The 5-HTTLPR polymorphism was analyzed. Hardy,Weinberg equilibrium was studied. The results of the study showed that the highest IR of SUD was cannabis abuse/dependence in both the ecstasy (IR: 48.6/100 person,year) and cannabis (IR: 2.5/100 person,year) groups. There were no new cases of SUD in non-drug users at follow-up. The highest IR of NSUD was primary mood disorder in both the ecstasy (IR: 4.2/100 person,year) and in the non-drug (IR: 1.3/100 person,year) groups (P < 0.282). There were no new cases of NSUD in the cannabis group at follow-up. 5-HTTLPR polymorphism was associated with lifetime of primary mood disorders in ecstasy group (P = 0.018). Ecstasy use was associated with a higher rate of cannabis abuse/dependence disorders and mood disorders than cannabis use. In the ecstasy users, 5-HTTLPR polymorphism may result in a high vulnerability to primary mood disorders. [source] Substance induced plasticity in noradrenergic innervation of the paraventricular hypothalamic nucleusEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 2 2003Arthur S. P. Jansen Abstract Single administration of the cytokine interleukin-1, (IL-1), or the psychostimulant amphetamine, enhanced adrenocorticotropin hormone and corticosterone responses to a stress challenge weeks later. This long-lasting hypothalamic-pituitary-adrenal (HPA)-sensitization is paralleled by an increase in electrically evoked release of noradrenaline in the paraventricular hypothalamic nucleus (PVN). We hypothesized that these functional changes may be associated with morphological plasticity of noradrenergic projections to the PVN, a parameter that shows high reproducibility. Specific alterations in relative (nor)adrenergic innervation density were studied by using dopamine-,-hydroxylase (DBH) as a marker. An image analysis system was used to detect changes in the relative DBH innervation density of the PVN. Groups of adult male rats were given IL-1 (10 µg/kg i.p.), amphetamine (5 mg/kg i.p.), or saline. Three weeks later, IL-1 and amphetamine primed rats showed enhanced adrenocorticotropin hormone and corticosterone responses to an amphetamine challenge. In another set of experiments, the relative DBH innervation density was measured in different PVN subnuclei at four rostro-caudal levels. Single administration of either IL-1 or amphetamine causes three weeks later a selective decrease in relative DBH innervation density in those subnuclei of the PVN that contain high numbers of corticotrophin-releasing hormone (CRH) producing neurons: the dorsal parvocellular and medial parvocellular PVN. We conclude that (1) long-lasting sensitization induced by single exposure to IL-1 and amphetamine induces specific pattern of neuroplastic changes in (nor)adrenergic innervation in the PVN and (2) reduction of relative DBH innervation density in CRH-rich areas is associated with paradoxical increase of electrically evoked release of (nor)adrenaline. [source] Form and Substance in European Constitutional Law: The ,Social' Character of Indirect EffectEUROPEAN LAW JOURNAL, Issue 4 2010Leone Niglia This article proposes to understand the constitutional discourse about individuals, rights and enforcement, as developed in the courtrooms, in relation to historic and contextual circumstances. It focuses on the interface between indirect effect and social policy, and argues that the creation of indirect effect has been integral to a judicial strategy centred on the key concern for sustaining the balance between market freedom and interventionism as achieved in the political process. [source] BDNF variability in opioid addicts and response to methadone treatment: preliminary findingsGENES, BRAIN AND BEHAVIOR, Issue 5 2008R. De Cid Brain-derived neurotrophic factor (BDNF) signaling pathways have been shown to be essential for opioid-induced plasticity. We conducted an exploratory study to evaluate BDNF variability in opioid addict responders and nonresponders to methadone maintenance treatment (MMT). We analyzed 21 single nucleotide polymorphisms (SNPs) across the BDNF genomic region. Responders and nonresponders were classified by means of illicit opioid consumption detected in random urinalysis. Patients were assessed by a structured interview (Psychiatric Research Interview for Substance and Mental Disorders (PRISM)-DSM-IV) and personality was evaluated by the Cloninger's Temperament and Character Inventory. No clinical, environmental and treatment characteristics were different between the groups, except for the Cooperativeness dimension (P < 0.001). Haplotype block analysis showed a low-frequency (2.7%) haplotype (13 SNPs) in block 1, which was more frequent in the nonresponder group than in the responder group (4/42 vs. 1/135; Pcorrected = 0.023). Fine mapping in block 1 allows us to identify a haplotype subset formed by only six SNPs (rs7127507, rs1967554, rs11030118, rs988748, rs2030324 and rs11030119) associated with differential response to MMT (global P sim = 0.011). Carriers of the CCGCCG haplotype had an increased risk of poorer response, even after adjusting for Cooperativeness score (OR = 20.25 95% CI 1.46,280.50, P = 0.025). These preliminary results might suggest the involvement of BDNF as a factor to be taken into account in the response to MMT independently of personality traits, environmental cues, methadone dosage and psychiatric comorbidity. [source] Substance misuse in elderly general hospital in-patientsINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 2 2002Jonathan Beckett No abstract is available for this article. [source] Interrater reliability of the Psychiatric Research Interview for Substance and Mental Disorders in an HIV-infected cohort: experience of the National NeuroAIDS Tissue ConsortiumINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 3 2006S. Morgello Abstract The interrater reliability of the Psychiatric Research Interview for Substance and Mental Disorders (PRISM) was assessed in a multicentre study. Four sites of the National NeuroAIDS Tissue Consortium performed blinded reratings of audiotaped PRISM interviews of 63 HIV-infected patients. Diagnostic modules for substance-use disorders and major depression were evaluated. Seventy-six per cent of the patient sample displayed one or more substance-use disorder diagnoses and 54% had major depression. Kappa coefficients for lifetime histories of substance abuse or dependence (cocaine, opiates, alcohol, cannabis, sedative, stimulant, hallucinogen) and major depression ranged from 0.66 to 1.00. Overall the PRISM was reliable in assessing both past and current disorders except for current cannabis disorders when patients had concomitant cannabinoid prescriptions for medical therapy. The reliability of substance-induced depression was poor to fair although there was a low prevalence of this diagnosis in our group. We conclude that the PRISM yields reliable diagnoses in a multicentre study of substance-experienced, HIV-infected individuals. Copyright © 2006 John Wiley & Sons, Ltd. [source] Psychosocial treatments for people with co-occurring severe mental illness and substance misuse: systematic reviewJOURNAL OF ADVANCED NURSING, Issue 2 2009Michelle Cleary Abstract Title.,Psychosocial treatments for people with co-occurring severe mental illness and substance misuse: systematic review. Aim., This study is a report of a systematic review to assess current evidence for the efficacy of psychosocial interventions for reducing substance use, as well as improving mental state and encouraging treatment retention, among people with dual diagnosis. Background., Substance misuse by people with a severe mental illness is common and of concern because of its many adverse consequences and lack of evidence for effective psychosocial interventions. Data sources., Several electronic databases were searched to identify studies published between January 1990 and February 2008. Additional searches were conducted by means of reference lists and contact with authors. Review methods., Results from studies using meta-analysis, randomized and non-randomized trials assessing any psychosocial intervention for people with a severe mental illness and substance misuse were included. Results., Fifty-four studies were included: one systematic review with meta-analysis, 30 randomized controlled trials and 23 non-experimental studies. Although some inconsistencies were apparent, results showed that motivational interviewing had the most quality evidence for reducing substance use over the short term and, when combined with cognitive behavioural therapy, improvements in mental state were also apparent. Cognitive behavioural therapy alone showed little consistent support. Support was found for long-term integrated residential programmes; however, the evidence is of lesser quality. Contingency management shows promise, but there were few studies assessing this intervention. Conclusion., These results indicate the importance of motivational interviewing in psychiatric settings for the reduction of substance use, at least in the short term. Further quality research should target particular diagnoses and substance use, as some interventions may work better for some subgroups. [source] Style Versus Substance: Multiple Roles of Language Power in PersuasionJOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 1 2008John R. Sparks This research explores how message style influences persuasion in conjunction with message substance. Using the elaboration likelihood model, the study operationalizes message style as language power and message substance as argument quality, then considers the multiple roles language power can assume in persuasion. The authors investigate whether language power acts as a (a) central argument, (b) peripheral cue, (c) biasing influence on assessment of arguments, or (d) distraction that inhibits argument processing. Additionally, they manipulate exposure time to examine how processing ability influences which persuasive roles language power assumes. The authors find empirical support for the multiple-roles perspective and conclude that the role of message style depends partially on the ability to process message details. [source] EFFECT OF IONIZING RADIATION ON BEEF BOLOGNA CONTAINING SOY PROTEIN CONCENTRATEJOURNAL OF FOOD SAFETY, Issue 3 2001C.H. SOMMERS ABSTRACT Soy protein concentrate (SPC), an extender, is a common additive in ready-to-eat (RTE) meat products. SPC contains antioxidants that could potentially interfere with the ability of ionizing radiation to eliminate Listeria monocytogenes from RTE meat products. When L. monocytogenes was inoculated into cooked beef bologna emulsion containing 0, 1.75, or 3.5% SPC the gamma radiation D10 values, at radiation doses of 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 kGy, were 0.66, 0.68, and 0.71kGy, respectively. Soluble antioxidant power, as determined by the Ferric Reducing Antioxidant Power (FRAP) assay was 1958, 3572, and 5494 mol in bologna emulsion containing 0, 1.75 and 3.5% SPC, respectively. Soluble antioxidant power was not affected by ionizing radiation. SPC did not prevent ionizing radiation induced lipid oxidation as determined by Thiobarbituric Acid Reactive Substance (TBARS) assay. Hunter color analysis of both unirradiated and irradiated bologna slices containing SPC indicated decreased a value as a result of irradiation, while the addition of SPC helped maintain b-value and L-value. The inclusion of SPC did not represent a barrier to ionizing radiation pasteurization of fine emulsion sausages for the parameters examined. [source] Substance Flow Analysis of Mercury Intentionally Used in Products in the United StatesJOURNAL OF INDUSTRIAL ECOLOGY, Issue 3 2007Alexis Cain Mercury-containing products release mercury (Hg) throughout their lifecycles, frequently in ways that are difficult to measure directly. Therefore, there are considerable uncertainties about the magnitude of mercury releases associated with products, about which products and which release pathways contribute the most to mercury releases, and about the likely impact on mercury releases of various possible interventions in the mercury content of products or in the management of mercury-containing wastes. This article presents an effort to use substance flow analysis to develop improved estimates of the environmental releases caused by mercury-containing products and to provide policy-makers with a better understanding of opportunities for reducing releases of mercury caused by products. [source] Substance misuse, offending and mental illness: a reviewJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 6 2000P. Phillips MSc RMN The literature concerning the associations between violence, mental disorder, comorbidity and substance misuse are discussed in this review, which focuses on the findings of several international studies that demonstrate significantly higher rates of violence in substance misuse and dual diagnosis (when compared with ,single' diagnosis groups). The need for the development of an effective psychiatric nursing response in terms of assessment, liaison and joint clinical management approaches to those with a dual diagnosis is discussed in the context of United Kingdom Government legislation and policy in both forensic mental health services, and in statutory substance misuse services. [source] Assessing the viability of treatment rights for prisoners with personality disorder: Substance or substantive?PERSONALITY AND MENTAL HEALTH, Issue 3 2009Leon McRae Personality disorder (PD) has long been criticized as a diagnosis, not least for the issue of its supposed untreatability. This has precluded many offenders with PD from receiving treatment for their disorder in a secure hospital, with detention in the potentially deleterious penal environment the result. However, transfers for public protection continue to occur. A further problematic issue for treatment considerations when diversion from prison hangs in the balance is the removal of the need for proposed treatment to provide a therapeutic benefit under the recently amended Mental Health Act 1983. In light of these developments, this paper considers the significance of human rights instruments, such as the European Prison Rules 2006, which aim to offer rights to treatment, giving the offender with a diagnosis of PD access to adequate and sustaining treatment, both in prison and secure hospitals. Copyright © 2009 John Wiley & Sons, Ltd. [source] Spinoza's Metaphysics of Substance: The Substance-Mode Relation as a Relation of Inherence and PredicationPHILOSOPHY AND PHENOMENOLOGICAL RESEARCH, Issue 1 2009YITZHAK Y. MELAMED First page of article [source] Substance, Attribute, and Mode in SpinozaPHILOSOPHY COMPASS (ELECTRONIC), Issue 2 2006Martin Lin Some of Spinoza's most well-known doctrines concern what kinds of beings there are and how they are related to each other. For example, he claims that: (1) there is only one substance; (2) this substance has infinitely many attributes; (3) this substance is God or nature; (4) each of these attributes express the divine essence; and (5) all else is a mode of the one substance. These claims have so astonished many of his readers that some of them have surely concluded that they must not know what Spinoza means by "substance,""attribute," and "mode." In this article I shall try to explain how Spinoza understands the basic ontological categories denoted by these expressions. [source] III,Moral Obligation: Form and SubstancePROCEEDINGS OF THE ARISTOTELIAN SOCIETY (HARDBACK), Issue 1pt1 2010Stephen Darwall Beginning from an analysis of moral obligation's form that I defend in The Second-Person Standpoint as what we are answerable for as beings with the necessary capacities to enter into relations of mutual accountability, I argue that this analysis has implications for moral obligation's substance. Given what it is to take responsibility for oneself and hold oneself answerable, I argue, it follows that if there are any moral obligations at all, then there must exist a basic pro tanto obligation not to undermine one another's moral autonomy. [source] On the Relation between Form and Substance in LawRATIO JURIS, Issue 1 2007PHILIP SOPER In particular, he concentrates on the hazy relationship between form and substance in Summers' theory. In order to analyze some major difficulties entailed in the thesis that form and substance are different and independent things, the author discusses three specific questions: (1) the difference between form and substance; (2) the possibility of a form meant to be value-neutral; (3) how to distinguish a form-centered approach from a formalistic approach when one has to interpret a statute. This last question is dealt with through examples taken from two legal decisions.* [source] Policy Substance and Performance in American Lawmaking, 1877,1994AMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 2 2008John S. Lapinski This article reconsiders the importance of including policy issue content and legislative significance in our study of lawmaking. Specifically, it demonstrates theoretically why lawmaking might vary by policy substance and empirically shows how incorrect conclusions would be drawn if lawmaking is studied by pooling enactments instead of disaggregating laws by policy issue content. It accomplishes this by bringing new tools, including a policy classification system and a way to measure the significance of public laws, to help overcome an array of measurement-related problems that have stymied our ability to better understand lawmaking. The policy coding schema introduced is applied, by careful individual human coding, to every public law enacted between 1877 and 1994 (n = 37,767). The policy issue and significance data are used to construct a number of new measures of legislative performance and are useful to test hypotheses within studies of Congress and American Political Development. [source] Incitement to Religious Hatred: All Talk and No Substance?THE MODERN LAW REVIEW, Issue 1 2007Kay Goodall The Racial and Religious Hatred Act 2006 has a frenetic history. It is the culmination of six attempts in Parliament in the last twelve years to make incitement to religious hatred unlawful.1 Each attempt has met with intense criticism. But now that the legislation is here, what may it achieve? [source] Diagnosing comorbidity: concepts, criteria, and methodsACTA NEUROPSYCHIATRICA, Issue 1 2004S. Samet Background:, The clinical and etiologic implications of comorbid psychiatric and substance-use disorders are relevant across countries and cultures. The DSM-IV now places greater emphasis on the clinical and research utility of the substance-induced disorders classification, and clarifies several important diagnostic issues specific to primary and substance-induced disorders. However, no research consensus exists over the core problem of identifying and differentiating the drug and alcohol intoxication and withdrawal symptoms that can mimic psychiatric symptoms in heavy drinkers and drug users. Objective:, To investigate how various diagnostic instruments have measured comorbid psychiatric and substance-use disorders and how each instrument operationalizes the DSM-IV classification. Method:, We review the evolution of the concept of comorbidity beginning with its formalization as the ,primary,secondary' distinction in the Feighner Criteria. We address the ,organic,non-organic' distinction found in the RDC, DSM-III, and DSM-III-R; and finally, review the ,primary' and ,substance-induced' categories of DSM-IV, DSM-IV-TR and ICD-10. We describe how these distinctions have been operationalized in widely used diagnostic instruments. Conclusion:, Further understanding of these classifications and the rela-tionship of co-occurring psychiatric and substance disorders can be accom-plished with the range of available measures, particularly the Psychiatric Research Interview for Substance and Mental Disorders (PRISM), which reliably utilizes and refines DSM-IV classification distinctions. [source] (.+-.)-cis-(6-Ethyl-tetrahydropyran-2-yl)-formic Acid: A Novel Substance with Antinociceptive Properties.CHEMINFORM, Issue 29 2004L. S. M. Miranda Abstract For Abstract see ChemInform Abstract in Full Text. [source] A Novel Leaf-Movement Inhibitor of a Nyctinastic Weed, Sesbania exaltata Cory, Designed on a Naturally Occurring Leaf-Opening Substance and Its Application to a Potential, Highly Selective Herbicide.CHEMINFORM, Issue 2 2003Noboru Takada Abstract For Abstract see ChemInform Abstract in Full Text. [source] Children Exposed to Parental Substance Misuse: Implications for Family PlacementCHILD & FAMILY SOCIAL WORK, Issue 4 2005Brynna Kroll No abstract is available for this article. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||