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Sun Et Al. (sun + et_al)
Selected AbstractsErasure of the paternal transcription program during spermiogenesis: The first step in the reprogramming of sperm chromatin for zygotic developmentDEVELOPMENTAL DYNAMICS, Issue 5 2008Junke Zheng Abstract Male germ cells possess a unique epigenetic program and express a male-specific transcription profile. However, when its chromatin is passed onto the zygote, it expresses an transcription/epigenetic program characteristic of the zygote. The mechanism underlying this reprogramming process is not understood at present. In this study, we show that an extensive range of chromatin factors (CFs), including essential transcription factors and regulators, remodeling factors, histone deacetylases, heterochromatin-binding proteins, and topoisomerases, were removed from chromatin during spermiogenesis. This process will erase the paternal epigenetic program to generate a relatively naive chromatin, which is likely to be essential for installation of the zygotic developmental program after fertilization. We have also showed that transcription termination in male germ cells was temporally correlated with CF dissociation. A genome-wide CF dissociation will inevitably disassemble the transcription apparatus and regulatory mechanism and lead to transcription silence. Based on data presented in this and previous studies (Sun et al., Cell Research [2007] 17:117,134), we propose that paternal-zygotic transcription reprogramming begins with a genome-wide CF dissociation to erase the existing transcription program in later stages of spermatogenesis. This will be followed by assembling of the zygotic equivalent after fertilization. The transcription/epigenetic program of the male germ cell is transformed into a zygotic one using an erase-and-rebuild strategy similar to that used in the maternal-zygotic transition. It is also noted that transcription is terminated long after meiosis is completed and before chromatin becomes highly condensed during spermatogenesis. The temporal order of these events suggests that transcription silence does not have to be coupled to meiosis or chromatin condensation. Developmental Dynamics 237:1463-1476, 2008. © 2008 Wiley-Liss, Inc. [source] A comparison of Granger causality and coherency in fMRI-based analysis of the motor systemHUMAN BRAIN MAPPING, Issue 11 2009Andrew S. Kayser Abstract The ability of functional MRI to acquire data from multiple brain areas has spurred developments not only in voxel-by-voxel analyses, but also in multivariate techniques critical to quantifying the interactions between brain areas. As the number of multivariate techniques multiplies, however, few studies in any modality have directly compared different connectivity measures, and fewer still have done so in the context of well-characterized neural systems. To focus specifically on the temporal dimension of interactions between brain regions, we compared Granger causality and coherency (Sun et al., 2004, 2005: Neuroimage 21:647,658, Neuroimage 28:227,237) in a well-studied motor system (1) to gain further insight into the convergent and divergent results expected from each technique, and (2) to investigate the leading and lagging influences between motor areas as subjects performed a motor task in which they produced different learned series of eight button presses. We found that these analyses gave convergent but not identical results: both techniques, for example, suggested an anterior-to-posterior temporal gradient of activity from supplemental motor area through premotor and motor cortices to the posterior parietal cortex, but the techniques were differentially sensitive to the coupling strength between areas. We also found practical reasons that might argue for the use of one technique over another in different experimental situations. Ultimately, the ideal approach to fMRI data analysis is likely to involve a complementary combination of methods, possibly including both Granger causality and coherency. Hum Brain Mapp, 2009. © 2009 Wiley-Liss, Inc. [source] Construction of Exact Simultaneous Confidence Bands for a Simple Linear Regression ModelINTERNATIONAL STATISTICAL REVIEW, Issue 1 2008Wei Liu Summary A simultaneous confidence band provides a variety of inferences on the unknown components of a regression model. There are several recent papers using confidence bands for various inferential purposes; see for example, Sun et al. (1999), Spurrier (1999), Al-Saidy et al. (2003), Liu et al. (2004), Bhargava & Spurrier (2004), Piegorsch et al. (2005) and Liu et al. (2007). Construction of simultaneous confidence bands for a simple linear regression model has a rich history, going back to the work of Working & Hotelling (1929). The purpose of this article is to consolidate the disparate modern literature on simultaneous confidence bands in linear regression, and to provide expressions for the construction of exact 1 ,, level simultaneous confidence bands for a simple linear regression model of either one-sided or two-sided form. We center attention on the three most recognized shapes: hyperbolic, two-segment, and three-segment (which is also referred to as a trapezoidal shape and includes a constant-width band as a special case). Some of these expressions have already appeared in the statistics literature, and some are newly derived in this article. The derivations typically involve a standard bivariate t random vector and its polar coordinate transformation. Résumé Un intervalle de confiance simultanée fournit une variété d'inférences sur les composantes inconnues d'un modéle de régression. Plusieurs articles récents utilisent des intervalles de confiance dans des buts variés; voir par exemple Sun, Raz et Faraway (1999), Spurrier (1999), Al-Saidy et al. (2003), Liu, Jamshidian et Zhang (2004), Bhargava et Spurrier (2004), Piegorsch et al. (2005), Liu et al. (2007). La construction d'intervalles de confiance simultanés pour un simple modéle de régression linéaire a une histoire riche, qui remonte aux travaux de Working et hotelling (1929). L'objet de cet article est de consolider la littérature moderne disparate sur les intervalles de confiance simultanés dans la régression linéaire, de fournir des expressions pour la construction d'intervalles de confiance simultanés de niveau exact 1 ,, pour un modéle de régression linéaire simple ou pour des formes unilatérales ou bilatérales. Nous concentrons notre attention sur les trois formes les plus reconnues: hyperbolique, à deux segments et à trois segments (qui est aussi appelée forme trapézoïdale et inclut un intervalle de largeur constante comme cas spécial). Certaines de ces expressions sont déjà apparues dans la littérature statistique, d'autres sont nouvellement introduites dans cet article. Les dérivations comprennent typiquement un vecteur aléatoire standard bivarié t et sa transformation en coordonnées polaires. [source] Regression Analysis of Doubly Censored Failure Time Data Using the Additive Hazards ModelBIOMETRICS, Issue 3 2004Liuquan Sun Summary Doubly censored failure time data arise when the survival time of interest is the elapsed time between two related events and observations on occurrences of both events could be censored. Regression analysis of doubly censored data has recently attracted considerable attention and for this a few methods have been proposed (Kim et al., 1993, Biometrics49, 13,22; Sun et al., 1999, Biometrics55, 909,914; Pan, 2001, Biometrics57, 1245,1250). However, all of the methods are based on the proportional hazards model and it is well known that the proportional hazards model may not fit failure time data well sometimes. This article investigates regression analysis of such data using the additive hazards model and an estimating equation approach is proposed for inference about regression parameters of interest. The proposed method can be easily implemented and the properties of the proposed estimates of regression parameters are established. The method is applied to a set of doubly censored data from an AIDS cohort study. [source] | |||||||||||||