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Strength
Kinds of Strength Terms modified by Strength Selected AbstractsMATING DENSITY AND THE STRENGTH OF SEXUAL SELECTION AGAINST DELETERIOUS ALLELES IN DROSOPHILA MELANOGASTEREVOLUTION, Issue 4 2008Nathaniel P. Sharp Deleterious alleles constantly enter populations via mutation. Their presence reduces mean fitness and may threaten population persistence. It has been suggested that sexual selection may be an efficient way by which deleterious alleles are removed from populations but there is little direct experimental evidence. Because of its potential role in mutational meltdowns, there is particular interest in whether the strength of sexual selection changes with density. For each of eight visible markers in Drosophila melanogaster we have compared the strength of sexual selection at two densities. We find evidence of strong sexual selection against most but not all of these alleles. There is no evidence that sexual selection tends to be stronger (or weaker) at high density relative to low density. In addition, we also measure the effects of these mutations on two key parameters relevant to population productivity,juvenile viability and female fecundity. In most cases, sexual selection is as strong or stronger than these other forms of selection. [source] HOW BRIGHT AND HOW NASTY: EXPLAINING DIVERSITY IN WARNING SIGNAL STRENGTHEVOLUTION, Issue 3 2007Michael P. Speed The conspicuous displays that warn predators of defenses carried by potential prey have been of interest to evolutionary biologists from the time of Wallace and Darwin to the present day. Although most studies implicitly assume that these "aposematic" warning signals simply indicate the presence of some repellent defense such as a toxin, it has been speculated that the intensity of the signal might reliably indicate the strength of defense so that, for example, the nastiest prey might "shout loudest" about their unprofitability. Recent phylogenetic and empirical studies of Dendrobatid frogs provide contradictory views, in one instance showing a positive correlation between toxin levels and conspicuousness, in another showing a breakdown of this relationship. In this paper we present an optimization model, which can potentially account for these divergent results. Our model locates the optimal values of defensive traits that are influenced by a range of costs and benefits. We show that optimal aposematic conspicuousness can be positively correlated with optimal prey toxicity, especially where population sizes and season lengths vary between species. In other cases, optimal aposematic conspicuousness may be negatively correlated with toxicity; this is especially the case when the marginal costs of aposematic displays vary between members of different populations. Finally, when displays incur no allocation costs there may be no single optimum value for aposematic conspicuousness, rather a large array of alternative forms of a display may have equal fitness. [source] THE RECONCILING SPIRIT: THE DOVE WITH COLOUR AND STRENGTHINTERNATIONAL REVIEW OF MISSION, Issue 372 2005Kirsteen Kim The dove is used as a symbol of the Holy Spirit, and also of peace and reconciliation. However, the usual depiction of the dove may not be a good representation of the content of reconciliation, or of the nature and work of the Spirit. This article aims to enhance our vision of the Spirit of reconciliation by examining the apostle Paul's teaching in 2 Corinthians about the ministry of the Spirit and the ministry of reconciliation. The article also considers the deliberations of several international meetings, and brings together a number of reflections on the Spirit from India and Korea. The paper concludes that the heavenly bird is not limited to the dove, nor is the imagery of the Holy Spirit restricted to the dove. The Spirit is not white and delicate but colourful and strong, and it is through these characteristics that the Spirit leads us in the way of Christ in the struggle to live together in reconciled life. [source] BEYOND THE ORDINARY: 10 STRENGTHS OF U.S. CONGREGATIONS by Cynthia Woolever and Deborah Bruce PLACES OF PROMISE: FINDING STRENGTH IN YOUR CONGREGATION'S LOCATION by Cynthia Woolever and Deborah BruceJOURNAL FOR THE SCIENTIFIC STUDY OF RELIGION, Issue 2 2010DEBORAH L. COE No abstract is available for this article. [source] Comparison of Effect of Aerobic Cycle Training and Progressive Resistance Training on Walking Ability After Stroke: A Randomized Sham Exercise,Controlled StudyJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 6 2008Mi-Joung Lee PhD OBJECTIVES: To determine whether changes in strength or cardiorespiratory fitness after exercise training improve walking ability in individuals who have had a stroke. DESIGN: A sham exercise-controlled, randomized two-by-two factorial design, in which the two factors investigated were cycle training (AEROBIC) and resistance training (STRENGTH). SETTING: University exercise laboratory. PARTICIPANTS: Fifty-two individuals with a history of stroke (aged 63±9; time since stroke, 57±54 months). INTERVENTION: Participants undertook 30 exercise sessions over 10 to 12 weeks. Depending on group allocation, individuals underwent aerobic cycling plus sham progressive resistance training (PRT) (n=13), sham cycling plus PRT (n=13), aerobic cycling plus PRT (n=14), or sham cycling plus sham PRT (n=12). MEASUREMENTS: Primary outcomes were 6-minute walk distance, habitual and fast gait velocities, and stair climbing power. Secondary outcomes included measures of cardiorespiratory fitness; muscle strength, power, and endurance; and psychosocial attributes. RESULTS: Neither AEROBIC nor STRENGTH improved walking distance or gait velocity significantly more than sham exercise, although STRENGTH significantly improved participants' stair climbing power by 17% (P=.009), as well as their muscle strength, power, and endurance; cycling peak power output; and self-efficacy. Conversely, AEROBIC improved indicators of cardiorespiratory fitness only. Cycling plus PRT produced larger effects than either single modality for mobility and impairment outcomes. CONCLUSION: Single-modality exercises targeted at existing impairments do not optimally address the functional deficits of walking but do ameliorate the underlying impairments. The underlying cardiovascular and musculoskeletal impairments are significantly modifiable years after stroke with targeted robust exercise. [source] THE INFLUENCE of FIELD STRENGTH, SUGAR and SOLID CONTENT ON ELECTRICAL CONDUCTIVITY of STRAWBERRY PRODUCTSJOURNAL OF FOOD PROCESS ENGINEERING, Issue 1 2003I. CASTRO ABSTRACT The effects of field strength, soluble solids (from 14 to 59.5 °Brix) and particle size (using two size distributions) on electrical conductivity were investigated. Electrical conductivity increased with temperature for all the products and conditions tested following linear or quadratic relations. Electrical conductivity was found to vary greatly between strawberry-based products. an increase of electrical conductivity with field strength was obvious for fresh strawberries and strawberry jelly but not for strawberry pulp, probably due to the presence of texturizing agents. This parameter decreases with the increase of solids and sugar content. For some of the formulations tested (solid content over 20% w/w and over 40 °Brix) a different design of ohmic heater may be necessary because of the low values of electrical conductivity. [source] COMPARING STRENGTHS OF DIRECTIONAL SELECTION: HOW STRONG IS STRONG?EVOLUTION, Issue 10 2004Joe Hereford Abstract The fundamental equation in evolutionary quantitative genetics, the Lande equation, describes the response to directional selection as a product of the additive genetic variance and the selection gradient of trait value on relative fitness. Comparisons of both genetic variances and selection gradients across traits or populations require standardization, as both are scale dependent. The Lande equation can be standardized in two ways. Standardizing by the variance of the selected trait yields the response in units of standard deviation as the product of the heritability and the variance-standardized selection gradient. This standardization conflates selection and variation because the phenotypic variance is a function of the genetic variance. Alternatively, one can standardize the Lande equation using the trait mean, yielding the proportional response to selection as the product of the squared coefficient of additive genetic variance and the mean-standardized selection gradient. Mean-standardized selection gradients are particularly useful for summarizing the strength of selection because the mean-standardized gradient for fitness itself is one, a convenient benchmark for strong selection. We review published estimates of directional selection in natural populations using mean-standardized selection gradients. Only 38 published studies provided all the necessary information for calculation of mean-standardized gradients. The median absolute value of multivariate mean-standardized gradients shows that selection is on average 54% as strong as selection on fitness. Correcting for the upward bias introduced by taking absolute values lowers the median to 31%, still very strong selection. Such large estimates clearly cannot be representative of selection on all traits. Some possible sources of overestimation of the strength of selection include confounding environmental and genotypic effects on fitness, the use of fitness components as proxies for fitness, and biases in publication or choice of traits to study. [source] ONE-YEAR TENSILE BOND STRENGTHS OF TWO SELF-ETCHING PRIMERS TO BOVINE ENAMELJOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY, Issue 4 2004John M. Powers PhD [source] A prelab tutoring system for Strength of Materials experimentCOMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 2 2004Chuin-Shan Chen Abstract We aim to resolve a long-standing problem on requiring students to study how to maneuver experiments before they actually conduct them in a laboratory. A prelab tutoring system for the Strength of Materials experiment is prototyped from desired outcomes. The tutoring system utilizes a game-like environment to engage students in learning. Consisting of highly interactive contents made by scalable vector graphics (SVGs), the system helps students to get acquainted with laboratory instruments as well as experimental procedures. The effectiveness and efficiency of the system have been confirmed through a survey among students. © 2004 Wiley Periodicals, Inc. Comput Appl Eng Educ 12: 98,105, 2004; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20004 [source] Data Preparation for Real-time High Quality Rendering of Complex ModelsCOMPUTER GRAPHICS FORUM, Issue 3 2006Reinhard Klein The capability of current 3D acquisition systems to digitize the geometry reflection behaviour of objects as well as the sophisticated application of CAD techniques lead to rapidly growing digital models which pose new challenges for interaction and visualization. Due to the sheer size of the geometry as well as the texture and reflection data which are often in the range of several gigabytes, efficient techniques for analyzing, compressing and rendering are needed. In this talk I will present some of the research we did in our graphics group over the past years motivated by industrial partners in order to automate the data preparation step and allow for real-time high quality rendering e.g. in the context of VR-applications. Strength and limitations of the different techniques will be discussed and future challenges will be identified. The presentation will go along with live demonstrations. [source] Reserved Strength of Reinforced Concrete Buildings with Masonry WallsCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 3 2005Nasreddin S. El Mezaini In this building, damage was limited to some cracks in the walls near the targeted zone. Other parts of the building remained intact. The building was analyzed using two different models. In one model, masonry walls were treated as nonstructural elements represented by applied loads. In the other model, walls were represented by membrane elements connected to concrete frames by link elements. Analysis was carried out for two cases, before and after damage. The study revealed that such buildings possess potential reserved strength. They have the ability to change their designated load path. The role of masonry walls is emphasized. In this case, masonry walls worked as a backup system that prevented major collapse of the building. It is estimated that, under normal conditions, masonry walls increase the building strength by 48%. [source] The effect of strength training on the force of twitches evoked by corticospinal stimulation in humansACTA PHYSIOLOGICA, Issue 2 2009T. J. Carroll Abstract Aim:, Although there is considerable evidence that strength training causes adaptations in the central nervous system, many details remain unclear. Here we studied neuromuscular responses to strength training of the wrist by recording electromyographic and twitch responses to transcranial magnetic stimulation (TMS) and cervicomedullary stimulation of the corticospinal tract. Methods:, Seventeen participants performed 4 weeks (12 sessions) of strength training for the radial deviator (RD) muscles of the wrist (n = 8) or control training without external load (n = 9). TMS recruitment curves were constructed from stimuli at five to eight intensities ranging between 15% below resting motor threshold and maximal stimulator output, both at rest and during isometric wrist extension (EXT) and RD at 10% and 50% of maximal voluntary contraction (MVC). Responses to weak TMS and cervicomedullary stimulation (set to produce a response of 10% maximal M wave amplitude during 10% MVC EXT contraction) were also compared at contraction strengths ranging from 10% to 75% MVC. Results:, Isometric strength increased following strength training (10.7% for the RD MVC, 8.8% for the EXT MVC), but not control training. Strength training also significantly increased the amplitude of TMS- and cervicomedullary-evoked twitches during low-force contractions. Increases in the force-generating capacity of the wrist extensor muscles are unlikely to account for this finding because training did not affect the amplitude of twitches elicited by supra-maximal nerve stimulation. Conclusion:, The data suggest that strength training induces adaptations that increase the net gain of corticospinal-motor neuronal projections to the trained muscles. [source] Variation among individual butterflies along a generalist,specialist axis: no support for the ,neural constraint' hypothesisECOLOGICAL ENTOMOLOGY, Issue 3 2007BRIAN WEE Abstract 1.,Degree of host specialisation was a continuous variable in a population of Edith's checkerspot butterfly (Euphydryas editha). A novel host, Collinsia torreyi, had been added to the diet in response to anthropogenic disturbance, and then abandoned prior to the current study. Butterflies either showed no preference or preferred their traditional host, Pedicularis semibarbata. 2.,Strength of preference for Pedicularis over Collinsia was measured in the field and used to estimate host specialisation of individual butterflies. Efficiency was estimated from the times taken by each insect to perform two tasks: (i) identification of a Pedicularis plant as a host, and (ii) successful initiation of oviposition after the decision to do so had been made. 3.,There was no clear trend for association between host specialisation and either measure of efficiency. Generalists were not slower than specialists at identifying Pedicularis as a host or at handling it after deciding to oviposit. 4.,Prior work indicated that generalists paid no detectable cost in terms of reduced discrimination among individuals of their preferred host species. 5.,In contrast to other species, generalist E. editha paid in neither time nor accuracy. Why then does the diet not expand? Behavioural adaptations to the traditional host caused maladaptations to the novel host and generated short-term constraints to evolutionary expansion of diet breadth. To date, however, no long-term constraints have been found in this system. In those traits investigated to date, increased adaptation to the novel host has not caused reduced adaptation to the traditional host. [source] Building Business Bench Strength,Reinventing Leadership DevelopmentEMPLOYMENT RELATIONS TODAY, Issue 1 2001Lois P. Frankel First page of article [source] Are Anorexia nervosa and bulimia nervosa separate disorders?EUROPEAN EATING DISORDERS REVIEW, Issue 1 2009Challenging the, transdiagnostic' theory of eating disorders Abstract Background Anorexia nervosa (AN) and bulimia nervosa (BN) are classified as separate and distinct clinical disorders. Recently, there has been support for a transdiagnostic theory of eating disorders, which would reclassify them as one disorder. Objective To determine whether AN and BN are a single disorder with one cause or separate disorders with different causes. Method Hill's Criteria of Causation were used to test the hypothesis that AN and BN are one disorder with a single cause. Hill's Criteria of Causation demand that the minimal conditions are needed to establish a causal relationship between two items which include all of the following: strength of association, consistency, temporality, biological gradient, plausibility, coherence, experimental evidence and analogy. Results The hypothesis that AN and BN have a single cause did not meet all of Hill's Criteria of Causation. Strength of association, plausibility, analogy and some experimental evidence were met, but not consistency, specificity, temporality, biological gradient, coherence and most experimental evidence. Conclusions The hypothesis that AN and BN are a single disorder with a common cause is not supported by Hill's Criteria of Causation. This argues against the notion of a transdiagnostic theory of eating disorders. Copyright © 2008 John Wiley & Sons, Ltd and Eating Disorders Association. [source] Enhanced Strength and Ductility of Ultrafine-Grained Ti Processed by Severe Plastic Deformation,ADVANCED ENGINEERING MATERIALS, Issue 8 2010Irina Semenova This work deals with the study of strength and ductility in ultrafine-grained (UFG) Ti Grade 4 produced by equal channel angular pressing (ECAP) in combination with subsequent thermomechanical treatments. We found that additional annealing of UFG Ti resulted in unusual enhancement of strength and ductility, which is associated with not only small grain size but also with a grain boundary structure. The origin of this phenomenon is investigated using the results of transmission electron microscopy and atom probe tomography. The innovation potential of UFG Ti for medical use is considered. [source] Microstructure and Compression Strength of Novel TRIP-Steel/Mg-PSZ Composites,ADVANCED ENGINEERING MATERIALS, Issue 12 2009Horst Biermann Abstract Novel composites on basis of austenitic stainless TRIP-steel as matrix with reinforcements of Mg-PSZ are presented. Compact rods were produced by cold isostatic pressing and sintering, square honeycomb samples by the ceramic extrusion technique. The samples are characterized by optical and scanning electron microscopy before and after deformation, showing the microstructure and the deformation- induced martensite formation. The mechanical properties of samples with 5,vol% zirconia are superior compared to zirconia-free samples and composites with higher zirconia contents in terms of bending and compression tests. The honeycomb samples exhibit extraordinary high specific energy absorption in compression. [source] High Strength (Ti58Ni28Cu8Si4Sn2)100,xMox Nanoeutectic Matrix,, -Ti Dendrite, BMG-Derived Composites with Enhanced Plasticity and Corrosion ResistanceADVANCED ENGINEERING MATERIALS, Issue 11 2009Hesham E. Khalifa Semi-solidly processed(Ti58Ni28Cu8Si4Sn2)100,xMox nanoeutectic matrix composites utilize a ductile dendritic , -Ti phase to achieve enhanced plasticity up to 15% total strain while maintaining fracture strengths up to 2300 MPa. The choice of Mo as the , -Ti stabilizer plays an important role in enhancing the work hardening exponent as well as the corrosion resistance in these alloys. [source] Lexical studies of Filipino person descriptors: adding personality-relevant social and physical attributesEUROPEAN JOURNAL OF PERSONALITY, Issue 4 2008Shellah Myra Imperio Abstract Lexical studies have focused on traits. In the Filipino language, we investigated whether additional dimensions can be identified when personality-relevant terms for social roles, statuses and effects, plus physical attributes, are included. Filipino students (N,=,496) rated themselves on 268 such terms, plus 253 markers of trait and evaluative dimensions. We identified 10 dimensions of social and physical attributes,Prominence, Uselessness, Attractiveness, Respectability, Uniqueness, Destructiveness, Presentableness, Strength, Dangerousness and Charisma. Most of these dimensions did not correspond in a one-to-one manner to Filipino or alternative trait models (Big Five, HEXACO, ML7). However, considerable redundancy was observed between the social and physical attribute dimensions and trait and evaluative dimensions. Thus, social and physical attributes communicate information about personality traits, and vice versa. Copyright © 2008 John Wiley & Sons, Ltd. [source] Effect of Hydrogen on Fatigue Strength of High-Strength Steels in the VHCF Regime,ADVANCED ENGINEERING MATERIALS, Issue 7 2009Yongde Li Diffusible hydrogen or non-diffusible hydrogen can decrease the fatigue strength of high-strength steels. The hydrogen influence factor f(C) describes the hydrogen damage level of fatigue strength. Fatigue strength decreases with increasing non-diffusible hydrogen content in the range 1 ppm,<,Ci,<,3.0,ppm. Fatigue strength decreases significantly with increasing diffusible hydrogen content in the range 1 ppm,<,Cr,<,3.0,ppm, but shows almost no obvious change in the range 3.0 ppm,<,Cr,<,10.0,ppm. [source] Impact of Recrystallization Defects on the High Temperature Strength of PM 3030ADVANCED ENGINEERING MATERIALS, Issue 1-2 2009Michel NganbeArticle first published online: 19 FEB 200 The paper focuses on the impact of recrystallization defects on material strength as well as potential optimizations of material properties and manufacturing process. Therefore, it can be of great interest for materials research and development, production and quality control in industry. [source] Improvement in the Specific Strength by Arranging Closed Pores in Fully Densified Zirconia Ceramics,ADVANCED ENGINEERING MATERIALS, Issue 1-2 2009Akira Kishimoto Superplastic-foamed porous ceramics containing numerous closed pores were fabricated. The bending strength of the fabricated ceramics with the smallest pores was close to half that of fully dense ones, even with a porosity of 27%. The smaller pores were introduced selectively between top and bottom surfaces. The resultant dense/porous/dense layered ceramics had a specific mechanical strength greater than that of monolithic dense ceramics. [source] The Optimal Grain Sized Nanocrystalline Ni with High Strength and Good Ductility Fabricated by a Direct Current Electrodeposition,ADVANCED ENGINEERING MATERIALS, Issue 6 2008X. Shen In this work, six pure Ni specimen which mean grain sizes spans a broad range from ultra-fine to nanometer were fabricated by direct current electrodeposition and a coarse grain Ni was obtained by annealing. A gradual transition of the crystallographic preferred orientation of the deposited Ni from (200) texture to isotropic or random orientation with decreasing the mean grain size was revealed by XRD. [source] The Effect of Intermetallic Compound on Shear Strength of Diffusion Soldered InterconnectionADVANCED ENGINEERING MATERIALS, Issue 3 2006J. Wojewoda The mechanical properties of diffusion soldered Cu/Cu interconnections were examined. Application of the indium-tin eutectic alloy as a solder material and different manufacturing temperatures resulted in creation of the intermetallics in the interconnection area. The calculated cross-sections of the Cu-In-Sn diagram combined with Scanning Electron Microscopy investigation allowed for the detailed description of the joints before the shear test and after it. [source] Enhanced Strength and Ductility in Ultrafine-Grained Aluminium Produced by Accumulative Roll Bonding,ADVANCED ENGINEERING MATERIALS, Issue 9 2004H.W. Höppel Due to a printing error in the Adv. Eng. Mater. 2004, 6, issue 4, this article, originally published on pages 219,222, had to be reprinted. Now the correct references are given to allow all readers the correct access to the literature. The editorial team apologizes for any inconveniences this may have caused. [source] Synthetic Hydrophilic Materials with Tunable Strength and a Range of Hydrophobic Interactions,ADVANCED FUNCTIONAL MATERIALS, Issue 14 2010Olha Hoy Abstract The ability to vary, adjust, and control hydrophobic interactions is crucial in manipulating interactions between biological objects and the surface of synthetic materials in aqueous environment. To this end a grafted polymer layer (multi-component mixed polymer brush) is synthesized that is capable of reversibly exposing nanometer-sized hydrophobic fragments at its hydrophilic surface and of tuning, turning on, and turning off the hydrophobic interactions. The reversible switching occurs in response to changes in the environment and alters the strength and range of attractive interactions between the layer and hydrophobic or amphiphilic probes in water. The grafted layer retains its overall hydrophilicity, while local hydrophobic forces enable the grafted layer to sense and attract the hydrophobic domains of protein molecules dissolved in the aqueous environment. The hydrophobic interactions between the material and a hydrophobic probe are investigated using atomic force microscopy measurements and a long-range attractive and contact-adhesive interaction between the material and the probe is observed, which is controlled by environmental conditions. Switching of the layer exterior is also confirmed via protein adsorption measurements. [source] Building Our Strength Through Languages: ACTFL 37th Annual Meeting and ExpositionFOREIGN LANGUAGE ANNALS, Issue 4 2003Article first published online: 31 DEC 200 First page of article [source] Going from Strength to StrengthFUEL CELLS, Issue 4 2007Deborah Jones No abstract is available for this article. [source] Increased Interface Strength in Carbon Fiber Composites through a ZnO Nanowire InterphaseADVANCED FUNCTIONAL MATERIALS, Issue 16 2009Yirong Lin Abstract One of the most important factors in the design of a fiber reinforced composite is the quality of the fiber/matrix interface. Recently carbon nanotubes and silicon carbide whiskers have been used to enhance the interfacial properties of composites; however, the high growth temperature degrade the fiber strength and significantly reduce the composite's in-plane properties. Here, a novel method for enhancing the fiber/matrix interfacial strength that does not degrade the mechanical properties of the fiber is demonstrated. The composite is fabricated using low-temperature solution-based growth of ZnO nanowires on the surface of the reinforcing fiber. Experimental testing shows the growth does not adversely affect fiber strength, interfacial shear strength can be significantly increased by 113%, and the lamina shear strength and modulus can be increased by 37.8% and 38.8%, respectively. This novel interface could also provide embedded functionality through the piezoelectric and semiconductive properties of ZnO. [source] Impact of the Alcohol-Dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese,HUMAN MUTATION, Issue 5 2007Keitaro Matsuo Abstract A linkage disequilibrium (LD) between the alcohol-dehydrogenase 1B (ADH1B) and alcohol-dehydrogenase 1C (ADH1C) polymorphisms adds complexity to differentiating the significance of these two genetic polymorphisms on drinking behavior and alcoholism. We have recently shown the importance of the ADH1B polymorphism on habitual drinking in the Japanese population; however, the issue regarding the LD between the ADH1B and ADH1C polymorphisms remains to be clarified. Here, we conducted a cross-sectional study in 2,299 nonalcoholic Japanese individuals. Drinking behavior was examined with regard to haplotypes of the ADH1B and ADH1C polymorphisms. Strength of association was assessed by sex and aldehyde-dehydrogenase 2 (ALDH2) adjusted odds ratios (OR) and their 95% confidence intervals (CIs) for the haplotype of the ADH1B and ADH1C polymorphisms. The ORs for habitual drinking were significant for ADH1B*2(rapid)- ADH1C*2(slow) (OR = 1.03; 95% CI: 1.01,1.05), ADH1B*1(slow)- ADH1C*1(rapid) (OR = 1.15; 95% CI: 1.14,1.16), and ADH1B*1(slow)- ADH1C*2(slow) (OR = 1.31; 95% CI: 1.29,1.32) compared with ADH1B*2(rapid)- ADH1C*1(rapid). This trend was evident among males. Similarly, a significantly increased risk of heavy drinking was observed for each haplotype compared with ADH1B*2(rapid)- ADH1C*1(rapid). In conclusion, this study showed a significant impact of the ADH1C polymorphism on habitual drinking, regardless of the ADH1B/ALDH2 polymorphisms. Hum Mutat 28(5), 506,510, 2007. © 2007 Wiley-Liss, Inc. [source] | ||||||||||||||||||||||||||||||||||||||||