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Strategic Position (strategic + position)
Selected AbstractsIndexing, cointegration and equity market regimesINTERNATIONAL JOURNAL OF FINANCE & ECONOMICS, Issue 3 2005Carol Alexander Abstract This paper examines, from a market efficiency perspective, the performance of a simple dynamic equity indexing strategy based on cointegration. A consistent ,abnormal' return in excess of the benchmark is demonstrated over different time horizons and in different real world and simulated stock markets. A measure of stock price dispersion is shown to be a leading indicator for the abnormal return and their relationship is modelled as a Markov switching process of two market regimes. We find that the entire abnormal return is associated with the high volatility regime as the indexing model implicitly adopts a strategic position that pays off during market crashes, whilst effectively tracking the benchmark in normal market circumstances. Therefore we find no evidence of market inefficiency. Nevertheless our results have implications for equity fund managers: we show how, without any stock selection, solely through a smart optimization that has an implicit element of market timing, the benchmark performance can be significantly enhanced. Copyright © 2005 John Wiley & Sons, Ltd. [source] Strategic decision-making in healthcare organizations: it is time to get serious,INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT, Issue 3 2006David W. Young Abstract New and continuing environmental demands and competitive forces require healthcare organizations to be increasingly careful in thinking about their strategies. They must do so in a highly unusual (multi-actor) marketplace where a variety of system interdependencies complicate decision-making. A good strategy requires an attempt to understand the real, as distinct from the perceived, environment, and is characterized by explicit tradeoffs along three dimensions: service or program variety, patient needs, and patient access. The quality of these tradeoffs can be assessed in terms of whether the strategy is (a) attuned to critical success factors in the organization's environment, (b) highly focused, (c) linked to the organization's capabilities, and (d) accompanied by an activity set that is difficult for competitors to imitate. An organization also must be capable of adapting appropriately to changes in its environment. Thus, even the best strategy must be reviewed constantly if it is to remain viable. A strategy's sustainability can be adversely affected by increased buyer or supplier power, lowered barriers to entry, growing rivalry, the threat of substitutes, and increased slack in resource usage. By thinking more creatively in the future than they have in the past, healthcare organizations can make tradeoffs and choose a focused strategic position. They then can design an activity set that is appropriate for that position, and that will assist them to achieve both financial viability and superior programmatic performance. A well-designed activity set also will assist them to sustain their performance in the face of changing environmental demands and competitive forces. Copyright © 2006 John Wiley & Sons, Ltd. [source] The Origins of American Power in Iraq, 1941,1945PEACE & CHANGE, Issue 3 2009Christopher O'Sullivan Utilizing archival sources in both the United States and Britain to describe the changes in American policy in Iraq during World War II, and tracing the emergence of the United States as an important factor in Iraq's politics and history, the authors challenge the notion that the United States was a passive bystander to events there during the war. Washington initially followed the British lead, but, beginning in 1942, the United States became more assertive in its relations with Iraq, with American diplomats, State Department officials, postwar planners, and intelligence officers promoting the ideals of the Atlantic Charter while simultaneously aiming to secure Iraq's petroleum and tying it into a network of Western alliances. Iraq's vital strategic position and its rich petroleum resources made it an important part, along with Saudi Arabia and Iran, of the American effort to secure, militarily and economically, the oil-rich Gulf region for the West in the postwar era. [source] An exploratory comparison of the management of innovation in the New and Old economiesR & D MANAGEMENT, Issue 5 2003Serghei Floricel This paper uses a combination of grounded theorising and exploratory quantitative analysis to compare the patterns of organising and managing innovation in the New and Old Economies. The results show that firms in the NE put in place structures and processes that give the R&D function a more strategic position, link it directly to customers and accelerate innovation throughput inside the firm. [source] The Durability of Managed Rivalry: Iran's Relations with Russia and the Saudi DimensionASIAN POLITICS AND POLICY, Issue 1 2009Mahjoob Zweiri Russia's Middle East policy faces a dilemma. On the one hand, Moscow maintains close, although frequently terse, ties with Iran, playing an important role in Iran's nuclear program and even using its position in the United Nations to shield Iran from harsh sanctions. In return, Moscow profits from the sales of arms and nuclear expertise, participates in Iran's energy sector, and may establish valuable cooperation on gas exports, both being obvious suppliers to the lucrative Western European market. On the other hand, Russia is also seeking to strengthen ties with Iran's neighbors, such as Saudi Arabia and Israel, many of whom see Tehran as the major threat to any nonproliferation regime in the region and recognize that Russian cooperation has increased the likelihood that Iran will acquire nuclear weapons. The impact on Russia's relationship with Saudi Arabia may be especially important to planners in Moscow. Saudi Arabia appears to be an increasingly willing client for Russian arms (and possibly also nuclear expertise), and Russia may value close relations with the next biggest oil exporter in the world. In the present study, we examine Russia's recent relations with Iran and Saudi Arabia and assess Russia's strategic position regarding the two countries. At the current time, Russia, as a permanent member of the U.N. Security Council and the primary source of technical cooperation with Tehran on the nuclear issue, is at the center of developments in the Middle East. How Moscow assesses its position in the Middle East, and whether it ultimately wishes to prioritize Riyadh or Tehran, could be central to the future stability of the region. [source] Alterations in connexin expression in the bladder of patients with urge symptomsBJU INTERNATIONAL, Issue 4 2005Jochen Neuhaus OBJECTIVE To compare the formation of gap junctions between detrusor smooth muscle cells in situ and the distribution of connexin (Cx)40, Cx43 and Cx45 expressions in bladder biopsies from a control group (with bladder tumour) and from patients with urge symptoms, as smooth muscle cells of the human detrusor muscle communicate via gap junctions and express several connexin subtypes, alterations of which may be involved in the causes of lower urinary tract symptoms. MATERIALS AND METHODS Connexin expression is prominent in myofibroblast-like cells, supposedly involved in afferent signalling pathways of the bladder. Their strategic position directly beneath the urothelium suggests they are a link between urothelial ATP signalling during bladder filling and afferent A,-fibre stimulation for co-ordination of bladder tonus and initialization of the micturition reflex. Modification of their coupling characteristics may have profound impact on bladder sensation. Bladder tissue probes of patients undergoing cystectomy or transurethral tumour resection for bladder cancer were used as controls. Tissue samples from patients with severe idiopathic urge symptoms were taken for exclusion diagnostics of interstitial cystitis (IC) and carcinoma in situ. The formation of functional syncytia between detrusor smooth muscle cells were examined in dye-coupling experiments by injecting with Lucifer Yellow. The morphology and structure of gap junctions were assessed by transmission electron microscopy and immunogold labelling of Cx43 and Cx45. The expression of connexin subtypes Cx40, Cx43 and Cx45 was compared by indirect immunofluorescence, and confocal laser scanning microscopy used for semiquantitative analysis. RESULTS There was dye coupling between smooth muscle cells of the detrusor in situ. Electron microscopy and immunogold labelling showed very small gap junctional plaques. These findings were confirmed by confocal immunofluorescence. Semiquantitative analyses showed significantly higher Cx43 expression in the detrusor muscle, and a tendency to higher Cx45 expression in the suburothelial layer associated with urge symptoms, whereas Cx40 expression was unaffected. CONCLUSIONS Smooth muscle cells of the human detrusor muscle are coupled by classical gap junctions, forming limited local functional syncytia. Both Cx43 and Cx45 are expressed at low levels in normal detrusor. Up-regulation of Cx43 in patients with urge incontinence supports the possibility of functional changes in the syncytial properties of detrusor smooth muscle cells in this condition. In addition, the observed increase of Cx45 in the myofibroblast cell layer supports the idea that alterations in sensory signalling are also involved. Comparison with previous reports implies that the pathophysiology of urgency is distinct from that of the unstable bladder and other forms of incontinence. [source] On Strategy and Management Control: The Importance of Classifying the Strategy of the BusinessBRITISH JOURNAL OF MANAGEMENT, Issue 3 2000Magnus Kald The point of departure for this paper is a number of contingency-theory studies on the relationship between business strategy and the design and use of management control. In these studies strategy has been operationalized in different ways , a major reason why the findings are ambiguous and difficult to integrate. Thus there is a strong need for a common frame of reference for classifying business strategy. In view of the multifaceted nature of the concept of strategy, however, it is neither desirable nor possible to arrive at a single method of classification that would be appropriate in all situations. Rather, the task is to integrate different strategic variables such as strategic pattern, strategic position and strategic mission. In this paper we show how these three variables may be assumed to influence, and be influenced by, what characterizes changes in strategy and how business units manage their product offerings. Unlike most previous studies in the field, this paper discusses how the strategic variables taken together may be assumed to influence the classification of strategy and thus the design and use of the management-control system. Our deductive analysis, and the hypotheses used in connection with it, show that studies which consider only one strategic variable may lead to erroneous conclusions about the relationship between strategy and management control. [source] 4212: Protective role of xanthophyllsACTA OPHTHALMOLOGICA, Issue 2010N ACAR Xanthophylls, also known as carotenoids are a group of natural fat-soluble pigments that are especially abundant in green and yellow-orange fruits and vegetables. Based on epidemiologic data, it is now evident that carotenoids provide health benefits and particularly in eye diseases. Molecular characterization of retinal carotenoids has shown that there were actually two xanthophylls that are concentrated in macular region, namely lutein and zeaxanthin. Thanks to a strategic position within inner retinal layers, lutein and zeaxanthin are suspected to act as antioxidants in the retina in order to limit oxidative stress that results from metabolism of light. In addition, they are also supposed to absorb blue light that enters the eye prior to its reaching the delicate functional structures including the photoreceptors and the retinal pigment epithelial cells. The aim of this paper is to summarize the knowledge about the biological mechanisms of the protective role of macular xanthophylls. [source] The practice of travel medicine in EuropeCLINICAL MICROBIOLOGY AND INFECTION, Issue 3 2010P. Schlagenhauf Clin Microbiol Infect 2010; 16: 203,208 Abstract Europe, because of its geographical location, strategic position on trade routes, and colonial past, has a long history of caring for travellers' health. Within Europe, there is great diversity in the practice of travel medicine. Some countries have travel medicine societies and provisions for a periodic distribution of recommendations, but many countries have no national pre-travel guidelines and follow international recommendations such as those provided by the WHO. Providers of travel medicine include tropical medicine specialists, general practice nurses and physicians, specialist ,travel clinics', occupational physicians, and pharmacists. One of the core functions of the European Centre for Disease Prevention and Control-funded network of travel and tropical medicine professionals, EuroTravNet, is to document the status quo of travel medicine in Europe. A three-pronged approach is used, with a real-time online questionnaire, a structured interview with experts in each country, and web searching. [source] Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricinFEBS JOURNAL, Issue 17 2002Goran Kragol Members of the proline-rich antibacterial peptide family, pyrrhocoricin, apidaecin and drosocin appear to kill responsive bacterial species by binding to the multihelical lid region of the bacterial DnaK protein. Pyrrhocoricin, the most potent among these peptides, is nontoxic to healthy mice, and can protect these animals from bacterial challenge. A structure,antibacterial activity study of pyrrhocoricin against Escherichia coli and Agrobacterium tumefaciens identified the N-terminal half, residues 2,10, the region responsible for inhibition of the ATPase activity, as the fragment that contains the active segment. While fluorescein-labeled versions of the native peptides entered E. coli cells, deletion of the C-terminal half of pyrrhocoricin significantly reduced the peptide's ability to enter bacterial or mammalian cells. These findings highlighted pyrrhocoricin's suitability for combating intracellular pathogens and raised the possibility that the proline-rich antibacterial peptides can deliver drug leads into mammalian cells. By observing strong relationships between the binding to a synthetic fragment of the target protein and antibacterial activities of pyrrhocoricin analogs modified at strategic positions, we further verified that DnaK was the bacterial target macromolecule. Inaddition, the antimicrobial activity spectrum of native pyrrhocoricin against 11 bacterial and fungal strains and the binding of labeled pyrrhocoricin to synthetic DnaK D-E helix fragments of the appropriate species could be correlated. Mutational analysis on a synthetic E. coli DnaK fragment identified a possible binding surface for pyrrhocoricin. [source] Total Syntheses in Solution of TOAC-Labelled Alamethicin F50/5 AnaloguesCHEMISTRY & BIODIVERSITY, Issue 6 2007Cristina Peggion Abstract Total syntheses in solution of a set of four selected analogues of the 19-mer component F50/5 of alamethicin, the most extensively studied among the channel-former peptaibol antibiotics, are planned and reported. All analogues bear three Glu(OMe) residues, replacing the Gln residues at positions 7, 18, and 19 of the naturally occurring compound. Three analogues are mono-labelled with the free-radical-containing amino acid residue TOAC at the strategic positions 1, 8, or 16. The fourth analogue is bis-labelled with the same EPR-active residue at both positions,1 and 16. In the native sequence, all of the positions where TOAC replacements have been introduced are characterized by residues of Aib, the prototype of the class of helicogenic C, -tetrasubstituted , -amino acids. All of the TOAC analogues synthesized exhibit significant membrane-modifying properties. [source] | |||||||||||||||||||