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Stochastic Orders (stochastic + order)

Distribution by Scientific Domains
Mathematics and Statistics100%

Selected Abstracts

Testing Marginal Homogeneity Against Stochastic Order in Multivariate Ordinal Data

BIOMETRICS, Issue 2 2009
B. Klingenberg
Summary Many assessment instruments used in the evaluation of toxicity, safety, pain, or disease progression consider multiple ordinal endpoints to fully capture the presence and severity of treatment effects. Contingency tables underlying these correlated responses are often sparse and imbalanced, rendering asymptotic results unreliable or model fitting prohibitively complex without overly simplistic assumptions on the marginal and joint distribution. Instead of a modeling approach, we look at stochastic order and marginal inhomogeneity as an expression or manifestation of a treatment effect under much weaker assumptions. Often, endpoints are grouped together into physiological domains or by the body function they describe. We derive tests based on these subgroups, which might supplement or replace the individual endpoint analysis because they are more powerful. The permutation or bootstrap distribution is used throughout to obtain global, subgroup, and individual significance levels as they naturally incorporate the correlation among endpoints. We provide a theorem that establishes a connection between marginal homogeneity and the stronger exchangeability assumption under the permutation approach. Multiplicity adjustments for the individual endpoints are obtained via stepdown procedures, while subgroup significance levels are adjusted via the full closed testing procedure. The proposed methodology is illustrated using a collection of 25 correlated ordinal endpoints, grouped into six domains, to evaluate toxicity of a chemical compound. [source]

Stochastic Orders by M. Shaked and J. G. Shantikumar

BIOMETRICS, Issue 2 2007
Subhash Kochar
No abstract is available for this article. [source]

Testing Marginal Homogeneity Against Stochastic Order in Multivariate Ordinal Data

BIOMETRICS, Issue 2 2009
B. Klingenberg
Summary Many assessment instruments used in the evaluation of toxicity, safety, pain, or disease progression consider multiple ordinal endpoints to fully capture the presence and severity of treatment effects. Contingency tables underlying these correlated responses are often sparse and imbalanced, rendering asymptotic results unreliable or model fitting prohibitively complex without overly simplistic assumptions on the marginal and joint distribution. Instead of a modeling approach, we look at stochastic order and marginal inhomogeneity as an expression or manifestation of a treatment effect under much weaker assumptions. Often, endpoints are grouped together into physiological domains or by the body function they describe. We derive tests based on these subgroups, which might supplement or replace the individual endpoint analysis because they are more powerful. The permutation or bootstrap distribution is used throughout to obtain global, subgroup, and individual significance levels as they naturally incorporate the correlation among endpoints. We provide a theorem that establishes a connection between marginal homogeneity and the stronger exchangeability assumption under the permutation approach. Multiplicity adjustments for the individual endpoints are obtained via stepdown procedures, while subgroup significance levels are adjusted via the full closed testing procedure. The proposed methodology is illustrated using a collection of 25 correlated ordinal endpoints, grouped into six domains, to evaluate toxicity of a chemical compound. [source]

Preservation of stochastic orders for random minima and maxima, with applications

NAVAL RESEARCH LOGISTICS: AN INTERNATIONAL JOURNAL, Issue 3 2004
Xiaohu Li
Abstract It is shown, in this note, that the right spread order and the increasing convex order are both preserved under the taking of random maxima, and the total time on test transform order and the increasing concave order are preserved under the taking of random minima. Some inequalities and preservation properties in reliability and economics are given as applications. © 2003 Wiley Periodicals, Inc. Naval Research Logistics, 2004. [source]

Properties of some stochastic orders: A unified study

NAVAL RESEARCH LOGISTICS: AN INTERNATIONAL JOURNAL, Issue 2 2004
Taizhong Hu
Abstract The notions of the likelihood ratio order of degree s (s , 0) are introduced for both continuous and discrete integer-valued random variables. The new orders for s = 0, 1, and 2 correspond to the likelihood ratio, hazard rate, and mean residual life orders. We obtain some basic properties of the new orders and their up shifted stochastic orders, and derive some closure properties of them. Such a study is meaningful because it throws an important light on the understanding of the properties of the likelihood ratio, hazard rate, and mean residual life orders. On the other hand, the properties of the new orders have potential applications. © 2003 Wiley Periodicals, Inc. Naval Research Logistics, 2004. [source]