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Solid-phase Reaction (solid-phase + reaction)
Selected AbstractsSolid-phase reactions as approach to the synthesis of organic compounds labelled with tritium,JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 9-10 2007Nikolay F. Myasoedov Abstract The solid-phase method for hydrogenolysis, hydrogenation and isotope exchange reactions is described. Its potential for tritium labelling of organic compounds including lipids, nucleotides, amino acids, peptides and pharmaceuticals is demonstrated. The influence of the reaction conditions on the yield and specific radioactivity of the labelled compounds is considered. It is shown that results can be interpreted by the dependence of tritium spillover reactions on the nature of the initial compound and other factors. Copyright © 2007 John Wiley & Sons, Ltd. [source] Synthesis of TiSe2 Nanotubes/Nanowires,ADVANCED MATERIALS, Issue 16 2003J. Chen The family of layered metal dichalcogenide nanomaterials has been enlarged with the successful preparation of TiSe2 nanotubes/ nanowires (see Figure). A solid-phase reaction is described and the characterization of the product,by X-ray diffraction, scanning and transmission electron microscopy, and Raman measurements,detailed. [source] Solid-phase incorporation of gaseous carbon dioxide into oxirane-containing copolymersJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 15 2004Bungo Ochiai Abstract Carbon dioxide was incorporated into poly(glycidyl methacrylate- co -methyl methacrylate) by a solid-phase reaction, which transformed the pendent oxirane moieties into cyclic carbonate moieties, with quaternary ammonium halide catalysts. The incorporation of carbon dioxide into the copolymer led to soluble carbonate-containing polymers, whereas the incorporation of carbon dioxide into the glycidyl methacrylate homopolymer produced an insoluble product. The copolymer composition, reaction temperature, and catalyst amount affected the incorporation efficiency and the side reaction that caused crosslinking. Effective incorporation was achieved under the following reaction conditions: the glycidyl methacrylate content was less than approximately 50%, the temperature was greater than the glass-transition temperature, and the catalyst concentration was 1.5,6 mol %. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 3812,3817, 2004 [source] From Solution-Phase to Solid-Phase Enyne Metathesis: Crossover in the Relative Performance of Two Commonly Used Ruthenium Pre-CatalystsCHEMISTRY - A EUROPEAN JOURNAL, Issue 17 2005Dominic E. A. Brittain Dr. Abstract A crossover in the ability of two distinct ruthenium-based metathesis pre-catalysts to effect the synthesis of dialkenylboronic esters in solution and on the solid-phase was observed. Specifically, while the Grubbs 2nd generation pre-catalyst 3 affords a greater degree of conversion to product than the Hoveyda,Grubbs pre-catalyst 2 in a solution-phase enyne-metathesis reaction, this trend is reversed in the solid-phase variant. Systematic investigation showed this trend to be general, regardless of variations in the homoallylic alcohol and alkynylboronic ester components of the reaction, as well as in the type of solid support employed. Experiments to determine a mechanistic hypothesis for this trend highlighted the significance of the ruthenium remaining bound to the substrate after metathetic rearrangement and found the presence of phosphine ligand to be detrimental to the success of the solid-phase reaction. Therefore, these results suggest an expanded role for phosphine-free pre-catalysts, such as 2, in challenging solid-phase metathesis reactions. [source] | |||||||||||||