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Medical Sciences40%

Selected Abstracts

Molecular imaging: The latest generation of contrast agents and tissue characterization techniques

JOURNAL OF CELLULAR BIOCHEMISTRY, Issue 3 2003
Francis G. BlankenbergArticle first published online: 25 AUG 200
Abstract Molecular Imaging technologies will have a profound impact on both basic research and clinical imaging in the near future. As the field covers many different specialties and scientific disciplines it is not possible to review all in a single article. In the current article we will turn our attention to those modalities that are either currently in use or in development for the medical imaging clinic. © 2003 Wiley-Liss, Inc. [source]

Complications of type 1 diabetes: new molecular findings

MOUNT SINAI JOURNAL OF MEDICINE: A JOURNAL OF PERSONALIZED AND TRANSLATIONAL MEDICINE, Issue 4 2008
Alin Stirban MD
Abstract Interventions targeting the treatment of diabetic complications have not been nearly as successful as initially estimated, despite a marked improvement in therapeutic options for diabetes. The need for understanding why some very promising interventions have failed demands a closer look at the pathomechanisms of the complications. Great strides have been made in understanding the pathology, and several important hypotheses have emerged in recent years. On this basis, Brownlee and coworkers suggested a unifying hypothesis integrating various mechanisms discussed in past years with an overproduction of reactive oxygen species as an initiating cause. This hypothesis and further hypotheses, as well as mechanisms, are highlighted in this article. The field of pathomechanisms of diabetic complications is very wide, and any attempt to completely cover it within a single article is unrealistic. Therefore, our purpose is to present the most relevant concepts underlying diabetic complications in an attempt to contribute to a better understanding and pinpoint areas that warrant further research. Mt Sinai J Med 75:328,351, 2008. © 2008 Mount Sinai School of Medicine [source]

Twenty-five pitfalls in the analysis of diffusion MRI data,

NMR IN BIOMEDICINE, Issue 7 2010
Derek K. Jones
Abstract Obtaining reliable data and drawing meaningful and robust inferences from diffusion MRI can be challenging and is subject to many pitfalls. The process of quantifying diffusion indices and eventually comparing them between groups of subjects and/or correlating them with other parameters starts at the acquisition of the raw data, followed by a long pipeline of image processing steps. Each one of these steps is susceptible to sources of bias, which may not only limit the accuracy and precision, but can lead to substantial errors. This article provides a detailed review of the steps along the analysis pipeline and their associated pitfalls. These are grouped into 1 pre-processing of data; 2 estimation of the tensor; 3 derivation of voxelwise quantitative parameters; 4 strategies for extracting quantitative parameters; and finally 5 intra-subject and inter-subject comparison, including region of interest, histogram, tract-specific and voxel-based analyses. The article covers important aspects of diffusion MRI analysis, such as motion correction, susceptibility and eddy current distortion correction, model fitting, region of interest placement, histogram and voxel-based analysis. We have assembled 25 pitfalls (several previously unreported) into a single article, which should serve as a useful reference for those embarking on new diffusion MRI-based studies, and as a check for those who may already be running studies but may have overlooked some important confounds. While some of these problems are well known to diffusion experts, they might not be to other researchers wishing to undertake a clinical study based on diffusion MRI. Copyright © 2010 John Wiley & Sons, Ltd. [source]

Literature, Pornography, and Libertine Education

ORBIS LITERARUM, Issue 1 2004
Jørgen Dines Johansen
The objective of this article is not to write an apology for pornography, not because it is impossible to defend, but rather because it has been done so brilliantly by Susan Sontag in her seminal essay ,,The Pornographic Imagination''.1 The objective is to analyze a certain kind of literary pornography from both literary and psychological, here psychoanalytic, points of view. The term covers, basically, pictorial and literary representations of sexual activities. Literary pornography has been cultivated in drama, poetry, and prose fiction, whether short stories or novels. Furthermore, there are representations of sexual activities in the visual arts and literature considered great by any artistic standard, and then there is a tremendous lot of mere trash. Finally, pornography is not something given once and for all, but a designation used relative to the norms of a given group at a given time. Much of what our great-grandparents, grandparents, and even our parents considered pornographic, seems to most of us today endowed with a certain innocence and sentimentality. To encompass all the facets of this subject in a single article is impossible. This essay considers a certain aspect of genre convention: pornography presented in a framework of education. [source]

The posthumous impact of Paul Drude,

ANNALEN DER PHYSIK, Issue 7-8 2006
M. Cardona
Abstract In this study the long-term impact of the works of Paul Drude has been analyzed by bibliometric methods. His overall citation impact and rank within the pre-1910 authors in chemistry and physics has been determined. The time-dependent number of mentions of his name, the overall citation impact and the citation numbers of single articles and books have been investigated. The impact time curves of his most frequently cited articles and books are presented and discussed. The scientific contributions of the most influential Drude works for solid state physics are analyzed, in particular their impact on recent research. [source]