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Significant Trend (significant + trend)
Selected AbstractsA Theoretical Model for the Myogenic Response Based on the Length,Tension Characteristics of Vascular Smooth MuscleMICROCIRCULATION, Issue 4 2005BRIAN E. CARLSON ABSTRACT Objective: A theoretical model is developed to describe the myogenic response of resistance vessels to changes in intravascular pressure, based on a consideration of the active and passive length,tension characteristics of vascular smooth muscle (VSM). The dependence of model parameters on vessel diameter is examined. Methods: The vessel wall is represented mechanically as a nonlinear passive component in parallel with an active contractile component. The level of VSM tone is assumed to have a sigmoidal dependence on circumferential wall tension or stress. Model parameters are optimized for each of 18 independent experimental data sets previously obtained using pressure or wire myograph systems. Results: Close fits between model predictions and experimental data are found in each case. An alternative formulation in which VSM tone depends on circumferential wall stress is found also to be consistent with available data. Significant trends in model parameters as a function of diameter are found. Conclusions: The results support the hypothesis that circumferential tension or stress in the wall provides the signal for myogenic responses. The model provides a basis for simulating steady-state myogenic responses in vascular networks containing a range of vessel diameters. [source] Cancer mortality among French nuclear contract workersAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 12 2009Sylvie Guérin PhD Abstract Background Nuclear workers from French contracting companies have received higher doses than workers from Electricité de France (EDF) or Commissariat à l'Energie Atomique (CEA). Methods A cohort study of 9,815 workers in 11 contracting companies, monitored for exposure to ionizing radiation between 1967 and 2000 were followed up for a median duration of 12.5 years. Standardized mortality ratios (SMRs) were computed. Results Between 1968 and 2002, 250 deaths occurred. Our study demonstrated a clear healthy worker effect (HWE) with mortality attaining half that expected from national mortality statistics (SMR,=,0.54, 95% CI,=,[0.47,0.61]). The HWE was lower for all cancers (SMR,=,0.65) than for non-cancer deaths (SMR,=,0.46). The analysis by cancer site showed no excess compared with the general population. Significant trends were observed according to the level of exposure to ionizing radiation for deaths from cancer, deaths from digestive cancer and deaths from respiratory cancer. Conclusions The mortality of nuclear workers from contracting companies is very low compared to French national mortality. Am. J. Ind. Med. 52:916,925, 2009. © 2009 Wiley-Liss, Inc. [source] The spatial epidemiology of cocaine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) use: a demonstration using a population measure of community drug load derived from municipal wastewaterADDICTION, Issue 11 2009Caleb J. Banta-Green ABSTRACT Aims To determine the utility of community-wide drug testing with wastewater samples as a population measure of community drug use and to test the hypothesis that the association with urbanicity would vary for three different stimulant drugs of abuse. Design and participants Single-day samples were obtained from a convenience sample of 96 municipalities representing 65% of the population of the State of Oregon. Measurements Chemical analysis of 24-hour composite influent samples for benzoylecgonine (BZE, a cocaine metabolite), methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA). The distribution of community index drug loads accounting for total wastewater flow (i.e. dilution) and population are reported. Findings The distribution of wastewater-derived drug index loads was found to correspond with expected epidemiological drug patterns. Index loads of BZE were significantly higher in urban areas and below detection in many rural areas. Conversely, methamphetamine was present in all municipalities, with no significant differences in index loads by urbanicity. MDMA was at quantifiable levels in fewer than half the communities, with a significant trend towards higher index loads in more urban areas. Conclusion This demonstration provides the first evidence of the utility of wastewater-derived community drug loads for spatial analyses. Such data have the potential to improve dramatically the measurement of the true level and distribution of a range of drugs. Drug index load data provide information for all people in a community and are potentially applicable to a much larger proportion of the total population than existing measures. [source] Climate change and abundance of the Atlantic-Iberian sardine (Sardina pilchardus)FISHERIES OCEANOGRAPHY, Issue 2 2004C. Guisande Abstract Climatic warming is affecting oceanic circulation patterns in coastal upwelling areas, but the impact of this climatic change on pelagic fish populations remains unclear. From juvenile landings collected over 38 years, the thresholds of environmental factors were determined that limited the optimal environmental window (OEW) for sardine (Sardina pilchardus recruitment success in the northwestern Iberian peninsula. The environmental factors considered were: water column stability in February, offshore water transport in March,April (QxMA), upwelling intensity in the preceding year from May to August (QxMJJA), and the winter North Atlantic Oscillation (NAO) index. From 1875 to the mid-1920s, the mean number of years within the OEW was relatively constant. However, since the mid-1920s, there have been oscillations and alternating decades with high and low number of years within the OEW, which were related to oscillations in sardine landings. From 1906 to 2000, there were four record, low sardine catches in the 1920s, 1950s, 1970s and 1990s, related to a high number of successive years with prevailing conditions out of the OEW. From 1875 to the present, a high year-to-year variation of the NAO, QxMJJA and water stability in February was observed, although with mean values usually within the OEW. The collapse in the 1950s was related, partly, to successive years with low QxMJJA. Successive years with high NAO values may be related to the collapse of the sardine fishery in the 1990s. QxMA has been the most significant factor controlling SRS in this area, being the factor related to the low catches observed in the 1920s, 1950s and 1970s. Water stability was not responsible for any of the collapses observed, but since the 1920s, there has been a significant trend toward decreasing water column stability before the onset of the spring bloom. [source] Annual cycle and inter-annual variability of gross primary production and ecosystem respiration in a floodprone river during a 15-year periodFRESHWATER BIOLOGY, Issue 5 2006URS UEHLINGER Summary 1. Temporal variation in ecosystem metabolism over a 15-year period (1986,2000) was evaluated in a seventh order channelised gravel bed river (mean annual discharge 48.7 m3 s,1) of the Swiss Plateau. The river is subject to frequent disturbance by bed-moving spates. Daily integrals of gross primary production (GPP) and ecosystem respiration (ER) were calculated based on single-station diel oxygen curves. 2. Seasonal decomposition of the time series of monthly metabolism rates showed that approximately 50% of the variation of GPP and ER can be attributed to season. Annual GPP averaged 5.0 ± 0.6 g O2 m,2 day,1 and showed no long-term trend. 3. Ecosystem respiration, averaging 6.2 ± 1.4 g O2 m,2 day,1, declined from 8.8 to 4.1 g O2 m,2 day,1 during the 15-year period. This significant trend paralleled a decline in nitrate and soluble reactive phosphorus concentrations, and the biochemical oxygen demand discharged by sewage treatment facilities upstream of the study reach. The ratio of GPP to ER (P/R) increased from 0.53 to about 1 as consequence of ER reduction. 4. Bed moving spates reduced GPP by 49% and ER by 19%. Postspate recovery of GPP was rapid between spring and autumn and slow during winter. Recovery of ER lacked any seasonal pattern. Annual patterns of daily GPP and to a minor extent of daily ER can be described as a sequence of recovery periods frequently truncated by spates. 5. The study showed that disturbance by frequent bed-moving spates resulted in major stochastic variation in GPP and ER but annual patterns were still characterised by a distinct seasonal cycle. It also became evident that stream metabolism is a suitable method to assess effects of gradual changes in water quality. [source] Large-scale pattern of biomass partitioning across China's grasslandsGLOBAL ECOLOGY, Issue 2 2010Yuanhe Yang ABSTRACT Aim, To investigate large-scale patterns of above-ground and below-ground biomass partitioning in grassland ecosystems and to test the isometric theory at the community level. Location, Northern China, in diverse grassland types spanning temperate grasslands in arid and semi-arid regions to alpine grasslands on the Tibetan Plateau. Methods, We investigated above-ground and below-ground biomass in China's grasslands by conducting five consecutive sampling campaigns across the northern part of the country during 2001,05. We then documented the root : shoot ratio (R/S) and its relationship with climatic factors for China's grasslands. We further explored relationships between above-ground and below-ground biomass across different grassland types. Results, Our results indicated that the overall R/S of China's grasslands was larger than the global average (6.3 vs. 3.7). The R/S for China's grasslands did not show any significant trend with either mean annual temperature or mean annual precipitation. Above-ground biomass was nearly proportional to below-ground biomass with a scaling exponent (the slope of log,log linear relationship between above-ground and below-ground biomass) of 1.02 across various grassland types. The slope did not differ significantly between temperate and alpine grasslands or between steppe and meadow. Main conclusions, Our findings support the isometric theory of above-ground and below-ground biomass partitioning, and suggest that above-ground biomass scales isometrically with below-ground biomass at the community level. [source] Quality of private personal care for elderly people with a disability living at home: correlates and potential outcomesHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 4 2008Claudio Bilotta MD Abstract To investigate correlates of the quality of private personal care for community-dwelling elderly people, this cross-sectional study enrolled 100 elderly outpatients living at home, along with their private aides and 88 informal caregivers, from May 2005 to January 2007. Cases were stratified according to the quality of private care as was described by both elderly participants and informal caregivers. In cases where the elderly person was suffering from overt cognitive impairment, only the opinions of the informal caregivers were taken into account. A comparison was made between the ,poor or fair care' group (n = 16), the ,intermediate care' group (n = 39) and the ,optimal care' group (n = 45). Considering the characteristics of private aides, there was a significant trend across the three groups in terms of language skills (P = 0.002) and level of distress with life conditions (P = 0.020). A statistical analysis performed on elderly participants without an overt cognitive impairment (n = 59) and informal caregivers showed an increase in the European Quality of Life Visual Analogue Scale score in the elderly group [mean ± standard deviation (SD) were, respectively, 45 ± 23.2, 63.7 ± 19.7 and 68.8 ± 21.6; P = 0.007], and a decrease in the Caregiver Burden Inventory score (mean ± SD were, respectively, 34.9 ± 25.3, 26 ± 17.7 and 17.6 ± 14.6; P = 0.020) across the three groups. We found no significant difference between elderly people in the three groups in terms of social variables, functional and cognitive status, prevalence of depressive disorders and morbidity. Therefore, good language skills and non-distressing life conditions of private aides appeared to be correlates of an optimal quality of care for community-dwelling elderly people with a disability, and also a better quality of life for them and less distress for their informal caregivers appeared to be potential outcomes of the quality of personal care. [source] Investigation of the Mekong River basin hydrology for 1980,2000 using the YHyMHYDROLOGICAL PROCESSES, Issue 9 2008Hapu Arachchige Prasantha Hapuarachchi Abstract This study investigates the Mekong River basin hydrology for the 1980,2000 period using a grid-based distributed hydrological model called Yamanashi Hydrological Model (YHyM). The performance of the model is evaluated using data observed at different locations and the results justify the physical soundness of the model. The seasonal variations of climatic and hydrological characteristics of the basin such as soil moisture, ground water saturation deficit, runoff, precipitation, evapotranspiration, etc. are analysed. On the basis of the simulated results, it is noticeable that there is no significant trend in the precipitation, discharge, or soil moisture state of the basin during the simulated period, though there are some seasonal variations which seem to be natural. However the analysis on the precipitation elasticity (E) of the river flow shows that the E values for all sub-basins are greater than unity, which indicates that x% change in annual precipitation can cause > x% change in annual river flow. Further the basin hydrological responses are analysed for a long term synthetically-induced drought the results of which show the significance of the base flow of the Mekong River basin. Copyright © 2008 John Wiley & Sons, Ltd. [source] Detection of trends in annual extreme rainfallHYDROLOGICAL PROCESSES, Issue 18 2003Kaz Adamowski Abstract Information on intensity,duration,frequency of rainfall is commonly required for a variety of hydrologic applications. In this study, trends are estimated for different durations of annual extreme rainfall using the regional average Mann,Kendall S trend test. The method of L-moments was employed to delineate homogeneous regions. The trend test was modified to account for observed autocorrelation, and a bootstrap methodology was used to account for the observed spatial correlation. Numerical analysis was performed on 44 rainfall stations from the province of Ontario, Canada, for a 20 year time frame. This was done using data from homogeneous regions established using the L-moments procedure for the annual maximum observations for the following durations: 5, 10, 15 and 30 min, and 1, 2, 6 and 12 h. Depending on different rainfall durations, four or five homogeneous regions were delineated. Based on a 5% significance level, approximately 23% of the regions tested had a significant trend, predominantly for short-duration storms. Serial dependency was observed in 2·3% of data sets and spatial correlation was found in 18% of the regions. The presence of serial and spatial correlation had a significant impact on trend determination. Copyright © 2003 John Wiley & Sons, Ltd. [source] Population dynamics and reproduction of Northern Lapwings Vanellus vanellus in a meadow restoration area in central SwedenIBIS, Issue 3 2002Åke Berg To investigate the effectiveness of a meadow restoration programme, we studied the relationships between population changes and environmental changes, return rates and hatching success in a population of Northern Lapwings Vanellus vanellus. The study was performed on mixed farmland (59 km2) in central Sweden, an area that underwent extensive meadow restoration between 1985 and 1994. The study included more than 2600 nests, supplemented with observations of 127 individually colour-ringed Northern Lapwings. The breeding population varied (2.7,5.3 pairs/km2), but showed no significant trend with time. The population increased in years with high spring flooding levels. Population size was unrelated to demographic factors (e.g. hatching success the previous year (14,50%), and return rate). Lapwings moved considerably between years and their nest site fidelity was unrelated to previous hatching success or other factors, suggesting that changes in habitat quality and migration between populations were important in regulating population size. Recent extensive meadow restoration did not seem to aid the Northern Lapwing population; birds continued nesting on tillage even though most nests were destroyed by farming activities. A relatively high relaying frequency improved hatching success, which was still lowest in the most preferred habitats (spring sown crops, total hatching success c. 30%). The few Northern Lapwings breeding in the least preferred habitats (meadows and cultivated grassland) had a better hatching success (> 70% total hatching success), suggesting that habitat selection was not determined by hatching success. From these results, recommendations are made for the management of Northern Lapwing (and associated species) populations on farmland. [source] Micronutrients and the risk of renal cell cancer: A case-control study from ItalyINTERNATIONAL JOURNAL OF CANCER, Issue 4 2007Cristina Bosetti Abstract The role of various micronutrients on the risk of renal cell cancer (RCC) was examined in a multicentric case-control study from Italy, in which information on dietary habits were collected using a validated food-frequency questionnaire. Cases were 767 patients (494 men and 273 women) with incident, histologically confirmed RCC; controls were 1,534 subjects (988 men and 546 women) admitted to the same hospitals as cases for a wide spectrum of acute, nonneoplastic conditions. After allowing for energy and other major covariates, a significant inverse association was found for vitamin E (odds ratio, OR, for the highest quintile of intake versus the lowest one 0.56, 95% confidence interval, CI 0.41,0.75), and vitamin C (OR = 0.72, 95% CI = 0.54,0.96), although the trend in risk for vitamin C was of borderline significance. No significant trend of decreasing risk was found for other micronutrients analyzed, although for most of them the risk estimates were below unity for intakes above the lowest. The ORs for the upper quintile of intake when compared with the lowest one were 0.80 (95% confidence interval, CI = 0.59,1.08) for retinol, 0.82 (95% CI = 0.61,1.10) for ,-carotene, 0.90 (95% CI = 0.68,1.20) for ,-carotene, 0.94 (95% CI = 0.73,1.21) for ,-criptoxanthin, 0.85 (95% CI = 0.63,1.14) for lutein/zeaxanthin, 0.76 (95% CI = 0.57,1.01) for vitamin D, 0.75 (95% CI = 0.55,1.01) for thiamine, 0.88 (95% CI = 0.66,1.19) for riboflavin, 0.85 for vitamin B6 (95% CI = 0.64,1.13), 0.85 (95% CI = 0.64,1.12) for folate and 0.80 (95% CI = 0.60,1.07) for niacin. No meaningful associations emerged for lycopene (OR = 1.11). The present findings support a possible beneficial effect of vitamin E and C on RCC. © 2006 Wiley-Liss, Inc. [source] Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China,INTERNATIONAL JOURNAL OF CANCER, Issue 4 2005Lori C. Sakoda Abstract Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case-control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma-optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls (p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32,1.03), 0.83 (0.48,1.42) and 0.50 (0.28,0.90), with a marginally significant trend in risk observed (p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. © 2005 Wiley-Liss, Inc. [source] Atmospheric moisture budget over Antarctica and the Southern Ocean based on the ERA-40 reanalysisINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 15 2008Hanna Tietäväinen Abstract The atmospheric moisture budget over Antarctica and the Southern Ocean was analysed for the period 1979,2001 on the basis of the ERA-40 reanalysis of the European Centre for Medium-Range Weather Forecasts. Meridional transport by transient eddies makes the largest contribution to the southward water vapour transport. The mean meridional circulation contributes to the northward transport in the Antarctic coastal areas, but this effect is compensated by the southward transport by stationary eddies. The convergence of meridional water vapour transport is at its largest at 64,68°S, while the convergence of zonal transport is regionally important in areas of high cyclolysis. Inter-annual variations in water vapour transport are related to the southern annular mode (SAM). The eastward transport has a significant (95% confidence level) positive correlation with the SAM index, while the northward transport has a significant negative correlation with SAM near 60°S. Hydrological balance is well-achieved in the ERA-40 reanalysis: the difference between the water vapour flux convergence (based on analysis) and the net precipitation (precipitation minus evaporation, based on 24-h forecasts) is only 13 mm yr,1 (3%) over the Southern Ocean and , 8 mm yr,1 (5%) over the continental ice sheet. Over the open ocean, the analysis methodology favours the accuracy of the flux convergence. For the whole study region, the annual mean flux convergence exceeded net precipitation by 11 mm yr,1 (3%). The ERA-40 result for the mean precipitation over the Antarctic continental ice sheet in 1979,2001 is 177 ± 8 mm yr,1, while previous estimates range from 173 to 215 mm yr,1. For the period 1979,2001, the ERA-40 data do not show any statistically significant trend in precipitation over the Antarctic grounded ice sheet and ice shelves. From the ERA-40 data, the annual average net evaporation (evaporation minus condensation) is positive over the whole continent. Copyright © 2008 Royal Meteorological Society [source] Evaporative climate change in the British IslesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 9 2008Gerald Stanhill Abstract Evaporation measurements made at 16 sites in the British Isles were analysed for evidence of long-term changes. Half of the series were from sites in Ireland measured with Class A evaporation pans between 1963 and 2005 and half in England and Scotland measured with the British Meteorological Office (MO) sunken evaporation tank between 1885 and 1968. Four of the Irish series showed significant linear trends, three of increasing and one of decreasing evaporation. These significant changes ranged between , 0.1 and + 0.1 mm year,1 equivalent to annual changes between , 0.22 and + 0.15%. Five of the UK series showed statistically significant linear trends, three of them decrease and two increase: These ranged in size between , 3.7 and + 2.1 mm year,1, equivalent to annual changes of , 1.05 to + 0.40% of the mean. Curvilinear time trends accounted for twice the amount of inter-annual variation in evaporation as did the linear trends. Differences in sunshine duration (SD), used as a proxy for global radiation, were found to be the major factor explaining spatial as well as temporal changes in evaporation in the British Isles. The pooled Irish data, expressed as normalized anomalies, showed a small and significant linear increase in evaporation over the last 40 years. Similarly parameterized the UK measurements showed no significant trend up till 1968; the one UK series that did extend till 2004 indicated a marked increase during the last 20 years. The long-term changes found in annual evaporation were similar to those in air temperatures both in Ireland and England. The relevance of these findings to the hypothesis of an acceleration in the hydrological cycle is discussed. Copyright © 2007 Royal Meteorological Society [source] Characteristics of wintertime daily and extreme minimum temperature over South KoreaINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 2 2004Sang-Boom Ryoo Abstract In South Korea, consecutive positive temperature anomalies have been observed since the mid-1980s. The objective of this study is to assess the recent trends in, and variability of, daily minimum temperature over South Korea with particular emphasis on its extremes. Temporal characteristics of wintertime daily and extreme minimum temperature-related variables were analysed on a seasonal basis for the period of 1958,59 to 2000,01. The results show continually fewer days with extreme low minimum temperature since the mid-1980s. However, no significant change in the 1 day temperature difference was observed during the same period, indicating little change in the frequency of cold surges. Also, during the period analysed, there is a significant positive trend in the seasonal mean temperature, a negative trend in the frequency of the extreme cold days, and no significant trend in the seasonal occurrence of cold surges. Northern Hemisphere geopotential height fields before and after 1986,87, i.e. the start of successive positive anomalies in the winter surface air temperature over South Korea, showed a substantial decrease throughout the troposphere over the polar region. In the upper levels the overall pattern becomes more wavelike, with eddies embedded between meanders. The differences in the lower troposphere are remarkably similar to the Arctic oscillation, although the centre in the North Atlantic is shifted toward western Europe and differences in the North Pacific are relatively weaker than those in the polar region. The recent positive phase of the Arctic oscillation may contribute to these abrupt changes in wintertime daily minimum temperatures over South Korea. El Niño,southern oscillation phenomena appear to contribute to the interannual variation of cold surge days in South Korea. Years with no cold surges were experienced during La Niña episodes. On the other hand, all years with more than four cases of cold surges were during El Niño episodes. Copyright © 2004 Royal Meteorological Society [source] Droughts and extreme events in regional daily Italian precipitation seriesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 5 2002Michele Brunetti Abstract This paper proposes a methodology to study daily precipitation series that include a significant proportion of missing data, without resorting to completion methods based on randomly generated numbers. It is applied to a data set consisting of 75 station records (1951,2000) covering the Italian territory. They are clustered by principal component analysis into six regions: the north-west, the northern part of the north-east, the southern part of the north-east, the centre, the south and the islands (i.e. Sicily and Sardinia). Complete annual and seasonal regional average series are obtained from the incomplete station records, and analysed for droughts and extreme precipitation events. Droughts are identified by means of two indicators: the longest dry period and the proportion of dry days. The most remarkable result is a systematic increase in winter droughts over all of Italy, especially in the north, due mainly to the very dry 1987,93 period. Extreme events are analysed considering 5 day regional totals. In this case, however, an attempt to search for a statistically significant trend is not successful because of the scarcity of events in such a short period. The reliability of the regional series is checked by computing some basic statistics concerning total precipitation, rainy days and precipitation intensity and comparing them with the same statistics computed for regional series obtained by station records completed with methods based on random number generators. Copyright © 2002 Royal Meteorological Society. [source] Venous stasis and routine hematologic testingINTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 5 2006G. LIPPI Summary Prolonged venous stasis, as generated by a long tourniquet placement, produces spurious variations in several measurable analytes. To verify to what extent venous stasis influences routine hematologic testing, we assessed routine hematologic parameters, including hemoglobin, hematocrit, red blood cell count (RBC), main cell hemoglobin (MHC), main cell volume (MCV), platelet count (PLT), main platelet volume (MPV), white blood cell count (WBC) and WBC differential on the Advia 120 automated hematology analyzer in 30 healthy volunteers, either without venous stasis (no stasis) or after application of a 60 mmHg standardized external pressure by a sphygmomanometer, for 1 (1-min stasis) and 3 min (3-min stasis). Although the overall correlation between measures was globally acceptable, the mean values for paired samples were significantly different in all parameters tested, except MCV, MHC, PLT, MPV, eosinophils, basophils and large unstained cells after 1-min stasis and all parameters except MCV, MHC, MPV and basophils after 3-min venous stasis. As expected RBC, hemoglobin and hematocrit displayed a significant trend towards increase, whereas WBC and the WBC subpopulations were decreased. Difference between measurements by Bland and Altman plots exceeded the current analytical quality specifications for desirable bias for WBC, RBC, hemoglobin, hematocrit, lymphocytes and monocytes in samples collected after either 1- and 3-min stasis. These results provide clear evidence that venous stasis during venipuncture might produce spurious and clinically meaningful biases in the measurement of several hematologic parameters, prompting further considerations on the usefulness of adopting appropriate preventive measures for minimizing such influences. [source] Leukoaraiosis Predicts Hidden Global Functioning Impairment in Nondisabled Older People: The LADIS (Leukoaraiosis and Disability in the Elderly) StudyJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 7 2006Leonardo Pantoni MD OBJECTIVES: To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients. DESIGN: Cross-sectional data analysis from an ongoing longitudinal multicenter and multinational study. SETTING: The Leukoaraiosis and Disability Study, a collaboration aimed at assessing leukoaraiosis as an independent predictor of the transition to disability in older people. PARTICIPANTS: Six hundred thirty-nine nondisabled subjects (288 men, 351 women, mean age±standard deviation 74.1±5.0) with magnetic resonance imaging,detected leukoaraiosis of different severity and presenting with one of the following: mild cognitive or motor disturbances, minor cerebrovascular events, or mood alterations or in whom leukoaraiosis was incidentally identified. MEASUREMENTS: Centralized assessment of leukoaraiosis severity according to the three severity degrees of the Fazekas scale; Disability Assessment for Dementia (DAD) Scale for measurement of global functioning. RESULTS: At baseline, 44% of participants had a mild, 31% a moderate, and 25% a severe degree of leukoaraiosis. A significant trend toward declining performance on the DAD Scale was apparent with increasing leukoaraiosis score severity (total score=98.8, 98.6, 97.5, respectively, in the three leukoaraiosis categories, analysis of variance P=.002). Similar trends were obtained for basic (P=.01) and instrumental (P<.001) function items. The statistical significance of these differences was confirmed in a multiple linear regression analysis correcting for numerous factors known to influence disability in older people. Executive function test performance declined along with increasing leukoaraiosis severity and was significantly related to DAD total score. CONCLUSION: Even in nondisabled elderly patients, levels of functional ability are related to white matter lesion severity. Executive dysfunction may mediate this relationship. [source] Adaptive radiation into ecological niches with eruptive dynamics: a comparison of tenthredinid and diprionid sawfliesJOURNAL OF ANIMAL ECOLOGY, Issue 3 2005PETER W. PRICE Summary 1We tested the hypothesis that the bottom-up influence of coniferous plant resources promotes the probability of outbreak or eruptive dynamics in sawflies. The literature was examined for three geographical regions , North America north of Mexico, Europe and Japan. 2In each region tenthredinid sawflies (Hymenoptera: Tenthredinidae) were significantly more likely to be eruptive on conifers than on angiosperms. 3The diprionid sawflies (Hymenoptera: Diprionidae) that attack conifers exclusively showed a significantly higher probability of eruptive dynamics than the tenthredinid sawflies on angiosperms in two regions, North America and Europe, and in Japan the trend was in the same direction. 4The probability of species showing eruptive dynamics on coniferous hosts was not significantly different among tenthredinids and diprionids on conifers in North America, Europe and Japan. 5The weight of evidence supports the hypothesis of conifers supporting a higher percentage of eruptive species than angiosperms. 6In the adaptive radiation of tenthredinid sawflies from flowering plants onto conifers, larches (Larix) appear to be particularly favourable for colonization, but pines (Pinus) have not been colonized in any region, a pattern likely to be explained by the growth characteristics of the host plants. 7Among tenthredinid species in Europe, where sawfly/host relationships are best known, there is a significant trend for an increasing proportion of outbreaking species from herbs, to shrubs, to trees. 8The results indicate for the first time the strong bottom-up effects of plant resources on the population dynamics of sawflies, involving general features of host plant taxa and growth characteristics. [source] Hyperkyphotic Posture and Risk of Future Osteoporotic Fractures: The Rancho Bernardo Study,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 3 2006Mei-Hua Huang Abstract It is unknown whether kyphosis of the thoracic spine is an independent risk factor for future osteoporotic fractures. In 596 community-dwelling women, we found that with increasing kyphosis, there was a significant trend of increasing fracture risk that was independent of previous history of fractures or BMD. Introduction: It is unknown whether kyphosis of the thoracic spine is an independent risk factor for future osteoporotic fractures. Materials and Methods: We conducted a prospective cohort study of 596 community-dwelling women, 47-92 years of age. Between 1988 and 1991, BMD of the hip and spine and kyphosis were measured. Kyphosis was measured by counting the number of 1.7-cm blocks necessary to place under the occiput so participants could lie flat without neck hyperextension. New fractures were reported over an average follow-up of 4 years. Results: Using a cut-off of at least one block, 18% of the participants had hyperkyphotic posture (range, one to nine blocks). There were 107 women who reported at least one new fracture (hip, spine, wrist, clavicle, shoulder, arm, hand, rib, pelvis, leg, or ankle). In logistic regression analyses, older women with hyperkyphotic posture (defined as at least one block) had a 1.7-fold increased risk of having a future fracture independent of age, prior fracture, and spine or hip BMD (95% CI: 1.00-2.97; p = 0.049). There was a significant trend of increasing fracture risk with increasing number of blocks, with ORs ranging from 1.5 to 2.6 as the number of blocks increased from one to at least three blocks compared with those with zero blocks (trend p = 0.03; models adjusted for age, baseline fracture, spine or hip BMD). Stratification by baseline fracture status and controlling for other possible confounders or past year falls did not change the results. Conclusions: Whereas hyperkyphosis may often result from vertebral fractures, our study findings suggest that hyperkyphotic posture itself may be an important risk factor for future fractures, independent of low BMD or fracture history. [source] Evaluation of the Personal Dental Services (Wave 1) for Lambeth, Southwark and Lewisham Primary Care Trusts , Part 1: Retrospective analyses of registration data and access issuesJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 3 2005Helen Best BDS MDS PhD Abstract Aim/objective, The purpose of the study was to undertake analyses of registration data for the personal dental services (PDS) of Lambeth, Southwark and Lewisham primary care trusts and relate the analyses to the PDS goal ,of ,increasing ,uptake ,of ,dental services. Method, Secondary analyses of registration statistics provided by the Dental Practice Board were undertaken for both 1 years pre-PDS (October 1997 to September 1998) and post-PDS (October 1998 to March 2003) periods. Three sets of analyses were undertaken to consider different aspects of changing registrations: (1) Absolute numbers of patients registered at each time interval; (2) Rates of change in numbers of patients registered for the entire period after the introduction of PDS; and (3) Rates of change in numbers of patients registered ,for ,the ,most recent 3 years of available data. Results, There was a significant increase in the numbers of children registered under capitation, post-PDS as compared to the pre-PDS level (all ages and both genders combined). Post-PDS, the rate of increase for the children was approximately one additional child per practice per month (0.96, 95% CI 0.41,1.52). Similarly there was a significant trend for increasing adults registrations over time of about two and a half adults per practice per month (2.42, 95% CI 0.90,3.95). There was no evidence of a change in registrations for children or adults in total over the most recent period of 3 years. Conclusions, The analysis of the absolute numbers of registered patients each month indicated that the PDS practices had more children registered than before the implementation of the PDS scheme, but not adults. Overall post-implementation there was a trend for increasing registrations in both children and adults, but the most recent data indicated a plateau effect. Further consideration of facilitators to achieve PDS goals of improved uptake of services is required, particularly as they relate to local contexts. [source] Comparative study in stingless bees (Meliponini) demonstrates that nest entrance size predicts traffic and defensivityJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 1 2008M. J. COUVILLON Abstract Stingless bees (Meliponini) construct their own species-specific nest entrance. The size of this entrance is under conflicting selective pressures. Smaller entrances are easier to defend; however, a larger entrance accommodates heavier forager traffic. Using a comparative approach with 26 species of stingless bees, we show that species with greater foraging traffic have significantly larger entrances. Such a strong correlation between relative entrance area and traffic across the different species strongly suggests a trade-off between traffic and security. Additionally, we report on a significant trend for higher forager traffic to be associated with more guards and for those guards to be more aggressive. Finally, we discuss the nest entrance of Partamona, known in Brazil as boca de sapo, or toad mouth, which has a wide outer entrance but a narrow inner entrance. This extraordinary design allows these bees to finesse the defensivity/traffic trade-off. [source] Alternative migration and host parasitism strategies and their long-term stability in river lampreys from the River Endrick, ScotlandJOURNAL OF FISH BIOLOGY, Issue 10 2008C. E. Adams The stability of a discrete body size dimorphism of sexually mature river lamprey Lampetra fluviatilis from the River Endrick, Scotland, was examined over a 21 year period. Stable isotope analysis was used to test the hypothesis that the two size forms comprise individuals with differing migration and parasitic foraging strategies. Maturing river lamprey and the brook lamprey Lampetra planeri were trapped over 3 months each year in the periods 1983,1984 and 2004,2005. Brook lamprey catches and catches of both species combined showed no significant trend in catch rate with time. The catch rate of small body size river lamprey declined between 1983,1984 and 2004,2005 (although the difference did not reach statistical significance; P = 0·055). In contrast, there was a significant increase in the catch rate of the large body size river lamprey and as a consequence, a significant change in the relative proportion of each of the two river lamprey morphs over the study period. Analysis of the stable isotopes of C and N in muscle tissue showed that brook lamprey tissue derived its carbon from a freshwater source and had a ,13C more consistent with that of the River Endrick than with Loch Lomond. ,15N values for this species showed it to be feeding at the base of the food chain, consistent with filter feeding as an ammocoete. The large body size and the small body size river lamprey adults differed substantially in their ,13C values, with the small body size ,13C signature indicative of a freshwater carbon source and the large body size morph of a marine source. The small body size morph had a ,13C signature that was consistent with that of Loch Lomond powan Coregonus lavaretus suggesting that they share a common carbon source. The large body size morph was clearly feeding at a higher trophic level than the small body size morph. A single small body size river lamprey individual with typical morphology for that group, however, had C and N signatures that clustered with those of the large body size morphs. This individual had either migrated to sea to forage, as is typical for the species, or had been feeding on an anadromous fish with a strong marine C signature in fresh water. It is concluded that the body size dimorphism is indicative of a differential migration and foraging strategy in the parasitic phase of the life cycle of river lamprey at this site. [source] Fat intake and food choices during weight reduction with diet, behavioural modification and a lipase inhibitorJOURNAL OF INTERNAL MEDICINE, Issue 5 2000K. Franson Abstract. Franson K, Rössner S (The Swedish Association for People with Bowel and Stomach Diseases, Stockholm and Huddinge Hospital, Huddinge, Sweden). Fat intake and food choices during weight reduction with diet, behavioural modification and a lipase inhibitor. J Intern Med 2000: 247: 607,614. Objective. To study the composition of fat intake and fat-rich meals consumed during a trial in which obese subjects were treated with a lipase-inhibitor or placebo, with emphasis on food choices and eating hours. Design. Patients were instructed to record all food and drink taken for four days prior to each dietician visit. The food diaries from all scheduled 15 treatment visits were analysed for nutritional content and composition and for temporal distribution. All meals containing 25 g of fat were defined as fat-rich. Subjects. Twenty-eight women and six men, mean age 45.2 ± 10.9 (SD) years with a mean body mass index of 37.3 ± 3.3 (SD) kg m,2 at the beginning of the study. Results. Fat intake, both as absolute weight and as energy % was generally higher in the placebo group but no significant trend over time could be seen. Fat rich meals were increased by 59% towards the end of the study. Most fat rich meals were eaten at lunch and dinner. Cooking fat, fatty sauces, meat dishes and cheese contributed to the major proportion of fat, both for placebo and drug treated subjects. No major changes were seen in food choice over time. Conclusion. A lipase inhibitor may affect the amount of fat ingested but does not seem to change major sources of fat. The typical fat-rich meal consumed by these subjects was a meat dish, consumed in the evening. [source] Decline of hepatitis B carrier rate in vaccinated and unvaccinated subjects: Sixteen years after newborn vaccination program in TaiwanJOURNAL OF MEDICAL VIROLOGY, Issue 4 2003Hans Hsienhong Lin Abstract Taiwan was an endemic area for hepatitis B virus (HBV) infection, and related liver diseases cause a significant drain of public resources. To control the endemic, a nation-wide newborn vaccination program was started in 1985. We reviewed the results of the annual survey for HBV surface antigen (HBsAg) performed in freshmen class of two high schools in Hualien, eastern Taiwan, from 1991 to 2001. A total of 10,194 students, most of them 15 years old, were tested for serum HBsAg using enzyme immunoassays. There is a significant trend (P,<,0.0001) of decreasing HBsAg carrier rate from 20.3 to 4.4% in males and 14.3% to 2.4% in females, respectively, over 11 years. The HBsAg carrier rate was 16.0,20.3% in students surveyed during 1991,1993 (born more than 6 years before the start of the national vaccination program), which decreased to 7.7,11.9% during 1994,1999 (born 1,6 years before the program). It further declined to 4.7% and 3.4% in 2000 and 2001 (born after the start of the program). The HBsAg carrier rate in male students was significantly higher than that in female students in most of the years. The HBV newborn vaccination program not only successfully prevented most of the perinatal transmission of HBV but also reduced horizontal transmission of HBV to children born up to 6 years before the start of the program. Also, the protection persisted for at least 15 years. J. Med. Virol. 69:471,474, 2003. © 2003 Wiley-Liss, Inc. [source] Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacementJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 1 2006B. I. ERIKSSON Summary.,Background:,Joint replacement surgery is an appropriate model for dose-ranging studies investigating new anticoagulants. Objectives:,To assess the efficacy and safety of a novel, oral, direct factor Xa (FXa) inhibitor , BAY 59-7939 , relative to enoxaparin in patients undergoing elective total hip replacement. Methods:,In this double-blind, double-dummy, dose-ranging study, patients were randomized to oral BAY 59-7939 (2.5, 5, 10, 20, or 30 mg b.i.d.), starting 6,8 h after surgery, or s.c. enoxaparin 40 mg once daily, starting on the evening before surgery. Treatment was continued until mandatory bilateral venography was performed 5,9 days after surgery. Results:,Of 706 patients treated, 548 were eligible for the primary efficacy analysis. The primary efficacy endpoint was the incidence of any deep vein thrombosis, non-fatal pulmonary embolism, and all-cause mortality; rates were 15%, 14%, 12%, 18%, and 7% for BAY 59-7939 2.5, 5, 10, 20, and 30 mg b.i.d., respectively, compared with 17% for enoxaparin. The primary efficacy analysis did not demonstrate any significant trend in dose,response relationship for BAY 59-7939. The primary safety endpoint was major, postoperative bleeding; there was a significant increase in the frequency of events with increasing doses of BAY 59-7939 (P = 0.045), but no significant differences between individual BAY 59-7939 doses and enoxaparin. Conclusions:,When efficacy and safety were considered together, the oral, direct FXa inhibitor BAY 59-7939, at 2.5,10 mg b.i.d., compared favorably with enoxaparin for the prevention of venous thromboembolism in patients undergoing elective total hip replacement. [source] Travel-Associated Dengue Infections in the United States, 1996 to 2005JOURNAL OF TRAVEL MEDICINE, Issue 1 2010Hamish P. Mohammed PhD Background. As the incidence of dengue increases globally, US travelers to endemic areas may be at an increased risk of travel-associated dengue. Methods. Data from the US Centers for Disease Control and Prevention's laboratory-based Passive Dengue Surveillance System (PDSS) were used to describe trends in travel-associated dengue reported from January 1, 1996 to December 31, 2005. The PDSS relies on provider-initiated requests for diagnostic testing of serum samples via state health departments. A case of travel-associated dengue was defined as a laboratory-positive dengue infection in a resident of the 50 US states and the District of Columbia who had been in a dengue-endemic area within 14 days before symptom onset. Dengue infection was confirmed by serologic and virologic techniques. Results. One thousand one hundred and ninety-six suspected travel-associated dengue cases were reported,334 (28%) were laboratory-positive, 597 (50%) were laboratory-negative, and 265 (22%) were laboratory-indeterminate. The incidence of laboratory-positive cases varied from 1996 to 2005, but had an overall increase with no significant trend (53.5 to 121.3 per 108 US travelers, p = 0.36). The most commonly visited regions were the Caribbean, Mexico and Central America, and Asia. The median age of laboratory-positive cases was 37 years (range: <1 to 75 y) and 166 (50%) were male. Of the 334 laboratory-positive cases, 41 (12%) were hospitalized, and 2 (1%) died. Conclusions. Residents of the US traveling to dengue-endemic regions are at risk of dengue infection and need to be instructed on appropriate prevention measures prior to travel. Especially in light of the potential transmissibility of dengue virus via blood transfusion, consistent reporting of travel-associated dengue infections is essential. [source] Frequency of Fish Consumption, Retinal Microvascular Signs and Vascular MortalityMICROCIRCULATION, Issue 1 2008Shweta Kaushik BMed (Hons) ABSTRACT Objective: Fish consumption has established cardiovascular and cerebrovascular benefits, but its effects on microvascular structure have not been examined in population-based studies. We investigated this association, in relation to vascular mortality in an Australian cohort (1992,2004). Methods: Of 3654 participants aged 49+ years, 2683 (73%) with available data were included. Retinal arteriolar and venular diameters were measured, and signs of arterio-venous nicking and retinopathy were assessed from digital retinal images. Fish consumption was evaluated using a food frequency questionnaire. Results: Both wider mean arteriolar diameter (p = 0.002) and narrower venular diameter (p = 0.02) were associated with increasing frequency of consuming any or oily fish, after adjusting for cardiovascular risk factors, diet, inflammatory factors and socioeconomic status. This association was mainly present in persons with hypertension. Greater frequency of fish consumption was associated with a reduced prevalence of arterio-venous nicking and a borderline significant trend for reduced retinopathy prevalence. Ten year stroke-related mortality was significantly lower in persons consuming fish at least once per week compared to less frequent consumption (hazard ratio 0.57, 95% CI: 0.35 to 0.93). Conclusions: Recent evidence shows that narrower arterioles and wider venules may predict vascular events. Our new findings suggest that the vascular protective effects of consuming fish could act, in part, by preventing pathological microvasculature change. [source] A Subaru/Suprime-Cam wide-field survey of globular cluster populations around M87 , I. Observation, data analysis and luminosity functionMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 2 2006Naoyuki Tamura ABSTRACT In this paper and a companion paper, we report on a wide-field imaging survey of the globular cluster (GC) populations around M87 carried out with Suprime-Cam on the 8.2-m Subaru telescope. Here, we describe the observations, data reduction and data analysis, and present luminosity functions of GC populations around M87 and NGC 4552, another luminous Virgo elliptical in our survey field. The imaging data were taken in the B, V and I bands with a sky coverage of extending from the M87 centre out to ,0.5 Mpc. GC candidates were selected by applying a colour criterion on the B,V and V,I diagram to unresolved objects, which greatly reduces contamination. The data from control fields taken with Subaru/Suprime-Cam were also analysed for subtraction of contamination in the GC sample. These control field data are compatible with those in the M87 field in terms of the filter set (BVI), limiting magnitudes and image quality, which minimize the possibility of introducing any systematic errors into the subtractive correction. We investigate GC luminosity functions (GCLFs) at distances , 10 arcmin (,45 kpc) from the host galaxy centre in detail. By fitting Gaussians to the GCLFs, the V -band turnover magnitude (VTO) is estimated to be 23.62 ± 0.06 and 23.56 ± 0.20 mag for the GC population in M87 and NGC 4552, respectively. The GCLF is found to be a function of GC colour; VTO of the red GC subpopulation (V,I > 1.1) is fainter than that of the blue GC subpopulation (V,I, 1.1) in both M87 and NGC 4552, as expected if the colour differences are primarily due to a metallicity effect, and the mass functions of the two subpopulations are similar. The radial dependence of the GCLF is also investigated for the GC population in M87. The GCLF of each subpopulation at 1 ,R, 5 arcmin is compared to that at 5 ,R, 10 arcmin, but no significant trend with distance is found in the shape of the GCLF. We also estimate GC-specific frequencies (SN) for M87 and NGC 4552. The SN of the M87 GC population is estimated to be 12.5 ± 0.8 within 25 arcmin. The SN value of the NGC 4552 GC population is estimated to be 5.0 ± 0.6 within 10 arcmin. [source] Left ventricular mass in hypertensive patients with mild-to-moderate reduction of renal functionNEPHROLOGY, Issue 2 2010GIOVANNI CERASOLA ABSTRACT: Aim: Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular (CV) morbidity and mortality. The aim of the present study was to evaluate the relationship between LV mass and mild-to-moderate renal dysfunction in a group of non-diabetic hypertensives, free of CV diseases, participating in the Renal Dysfunction in Hypertension (REDHY) study. Methods: Patients with diabetes, a body mass index (BMI) of more than 35 kg/m2, secondary hypertension, CV diseases and a glomerular filtration rate (GFR) of less than 30 mL/min per 1.73 m2 were excluded. The final sample included 455 patients, who underwent echocardiographic examination and ambulatory blood pressure monitoring. Results: There was a significant trend for a stepwise increase in LV mass, indexed by both body surface area (LVMI) and height elevated to 2.7 (LVMH2.7), with the declining renal function, that remained statistically significant after correction for potential confounders. The prevalence of LVH, defined either as LVMI of 125 g/m2 or more or as LVMH2.7 of 51 g/m2.7 or more, was higher in subjects with lower values of GFR than in those with normal renal function (P < 0.001 in both cases). The multiple regression analysis confirmed that the inverse association between GFR and LVM was independent of confounding factors. Conclusion: The present study confirms the high prevalence of LVH in patients with mild or moderate renal dysfunction. In the patients studied (all with a GFR of 30 mL/min per 1.73 m2), the association between LVM and GFR was independent of potential confounders, including 24 h blood pressure load. Taking into account the negative prognostic impact of LVH, further studies focusing on a deeper comprehension of the mechanisms underlying the development of LVH in chronic kidney disease patients are needed. [source] | |||||||||||||||||||||||||||||||||||||||||||