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Short Route (short + route)
Selected AbstractsChemInform Abstract: A Short Route to [1,2,3]-Triazolyl Coumarin and Quinolone Derivatives by Cu(I) Catalyzed 1,3-Dipolar Cycloaddition and Fluorescence Studies.CHEMINFORM, Issue 24 2009Krishna C. Majumdar Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Aromatic Allylation via Diazotization: Variation of the Allylic Moiety and a Short Route to a Benzazepine Derivatives.CHEMINFORM, Issue 28 2003Fredrik Ek Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis of a Benzolactone Collection using Click ChemistryEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 1 2007Jan Ritschel Abstract A collection of benzotriazoles consisting of seven compounds was prepared from the propynyl-substituted benzolactone 1 and various azides using click chemistry. The lactone 1 was obtained through a short route by direct esterification of the allylbenzoic acid 9 with the alkynol 7 giving the benzoate 2. The homopropargyl alcohol 7 in turn was obtained by opening the epoxide 6 with triisopropylsilyl acetylide. Ring-closing metathesis of the ester 2 using Grubbs catalyst II followed by removal of the silicon protecting group furnished the lactone 1. Two of the benzotriazoles, 17a and 17b, were also converted into the corresponding phenols to probe the role of the phenolic OH on the biological activity. All nine benzotriazoles showed cytotoxic activity in a L929 mouse fibroblast assay with IC50 values in the low micromolar range. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source] A simple and efficient synthesis of novel N,N,-bis (1H -pyrrol-1-yl)-1-[2-(2-aryl-5-methyl-3-oxo-2,4-dihydro-3H -1,2,4-triazol-4-yl)ethyl]-1H -1,2,3-triazole-4,5-dicarboxamidesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 6 2007Prashant R. Latthe One-pot reaction of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones 1a-g with ethanolamine yielded the 4-(2-hydroxyethyl)-2-aryl-5-methyl-2,4-dihydro-3H -1,2,4-triazolin-3-ones 2a-g which were converted to the azido compounds 6a-g. These azides on 1,3-dipolar cycloaddition with DMAD afforded the dimethyl-1-[2-(2-aryl-5-methyl-3-oxo-1,2,4-triazol-4-yl)ethyl]-1H -1,2,3-triazol-4,5-dicarboxylates 7a-g which on conversion to bishydrazides 8a-g and further cyclisation with 2,5-hexanedione afforded the title compounds 9a-g. This new short route for the so far unkown bis-(triazolinone-triazole)ethanes involves mild and convergent 1,3-dipolar cycloaddition reaction yielding overall good yields of the products. [source] Biomimetic Synthesis of Twenty-four Long-chained Diketones as Precursors for Muscone and Further Macrocyclic KetonesCHINESE JOURNAL OF CHEMISTRY, Issue 12 2008Yuan GUO Abstract The one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. Bisbenzimidazolium salts were used as a tetrahydrofolate coenzyme model, and thus the biomimetic synthesis of twenty-four acyclic diketones as precursors for macrocyclic ketones was successfully accomplished by using the addition-hydrolysis reaction of the bisbenzimidazolium salts with alkyl magnesium halide, wherein six diketones have not been reported in literature. Accordingly, a short route to muscone analogues was provided. [source] Facile Synthesis of 3-Substituted-1,2,3,4-tetrahydropyrido-[3,2- d]pyrimidine-2,4-dione on Poly(ethylene glycol)CHINESE JOURNAL OF CHEMISTRY, Issue 3 2008Feng-Ying XIANG Abstract An efficient and short route to synthesize pyrido[3,2- d]pyrimidinediones was achieved using poly(ethylene glycol) as a soluble polymeric support and phase transfer catalyst. The poly(ethylene glycol) (PEG) was reacted with 2,3-pyridinedicarboxylic anhydride to give PEG-bound ester 1, which was transformed into corresponding PEG-bound acyl azide 2. Then the PEG-supported acyl azide 2 was rearranged, reacted with a series of amines and spontaneously cycled to give product 5 in 84%,88% overall yields. [source] | ||||||||||