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Sharp Rise (sharp + rise)
Selected AbstractsOntogenetic effects of MAO-A inhibition on rat pineal n -acetylserotonin and melatonin during the first month of neonatal lifeHUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 8 2000Gregory F Oxenkrug Abstract Inhibitors of monoamine oxidase A (MAO-A) but not MAO-B stimulate the activity of pineal serotonin N -acetyltransferase (AANAT) in the adult rat pineal leading to increased formation of N -acetyl serotonin (NAS) and melatonin (MEL). The pineal gland of the neonatal rat has AANAT activity, but the second enzyme in melatonin biosynthesis, HIOMT (hydroxyindole- O -methyltransferase) converting NAS to MEL, is absent during the first week of neonatal life. In this study we examined the effects of acute clorgyline treatment in vitro and in vivo, on pineal indoles over the first month of neonatal life. The results show that clorgyline stimulates NAS production by pineal both in vitro and in vivo from day five on with a marked increase between day 14 and day 21. In contrast, MEL is not increased until day 21, with a sharp rise thereafter. Copyright © 2000 John Wiley & Sons, Ltd. [source] Accounting for the trend in trade union recognition in IrelandINDUSTRIAL RELATIONS JOURNAL, Issue 1 2001William K. Roche Considerable controversy surrounds the issue of union recognition in Irish industrial relations. Academic commentators have sought to identify and explain the trend in recognition since the 1980s. Their arguments are examined and tested. No secular rise in non-recognition is evident, and ,individualisation' and ,union substitution' are shown to add little to explaining the trend. No evidence is found that the trend reflects Irish employers pursuing union suppression and US-employers pursuing union substitution. The significant development is a sharp rise in non-recognition among new US employers. Their anti-union animus does not, however, appear to be coupled with any distinctive or generalised union avoidance strategy. [source] Hepatitis C virus infection in a Japanese leprosy sanatorium for the past 67 yearsJOURNAL OF MEDICAL VIROLOGY, Issue 4 2010Kazuya Shiogama Abstract Oku-Komyo-En is one of the national leprosy sanatoria, located on a small island in Setouchi city, Okayama prefecture of Japan since 1938. Since autopsies were carried out routinely on almost all patients who had died in the sanatorium up to 1980, approximately 1,000 formalin-fixed autopsy tissue samples were available for analysis. When these samples were reviewed, the pathological data indicated a sharp rise in the death rate caused by cirrhosis of the liver and hepatocellular carcinoma (HCC) since 1960 and 1970, respectively. Hepatitis C virus (HCV) infection is a common cause of HCC in Japan. The presence of HCV RNA was demonstrated in paraffin sections prepared from the autopsied liver tissue fixed in formalin for a prolonged period of time, by employing nested RT-PCR using type-specific primers. The data showed that HCV RNA was detectable in samples of the liver archived as early as 1940, representing the liver tissues kept in formalin for up to 67 years. HCV genotypes 1b and 2a were found by RT-PCR at 85.7% and 14.3%, respectively, in patients with leprosy. J. Med. Virol. 82:556,561, 2010. © 2010 Wiley-Liss, Inc. [source] Isotope and disorder effects in the Raman spectra of LiHxD1,x crystalsJOURNAL OF RAMAN SPECTROSCOPY, Issue 8 2001V. G. Plekhanov Most of the physical properties of a solid depend on its isotopic composition in some way or another. Scientific interest, technological promise and increased availability of highly enriched isotopes have led to a sharp rise in the number of experimental and theoretical studies with isotopically controlled crystals. A great number of stable isotopes and well-developed methods for their separation have made it possible to grow crystals of C, LiH, ZnO, ZnSe, CuCl, GaN, GaAs, CdS, Cu2O, Si, Ge and ,-Sn with a controllable isotopic composition. Among these compounds, LiH possesses the largest value of the isotope effect. The great number of theoretical and experimental data suggest that the isotopic composition of a crystal lattice exerts some influence on the vibrational properties of crystals. These effects are fairly large and can be readily measured by modern experimental techniques (ultrasound, Brillouin and Raman scattering and neutron scattering). In addition, crystals of different isotopic compositions possess different Debye temperatures. This difference between an LiH crystal and its deuterated analogue exceeds a 100 K. Very pronounced and general effects of isotopic substitution are observed in phonon spectra. The scattering lines in isotopically mixed crystals are not only shifted (the shift of LO lines exceeds 100 cm,1) but are also broadened. This broadening is related to the isotopic disorder of the crystal lattice. It is shown that the degree of a change in the scattering potential is different for different isotopic mixed crystals. In the case of germanium and diamond crystals, phonon scattering is weak, which allows one to apply successfully the coherent potential approximation (CPA) for describing the shift and broadening of scattering lines. In the case of lithium hydride, the change in the scattering potential is so strong that it results in phonon localization, which is directly observed in experiments. The common nature of the isotopic and disorder effects in a wide range of crystals is emphasized. Copyright © 2001 John Wiley & Sons, Ltd. [source] Coming back to life: From indicator to stereotype and a strange story of frequency1JOURNAL OF SOCIOLINGUISTICS, Issue 4 2009Jessi Elana Aaron In the history of Spanish there are five forms, originally from the same lexical item, co-existing:,así,,asín,,ansí,,asina, and,ansina, all meaning ,like that'. Standard Modern Spanish includes only one of these:,así. This is not the case, however, in New Mexican Spanish. This corpus-based study examines the patterns of synchronic variation in New Mexican Spanish, as well as the near death and transformed rebirth of forms other than standard,así,in literature. Multivariate analysis suggests a decline in non-standard variants in New Mexico, associated with rural activities and objects, and with older, less-educated speakers. The synchronic idiosyncrasy of stereotypes is confirmed, while the quantitative diachronic patterns found may prove to be a regular pattern for developing stereotypes in literary texts: a slow decline in frequency followed by a sharp rise. [source] Network influences on scholarly communication in developmental dyslexia: A longitudinal follow-upJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 14 2003Claudia A. Perry Author cocitation analysis was used to explore ongoing changes in the intellectual structure of the hybrid problem area of developmental dyslexia for the period 1994,1998, and to address ambiguities in results raised by an earlier study of these researchers for the years 1976,1993. Results suggest that: (1) discrepancies between the structure of the sociometric (personal) and author cocitation networks reflect real differences, not temporal factors; (2) differences between cocitation patterns and reports in the literature, and corresponding delays in the visibility of emerging perspectives, are likely due to the "inertia" of aggregate cocitation data and/or by shifts by neuroscience-vision researchers to publication in more prominent journals; (3) a sharp rise in link density for the neuroscience-vision subgroup indicates increased cohesiveness and growing maturation for this emerging perspective; (4) shifts in subgroup membership, link density, patterns of coauthorship, and multiple factor loadings suggest possible convergence between other subgroups in the network and identify individuals who may play boundary-spanning roles within the network; and (5) changing patterns of cocitation throughout the network suggest the increasing influence of studies relating to neurobiological mechanisms underlying dyslexia. The possible contributions of such boundary spanners in addressing the substantial information and communication challenges posed by the increased interdisciplinary character of scholarship in general, also are discussed. [source] Palaeoclimate reconstruction on Big Lyakhovsky Island, north Siberia,hydrogen and oxygen isotopes in ice wedgesPERMAFROST AND PERIGLACIAL PROCESSES, Issue 2 2002Hanno Meyer Abstract Late Quaternary permafrost deposits on Big Lyakhovsky Island (New Siberian Islands, Russian Arctic) were studied with the aim of reconstructing the palaeoclimatic and palaeoenvironmental conditions of northern Siberia. Hydrogen and oxygen stable isotope analyses are presented for six different generations of ice wedges as well as for recent ice wedges and precipitation. An age of about 200 ka BP was determined for an autochtonous peat layer in ice-rich deposits by U/Th method, containing the oldest ice wedges ever analysed for hydrogen and oxygen isotopes. The palaeoclimatic reconstruction revealed a period of severe winter temperatures at that time. After a gap in the sedimentation history of several tens of thousands of years, ice-wedge growth was re-initiated around 50 ka BP by a short period of extremely cold winters and rapid sedimentation leading to ice-wedge burial and characteristic ice-soil wedges (,polosatics'). This corresponds to the initial stage for the Late Weichselian Ice Complex, a peculiar cryolithogenic periglacial formation typical of the lowlands of northern Siberia. The Ice Complex ice wedges reflect cold winters and similar climatic conditions as around 200 ka BP. With a sharp rise in ,18O of 6, and ,D of 40,, the warming trend between Pleistocene and Holocene ice wedges is documented. Stable isotope data of recent ice wedges show that Big Lyakhovsky Island has never been as warm in winter as today. Copyright © 2002 John Wiley & Sons, Ltd. [source] The Entry Cost Shock and the Re-rating of Power Prices in New South Wales, AustraliaTHE AUSTRALIAN ECONOMIC REVIEW, Issue 2 2010Paul Simshauser Australia has long been the beneficiary of low, stable power prices. A decade-long state of oversupply underpinned this result and while plant capital costs had been rising, the cost of capital had been declining. These offsetting effects locked the wholesale market into an average cost of $35,$40/MWh. However, from 2007, a simultaneous and sharp rise in new entrant plant capital costs and the cost of capital occurred. The combined effects crept up on the industry while it was in a state of oversupply. This ,entry cost shock' disrupted a 7 year long equilibrium price, with average power system cost rising to $60/MWh. [source] The Pattern and Determinants of Intra-Industry Trade in Australian ManufacturingTHE AUSTRALIAN ECONOMIC REVIEW, Issue 3 2000Kishor Sharma This paper presents the pattern and determinants of intra-industry trade (IIT) in Australian manufacturing since the late 1970s. The results point to a sharp rise in IIT from the mid 1980s which appears to be linked with an outward-oriented policy. Industry-level analysis indicates that industries which experienced a sharp fall in protection are the industries with the higher levels of IIT. These include textiles, garments, rubber products, and machinery and equipment. An increasing trend in IIT suggests that the short-term adjustment costs associated with trade liberalisation are likely to be lower, and that liberalisation can proceed without huge short-term adjustment costs. Using a logit model the determinants of IIT are investigated. Results indicate that IIT is positively related to product differentiation and scale economies, and negatively related to the levels of protection and foreign ownership in the pre-liberalisation period. In the post-liberalisation period, however, scale economies explain the inter-industry variations in IIT. R&D intensity and close economic integration appear to have no impact on IIT regardless of the nature of the policy regime. [source] Executive Remuneration in AustraliaAUSTRALIAN ACCOUNTING REVIEW, Issue 1 2010Allan Fels A fierce debate is raging about the legitimacy of executive pay rises. Australia's chief executive salaries are not as high as in the United States and the big European economies, but between 1993 and 2007 there was a sharp rise in remuneration. Most of the rise came in the form of incentive payments. In the Australian context, the size of the executive salary is closely linked with the size of the company. The evidence is mixed about how efficient executive remuneration has been, but what is clear is that the responsibility to ensure it is appropriate resides with boards, and that there is a need for greater shareholder participation. Accordingly, it is recommended that shareholders have a greater ,say on pay', and that two successive ,no' votes on remuneration by shareholders will have formal consequences for boards. The challenge is to improve agency between shareholders and management, and between shareholders and boards. An evolutionary approach is proposed. [source] Self-regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperatureCANCER SCIENCE, Issue 4 2008Hajime Saito Hyperthermia has been used for many years to treat a variety of malignant tumors. The Curie temperature (Tc) is a transition point at which magnetic materials lose their magnetic properties, causing a cessation of current and thus heat production. The Tc enables automatic temperature control throughout a tumor as a result of the self-regulating nature of the thermosensitive material. We have developed a method of magnetically-induced hyperthermia using thermosensitive ferromagnetic particles (FMPs) with low Tc (43°C), enough to mediate automatic temperature control. B16 melanoma cells were subcutaneously injected into the backs of C57BL/6 mice, after which tumors were allowed to grow to 5 mm in diameter. FMPs were then injected into the tumors, and the mice were divided into three groups: group I (no hyperthermia, control); group II (one hyperthermia treatment); and group III (hyperthermia twice a week for 4 weeks). When exposed to a magnetic field, the FMPs showed a sharp rise in heat production, reaching the Tc in tissue within 7 min, after which the tissue temperature stabilized at approximately the Tc. In groups I and II, all mice died within 30,45 days. In group III, however, 6 of 10 mice remained alive 120 days after beginning treatment. Our findings suggest that repeated treatment with magnetically-induced self-regulating hyperthermia, mediated by FMPs with a low Tc, is an effective means of suppressing melanoma growth. A key advantage of this hyperthermia system is that it is minimally invasive, requiring only a single injection for repeated treatments with automatic temperature control. (Cancer Sci 2008; 99: 805,809) [source] Jack Tizard Memorial Lecture: Educational Reform and the Mental Health of Vulnerable Children and Young PeopleCHILD AND ADOLESCENT MENTAL HEALTH, Issue 4 2001David Galloway Although research has demonstrated the differential influence of schools on children's psychosocial adjustment, the influence of radical legislative changes since 1979 is less clear. Evidence of a sharp rise in exclusions and in referral for special educational needs is contrasted with evidence that behaviour in most schools is good, and with data showing a steep reduction in the number of pupils leaving school with no qualifications. It is argued that these reforms have improved overall standards and may thereby have contributed positively to the mental health of many vulnerable children. However, the way they have been implemented has undermined teachers in some schools and, as a result, pupils there experience education as an additional source of stress rather than of stability and support. [source] | ||||||||||||||||