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Sharp Reduction (sharp + reduction)
Selected AbstractsEnvironmental novelty is signaled by reduction of the hippocampal theta frequencyHIPPOCAMPUS, Issue 4 2008A. Jeewajee Abstract The hippocampal formation (HF) plays a key role in novelty detection, but the mechanisms remain unknown. Novelty detection aids the encoding of new information into memory,a process thought to depend on the HF and to be modulated by the theta rhythm of EEG. We examined EEG recorded in the HF of rats foraging for food within a novel environment, as it became familiar over the next five days, and in two more novel environments unexpectedly experienced in trials interspersed with familiar trials over three further days. We found that environmental novelty produces a sharp reduction in the theta frequency of foraging rats, that this reduction is greater for an unexpected environment than for a completely novel one, and that it slowly disappears with increasing familiarity. These results do not reflect changes in running speed and suggest that the septo-hippocampal system signals unexpected environmental change via a reduction in theta frequency. In addition, they provide evidence in support of a cholinergically mediated mechanism for novelty detection, have important implications for our understanding of oscillatory coding within memory and for the interpretation of event-related potentials, and provide indirect support for the oscillatory interference model of grid cell firing in medial entorhinal cortex. © 2007 Wiley-Liss, Inc. [source] If pemphigus vulgaris IgG are the cause of acantholysis, new IgG-independent mechanisms are the concauseJOURNAL OF CELLULAR PHYSIOLOGY, Issue 3 2007Nicola Cirillo Pemphigus vulgaris (PV) is a disease of epidermal adhesion. Its pathogenesis is currently traced back to the action of autoantibodies against antigens located within the intercellular substance of keratinocytes, such as desmogleins and acetylcholine receptors. In the present paper, we sought to elucidate the non-IgG-mediated effects of PV sera on keratinocytes. Results showed that PV sera depleted of IgG were able to induce well-defined changes on keratinocyte morphology and metabolic activity. Indeed, PV IgG-free sera determined marked alterations on cell shape, accompanied by partial loss of keratinocyte,keratinocyte interactions within 48 h after treatment. Furthermore, PV IgG-depleted sera caused a sharp reduction of cell viability along with a less sustained weakening of intercellular adhesion strength. In light of the above findings, loss of cell,cell adhesion in PV occurs as a result of the cooperating action of both IgG and non-IgG-mediated mechanisms. These data have remarkable consequences on experimental models of PV and might open new "biological" approaches to its therapy. Thus, researchers are well advised that PV pathophysiology cannot be faithfully reproduced by leaving non-IgG serum factors out of consideration. J. Cell. Physiol. 212:563,567, 2007. © 2007 Wiley-Liss, Inc. [source] Effect of natural and controlled fermentation on flatus-producing compounds of beans (Phaseolus vulgaris)JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 10 2003Marisela Granito Abstract Fermentation of grain legumes is an efficient method to reduce the concentration of ,-galactosidic compounds that are known to be flatulence producers. Soluble dietary fibre has also been implicated in flatulence production; however, little information exists about the effectiveness of fermentation in diminishing the effects of these compounds. The objective of this work was to study the effect of natural fermentation (NF) and controlled fermentation (CF) on the content of ,-galactosides and dietary fibre in dry beans (Phaseolus vulgaris) for 24, 48, 72 and 96 h. After 48 h, the pH during NF dropped from 6.15 to 4.00 and the nominal acidity increased six times; for CF, however, although the decrease in pH was similar to that for NF, the nominal acidity increased only three times after 48 h. Insoluble fibre content did not change the pH significantly after 96 h for NF and CF. Soluble fibre suffered an apparent removal after 48 h of NF and underwent a sharp reduction of 66% after 96 h of CF. The concentration of stachyose (the main ,-galactoside in raw beans) diminished notably after 48 h and 96 h NF (72% and 95% respectively), whereas with CF only 11% was removed after 96 h. NF of P vulgaris seems to be more effective than CF in reducing the flatulence-producer factors (,-galactosides and soluble dietary fibre). Copyright © 2003 Society of Chemical Industry [source] Holocene vegetation and climate changes in Hoton-Nur basin, northwest MongoliaBOREAS, Issue 2 2000PAVEL TARASOV Radiocarbon-dated pollen and diatom records from Hoton-Nur lake (48°40'N, 88°18'E), northwest Mongolia are used to reconstruct Holocene vegetation and climate changes. Steppe, which covered the area some time before 9000 BP (all ages are given in 14C BP), was replaced by boreal conifer forest-steppe by 9000,8500 BP. At the same time, planktonic diatoms increased in abundance from 5 to 45%. After 4000 BP there was a sharp reduction in forest and re-establishment of steppe. Changes in the pollen composition were accompanied by a decrease in the abundance of planktonic diatoms from 35,50% (between 9000 and 5500 BP) to less than 10% soon after 4000 BP. These and other published data from Mongolia suggest wetter conditions during the early and middle Holocene than those of today. This pattern probably reflects an expansion of the Pacific monsoon recorded in geological data from China and simulated in climate-model experiments, and suggests that the summer monsoon influenced a larger area than might appear if the Chinese records only are taken into consideration. [source] Food consumption impacts of adherence to dietary norms in the United States: a quantitative assessmentAGRICULTURAL ECONOMICS, Issue 2-3 2007C. S. Srinivasan Dietary norms; Dietary adjustment; Food consumption impacts; Quadratic programming Abstract Promotion of adherence to healthy-eating norms has become an important element of nutrition policy in the United States and other developed countries. We assess the potential consumption impacts of adherence to a set of recommended dietary norms in the United States using a mathematical programming approach. We find that adherence to recommended dietary norms would involve significant changes in diets, with large reductions in the consumption of fats and oils along with large increases in the consumption of fruits, vegetables, and cereals. Compliance with norms recommended by the World Health Organization for energy derived from sugar would involve sharp reductions in sugar intakes. We also analyze how dietary adjustments required vary across demographic groups. Most socio-demographic characteristics appear to have relatively little influence on the pattern of adjustment required to comply with norms. Income levels have little effect on required dietary adjustments. Education is the only characteristic to have a significant influence on the magnitude of adjustments required. The least educated rather than the poorest have to bear the highest burden of adjustment. Our analysis suggests that fiscal measures like nutrient-based taxes may not be as regressive as commonly believed. Dissemination of healthy-eating norms to the less educated will be a key challenge for nutrition policy. [source] | ||||||||||