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Severe CHD (severe + chd)

Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

Feeding infants with CHD with breast milk: Norwegian Mother and Child Cohort Study

ACTA PAEDIATRICA, Issue 3 2010
B. S. Tandberg
Abstract Objective:, To explore the prevalence of breast milk feeding (BMF) of infants with congenital heart defects (CHD) during first 6 months of life, as compared with general population. Design:, The study is based on a subsample of the Norwegian Mother and Child Cohort Study conducted by Norwegian Institute of Public Health. A total of 60 600 mothers completed a questionnaire about infant feeding at 6 months postpartum. Infants with moderate/severe CHD (n = 131) were identified using nationwide CHD registry. A group of infants with CHD with comorbidity was also defined (n = 65). BMF was classified as predominant, continued, or no BMF. Month to month feeding status was analysed by means of Cox regression analyses. Results:, Between child age 2,6 months, mothers of infants with CHD had a hazard ratio (HR) of 1.69 of weaning their child compared with mothers of controls. Mothers of infants with CHD with comorbidity weaned at an even faster rate (HR 3.54). At age 6 months, 9.9% of infants with CHD were fed with breast milk predominately, 64.1% continued to receive breast milk, and only 26% were fed no breast milk. For infants with CHD with comorbidity, corresponding percentages were 7.7%, 43.1% and 49.2%, respectively. Conclusions:, Although CHD alone and particularly CHD with comorbidity increased risk that mothers wean earlier, a relatively high rate of continued breastfeeding was maintained. Future studies should investigate factors that support continued BMF even in the most severely affected children with CHD. [source]

Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 4 2001
Z. Prohászka
Background Recent observations indicate an association between antibodies against mycobacterial heat shock protein (hsp65) and coronary heart disease (CHD). Previously, we reported on marked differences in antigen specificity and complement activating ability of anti-hsp65 antibodies and auto-antibodies against human heat shock protein, hsp60. Here, we investigated whether there are differences between antih-sp65 and anti-hsp60 antibodies in their association with CHD. Design We measured by ELISA the levels of antibodies to hsp65, hsp60 and E. coli -derived GroEL in three groups: Group I, 357 patients with severe CHD who underwent by-pass surgery; Group II, 67 patients with negative coronary angiography; Group III, 321 healthy blood donors. Antibodies against Helicobacter pylori were also measured by commercial ELISA. Results As calculated by multiple regression analysis, the levels of anti-hsp60 auto-antibodies were significantly higher in Group I compared to Group II (P = 0·007) or Group III (P < 0·0001). By contrast, although concentrations of anti-hsp65 and anti-GroEL antibodies in Group I were higher than in Group III, no significant differences between Group I and Group II were found. Antibodies to the two bacterial hsp strongly correlated to each other, but either did not correlate or weakly correlated to hsp60. In Group I, serum concentrations of anti- H.pylori antibodies significantly correlated with those of anti-hsp65 and anti-GroEL antibodies but they did not correlate with the anti-hsp60 antibodies. Conclusion As to their clinical relevance, a remarkable difference become evident between antibodies to human hsp60 and antibodies against bacterial hsp in the extent of association with CHD. On the basis of these findings and some pertinent literature data, an alternative explanation for the association between high level of anti-hsp antibodies and atherosclerotic vascular diseases is raised. [source]

Mothers' Attachment Style, Their Mental Health, and Their Children's Emotional Vulnerabilities: A 7-Year Study of Children With Congenital Heart Disease

JOURNAL OF PERSONALITY, Issue 1 2008
Ety Berant
ABSTRACT The long-term contribution of mothers' attachment insecurities to their own and their children's psychological functioning was examined in a 7-year prospective longitudinal study of children with Congenital Heart Disease (CHD). Sixty-three mothers of newborns with CHD participated in a three-wave study, beginning with the CHD diagnosis (T1), then 1 year later (T2), and again 7 years later (T3). At T1, the mothers reported on their attachment style and mental health. At T2, the mental health measure was administered again, along with a marital satisfaction scale. At T3, participants completed these two measures again, and their children reported on their self-concept and completed the Children's Apperception Test. Maternal avoidant attachment at T1 was the best predictor of deterioration in the mothers' mental health and marital satisfaction over the 7-year period, especially in a subgroup whose children had severe CHD. In addition, mothers' attachment insecurities (both anxiety and avoidance) at the beginning of the study were associated with their children's emotional problems and poor self-image 7 years later. [source]

Emotional reactivity in infants with congenital heart defects: findings from a large case-cohort study in Norway

ACTA PAEDIATRICA, Issue 1 2010
K Stene-Larsen
Abstract Aim:, Advances in medical treatment in recent years have led to dramatically improved survival rates of children with severe congenital heart defects (CHD). However, very little is known about the psychological consequences for these children, particularly during and after the early period of invasive treatment. In this study, we investigated the extent to which the severity of the CHD affects the child's emotional reactivity at 6 months of age. Method:, We linked prospective data from the Norwegian Mother and Child Cohort Study, conducted by the Norwegian Institute of Public Health with a nationwide medical CHD registry and identified 212 infants with CHD in a cohort of 61 299 infants. Mothers reported on their child's emotional reactivity at age 6 months by means of a standardized questionnaire. Results:, Infants with severe to moderate CHD had 60% higher odds for severe emotional reactivity (cut-off at the 85 percentile) compared with healthy infants, after controlling for important maternal and child confounders. Conclusion:, Our study is the first to show elevated emotional reactivity in children with moderate to severe CHD, suggesting a need for special parental attention to soothe their distress. Follow-up studies will show whether this emotional reactivity is transient or an early marker of continuing emotional or behavioural problems. [source]