			Home About us Contact

Serum Bactericidal Activity (serum + bactericidal_activity)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Mode of splenectomy and immunogenicity of meningococcal vaccination in patients with hereditary spherocytosis,

BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 4 2008
G. A. Stoehr
Background: Splenectomy predisposes patients to invasive disease from pneumococci, meningococci, and Haemophilus influenzae; immunization is mandatory. However, data on the impact of the splenectomy on vaccine immunogenicity are scarce. Methods: A total of 41 children with hereditary spherocytosis (aged 5·8,14·4 years) had complete (16) or near-total (25) splenectomy. All received one dose of monovalent meningococcal C conjugate vaccine (MCV-C) and, 2 months later, a tetravalent meningococcal polysaccharide vaccine (MPV-ACWY). Serum bactericidal activity and antibodies against serogroups A and C were determined before and after they received MCV-C, and 4 weeks after they received MPV-ACWY. Results: Before vaccination, only four of the 16 children who had a complete splenectomy were protected against serogroup A, compared with 15 of the 25 who had near-total splenectomy (P < 0·050), with the latter responding to immunization with significantly higher serogroup A serum bactericidal activity: geometric mean (95 per cent confidence interval) 1625.5 (49.9 to 3201.1) versus 980.6 (2.00 to 6204.1) (P < 0·050). All patients achieved putative protective serum bactericidal activity titres (at least 8) against serogroup C. Conclusion: Near-total splenectomy provides a favourable immunological basis for natural and vaccine-induced protection against meningococcal serogroup A and C infections. Sequential meningococcal vaccination is immunogenic in patients splenectomized for hereditary spherocytosis. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. [source]

Immune response, growth and survival of Labeo rohita fingerlings fed with levamisole supplemented diets for longer duration

AQUACULTURE NUTRITION, Issue 4 2009
C.K. MISRA
Abstract The study was to determine the effect of long-term administration of different dosages of levamisole on growth, immune response and disease resistance against Aeromonas hydrophila & Edwardsiella tarda in Labeo rohita fingerlings. Fish were fed with four different dosages of levamisole (0, 125, 250 and 500 mg kg,1 diet) for 56 days. Different serum biochemical and haematological parameters such as serum total protein content, albumin content, globulin content, albumin/globulin ratio, glucose content, leucocytes count; cellular immune parameters including superoxide anion production, phagocytic activities, lymphokine production index; humoural immune parameters including lysozyme, complement and serum bactericidal activities were evaluated after 14 days interval. After 56 days, fish were divided into two subgroups under each treatment group for challenge with pathogens A. hydrophila and E. tarda. The cumulative mortality (%) and agglutinating antibody titre was recorded on 28th day postchallenge. WBC count, phagocytic ratio, lymphokine production index, lysozyme activity and serum bactericidal activity were increased upon administration of levamisole dosages for long term. However, the growth performance and survival against pathogens was not significantly changed over 56 days administration of levamisole. But incorporation of moderate dosage of levamisole for 42 days results better immune response without effect on growth and survival of L. rohita fingerlings. [source]

Neisseria meningitidis serogroup B: laboratory correlates of protection

FEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, Issue 2 2002
Clementien Vermont
Abstract Meningococcal disease in the Western countries is frequently caused by Neisseria meningitidis serogroup B. Major efforts have been made to develop a safe and efficacious vaccine against this serogroup which is suitable for use in infants and young children. To assess the quality of the immune response after vaccination with candidate vaccines, laboratory correlates of protection are needed. For serogroups A and C, serum bactericidal activity (SBA) is a well established predictor for protection, but for serogroup B other mechanisms besides SBA may also be involved in conferring protection from disease. Several laboratory methods for identification and evaluation of the immunogenicity of possible vaccine antigens are described in this review. [source]

Immune response, growth and survival of Labeo rohita fingerlings fed with levamisole supplemented diets for longer duration

The effect of vitamin C on stress withstanding capability in the juvenile soft-shelled turtle (Pelodiscus sinensis)

AQUACULTURE NUTRITION, Issue 3 2005
XIAN-QING ZHOU
Abstract The study was conducted to determine the effect of dietary supplementation of vitamin C on anti-acid stress ability in juvenile soft-shelled turtle. The soft-shelled turtles were fed vitamin C supplemented diets at levels of 0, 250, 500, 2500, 5000 and 10 000 mg kg,1 for 4 weeks. The results showed that the phagocytic rate of blood cell in the group fed vitamin C deficient diets, the serum bacteriolytic activity in the two groups fed vitamin C supplemented diet at 0 and 250 mg kg,1 and the serum bactericidal activity in all groups after acid stress significantly decreased compared with those of before stress (P < 0.1). The phagocytic rate of blood cells in the two groups fed vitamin C supplemented diet at 2500 and 5000 mg kg,1 were significantly higher than those of the four groups fed at 0, 250, 500 and 10 000 mg kg,1 (P < 0.01). The serum bacteriolytic activity in the groups fed vitamin C supplemented diet at 500, 2500, 5000 and 10 000 mg kg,1 were significantly higher than that of the group fed vitamin C deficient diets (P < 0.05), and the two groups fed vitamin C at 2500 and 5000 mg kg,1 were significantly higher than those of the groups fed at 250 and 10 000 mg kg,1 (P < 0.05). The serum bactericidal activities in the four groups fed vitamin C supplemented diet at 500, 2500, 5000 and 10 000 mg kg,1 were significantly higher than those of the two groups fed at 0 and 250 mg kg,1 diet (P < 0.01), and the two groups fed vitamin C at 2500 and 5000 mg kg,1 were significantly higher than those of the two groups fed at 500 and 10 000 mg kg,1 (P < 0.1). These results suggest that supplementation of vitamin C higher than 250 mg kg,1 is necessary to reduce the adverse effects of acid stress. [source]