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Secondary Parameters (secondary + parameter)
Selected AbstractsGlucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator,ARTHRITIS & RHEUMATISM, Issue 2 2007Gabriel Herrero-Beaumont Objective To assess the effects of the prescription formulation of glucosamine sulfate (1,500 mg administered once daily) on the symptoms of knee osteoarthritis (OA) during a 6-month treatment course. Methods Three hundred eighteen patients were enrolled in this randomized, placebo-controlled, double-blind trial in which acetaminophen, the currently preferred medication for symptomatic treatment of OA, was used as a side comparator. Patients were randomly assigned to receive oral glucosamine sulfate 1,500 mg once daily (n = 106), acetaminophen 3 gm/day (n = 108), or placebo (n = 104). The primary efficacy outcome measure was the change in the Lequesne index after 6 months. Secondary parameters included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and response according to the Osteoarthritis Research Society International criteria. These outcome measures were assessed using an intent-to-treat analysis. Results At baseline, the study patients had moderately severe OA symptoms (mean Lequesne index ,11 points). Glucosamine sulfate was more effective than placebo in improving the Lequesne score, with a final decrease of 3.1 points, versus 1.9 with placebo (difference between glucosamine sulfate and placebo ,1.2 [95% confidence interval ,2.3, ,0.8]) (P = 0.032). The 2.7-point decrease with acetaminophen was not significantly different from that with placebo (difference ,0.8 [95% confidence interval ,1.9, 0.3]) (P = 0.18). Similar results were observed for the WOMAC. There were more responders to glucosamine sulfate (39.6%) and acetaminophen (33.3%) than to placebo (21.2%) (P = 0.004 and P = 0.047, respectively, versus placebo). Safety was good, and was comparable among groups. Conclusion The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms. Although acetaminophen also had a higher responder rate compared with placebo, it failed to show significant effects on the algofunctional indexes. [source] Application of modern tensor calculus to engineered domain structures.ACTA CRYSTALLOGRAPHICA SECTION A, Issue 2 2006The theory of domain states is reviewed as a prerequisite for consideration of tensorial distinction of domain states. It is then shown that the parameters of the first domain in a ferroic phase transition from a set of isomorphic groups of the same oriented Laue class can be systematically and suitably represented in terms of typical variables. On replacing these variables by actual tensor components according to the previous paper [Kopský (2006), Acta Cryst. A62, 4764], we can reveal the tensorial parameters associated with each particular symmetry descent. Parameters are distinguished by the ireps to which they belong and this can be used to determine which of them are the principal parameters that distinguish all domain states, in contrast to secondary parameters which are common to several domain states. In general, the parameters are expressed as the covariant components of the tensors. A general procedure is described which is designed to transform the results to Cartesian components. It consists of two parts: the first, called the labelling of covariants, and its inverse, called the conversion equations. Transformation of parameters from the first domain state to other states is now reduced to irreducible subspaces whose maximal dimension is three in contrast with higher dimensions of tensor spaces. With this method, we can explicitly calculate tensor parameters for all domain states. To find the distinction of pairs of domain states, it is suitable to use the concept of the twinning group which is briefly described. [source] No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRIBIOELECTROMAGNETICS, Issue 4 2003Ilka B. Schiffer Abstract The purpose of this study was to examine whether exposure to magnetic fields (MFs) relevant for magnetic resonance imaging (MRI) in clinical routine influences cell cycle progression in two tumor cell lines in vitro. HL60 and EA2 cells were exposed to four types of MFs: (i) static MF of 1.5 and 7.05 T, (ii) extremely low frequency magnetic gradient fields (ELFMGFs) with ±,10 mT/m and 100 Hz, as well as ±,100 mT/m and 100 Hz, (iii) pulsed high frequency MF in the radiofrequency (RF) range (63.6 MHz, 5.8 ,T), and (iv) a combination of (i,iii). Exposure periods ranged from 1 to 24 h. Cell cycle distribution (G0/G1, S, and G2/M phases) was analyzed by flow cytometry. Cell cycle analysis did not reveal differences between the exposed and the control cells. As expected, positive controls with irradiated (8 Gy) HL60 and EA2 cells showed a strong G2/M arrest. Using conditions that are relevant for patients during MRI, no influence of MFs on cell cycle progression was observed in these cell lines. Care was taken to control secondary parameters of influence, such as vibration by the MR scanner or temperature to avoid false positive results. Bioelectromagnetics 24:241-250, 2003. © 2003 Wiley-Liss, Inc. [source] Use of a new cross-linked collagen membrane for the treatment of dehiscence-type defects at titanium implants: a prospective, randomized-controlled double-blinded clinical multicenter studyCLINICAL ORAL IMPLANTS RESEARCH, Issue 7 2009Jürgen Becker Abstract Objectives: The aim of the present randomized-controlled double-blinded clinical multicenter study was to assess the use of either a new cross-linked (VN) or a native collagen membrane (BG) for the treatment of dehiscence-type defects at titanium implants. Material and methods: A total of n=54 patients were recruited in four German university clinics. According to a parallel-groups design, dehiscence-type defects at titanium implants were filled with a natural bone mineral and randomly assigned to either VN or BG. Submerged sites were allowed to heal for 4 months. Primary (e.g., changes in defect length ,,DL, quality of newly formed tissue [0,4] , TQ) and secondary parameters (e.g., membrane exposure, tissue conditions at dehisced sites) were consecutively recorded. Results: Four patients were excluded due to an early wound infection (VN:3; BG:1), and one patient was lost during follow-up (VN). The mean ,DL was 3.0 ± 2.5 mm in the VN, and 1.94 ± 2.13 mm in the BG group. The assessment of TQ revealed comparable mean values in both groups (VN: 3.05 ± 1.66, BG: 3.46 ± 1.48). A significant correlation between membrane exposure and inflammation of the adjacent soft tissue was observed in the VN group. In both groups, the mean DL and TQ values were not significantly different at either non-exposed or exposed implant sites. Conclusion: The results of the present study have indicated that VN supported bone regeneration on a level non-inferior to BG. However, in case of a premature membrane exposure, cross-linking might impair soft-tissue healing or may even cause wound infections. [source] | ||||||||||