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Secondary Amines (secondary + amine)
Kinds of Secondary Amines Selected AbstractsChemInform Abstract: A Novel Three-Component Reaction of a Secondary Amine and a 2-Hydroxybenzaldehyde Derivative with an Isocyanide in the Presence of Silica Gel: An Efficient One-Pot Synthesis of Benzo[b]furan Derivatives.CHEMINFORM, Issue 2 2010Ali Ramazani Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Highly Enantio- and Diastereoselective Michael Addition of Cyclohexanone to Nitroolefins Catalyzed by a Chiral Glucose-Based Bifunctional Secondary Amine,Thiourea Catalyst.CHEMINFORM, Issue 51 2009Aidang Lu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: An Enantioselective Biginelli Reaction Catalyzed by a Simple Chiral Secondary Amine and Achiral Broensted Acid by a Dual-Activation Route.CHEMINFORM, Issue 32 2008Junguo Xin Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] A New Method for the Synthesis of Functionalized 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-one: Reaction of an Enamine, Derived from Addition of a Secondary Amine to Dibenzoylacetylene, with an Arylsulfonyl Isocyanate.CHEMINFORM, Issue 10 2007Abdolali Alizadeh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Catalytic Reductive Alkylation of Secondary Amine with Aldehyde and Silane by an Iridium Compound.CHEMINFORM, Issue 32 2005Tomoya Mizuta Abstract For Abstract see ChemInform Abstract in Full Text. [source] Selective Analysis of Secondary Amines Using Liquid Chromatography with Electrochemical Detection (LC-EC)ELECTROANALYSIS, Issue 21 2006Celia Abstract In a mixture of primary and secondary aliphatic amines, the primary amines were derivatized (masked) with o -phthalaldehyde (OPA) followed by derivatization of the remaining secondary amines with ferrocenecarboxylic acid chloride (FAC). The "tagged" amines were analyzed by LC-EC (liquid chromatography with electrochemical detection) using in-series dual electrode detection. Chemically-reversible oxidation of the FAC tagged secondary amines and their subsequent complementary oxidation and reduction signals coupled with chemically-irreversible oxidation of OPA tagged primary amines provided the selectivity for quantitative secondary amine analysis. The procedure was also applied for the selective identification of fragment 4,11 (N -terminus-proline) of Substance P in the presence of other Substance P fragments with primary amino acids as their N -termini. [source] Effective Oxidation of Secondary Amines to Nitrones with Alkyl Hydroperoxides Catalysed by (Trialkanolaminato)titanium(IV) ComplexesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 4 2010Massimiliano Forcato Abstract The effective catalytic oxidation of secondary amines to nitrones with alkyl hydroperoxides as the primary oxidants is described. The titanium alkoxide catalysts are protected from the water co-product by the combined use of a tightly binding trialkanolamine ligand and molecular sieves. Nitrones can be obtained in high yields (up to 98,%) under homogeneous, anhydrous conditions and even in the absence of solvent. The reactions are fast (2,7 h) and good selectivity and complete conversion can be achieved with as little as 1,% catalyst. [source] Cobalt-Catalyzed C,N Bond-Forming Reaction between N-Aromatic 2-Chlorides and Secondary AminesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 27 2009Gabriel Toma Abstract Secondary amines react with N-aromatic 2-chlorides in the presence of a catalytic amount of cobalt chloride. When DPPP was added as ligand, the yield was further improved. The N-aromatic-containing tertiary amines formed are interesting due to their potential biological activity. This work represents the first cobalt-catalyzed approach to C,N bond formation involving N-aromatic 2-chlorides and secondary amines having a certain amount of versatility and functional group tolerance.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] Exclusive ,-Substitution in the Reaction of Octafluoronaphthalene with Secondary AminesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 4 2004Vladimir I. Sorokin Abstract The reaction between octafluoronaphthalene and dimethylamine, pyrrolidine or piperidine in DMF, dimethyl(ethylene)urea (DMEU) or without solvent leads to the exclusive substitution of ,-fluorine atoms giving naphthalene derivatives with four NR2 groups. This was proved by 19F NMR of the products and a crystal structure determination for 1,4,5,8-tetrafluoro-2,3,6,7-tetrakis(piperidin-1-yl)naphthalene. The main feature of the reaction in DMF was a transamidation process. The remaining four fluorine atoms in the synthesised tetraamines could be smoothly replaced by reduction with LiAlH4. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source] The Reaction of Peroxynitrite with Morpholine (Secondary Amines) Revisited: The Overlooked Hydroxylamine FormationHELVETICA CHIMICA ACTA, Issue 10 2006Michael Kirsch Abstract The reaction of peroxynitrite/peroxynitrous acid with morpholine as a model compound for secondary amines is reinvestigated in the absence and presence of carbon dioxide. The concentration- and pH-dependent formation of N -nitrosomorpholine and N -nitromorpholine as reported in three previous papers ([25],[26],[14]) is basically confirmed. However, 13C-NMR spectroscopic product analysis shows that, in the absence of CO2, N -hydroxymorpholine is, at pH,,,7, the major product of this reaction, even under anaerobic conditions. The formation of N -hydroxymorpholine has been overlooked in the three cited papers. Additional (ring-opened) oxidation products of morpholine are also detected. The data account for radical pathways for the formation of these products via intermediate morpholine-derived aminyl and , -aminoalkyl radicals. This is further supported by EPR-spectrometric detection of morpholine-derived nitroxide radicals, i.e., morpholin-4-yloxy radicals. N -Nitrosomorpholine, however, is very likely formed by electrophilic attack of peroxynitrite-derived N2O4. 15N-CIDNP Experiments establish that, in the presence of CO2, N -nitro- and C -nitromorpholine are generated by radical recombination. The present results are in full accord with a fractional (28,±,2%) homolytic decay of peroxynitrite/peroxynitrous acid with release of free hydroxyl and nitrogen dioxide radicals. [source] Efficient Catalytic Synthesis of Tertiary and Secondary Amines from Alcohols and Urea,ANGEWANDTE CHEMIE, Issue 52 2009Jinling He Dr. Harnstoff als Stickstoffquelle: Trägerfixiertes Rutheniumhydroxid, Ru(OH)x/TiO2, dient in der Titelreaktion als effizienter Heterogenkatalysator. Der nach der Reaktion zurückgewonnene Katalysator konnte ohne merklichen Verlust an katalytischer Aktivität wiederverwendet werden. [source] Tantalum,Amidate Complexes for the Hydroaminoalkylation of Secondary Amines: Enhanced Substrate Scope and Enantioselective Chiral Amine Synthesis,ANGEWANDTE CHEMIE, Issue 44 2009Patrick Eisenberger Dr. Mono- und Diamidat-Tantalkomplexe wurden synthetisiert und in der katalytischen ,-Alkylierung sekundärer Amine getestet (siehe Schema). Eine spontane ,-Wasserstoffabstraktion führt zu einem katalytisch aktiven Tantalaaziridin, das als erste Verbindung seiner Klasse vollständig charakterisiert werden konnte. [source] ChemInform Abstract: Cobalt-Catalyzed C,N Bond-Forming Reaction Between N-Aromatic 2-Chlorides and Secondary Amines.CHEMINFORM, Issue 4 2010Gabriel Toma Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Biomimetic Electrocatalytic System for the Atom-Economical Chemoselective Synthesis of Secondary Amines.CHEMINFORM, Issue 25 2009Martine Largeron Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Efficient Procedure for Chemoselective N-Nitrosation of Secondary Amines with Trichloromelamine,NaNO2.CHEMINFORM, Issue 8 2008A. Bamoniri Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Catalytic Addition of Secondary Amines to Carbodiimides by a Half-Sandwich Yttrium Complex: An Efficient Route to N,N,,N,,,N,,-Tetrasubstituted Guanidines.CHEMINFORM, Issue 37 2006Wen-Xiong Zhang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis of 5-Bromomethylisoxazoles and Their Reactions with Secondary Amines.CHEMINFORM, Issue 16 2006A. G. Aliev Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Mercurous Chloride Catalyzed Mannich Condensation of Terminal Alkynes with Secondary Amines and Aldehydes.CHEMINFORM, Issue 50 2005Pin-Hua Ll Abstract For Abstract see ChemInform Abstract in Full Text. [source] Selective Access to Secondary Amines by a Highly Controlled Reductive Mono-N-Alkylation of Primary Amines.CHEMINFORM, Issue 7 2004Hephzibah J. Kumpaty Abstract For Abstract see ChemInform Abstract in Full Text. [source] Selective Cleavage of N-Benzyl-Protected Secondary Amines by Triphosgene.CHEMINFORM, Issue 22 2003Martin G. Banwell Abstract For Abstract see ChemInform Abstract in Full Text. [source] A New Protocol for the One-Pot Preparation of Highly Diastereomerically Enriched Secondary Amines and ,-Amino Esters Mediated by Lithium Perchlorate Solution in Diethyl Ether.CHEMINFORM, Issue 15 2003Mohammad R. Saidi No abstract is available for this article. [source] Interaction of Diazoimidazoles and Their Diazonium Salts with Primary and Secondary Amines.CHEMINFORM, Issue 39 2002Elena V. Sadtchikova Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: Chemoselective N-Nitrosation of Secondary Amines under Mild and Heterogeneous Conditions.CHEMINFORM, Issue 31 2001Mohammad Ali Zolfigol Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Cobalt-Catalyzed C,N Bond-Forming Reaction between N-Aromatic 2-Chlorides and Secondary AminesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 27 2009Gabriel Toma Abstract Secondary amines react with N-aromatic 2-chlorides in the presence of a catalytic amount of cobalt chloride. When DPPP was added as ligand, the yield was further improved. The N-aromatic-containing tertiary amines formed are interesting due to their potential biological activity. This work represents the first cobalt-catalyzed approach to C,N bond formation involving N-aromatic 2-chlorides and secondary amines having a certain amount of versatility and functional group tolerance.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] Aiding Factors in the Formation of Azaplatinacyclobutane Rings , X-ray and Crystal Structure of [Pt{CH(Ph)CH2NEt2 -,C,,N}(N,N,N,,N, -tetramethylethylenediamine)]+ and of Its Open-Chain PrecursorEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 15 2007Giuseppe Lorusso Abstract The addition products 2 of a secondary amine to a coordinated olefin, in the cationic complexes [PtCl(,2 -CH2=CHR)(tmeda)]+ (tmeda = N,N,N,,N, -tetramethylethylenediamine; R = Me, 1a; Ph, 1b, H, 1c), undergo in basic medium an intramolecular nucleophilic substitution with elimination of the chlorido ligand and formation of an azaplatinacyclobutane ring 3. The ring-closing process occurs notwithstanding the absence of a labilizing ligand trans to the leaving chlorido ligand and of bulky substituents on the amino,ethanide chain. If the addition product 2 is a mixture of Markovnikov and anti-Markovnikov isomers, the ring-closing reaction is faster for the anti-Markovnikov form, and this leads to an increase of the relative amount of the anti-Markovnikov isomer in the cyclized species 3. The difference in the rate of formation of the azaplatinacyclobutane ring between the two isomers has been interpreted on the basis of a more favorable stereochemistry in the case of the anti-Markovnikov form. The X-ray crystal structures of [Pt{CH(Ph)CH2NEt2 -,C,,N}(tmeda)]+ (3bn) and of its open-chain precursor, [PtCl{CH(Ph)CH2NHEt2}(tmeda)]+ (2bn) fully support this hypothesis.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source] A New Approach to the Synthesis of N,N -Dialkyladenine DerivativesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 29 2007M. José Alves Abstract N,N- Dialkyladenine derivatives were prepared by two different reaction sequences starting from 5-amino-4-cyanoformimidoylimidazoles. When these imidazoles were treated with dimethylformamide diethyl acetal, a 5-aminomethyleneamino-4-cyanoformimidoylimidazole was isolated and evolved to the N,N- dialkyladenine in the presence of a secondary alkylamine. The same purine structure was isolated when the 5-amino-4-cyanoformimidoylimidazole was first treated with a secondary amine to give a stable 4-amidino-5-aminoimidazole. The desired product was generated when the 4-amidino-5-aminoimidazole was combined with dimethylformamide diethyl acetal, at room temperature. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source] Synthesis of 2-Azabicyclo[3.2.2]nonane-Derived Monosaccharide Mimics and Their Evaluation as Glycosidase InhibitorsHELVETICA CHIMICA ACTA, Issue 3 2006Stephan Buser Abstract The racemic 2-azabicyclo[3.2.2]nonanes 5 and 18 were synthesized and tested as , -glycosidase inhibitors. The intramolecular Diels,Alder reaction of the masked o -benzoquinone generated from 2-(allyloxy)phenol (6) gave the , -keto acetal 7 which was reduced with SmI2 to the hydroxy ketone 8. Dihydroxylation, isopropylidenation (,,12), and Beckmann rearrangement provided lactam 15. N -Benzylation of this lactam, reduction to the amine 17, and deprotection provided the amino triol 19 which was debenzylated to the secondary amine 5. Both 5 and 19 proved weak inhibitors of snail , -mannosidase (IC50,>,10,mM), Caldocellum saccharolyticum , -glucosidase (IC50,>,10,mM), sweet almond , -glucosidase (IC50,>,10,mM), yeast , -glucosidase (5: IC50,>,10,mM; 19: IC50,=,1.2,mM), and Jack bean , -mannosidase (no inhibition detected). [source] Efficient and General Synthesis of 3-Aminoindolines and 3-Aminoindoles via Copper-Catalyzed Three-Component Coupling ReactionADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2010Dmitri Chernyak Abstract An efficient three-component coupling (TCC) reaction toward a variety of 3-aminoindoline and 3-aminoindole derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction between 2-aminobenzaldehyde, a secondary amine, and an alkyne leading to a propargylamine intermediate which, under the reaction conditions, undergoes cyclization into the indoline core. The latter, upon treatment with a base, smoothly isomerizes into the indole. Alternatively, the indole can directly be synthesized in a one-pot sequential reaction. [source] Solid-phase synthesis of C -terminally modified peptidesJOURNAL OF PEPTIDE SCIENCE, Issue 11 2006Hefziba T. Ten Brink Abstract In this paper, a straightforward and generic protocol is presented to label the C -terminus of a peptide with any desired moiety that is functionalized with a primary amine. Amine-functional molecules included are polymers (useful for hybrid polymers), long alkyl chains (used in peptide amphiphiles and stabilization of peptides), propargyl amine and azido propyl-amine (desirable for ,click' chemistry), dansyl amine (fluorescent labeling of peptides) and crown ethers (peptide switches/hybrids). In the first part of the procedure, the primary amine is attached to an aldehyde-functional resin via reductive amination. To the secondary amine that is produced, an amino acid sequence is coupled via a standard solid-phase peptide synthesis protocol. Since one procedure can be applied for any given amine-functional moiety, a robust method for C -terminal peptide labeling is obtained. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd. [source] Reactivity of C4-indolyl substituted 1,4-dihydropyridines toward superoxide anion (O2,) in dimethylsulfoxideJOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 6 2009Ricardo Salazar Abstract Reactivity of two new C4-indolyl substituted 1,4-dihydropyridines (1,4-DHPs) toward superoxide anion (O2,) in dimethylsulfoxide (DMSO) is reported. Reactivity was followed by electrochemical and spectroscopic techniques. Gas chromatography-mass spectrometry (GC,MS) was used to identify the final products of the reaction. C4 indolyl-substituted-1,4-DHPs reacted toward O2, at significant rates, according to the calculated kinetic rate constants. Results are compared with 4-phenyl-DHP and the commercial 1,4-DHPs, nimodipine, nisoldipine, and amlodipine. Indolyl-substituted 1,4-DHPs were more reactive than the commercial derivatives. The direct participation of proton of the 1-position of the secondary amine in the quenching of O2, was demonstrated. Copyright © 2008 John Wiley & Sons, Ltd. 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