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Avoidance Learning (avoidance + learning)

Distribution by Scientific Domains

Life Sciences	72%

Kinds of Avoidance Learning

passive avoidance learning

Selected Abstracts

A Synthetic Peptide Ligand of Neural Cell Adhesion Molecule (NCAM) IgI Domain Prevents NCAM Internalization and Disrupts Passive Avoidance Learning

JOURNAL OF NEUROCHEMISTRY, Issue 6 2000
Andrew G. Foley
Abstract: The neural cell adhesion molecule (NCAM) mediates cell adhesion and signal transduction through trans -homophilic- and/or cis -heterophilic-binding mechanisms. Intraventricular infusions of anti-NCAM have revealed a functional requirement of NCAM for the consolidation of memory in rats and chicks in a specific interval 6-8 h after training. We have now extended these studies to a synthetic peptide ligand of NCAM (C3) with an affinity for the IgI domain and the capability of inhibiting NCAM-mediated neurite outgrowth in vitro. Intraventricular administration of a single 5 ,g bolus of C3 strongly inhibited recall of a passive avoidance response in adult rats, when given during training or in the 6-8-h posttraining period. The effect of C3 on memory consolidation was similar to that obtained with anti-NCAM as the amnesia was not observed until the 48-h recall time. The unique amnesic action of C3 during training could be related to disrupted NCAM internalization following training. In the 3-4-h posttraining period NCAM 180, the synapse-associated isoform, was down-regulated in the hippocampal dentate gyrus. This effect was mediated by ubiquitination and was prevented by C3 administration during training. These findings indicate NCAM to be involved in both the acquisition and consolidation of a passive avoidance response in the rat. Moreover, the study provides the first in vivo evidence for NCAM internalization in learning and identifies a synthetic NCAM ligand capable of modulating memory processes in vivo. [source]

Defensive Copers Show a Deficit in Passive Avoidance Learning on Newman's Go/No-Go Task: Implications for Self-Deception and Socialization

JOURNAL OF PERSONALITY, Issue 5 2004
Matthew S. Shane
High-anxious individuals, low-anxious individuals, and defensive copers completed a computerized go/no-go task, in which they learned when to press or not to press a button, in response to contingent positive and negative feedback. The duration that feedback remained onscreen was self-regulated. Defensive copers showed preferential reflection away from negative feedback, committed more passive-avoidance errors, and were characterized by impaired learning, overall. Further, the ratio of reflection on negative feedback to reflection on positive feedback directly mediated both passive-avoidance errors and overall learning. Defensive coping strategies, therefore, appear to interfere with passive avoidance learning, thereby fostering perseverative, dysfunctional action patterns by reducing knowledge gained from previous mistakes. Implications for the learning of effective socialization strategies, and for psychopathy,which is commonly characterized by similar passive-avoidance deficits,are subsequently considered. [source]

Passive avoidance training decreases synapse density in the hippocampus of the domestic chick

EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 4 2006
A. M. Nikolakopoulou
Abstract The bird hippocampus (Hp), although lacking the cellular lamination of the mammalian Hp, possesses comparable roles in spatial orientation and is implicated in passive avoidance learning. As in rodents it can be divided into dorsal and ventral regions based on immunocytochemical, tracing and electrophysiological studies. To study the effects of passive avoidance learning on synapse morphometry in the Hp, spine and shaft synapse densities of 1-day-old domestic chicks were determined in dorsal and ventral Hp of each hemisphere by electron microscopy, 6 and 24 h following training to avoid pecking at a bead coated with a bitter-tasting substance, methyl anthranilate (MeA). The density of asymmetric spine and shaft synapses in MeA-trained birds at 6 h post-training was significantly lower in the dorsal and ventral Hp of the right hemisphere relative to control (untrained) chicks, but by 24 h this difference was absent. A hemispheric asymmetry was apparent in the ventral Hp where the water-trained group showed enhanced shaft and spine synapse density in the left hemisphere, whilst in the MeA-trained group only asymmetric shaft synapses follow the same pattern in relation to the right hemisphere. There were no differences in asymmetric shaft synapses in the dorsal Hp at 6 h post-training, but at 24 h post-training there was a reduction in the density of shaft synapses in the right hemisphere in MeA compared with control birds. These data are discussed in relation to the pruning effects of stress and learning on synapse density in chick Hp. [source]

THE EFFECT OF ALTERNATIVE PREY ON THE DYNAMICS OF IMPERFECT BATESIAN AND MÜLLERIAN MIMICRIES

EVOLUTION, Issue 6 2004
Leena Lindström
Abstract Both Batesian and Müllerian mimicries are considered classical evidence of natural selection where predation pressure has, at times, created a striking similarity between unrelated prey species. Batesian mimicry, in which palatable mimics resemble unpalatable aposematic species, is parasitic and only beneficial to the mimics. By contrast, in classical Müllerian mimicry the cost of predators' avoidance learning is shared between similar unpalatable co-mimics, and therefore mimicry benefits all parties. Recent studies using mathematical modeling have questioned the dynamics of Müllerian mimicry, suggesting that fitness benefits should be calculated in a way similar to Batesian mimicry; that is, according to the relative unpalatability difference between co-mimics. Batesian mimicry is very sensitive to the availability of alternative prey, but the effects of alternative prey for Müllerian dynamics are not known and experiments are rare. We designed two experiments to test the effect of alternative prey on imperfect Batesian and Müllerian mimicry complexes. When alternative prey were scarce, imperfect Batesian mimics were selected out from the population, but abundantly available alternative prey relaxed selection against imperfect mimics. Birds learned to avoid both Müllerian models and mimics irrespective of the availability of alternative prey. However, the rate of avoidance learning of models increased when alternative prey were abundant. This experiment suggests that the availability of alternative prey affects the dynamics of both Müllerian and Batesian mimicry, but in different ways. [source]

Characterizing the pigment composition of a variable warning signal of Parasemia plantaginis larvae

FUNCTIONAL ECOLOGY, Issue 4 2010
Carita Lindstedt
Summary 1.,Aposematic animals advertise their defences to predators via warning signals that often are bright colours combined with black patterns. Predation is assumed to select for large pattern elements and conspicuousness of warning signals because this enhances avoidance learning of predators. However, conspicuousness of the colour pattern can vary among individuals of aposematic species, suggesting that warning signal expression may be constrained by opposing selection pressures. If effective warning signals are costly to produce, variation in signal expression may be maintained via physiological trade-offs. To understand the costs of signalling that might underlay both physiological and ecological trade-offs, it is crucial to identify the pigments involved in aposematic traits, how they or their precursors are acquired and how their production and/or deposition interact with other physiological processes. 2.,We characterized the pigments responsible for the genetically and phenotypically variable orange-black warning signal of the hairy larvae of an Arctiid moth, Parasemia plantaginis. We tested orange and black coloured hairs for the presence of six candidate pigment types using high-performance liquid chromatography, spectral and solubility analyses. 3.,After excluding the presence of carotenoids, ommochromes, pterins and pheomelanins in orange hairs, our results suggest that tiger moth larvae produce their orange warning signal by depositing both diet-derived flavonoids and trace levels of synthesized eumelanin in their hairs. The nearby black hairs are coloured by eumelanin. 4.,In light of previous studies, we conclude that although a large orange patch increases the 1larvae's antipredator efficacy, variation in the size of orange patches within a population can be driven by scarcity of flavonoids in diet. However, traces of eumelanin found in the orange hairs of the larvae may also play a significant role in the maintenance of the signal pattern on poor quality diets. 5.,The goal of the future studies will be to test the condition dependence of pigment deposition in aposematic colour patterns by directly manipulating relevant nutritional parameters such as dietary flavonoid or nitrogen content (i.e. amino acid content). [source]

Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease

GENES, BRAIN AND BEHAVIOR, Issue 2 2009
M. Filali
Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an Alzheimer's disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left,right discrimination learning, concordant with previous findings in other Alzheimer-like models. [source]

BDNF,triggered events in the rat hippocampus are required for both short- and long-term memory formation

HIPPOCAMPUS, Issue 4 2002
Mariana Alonso
Abstract Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic factor (BDNF) modulates both short-term synaptic function and activity-dependent synaptic plasticity in the adult hippocampus, we examined the role of BDNF in STM and LTM formation of a hippocampal-dependent one-trial fear-motivated learning task in rats. Using a competitive RT-PCR quantitation method, we found that inhibitory avoidance training is associated with a rapid and transient increase in BDNF mRNA expression in the hippocampus. Bilateral infusions of function-blocking anti-BDNF antibody into the CA1 region of the dorsal hippocampus decreased extracellular signal,regulated kinase 2 (ERK2) activation and impaired STM retention scores. Inhibition of ERK1/2 activation by PD098059 produced similar effects. In contrast, intrahippocampal administration of recombinant human BDNF increased ERK1/2 activation and facilitated STM. The infusion of anti-BDNF antibody impaired LTM when given 15 min before or 1 and 4 hr after training, but not at 0 or 6 hr posttraining, indicating that two hippocampal BDNF-sensitive time windows are critical for LTM formation. At the same time points, PD098059 produced no LTM deficits. Thus, our results indicate that endogenous BDNF is required for both STM and LTM formation of an inhibitory avoidance learning. Additionally, they suggest that this requirement involves ERK1/2-dependent and -independent mechanisms. Hippocampus 2002;12:551,560. © 2002 Wiley-Liss, Inc. [source]

"Juvenile stress" alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: Relevance for stress-related psychopathologies

JOURNAL OF NEUROSCIENCE RESEARCH, Issue 2 2010
M.M. Tsoory
Abstract L1 is critically involved in neural development and maturation, activity-dependent synaptic plasticity, and learning processes. Among adult rats, chronic stress protocols that affect L1 functioning also induce impaired cognitive and neural functioning and heightened anxiety reminiscent of stress-induced mood and anxiety disorders. Epidemiological studies indicate that childhood trauma is related predominantly to higher rates of both mood and anxiety disorders in adulthood and is associated with altered limbic system functioning. Exposing rats to stress during the juvenile period ("juvenile stress") has comparable effects and was suggested as a model of induced predisposition for these disorders. This study examined the effects of juvenile stress on rats aversive learning and on L1 expression soon after exposure and in adulthood, both following additional exposure to acute stress and in its absence. Adult juvenile-stressed rats exhibited enhanced cued fear conditioning, reduced novel-setting exploration, and impaired avoidance learning. Furthermore, juvenile stress increased L1 expression in the BLA, CA1, DG, and EC both soon after the stressful experience and during adulthood. It appears that juvenile stress affects the normative maturational decrease in L1 expression. The results support previous indications that juvenile stress alters the maturation of the limbic system and further support a role for L1 regulation in the mechanisms that underlie the predisposition to exhibit mood and/or anxiety disorders in adulthood. Furthermore, the findings support the "network hypothesis," which postulates that information-processing problems within relevant neural networks might underlie stress-induced mood and anxiety disorders. © 2009 Wiley-Liss, Inc. [source]

Defensive Copers Show a Deficit in Passive Avoidance Learning on Newman's Go/No-Go Task: Implications for Self-Deception and Socialization

Enhanced conditioned inhibitory avoidance by a combined extract of Zingiber officinale and Ginkgo biloba

PHYTOTHERAPY RESEARCH, Issue 4 2002
B. Topic
Abstract Previous work has shown that intragastric administration of Zingicomb®, a preparation consisting of Zingiber officinale and Ginkgo biloba extracts, has anxiolytic-like properties. The aim of the present study was to assess the effects of acute treatment with this preparation on inhibitory avoidance learning. The influence of pre-trial administered Zingicomb (ZC) on inhibitory avoidance conditioning was investigated in adult male Wistar rats, with a one-trial step-through avoidance task. The animals were treated intragastrically with either vehicle, 0.5, 1, 10 or 100,mg/kg ZC 60,min prior to the acquisition trial. When tested 24,h after training, rats which had received 10,mg/kg ZC exhibited significantly longer step-through latencies than vehicle treated animals. This result, thus, demonstrates the beneficial effects of Zingicomb on conditioned inhibitory avoidance. Unlike conventional anxiolytic drugs, such as the benzodiazepines, which tend to have amnesic properties, this phytopharmacon is a potent anxiolytic agent which, additionally, can facilitate performance on a learning task, indicating promising clinical applications. Copyright © 2002 John Wiley & Sons, Ltd. [source]