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Selected AbstractsThe Amiel-Tison neurological assessment at term: Conceptual and methodological continuity in the course of follow-upDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 1 2005Julie Gosselin Abstract The Amiel-Tison Neurological Assessment at Term (ATNAT) is part of a set of three different instruments based on a neuro-maturative framework. By sharing a same methodology and a similar scoring system, the use of these three assessments prevents any rupture in the course of high risk children follow-up from 32 weeks post-conception to 6 years of age. The ATNAT which takes 5 minutes to administer may be used in clinical setting as well as in research. Clustering of severe to mild neuro-cranial signs in the neonatal period permits identification of children who could benefit from early intervention. © 2005 Wiley-Liss, Inc. MRDD Research Reviews 2005;11:34,51. [source] A comparison of two spectral approaches for computing the Earth response to surface loadsGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 2 2000E. Le Meur Summary When predicting the deformation of the Earth under surface loads, most models follow the same methodology, consisting of producing a unit response that is then con-volved with the appropriate surface forcing. These models take into account the whole Earth, and are generally spherical, computing a unit response in terms of its spherical harmonic representation through the use of load Love numbers. From these Love numbers, the spatial pattern of the bedrock response to any particular scenario can be obtained. Two different methods are discussed here. The first, which is related to the convolution in the classical sense, appears to be very sensitive to the total number of degrees used when summing these Love numbers in the harmonic series in order to obtain the corresponding Green's function. We will see from the spectral properties of these Love numbers how to compute these series correctly and how consequently to eliminate in practice the sensitivity to the number of degrees (Gibbs Phenomena). The second method relies on a preliminary harmonic decomposition of the load, which reduces the convolution to a simple product within Fourier space. The convergence properties of the resulting Fourier series make this approach less sensitive to any harmonic cut-off. However, this method can be more or less computationally expensive depending on the loading characteristics. This paper describes these two methods, how to eliminate Gibbs phenomena in the Green's function method, and shows how the load characteristics as well as the available computational resources can be determining factors in selecting one approach. [source] Sedation and antihistamines: an update.HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 7 2008Review of inter-drug differences using proportional impairment ratios Abstract Background The use of antihistamines (AHs) has been associated with cognitive and psychomotor impairments, largely caused by the sedative properties of many of these drugs. Due to the ambulant nature of the population using AHs, it is important to evaluate these effects using standardised methodology and psychometric tests. A previous extensive review of the literature collated the results of studies of H1 receptor antagonists to determine the extent to which a particular AH produced impairments on a battery of psychometric tests by calculating a proportional impairment ratio for each AH. Objective In light of a number of major studies published following the previous review, and the development of the second and new-generation AHs, the present review aims to add to the database and update the review, using the same methodology. Results and Conclusion The newer generation AHs appear to be the least impairing, and the first generation, as expected, appear to be the most impairing. There are also differences within the AH drug generations. The review highlights the necessity to consider the sedating potential of AHs, along with other factors such as efficacy, when prescribing AHs to ambulant patients. Copyright © 2008 John Wiley & Sons, Ltd. [source] Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserineHUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 4 2007D. O. Kennedy Abstract Recent data suggest that the complexation of standardised Ginkgo biloba extract (GBE) with soy-derived phospholipids enhances the bio-availablity of GBE's active components. The current study therefore aimed to assess the comparative cognitive and mood effects of a low dose of GBE and products complexing the same extract with either phosphatidylserine or phosphatidylcholine. The study utilised a placebo-controlled, multi-dose, double-blind, balanced-crossover design. Twenty-eight healthy young participants received 120,mg GBE, 120,mg GBE complexed with phosphatidylserine (VirtivaÔ), 120,mg GBE complexed with phosphatidylcholine and a matching placebo, on separate days 7 days apart. Cognitive performance was assessed using the Cognitive Drug Research (CDR) computerised test battery and Serial Subtraction tasks immediately prior to dosing and at 1, 2.5, 4 and 6,h thereafter. The primary outcome measures were the four aspects of cognitive performance, which have previously been derived by factor analysis of CDR subtests. Levels of terpenoids (bilobalide, ginkgolide A and ginkgolide B) were concomitantly assessed in plasma samples taken pre-dose and at 3 and 6.5,h post-dose. In keeping with previous research utilising the same methodology, 120,mg of GBE was not associated with markedly improved performance on the primary outcomes. However, administration of GBE complexed with phosphatidylserine resulted both in improved secondary memory performance and significantly increased speed of memory task performance across all of the post-dose testing sessions. Enhancement following GBE complexed with phosphatidylcholine was restricted to a modest improvement in secondary memory performance which was restricted to one post-dose time point. All three treatments were associated with improved calmness. There were no significant differences in post-dose levels of terpenoids between the Ginkgo containing treatments, although this latter finding may be attributable to methodological factors. Complexation with phosphatidylserine appears to potentiate the cognitive effects associated with a low dose of GBE. Further research is required to identify whether this effect is due to the complexation of the extracts, their mere combination, or the separate psychopharmacological actions of the two extracts. Copyright © 2007 John Wiley & Sons, Ltd. [source] A comparative study of the magnitude, frequency and distribution of intense rainfall in the United KingdomINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 12 2010John C. Rodda Abstract During the 1960s, a study was made of the magnitude, frequency and distribution of intense rainfall over the United Kingdom, employing data from more than 120 daily read rain gauges covering the period 1911 to 1960. Using the same methodology, that study was recently updated utilizing data for the period 1961 to 2006 for the same gauges, or from those nearby. This paper describes the techniques applied to ensure consistency of data and statistical modelling. It presents a comparison of patterns of extreme rainfalls for the two periods and discusses the changes that have taken place. Most noticeably, increases up to 20% have occurred in the north-west of the country and in parts of East Anglia. There have also been changes in other areas, including decreases of the same magnitude over central England. The implications of these changes are considered. Copyright © 2009 Royal Meteorological Society [source] Incidence of severe anorexia nervosa in Switzerland: 40 years of developmentINTERNATIONAL JOURNAL OF EATING DISORDERS, Issue 3 2004Gabriella Milos Abstract Objective The current study examined the development of the incidence of severe anorexia nervosa with five sampling periods covering the years 1956,1995 in a geographically defined region of Switzerland. Method Applying the same methodology as in the earlier sampling periods, the medical records of all hospitals of the canton of Zurich were screened manually for first-time hospitalizations of female anorexia nervosa patients during the years 1993,1995. Incidence rates were compared with the previous sampling period (1956,1985). Results The incidence rate of severe anorexia nervosa in the total population and the rate in the population at risk (females 12,25 years old) did not differ significantly from the incidence rates of 1983,1985. Discussion The incidence of severe anorexia nervosa in the canton of Zurich rose significantly during the 1960s and 1970s. Since then, the incidence appears to have reached a plateau. © 2004 by Wiley Periodicals, Inc. Int J Eat Disord 35: 250,258, 2004. An erratum to this article is published in International Journal of Eating Disorders (2004) 36(1) 118,119. [source] Restricted rotation/tautomeric equilibrium and determination of the site and extent of protonation in bi-imidazole nucleosides by multinuclear NMR and GIAO-DFT calculationsJOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 3 2005Jukka Mäki Abstract The restricted rotation about the conjoining bond in a series of 4,-substituted bi-imidazole nucleosides {5-amino-4-[4,-R-imidazol-2,-yl]-1-(,- d -ribofuranosyl)-1H -imidazole; where R=H, methyl, hydroxymethyl, oxalo, formyl} due to intramolecular hydrogen bonding between N-3, and the N-6 protons concomitant with prototropic tautomerism has been examined using multinuclear (1H, 13C and 15N) experimental NMR. Substitution at the 4, position causes the interconversion, whilst still an intramolecular process, to yield complex spectra as the dynamic process consists of a two-site exchange between non-degenerate tautomeric forms (asymmetric sites). The preferred tautomers were identified experimentally in each case and compared with theoretically determined structures geometry optimized using density functional theory (DFT) at the B3LYP/6,31G(d,p) level of theory on which gauge-independent atomic orbital-DFT (GIAO-DFT) computations at the B3LYP/cc-pVTZ level of theory were applied to calculate the chemical shifts of the 1H, 13C and 15N nuclei. Both the site and the extent of protonation of the bi-imidazole nucleosides were also similarly ascertained using the same methodology. Protonation at the pyridine-type nitrogen (N-3,) of the outer imidazole ring, the principle site of protonation, effectively eliminated the barrier to rotation about the conjoining bond yielding time-averaged spectra experimentally. Copyright © 2004 John Wiley & Sons, Ltd. [source] Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase ThreeALLERGY, Issue 1 2009N. Aït-Khaled Background:, Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global patterns of prevalence and severity of symptoms of rhinoconjunctivitis in children in 1993,1997. Methods:, International Study of Asthma and Allergies in Childhood Phase Three was a cross-sectional survey performed 5,10 years after Phase One using the same methodology. Phase Three covered all of the major regions of the world and involved 1 059 053 children of 2 age groups from 236 centres in 98 countries. Results:, The average overall prevalence of current rhinoconjunctivitis symptoms was 14.6% for the 13- to 14-year old children (range 1.0,45%). Variation in the prevalence of severe rhinoconjunctivitis symptoms was observed between centres (range 0.0,5.1%) and regions (range 0.4% in western Europe to 2.3% in Africa), with the highest prevalence being observed mainly in the centres from middle and low income countries, particularly in Africa and Latin America. Co-morbidity with asthma and eczema varied from 1.6% in the Indian sub-continent to 4.7% in North America. For 6- to 7-year old children, the average prevalence of rhinoconjunctivitis symptoms was 8.5%, and large variations in symptom prevalence were also observed between regions, countries and centres. Discussion:, Wide global variations exist in the prevalence of current rhinoconjunctivitis symptoms, being higher in high vs low income countries, but the prevalence of severe symptoms was greater in less affluent countries. Co-morbidity with asthma is high particularly in Africa, North America and Oceania. This global map of symptom prevalence is of clinical importance for health professionals. [source] Stabilization of asthma prevalence among adolescents and increase among schoolchildren (ISAAC phases I and III) in Spain,ALLERGY, Issue 12 2004L. García-Marcos Background:, Most studies show a steep increase in asthma prevalence in the last decades, although few studies had applied the same methodology. Recent reports point out the possibility that the epidemic has come to an end. We have studied the prevalence of asthma in a very large sample of children, repeating the study eight years apart. Methods:, Repeated cross-sectional studies using the International Study of Asthma and Allergies in Childhood (ISAAC) protocol in a sample of Spanish schoolchildren 6,7 (parent-reported) and 13,14 (self-reported) years old in 1994,95 (phase I) and 2002,2003 (phase III). The number of participants was 42 417 in phase I and 42 813 in phase III. The participation rate was over 87% (13,14 years) and 70% (6,7 years). Results:, The prevalence of wheezing in the previous year in children aged 13,14 years was 9.0 and 9.3% for boys and 9.6 and 9.2% for girls for phases I and III, respectively. Children 6,7 years of age showed a substantial increase in wheezing in the previous year (7.0 and 10.7% for boys and 5.3 and 8.2% for girls). Other symptoms and severity indexes followed the same patterns. Conclusions:, In the last 8 years, the prevalence of asthma has not changed in 13,14-year-old Spanish children but has increased substantially in 6,7-year olds. [source] Geographical difference in Parkinson's disease prevalence within West Scotland,MOVEMENT DISORDERS, Issue 3 2009Edward J. Newman MRCP Abstract The wide range in reported prevalence of Parkinson's disease (PD) in the United Kingdom (between 108 and 164 per 100,000) is usually attributed to differences in study methodology. We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7,128.6) and age-adjusted prevalence was 129.5 (95% CI 119.6,139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7,117.9; women 83.9, CI 65.6,102.2) than South Lanarkshire (men 202.7, CI 175.0,230.4; women 151.1, CI 127.7,174.5), age-adjusted rates, both P < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. Explorationof these factors is justified to explain further such wide variation in PD prevalence. © 2008 Movement Disorder Society [source] Facial Pain: A Possible Therapy with Stellate Ganglion BlockPAIN MEDICINE, Issue 7 2008Ilaria Salvaggio MD ABSTRACT Objective., The goal of the present study is to verify the efficacy of stellate ganglion block (SGB) in the treatment of facial pain that can be found in different pathological syndromes, and also to examine whether the efficacy is dependent upon when this therapy is administered. Patients., Fifty patients (divided into two randomized groups) with facial pain caused by traumas, iatrogenic issues, herpes zoster, or neurological pathologies participated in this study. Design and Interventions., The first group (N = 25) was treated with SGB produced by 10 administrations of 10 mg of levobupivacaine given every other day, followed by one administration per month for 6 months thereafter. The second group was treated with the drugs tramadol 100 mg/day and gabapentin 1800 mg/day orally for 6 months; during the 7th month they were given SGB therapy using the same methodology as that described for the first group. Results., Before treatment, the mean visual analog scale (VAS) pain score for the first group was 8.89; after the 10th block treatment it was just 0.2, and it remained at that reduced level for the 6th and 12th months. Before treatment, the mean VAS pain score for the second group was 8.83; after the 20th day on medication it was reduced to 4.1, after 6 months it was 5.7 and after 12 months it was 4.9. Conclusions., Our results indicate that patients must be treated with SGB therapy precociously to receive its full benefits. [source] Seasonal variability in exercise test responses in GhanaPEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 4 2002Emmanuel O. D. Addo-Yobo Exercise-induced bronchospasm (EIB) is widely used in epidemiological studies to investigate the prevalence of asthma. We aimed to determine seasonal variations in the prevalence of EIB in Ghanaian school children from urban-rich (UR), urban-poor (UP), and rural (R) schools. We have previously reported the prevalence of EIB in 9,16-year-old children to be 3.1% in the dry season, with UR children having a significantly higher prevalence of both EIB and atopy compared to UP or R children. In the current study, the prevalence of EIB was assessed in the same 1,095 children in the wet season (5 months following the initial study) using the same methodology. Exercise provocation consisted of free running outdoors for 6 min. In the wet season, 17/1,095 children [mean 1.55%, 95% confidence interval (CI): 0.91,2.47] had a positive response to exercise, compared to our previous report of 34 children (mean 3.1%, 95% CI: 2.15,4.32) with EIB in the dry season (dry vs. wet season, difference 1.55, 95% CI: 0.41,2.69). The proportion of children with a positive response to exercise in the UR school fell from 4.2% (25/599) to 1.3% (8/599) (difference 2.9, 95% CI: 1.2,4.5). In the wet season, there was no difference in the prevalence of EIB among the UR, UP, and R children. Only five of 1,095 subjects (mean 0.5%, 95% CI: 0.15,1.07) demonstrated EIB in both seasons. In conclusion, although exercise challenge remains a useful tool for determining asthma prevalence in epidemiological studies, seasonal variations in the pattern of responses may occur and the results should be interpreted with caution. [source] Evaluation of prenatal diagnosis of associated congenital heart diseases by fetal ultrasonographic examination in EuropePRENATAL DIAGNOSIS, Issue 4 2001C. Stoll Abstract Ultrasound scans in the mid trimester of pregnancy are now a routine part of antenatal care in most European countries. With the assistance of Registries of Congenital Anomalies a study was undertaken in Europe. The objective of the study was to evaluate prenatal detection of congenital heart defects (CHD) by routine ultrasonographic examination of the fetus. All congenital malformations suspected prenatally and all congenital malformations, including chromosome anomalies, confirmed at birth were identified from the Congenital Malformation Registers, including 20 registers from the following European countries: Austria, Croatia, Denmark, France, Germany, Italy, Lithuania, Spain, Switzerland, The Netherlands, UK and Ukrainia. These registries follow the same methodology. The study period was 1996,1998, 709,030 births were covered, and 8126 cases with congenital malformations were registered. If more than one cardiac malformation was present the case was coded as complex cardiac malformation. CHD were subdivided into ,isolated' when only a cardiac malformation was present and ,associated' when at least one other major extra cardiac malformation was present. The associated CHD were subdivided into chromosomal, syndromic non-chromosomal and multiple. The study comprised 761 associated CHD including 282 cases with multiple malformations, 375 cases with chromosomal anomalies and 104 cases with non-chromosomal syndromes. The proportion of prenatal diagnosis of associated CHD varied in relation to the ultrasound screening policies from 17.9% in countries without routine screening (The Netherlands and Denmark) to 46.0% in countries with only one routine fetal scan and 55.6% in countries with two or three routine fetal scans. The prenatal detection rate of chromosomal anomalies was 40.3% (151/375 cases). This rate for recognized syndromes and multiply malformed with CHD was 51.9% (54/104 cases) and 48.6% (137/282 cases), respectively; 150/229 Down syndrome (65.8%) were livebirths. Concerning the syndromic cases, the detection rate of deletion 22q11, situs anomalies and VATER association was 44.4%, 64.7% and 46.6%, respectively. In conclusion, the present study shows large regional variations in the prenatal detection rate of CHD with the highest rates in European regions with three screening scans. Prenatal diagnosis of CHD is significantly higher if associated malformations are present. Cardiac defects affecting the size of the ventricles have the highest detection rate. Mean gestational age at discovery was 20,24 weeks for the majority of associated cardiac defects. Copyright © 2001 John Wiley & Sons, Ltd. [source] A Pilot Study of Quantitative Aspiration in Patients with Symptoms of Obstructive Sleep Apnea: Comparison to a Historic Control Group,THE LARYNGOSCOPE, Issue 6 2004Michael Beal MD Abstract Objective: It has been shown that many healthy people aspirate secretions at night. Patients with obstructive sleep apnea (OSA) have frequent episodes of gasping at night that may predispose them to aspiration. The purpose of this study was to determine whether patients with symptoms of OSA are predisposed to pharyngeal aspiration. Study Design: A prospective study in which patients with symptoms of OSA were compared with a historic group of normal controls by using the same methodology. Methods: The study was offered to patients with symptoms of OSA undergoing a sleep study. The radiotracer Technicium99 was infused through a plastic tube placed in the nasopharynx after the patient achieved stage II sleep. A chest radionuclide scan determined the amount of material aspirated. The Wilcoxon-rank sum test was used to compare the mean amount aspirated between the experimental and historic control groups. Results: Fourteen patients successfully completed the study. One normal volunteer in our study aspirated a quantity similar to the historic normal control group. The amount of aspirated material in the study group ranged from 0.152 to 3.648 mL, with a mean of 1.24 mL ± 0.905 (SD). When compared with the historic normal control group, the patients with symptoms of OSA aspirated significantly more radio-tracer (P <.01). There was a lack of association between respiratory disturbance index and amount aspirated. Conclusions: The results suggest there is an apparent risk of increased pharyngeal aspiration in patients with symptoms of OSA. [source] Temporal changes in the island flora at different scales in the archipelago of SW FinlandAPPLIED VEGETATION SCIENCE, Issue 4 2010Jens-Johan Hannus Abstract Question: How have species richness and vegetation patterns changed in a group of islands in the northern Baltic Sea over a 58-yr period of changing land use and increasing eutrophication? Location: A group of 116 islands, the Brunskär sub-archipelago, in SW Finland. Methods: A complete survey of vascular plant species performed in 1947,1949 by Skult was repeated by our group using the same methodology in 2005,2007 (historical versus contemporary, respectively). DCAs were performed and total number of species, extinction,colonization rates, species frequency changes and mean Ellenberg indicator values for light, moisture and nitrogen and Eklund indicator values for dependence of human cultural influence were obtained for each island and relevé. Results: Species richness has declined on large islands and increased on small islands. The increase in number of species on small islands is driven by a strong increase in frequency of shore species, which in turn is induced by more productive shores. The decrease in species richness on large islands is related to overgrowth of open semi-natural habitats after cessation of grazing and other agricultural practices. Conclusions: After the late 1940s, open habitats, which were created and maintained by cattle grazing and other traditional agricultural activities, have declined in favour of woody shrub and forest land. Shores have been stabilized and influenced by the eutrophication of the Baltic Sea, and the vegetation has become more homogeneous. This development, resulting in lower species diversity, poses a challenge for the preservation of biodiversity both on a local and on a landscape level. [source] Decadal changes (1996,2006) in coastal ecosystems of the Chagos archipelago determined from rapid assessmentAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 6 2009Andrew R.G. Price Abstract 1.The atolls and islands comprising Chagos are a biodiversity hotspot of global conservation significance in a remote part of the central Indian Ocean. 2.This study examines the condition of the archipelago's coastal ecosystems by rapid environmental assessment at 21 sites/islands, which were also investigated a decade earlier using the same methodology. Major changes in ecosystem structure and environmental disturbance were determined. 3.Coral fish abundance was significantly lower in 2006 than 1996. Decrease in the physical structural complexity of the reefs, as a result of coral bleaching and mortality induced by the 1998 warming event, may have been a contributing factor. 4.Evidence of collecting/fishing was significantly greater in 2006 than 1996. This is attributed mainly to an illegal fishery for holothurians (sea cucumbers), which has expanded over recent years and now exerts substantial pressure on the resource. The significant decline observed in beach wood, a readily accessible fuel for fishing camps, is consistent with this. 5.Solid waste on islands was high (median 2 to 20 items m,1 beach) in both 1996 and 2006. Potentially harmful biological impacts, determined from other studies, include entanglement, toxic effects and provision of transport for invasives or other ,hitchhiker' species. 6.Significantly higher bird abundances were recorded in protected areas than ,unprotected' areas, attributed mainly to absence of predation by rats. 7.Rapid assessment augments more comprehensive ecosystem investigations. It provides a valuable snapshot of environmental conditions based upon a broad suite of features (ecosystems and disturbances) determined, concurrently, within the same site inspection quadrats and using the same scale of assessment. Copyright © 2009 John Wiley & Sons, Ltd. [source] Prevalence of Parkinson's disease in SydneyACTA NEUROLOGICA SCANDINAVICA, Issue 1 2005D. K. Y. Chan Objective,,, To examine the prevalence of Parkinson's disease (PD) in Bankstown, Sydney, using the same methodology as a previous study in Randwick, Sydney, Australia (1998,1999). Participants and methods,,, Twenty census districts (CDs) for the Bankstown local government area were randomly selected. Research personnel door-knocked every household within the CDs to locate people aged ,55 years. A structured questionnaire (containing four screening questions for PD) was administered to those agreeing to participate. Screened positive participants were invited to come for a clinical examination. This is a continuation of the previous study and data have been combined. Results,,, Combining data for Bankstown and Randwick gave 1028 participants; crude prevalence, 780 per 100,000 (CI: 546,1077). In Bankstown, there were 501 participants aged ,55 years (response rate 70%); 135 were screened positive with 101 (74.8%) agreeing to a clinical examination. The prevalence of PD in the Bankstown community was 3.4% (17 of 501) (95% CI: 1.98,5.43) for those aged ,55 years; crude prevalence 776 per 100,000 (CI: 452,1241). Conclusion,,, The combined results of two Sydney studies appear to indicate that Sydney has one of the highest prevalence estimates of PD in developed countries. [source] Does Playing Blindfold Chess Reduce the Quality of Game: Comments on Chabris and Hearst (2003)COGNITIVE SCIENCE - A MULTIDISCIPLINARY JOURNAL, Issue 1 2010Veljko Jeremic Abstract Blindfold chess is a special type of chess game where both the board and pieces are not visible to its players. This paper aims to determine whether the quality of the game played blindfolded is lower than when played under normal conditions. The best chess program was used to analyze games played by the world's top Grandmasters under both conditions. We have analyzed the Monaco 1993,1998 data set introduced by Chabris and Hearst (2003). The results showed that although a larger number of mistakes occurred while playing blindfolded, no significant statistical difference between the rapid and blindfold games has been found. Nevertheless, by applying the same methodology to the Monaco 2002,2007 data set a substantial difference between the blindfold and the rapid chess game was noticed. In this paper, we have addressed the possible improvement of the chess game quality and the advances in chess programs that may be responsible for detecting more blunders. [source] | |||||||||||||||||||||||||||||||