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Distribution by Scientific Domains

Engineering	33%

Selected Abstracts

Narcissistic Subtypes and Contingent Self-Esteem: Do All Narcissists Base Their Self-Esteem on the Same Domains?

JOURNAL OF PERSONALITY, Issue 4 2008
Virgil Zeigler-Hill
ABSTRACT It has been suggested that there are two forms of narcissism: a grandiose subtype and a vulnerable subtype. Although these forms of narcissism share certain similarities, it is believed that these subtypes may differ in the domains upon which their self-esteem is based. To explore this possibility, the present study examined the associations between these narcissistic subtypes and domain-specific contingencies of self-worth. The results show that vulnerable narcissism was positively associated with contingencies of self-worth across a variety of domains. In contrast, the associations between grandiose narcissism and domain-specific contingencies of self-worth were more complex and included both positive and negative relationships. These results provide additional support for the distinction between grandiose and vulnerable narcissism by showing that the domains of contingent self-esteem associated with grandiose narcissism may be more limited in scope than those associated with vulnerable narcissism. [source]

A picture says more than a thousand words: Structural insights into hepatitis C virus translation initiation,

HEPATOLOGY, Issue 6 2006
Pantxika Bellecave Ph.D.
Protein synthesis in mammalian cells requires initiation factor eIF3, a ,750-kilodalton complex that controls assembly of 40S ribosomal subunits on messenger RNAs (mRNAs) bearing either a 5,-cap or an internal ribosome entry site (IRES). Cryoelectron microscopy reconstructions show that eIF3, a five-lobed particle, interacts with the hepatitis C virus (HCV) IRES RNA and the 5,-cap binding complex eIF4F via the same domain. Detailed modeling of eIF3 and eIF4F onto the 40S ribosomal subunit reveals that eIF3 uses eIF4F or the HCV IRES in structurally similar ways to position the mRNA strand near the exit site of 40S, promoting initiation complex assembly. [source]

Performance analysis of different meteorological data and resolutions using MaScOD hydrological model

HYDROLOGICAL PROCESSES, Issue 16 2004
Roshan Shrestha
Abstract Distributed meteorological data collected from different sources are rarely identical within the same domain of space and time. Discrepancies of these data in magnitude, pattern, and resolution play an important role in hydrological simulation. Using four different sets of distributed meteorological data (from the HUBEX-Intense Observation Period and GAME experimental products at different resolutions), hydrological simulations are conducted through a distributed hydrological model called MaScOD (macro-scale OHyMoS assisted distributed) hydrological model. The model's performance is measured using 12 different indexes. Based on these indexes, a relative normalized score is calculated to evaluate the overall performance of the result from each data set. Three sub-basins of the Huaihe River basin in China, taking the cases at Bengbu (132 350 km2), Wangjiaba (29 844 km2) and Suiping (2093 km2), are used for numerical experiments. This study shows the competence of coarse-resolution meteorological data, the GAME reanalysis 1·25° data, to apply in hydrological simulations of large catchments. However, that data failed to simulate the hydrograph in smaller catchments. The results are significantly improved by including spatial variability at finer resolution in that data. Copyright © 2004 John Wiley & Sons, Ltd. [source]

Incorporating linguistic, probabilistic, and possibilistic information in a risk-based approach for ranking contaminated sites

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, Issue 4 2010
Kejiang Zhang
Abstract Different types of uncertain information,linguistic, probabilistic, and possibilistic,exist in site characterization. Their representation and propagation significantly influence the management of contaminated sites. In the absence of a framework with which to properly represent and integrate these quantitative and qualitative inputs together, decision makers cannot fully take advantage of the available and necessary information to identify all the plausible alternatives. A systematic methodology was developed in the present work to incorporate linguistic, probabilistic, and possibilistic information into the Preference Ranking Organization METHod for Enrichment Evaluation (PROMETHEE), a subgroup of Multi-Criteria Decision Analysis (MCDA) methods for ranking contaminated sites. The identification of criteria based on the paradigm of comparative risk assessment provides a rationale for risk-based prioritization. Uncertain linguistic, probabilistic, and possibilistic information identified in characterizing contaminated sites can be properly represented as numerical values, intervals, probability distributions, and fuzzy sets or possibility distributions, and linguistic variables according to their nature. These different kinds of representation are first transformed into a 2-tuple linguistic representation domain. The propagation of hybrid uncertainties is then carried out in the same domain. This methodology can use the original site information directly as much as possible. The case study shows that this systematic methodology provides more reasonable results. Integr Environ Assess Manag 2010;6:711,724. © 2010 SETAC [source]

Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase

ACTA CRYSTALLOGRAPHICA SECTION D, Issue 7 2002
Patricia A. Elkins
The X-ray crystal structure of the proform of human matrix metalloproteinase MMP9 has been solved to 2.5,Å resolution. The construct includes the prodomain, the catalytic domain and three FnII (fibronectin type II) domains. The prodomain is inserted into the active-site cleft, blocking access to the catalytic zinc. Comparison with the crystal structure of the most closely related MMP, MMP2, indicates that the conformations of residues in the active-site cleft and in the cysteine-switch peptide of the prodomain are highly conserved and that design of MMP9-specific inhibitors will be challenging. In common with MMP2, the MMP9 S1, inhibitor-binding pocket is large compared with that of other MMPs. One small point of difference in the S1, binding pockets of MMP9 and MMP2 may provide an opportunity to explore the design of specific inhibitors. The side chain of Arg424 in MMP9 is angled slightly away from the S1, pocket when compared with the corresponding residue in MMP2, Thr424. The secondary structure of the FnII domains is conserved between the two closely related MMPs, although the second FnII domain makes no contact with the catalytic domain in MMP9, while the same domain in MMP2 has a substantial area of interaction with the catalytic domain. [source]

Automated software development with XML and the Java* language

BELL LABS TECHNICAL JOURNAL, Issue 2 2000
Glenn R. Bruns
In software development with domain-specific languages (DSLs), one defines a requirements language for an application domain and then develops a compiler to generate an implementation from a requirements document. Because DSLs and DSL compilers are expensive to develop, DSLs are seen as cost effective only when many products of the same domain will be developed. In this paper, we show how the cost of DSL design and DSL compiler development can be reduced by defining DSLs as Extensible-Markup-Language (XML) dialects and by developing DSL compilers using commercial XML tools and the Java* language. This approach is illustrated through the Call View Data Language (CDL), a new DSL that generates provisioning support code and database table definitions for Lucent Technologies' 7R/EÔ Network Feature Server. [source]